JP5401639B2 - タンパク質チロシンキナーゼ７（ｐｔｋ７）に対するヒトモノクローナル抗体およびそれらの使用 - Google Patents

タンパク質チロシンキナーゼ７（ｐｔｋ７）に対するヒトモノクローナル抗体およびそれらの使用 Download PDF

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JP5401639B2
JP5401639B2 JP2008544528A JP2008544528A JP5401639B2 JP 5401639 B2 JP5401639 B2 JP 5401639B2 JP 2008544528 A JP2008544528 A JP 2008544528A JP 2008544528 A JP2008544528 A JP 2008544528A JP 5401639 B2 JP5401639 B2 JP 5401639B2
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antibody
seq
variable region
chain variable
ptk7
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JP2009518039A (ja
JP2009518039A5 (enExample
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リ−シェン ルー，
ジョナサン アレクサンダー テレット，
チン パン，
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メダレックス エル．エル．シー．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2008544528A 2005-12-08 2006-12-08 タンパク質チロシンキナーゼ７（ｐｔｋ７）に対するヒトモノクローナル抗体およびそれらの使用 Expired - Fee Related JP5401639B2 (ja)

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US74837305P 2005-12-08 2005-12-08
US60/748,373 2005-12-08
PCT/US2006/046837 WO2007067730A2 (en) 2005-12-08 2006-12-08 Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use

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JP2009518039A JP2009518039A (ja) 2009-05-07
JP2009518039A5 JP2009518039A5 (enExample) 2010-02-04
JP5401639B2 true JP5401639B2 (ja) 2014-01-29

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CN (1) CN101360761B (enExample)
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CA (1) CA2632552C (enExample)
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EA (1) EA017812B1 (enExample)
ES (1) ES2406063T3 (enExample)
IL (1) IL191788A (enExample)
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NO (1) NO20082559L (enExample)
NZ (2) NZ569236A (enExample)
PL (1) PL1957539T3 (enExample)
PT (1) PT1957539E (enExample)
RS (1) RS52804B (enExample)
SG (1) SG177194A1 (enExample)
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SG177194A1 (en) 2012-01-30
US9505845B2 (en) 2016-11-29
ES2406063T3 (es) 2013-06-05
BRPI0619582A2 (pt) 2012-12-11
US20100034826A1 (en) 2010-02-11
PL1957539T3 (pl) 2013-08-30
HK1121174A1 (en) 2009-04-17
CN101360761A (zh) 2009-02-04
US9102738B2 (en) 2015-08-11
CA2632552C (en) 2015-02-03
JP2009518039A (ja) 2009-05-07
WO2007067730A3 (en) 2007-11-01
NO20082559L (no) 2008-07-07
KR101373464B1 (ko) 2014-03-14
EA200801509A1 (ru) 2008-12-30
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CN101360761B (zh) 2012-09-12
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CA2632552A1 (en) 2007-06-14
EP1957539B1 (en) 2013-04-17
AU2006321841B2 (en) 2012-08-30
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US20120219557A1 (en) 2012-08-30
WO2007067730A2 (en) 2007-06-14
PT1957539E (pt) 2013-06-25
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EP1957539A2 (en) 2008-08-20
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