JP5191884B2 - キトサンおよびシクロデキストリンを含んでなるナノ粒子 - Google Patents

キトサンおよびシクロデキストリンを含んでなるナノ粒子 Download PDF

Info

Publication number
JP5191884B2
JP5191884B2 JP2008514129A JP2008514129A JP5191884B2 JP 5191884 B2 JP5191884 B2 JP 5191884B2 JP 2008514129 A JP2008514129 A JP 2008514129A JP 2008514129 A JP2008514129 A JP 2008514129A JP 5191884 B2 JP5191884 B2 JP 5191884B2
Authority
JP
Japan
Prior art keywords
cyclodextrin
chitosan
nanoparticles
biologically active
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008514129A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008542342A5 (https=
JP2008542342A (ja
Inventor
マリア、ホセ、アロンソ、フェルナンデス
マルコス、フエンテス、ガルシア
フランセスカ、マエストレリ
パオラ、ムラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Santiago de Compostela
Original Assignee
Universidade de Santiago de Compostela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade de Santiago de Compostela filed Critical Universidade de Santiago de Compostela
Publication of JP2008542342A publication Critical patent/JP2008542342A/ja
Publication of JP2008542342A5 publication Critical patent/JP2008542342A5/ja
Application granted granted Critical
Publication of JP5191884B2 publication Critical patent/JP5191884B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2008514129A 2005-06-02 2006-06-01 キトサンおよびシクロデキストリンを含んでなるナノ粒子 Expired - Fee Related JP5191884B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP200501331 2005-06-02
ES200501331A ES2277743B2 (es) 2005-06-02 2005-06-02 Nanoparticulas que comprenden quitosano y ciclodextrina.
PCT/ES2006/000322 WO2006128937A2 (es) 2005-06-02 2006-06-01 Nanoparticulas que comprenden quitosano y ciclodextrina

Publications (3)

Publication Number Publication Date
JP2008542342A JP2008542342A (ja) 2008-11-27
JP2008542342A5 JP2008542342A5 (https=) 2009-07-16
JP5191884B2 true JP5191884B2 (ja) 2013-05-08

Family

ID=37482018

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008514129A Expired - Fee Related JP5191884B2 (ja) 2005-06-02 2006-06-01 キトサンおよびシクロデキストリンを含んでなるナノ粒子

Country Status (11)

Country Link
US (1) US20080220030A1 (https=)
EP (1) EP1891943A2 (https=)
JP (1) JP5191884B2 (https=)
KR (1) KR20080019014A (https=)
CN (1) CN101217947B (https=)
AU (1) AU2006254128A1 (https=)
BR (1) BRPI0613234A2 (https=)
CA (1) CA2610403A1 (https=)
ES (1) ES2277743B2 (https=)
IL (1) IL187696A0 (https=)
WO (1) WO2006128937A2 (https=)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2310122B1 (es) * 2007-04-20 2009-10-30 Instituto Cientifico Y Tecnologico De Navarra, S.A Nanoparticulas que comprenden una ciclodextrina y una molecula biologicamente activa y sus aplicaciones.
US20110064664A1 (en) * 2007-10-08 2011-03-17 The Board Of Regents Of The University Of Texas System Methods and compositions involving chitosan nanoparticles
UA90013C2 (ru) * 2008-03-19 2010-03-25 Давид Анатолійович Нога Фармацевтическая композиция, содержащая инсулин, и способ его получения
TWI328565B (en) * 2008-12-19 2010-08-11 Taiwan Textile Res Inst Dispersions of conductive carbon materials and methods for preparing the same
JP5841044B2 (ja) * 2009-03-23 2016-01-06 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． 複合糖質ワクチン
JP5804453B2 (ja) * 2009-05-14 2015-11-04 国立大学法人 東京大学 結晶性ポリオール微粒子及びその調製方法
CN102481360B (zh) * 2009-06-25 2015-06-17 生物领先公司 包含聚γ谷氨酸-壳聚糖纳米颗粒的佐剂组合物
US8372877B2 (en) 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
CN102008450B (zh) * 2010-12-10 2013-01-30 杭州艾瑞莎生物医药科技有限公司 一种药物-环糊精纳米颗粒及其制备方法
CN102416000B (zh) * 2011-12-13 2013-04-10 张维芬 一种用于肺吸入的壳聚糖季铵盐大孔微球及其制备方法
FR2989001B1 (fr) * 2012-04-06 2017-07-21 Centre Nat Rech Scient Microparticules et nanoparticules constituees de polysaccharides hydrophobises et d'une alpha-cyclodextrine
CN102908315B (zh) * 2012-11-02 2014-06-04 上海现代药物制剂工程研究中心有限公司 小分子干扰核糖核酸的壳聚糖纳米粒传递系统及制备方法
JP2016510001A (ja) * 2013-02-21 2016-04-04 マサチューセッツ インスティテュート オブ テクノロジー シスプラチン充填キトサンナノ粒子を含む標的化された頬側送達
FR3006315B1 (fr) 2013-05-31 2015-10-02 Centre Nat Rech Scient Microparticules et nanoparticules auto-associatives composees de proteines
FR3011470B1 (fr) * 2013-10-09 2017-01-06 Centre Nat De La Rech Scient (Cnrs) Composition antifongique comprenant un agent antifongique et du chitosane hydrophobise
US20160046732A1 (en) * 2014-08-15 2016-02-18 Empire Technology Development Llc Aseptic polymeric compositions and methods of using the same
WO2016066864A1 (es) 2014-10-30 2016-05-06 Innovaciones Fisicas Y Quimicas Sostenibles, S.L. Nanopartículas para la liberación controlada de ingredientes activos
CN104738815B (zh) * 2015-02-11 2018-01-30 浙江中烟工业有限责任公司 一种降低卷烟烟气中苯酚的纳米环糊精复合添加剂及其制备方法和应用
CN104720108B (zh) * 2015-02-11 2018-01-30 浙江中烟工业有限责任公司 一种纳米环糊精复合添加剂及其制备方法和应用
CA3015172A1 (en) 2016-02-18 2017-08-24 Privo Technologies, Inc. Two-stage microparticle-based therapeutic delivery system and method
WO2018081291A1 (en) * 2016-10-25 2018-05-03 Washington University Nanoparticle compositions comprising cd38 and methods of use thereof
CN106822914A (zh) * 2017-01-10 2017-06-13 安徽师范大学 一种羧甲基‑β‑环糊精接枝壳聚糖离子交联纳米粒、制备方法及其应用
WO2018151849A1 (en) 2017-02-17 2018-08-23 Privo Technologies, Inc. Particle-based multi-layer therapeutic delivery device and method
US10478403B1 (en) 2017-05-03 2019-11-19 Privo Technologies, Inc. Intraoperative topically-applied non-implantable rapid release patch
US11623202B2 (en) * 2017-05-18 2023-04-11 Agency For Science, Technology And Research Composite structure and method of forming the same
US20200338011A1 (en) * 2017-10-20 2020-10-29 The General Hospital Corporation Macrophage Targeted Immunotherapeutics
CN110522921A (zh) * 2018-05-24 2019-12-03 广东省医疗器械研究所 一种具有胰岛素捕获功能的胰岛素输运体系的合成方法
CN108849995B (zh) * 2018-06-12 2020-06-30 甘肃省科学院生物研究所 黄帚橐吾提取物纳米杀虫剂及其制备方法
CN109012629B (zh) * 2018-08-16 2021-07-30 南京大学 一种制备磁性羧甲基β-环糊精聚合物的方法及其应用
KR102034982B1 (ko) 2019-03-08 2019-10-21 주식회사 제론바이오 Pdrn이 캡슐화된 키토산 나노 입자가 포함된 점안제 및 이의 제조 방법
CN109908367A (zh) * 2019-04-30 2019-06-21 南开大学 磺胺酸-β-环糊精介导的超分子纳米粒子在胰岛素的控制释放方面的应用
CN110384684B (zh) * 2019-08-26 2021-04-06 安徽农业大学 一种单羧基壳聚糖/紫草素复合纳米颗粒及其制备方法
KR102904096B1 (ko) * 2019-12-06 2025-12-24 (주) 에이치엔에이파마켐 공유결합성 유기 골격체 및 폴리머를 이용한 경피전달용 복합체
JP7319931B2 (ja) * 2020-01-22 2023-08-02 オリエンタル酵母工業株式会社 キトサン部分分解物の安定化方法、キトサン部分分解物の保存方法および食品用保存剤
KR102172667B1 (ko) * 2020-02-05 2020-11-02 이채현 덱스트린 글루코노 락톤 술폰 유도체의 제조 방법 및 약제학적 조성물 이를 이용한 동물, 인간, 어류 등의 바이러스 질환 예방 및 치료제
CN111437381B (zh) * 2020-02-13 2023-12-12 汕头大学 一种水凝胶微粒及其制备方法
CN112843336B (zh) * 2021-03-04 2022-10-25 首都医科大学 一种促进牙本质再生的纳米颗粒、凝胶及其制备方法和应用
KR20240041285A (ko) 2021-06-01 2024-03-29 프리보 테크놀로지스, 인코포레이티드 향상된 2단계 미세입자 기반 국소 치료제 전달 시스템
CN113773161B (zh) * 2021-10-12 2022-12-09 龙蟒大地农业有限公司 一种圆颗粒钾肥及其制备方法
CN113995834A (zh) * 2021-11-08 2022-02-01 江南大学 一种基于环糊精接枝壳聚糖的疫苗、制备方法及应用
CN114176157A (zh) * 2021-11-15 2022-03-15 安佑生物科技集团股份有限公司 一种抑制畜禽球虫的绿色添加剂、制备方法及应用
CN114904493B (zh) * 2022-03-31 2024-09-06 中科院广州化学有限公司 一种离子交联β-环糊精聚合物及其制备方法与应用
CN114451426B (zh) * 2022-04-13 2022-07-15 山东健源生物科技有限公司 用于畜禽环境改良的消毒抑菌生物复合制剂及其制备方法
CN115595809A (zh) * 2022-10-25 2023-01-13 东莞市伊时针织印花有限公司（Cn） 一种用于蛋白质纤维织物的酸性染料及其制备方法
AU2023420130A1 (en) * 2022-12-30 2025-08-14 Cornell University Acid cyclodextrins for the treatment of lipofuscin buildups and ocular diseases
CN116515147A (zh) * 2023-05-24 2023-08-01 江南大学 一种拓扑型环糊精/壳聚糖复合膜及其制备方法与应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US619757A (en) 1899-02-21 Knockdown or collapsible box
US5215756A (en) * 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution
DE59107006D1 (de) * 1990-04-25 1996-01-18 Hoechst Ag Pharmakologische Zubereitung, enthaltend Polyelektrolytkomplexe in mikropartikulärer Form und mindestens einen Wirkstoff.
IT1246188B (it) 1990-07-27 1994-11-16 Resa Farma Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute.
CN1037232C (zh) * 1992-09-04 1998-02-04 付伟 β-常温保鲜剂
NZ262679A (en) 1993-02-22 1997-08-22 Vivorx Pharmaceuticals Inc Compositions for in vivo delivery of pharmaceutical agents where the agents are contained in a polymeric shell
US5843347A (en) * 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
US5849327A (en) * 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
GB9416884D0 (en) * 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
JP3699141B2 (ja) 1994-09-24 2005-09-28 伸彦 由井 超分子構造の生体内分解性医薬高分子集合体及びその調製方法
US5686113A (en) * 1995-03-21 1997-11-11 Temple University Of The Commonwealth System Of Higher Education Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses
WO1997004747A1 (en) 1995-07-27 1997-02-13 Dunn James M Drug delivery systems for macromolecular drugs
ES2114502B1 (es) * 1996-07-29 1999-07-01 Univ Santiago Compostela Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas.
US6649192B2 (en) 1996-07-29 2003-11-18 Universidade De Santiago De Compostela Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms
GB9711643D0 (en) * 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
DE69921773D1 (de) * 1998-01-16 2004-12-16 Univ Johns Hopkins Orale verabreichung von nukleinsäure-impstoffen durch partikelkomplexe
WO1999061062A1 (en) 1998-05-29 1999-12-02 Massachusetts Institute Of Technology Cyclodextrin complexes
US6630169B1 (en) 1999-03-31 2003-10-07 Nektar Therapeutics Particulate delivery systems and methods of use
TR200103613T2 (tr) 1999-06-16 2004-08-23 Nastech Pharmaceutical Co., Inc. Burun içinden tatbik edilen morfini içeren farmasötik formülasyonlar ve yöntemler.
US7030097B1 (en) * 1999-07-14 2006-04-18 Cornell Research Foundation, Inc. Controlled nucleic acid delivery systems
HU229705B1 (en) * 2000-02-08 2014-05-28 Euro Celtique Sa Tamper-resistant oral opioid agonist formulations
US6497901B1 (en) 2000-11-02 2002-12-24 Royer Biomedical, Inc. Resorbable matrices for delivery of bioactive compounds
JP4593846B2 (ja) * 2001-09-07 2010-12-08 信越化学工業株式会社 医薬品又は食品用マイクロカプセルの製造方法
FR2830017B1 (fr) 2001-09-27 2005-11-04 Centre Nat Rech Scient Materiau compose d'au moins un polymere biodegradable et de cyclodextrines
JP3908969B2 (ja) * 2002-03-18 2007-04-25 ピアス株式会社 化粧料
FR2841137B1 (fr) * 2002-06-20 2004-08-13 Bioalliance Pharma Systeme de vectorisation comprenant des nanoparticules de taille homogene d'au moins un polymere et d'au moins un polysaccharide charge positivement
FR2842106B1 (fr) * 2002-07-11 2006-07-14 Centre Nat Rech Scient Dispersions aqueuses de particules nanometriques ou micrometriques pour l'encapsulation de composes chimiques
CN1255433C (zh) * 2002-10-15 2006-05-10 浙江大学 壳聚糖－β－环糊精树脂的制备方法
WO2004096998A2 (en) * 2003-04-29 2004-11-11 Vanderbilt University Nanoparticular tumor targeting and therapy
JP4747256B2 (ja) * 2003-11-04 2011-08-17 Ｊｎｃ株式会社 複合刺激応答材料

Also Published As

Publication number Publication date
KR20080019014A (ko) 2008-02-29
CN101217947A (zh) 2008-07-09
ES2277743B2 (es) 2008-12-16
ES2277743A1 (es) 2007-07-16
AU2006254128A1 (en) 2006-12-07
EP1891943A2 (en) 2008-02-27
WO2006128937A3 (es) 2007-02-15
JP2008542342A (ja) 2008-11-27
CA2610403A1 (en) 2006-12-07
US20080220030A1 (en) 2008-09-11
CN101217947B (zh) 2012-04-25
WO2006128937A2 (es) 2006-12-07
BRPI0613234A2 (pt) 2010-12-28
IL187696A0 (en) 2008-08-07

Similar Documents

Publication Publication Date Title
JP5191884B2 (ja) キトサンおよびシクロデキストリンを含んでなるナノ粒子
Singh et al. Alginate based nanoparticles and its application in drug delivery systems
Matalqah et al. Chitosan nanoparticles as a novel drug delivery system: a review article
JP4959326B2 (ja) ヒアルロン酸ナノ粒子
Desai Chitosan nanoparticles prepared by ionotropic gelation: An overview of recent advances
JP4651192B2 (ja) 少なくとも一つの重合体および一つ又は複数の有効成分と複合体を形成できる少なくとも一つの化合物から成るナノ粒子およびその製造方法
Gonzalez-Gaitano et al. Drug carrier systems based on cyclodextrin supramolecular assemblies and polymers: present and perspectives
US20110142890A1 (en) Nanoparticles of chitosan and hyaluronan for the administration of active molecules
US20170319506A1 (en) Shear-thinning self-healing networks
US20100092572A1 (en) Chitosan-based colloidal particles for rna delivery
JP2002504526A5 (https=)
Rajan et al. Potential drug delivery applications of chitosan based nanomaterials
CN108102006A (zh) 可交联的两亲性天然多糖及其应用
JP2009511549A (ja) キトサンおよびヘパリンナノ粒子
CN101448489A (zh) 用于活性分子给药的壳聚糖和乙酰透明质酸的纳米颗粒
US20030170313A1 (en) Micro-particulate and nano-particulate polymeric delivery system
Celia Monteiro de Paula et al. Polysaccharide based copolymers as supramolecular systems in biomedical applications
Leyva-Gómez et al. Natural polymers in pharmaceutical nanotechnology
Babaei et al. Fabrication and evaluation of gelatin nanoparticles for delivering of anti-cancer drug
Hooda et al. Chitosan nanoparticles: A marine polysaccharide for biomedical research
Pérez-Álvarez et al. Chitosan-based nanogels for biomedical applications
Khan Gelatin nanoparticles as potential nanocarriers for macromolecular drugs
Khan et al. Design and structure of polysaccharide-based nanoparticles: state of the art
Borumand et al. Preparation of Sodium Alginate Nanoparticles Containing Bovin Serum Albomin (BSA)
Vedavahini et al. Comparative Study of Chitosan and Carboxy Methyl Chitosan Nanoparticles in Mefenamic Acid Drug Delivery.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090601

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090601

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20120229

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120313

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120612

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120720

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121017

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130104

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130130

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160208

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees