JP2008542342A5 - - Google Patents
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- Publication number
- JP2008542342A5 JP2008542342A5 JP2008514129A JP2008514129A JP2008542342A5 JP 2008542342 A5 JP2008542342 A5 JP 2008542342A5 JP 2008514129 A JP2008514129 A JP 2008514129A JP 2008514129 A JP2008514129 A JP 2008514129A JP 2008542342 A5 JP2008542342 A5 JP 2008542342A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- chitosan
- derivative
- active molecule
- biologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000858 Cyclodextrin Polymers 0.000 claims 15
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 12
- 229920001661 Chitosan Polymers 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 8
- 239000002105 nanoparticle Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000012736 aqueous medium Substances 0.000 claims 4
- 239000002798 polar solvent Substances 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 239000002537 cosmetic Substances 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 claims 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims 1
- 208000001840 Dandruff Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 229920000388 Polyphosphate Polymers 0.000 claims 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 239000006096 absorbing agent Substances 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 239000000058 anti acne agent Substances 0.000 claims 1
- 230000001166 anti-perspirative effect Effects 0.000 claims 1
- 229940124340 antiacne agent Drugs 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000003213 antiperspirant Substances 0.000 claims 1
- 229960004853 betadex Drugs 0.000 claims 1
- -1 carboxymethyl Cyclodextrin Chemical compound 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 229940097362 cyclodextrins Drugs 0.000 claims 1
- 230000006196 deacetylation Effects 0.000 claims 1
- 238000003381 deacetylation reaction Methods 0.000 claims 1
- 239000002781 deodorant agent Substances 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 229960003883 furosemide Drugs 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 239000001205 polyphosphate Substances 0.000 claims 1
- 235000011176 polyphosphates Nutrition 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 235000019832 sodium triphosphate Nutrition 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 1
- 229960003500 triclosan Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP200501331 | 2005-06-02 | ||
| ES200501331A ES2277743B2 (es) | 2005-06-02 | 2005-06-02 | Nanoparticulas que comprenden quitosano y ciclodextrina. |
| PCT/ES2006/000322 WO2006128937A2 (es) | 2005-06-02 | 2006-06-01 | Nanoparticulas que comprenden quitosano y ciclodextrina |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542342A JP2008542342A (ja) | 2008-11-27 |
| JP2008542342A5 true JP2008542342A5 (https=) | 2009-07-16 |
| JP5191884B2 JP5191884B2 (ja) | 2013-05-08 |
Family
ID=37482018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008514129A Expired - Fee Related JP5191884B2 (ja) | 2005-06-02 | 2006-06-01 | キトサンおよびシクロデキストリンを含んでなるナノ粒子 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080220030A1 (https=) |
| EP (1) | EP1891943A2 (https=) |
| JP (1) | JP5191884B2 (https=) |
| KR (1) | KR20080019014A (https=) |
| CN (1) | CN101217947B (https=) |
| AU (1) | AU2006254128A1 (https=) |
| BR (1) | BRPI0613234A2 (https=) |
| CA (1) | CA2610403A1 (https=) |
| ES (1) | ES2277743B2 (https=) |
| IL (1) | IL187696A0 (https=) |
| WO (1) | WO2006128937A2 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2310122B1 (es) * | 2007-04-20 | 2009-10-30 | Instituto Cientifico Y Tecnologico De Navarra, S.A | Nanoparticulas que comprenden una ciclodextrina y una molecula biologicamente activa y sus aplicaciones. |
| US20110064664A1 (en) * | 2007-10-08 | 2011-03-17 | The Board Of Regents Of The University Of Texas System | Methods and compositions involving chitosan nanoparticles |
| UA90013C2 (ru) * | 2008-03-19 | 2010-03-25 | Давид Анатолійович Нога | Фармацевтическая композиция, содержащая инсулин, и способ его получения |
| TWI328565B (en) * | 2008-12-19 | 2010-08-11 | Taiwan Textile Res Inst | Dispersions of conductive carbon materials and methods for preparing the same |
| JP5841044B2 (ja) * | 2009-03-23 | 2016-01-06 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 複合糖質ワクチン |
| JP5804453B2 (ja) * | 2009-05-14 | 2015-11-04 | 国立大学法人 東京大学 | 結晶性ポリオール微粒子及びその調製方法 |
| CN102481360B (zh) * | 2009-06-25 | 2015-06-17 | 生物领先公司 | 包含聚γ谷氨酸-壳聚糖纳米颗粒的佐剂组合物 |
| US8372877B2 (en) | 2010-04-16 | 2013-02-12 | Cumberland Pharmaceuticals | Stabilized statin formulations |
| CN102008450B (zh) * | 2010-12-10 | 2013-01-30 | 杭州艾瑞莎生物医药科技有限公司 | 一种药物-环糊精纳米颗粒及其制备方法 |
| CN102416000B (zh) * | 2011-12-13 | 2013-04-10 | 张维芬 | 一种用于肺吸入的壳聚糖季铵盐大孔微球及其制备方法 |
| FR2989001B1 (fr) * | 2012-04-06 | 2017-07-21 | Centre Nat Rech Scient | Microparticules et nanoparticules constituees de polysaccharides hydrophobises et d'une alpha-cyclodextrine |
| CN102908315B (zh) * | 2012-11-02 | 2014-06-04 | 上海现代药物制剂工程研究中心有限公司 | 小分子干扰核糖核酸的壳聚糖纳米粒传递系统及制备方法 |
| JP2016510001A (ja) * | 2013-02-21 | 2016-04-04 | マサチューセッツ インスティテュート オブ テクノロジー | シスプラチン充填キトサンナノ粒子を含む標的化された頬側送達 |
| FR3006315B1 (fr) | 2013-05-31 | 2015-10-02 | Centre Nat Rech Scient | Microparticules et nanoparticules auto-associatives composees de proteines |
| FR3011470B1 (fr) * | 2013-10-09 | 2017-01-06 | Centre Nat De La Rech Scient (Cnrs) | Composition antifongique comprenant un agent antifongique et du chitosane hydrophobise |
| US20160046732A1 (en) * | 2014-08-15 | 2016-02-18 | Empire Technology Development Llc | Aseptic polymeric compositions and methods of using the same |
| WO2016066864A1 (es) | 2014-10-30 | 2016-05-06 | Innovaciones Fisicas Y Quimicas Sostenibles, S.L. | Nanopartículas para la liberación controlada de ingredientes activos |
| CN104738815B (zh) * | 2015-02-11 | 2018-01-30 | 浙江中烟工业有限责任公司 | 一种降低卷烟烟气中苯酚的纳米环糊精复合添加剂及其制备方法和应用 |
| CN104720108B (zh) * | 2015-02-11 | 2018-01-30 | 浙江中烟工业有限责任公司 | 一种纳米环糊精复合添加剂及其制备方法和应用 |
| CA3015172A1 (en) | 2016-02-18 | 2017-08-24 | Privo Technologies, Inc. | Two-stage microparticle-based therapeutic delivery system and method |
| WO2018081291A1 (en) * | 2016-10-25 | 2018-05-03 | Washington University | Nanoparticle compositions comprising cd38 and methods of use thereof |
| CN106822914A (zh) * | 2017-01-10 | 2017-06-13 | 安徽师范大学 | 一种羧甲基‑β‑环糊精接枝壳聚糖离子交联纳米粒、制备方法及其应用 |
| WO2018151849A1 (en) | 2017-02-17 | 2018-08-23 | Privo Technologies, Inc. | Particle-based multi-layer therapeutic delivery device and method |
| US10478403B1 (en) | 2017-05-03 | 2019-11-19 | Privo Technologies, Inc. | Intraoperative topically-applied non-implantable rapid release patch |
| US11623202B2 (en) * | 2017-05-18 | 2023-04-11 | Agency For Science, Technology And Research | Composite structure and method of forming the same |
| US20200338011A1 (en) * | 2017-10-20 | 2020-10-29 | The General Hospital Corporation | Macrophage Targeted Immunotherapeutics |
| CN110522921A (zh) * | 2018-05-24 | 2019-12-03 | 广东省医疗器械研究所 | 一种具有胰岛素捕获功能的胰岛素输运体系的合成方法 |
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| CN109012629B (zh) * | 2018-08-16 | 2021-07-30 | 南京大学 | 一种制备磁性羧甲基β-环糊精聚合物的方法及其应用 |
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| CN109908367A (zh) * | 2019-04-30 | 2019-06-21 | 南开大学 | 磺胺酸-β-环糊精介导的超分子纳米粒子在胰岛素的控制释放方面的应用 |
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| CN113995834A (zh) * | 2021-11-08 | 2022-02-01 | 江南大学 | 一种基于环糊精接枝壳聚糖的疫苗、制备方法及应用 |
| CN114176157A (zh) * | 2021-11-15 | 2022-03-15 | 安佑生物科技集团股份有限公司 | 一种抑制畜禽球虫的绿色添加剂、制备方法及应用 |
| CN114904493B (zh) * | 2022-03-31 | 2024-09-06 | 中科院广州化学有限公司 | 一种离子交联β-环糊精聚合物及其制备方法与应用 |
| CN114451426B (zh) * | 2022-04-13 | 2022-07-15 | 山东健源生物科技有限公司 | 用于畜禽环境改良的消毒抑菌生物复合制剂及其制备方法 |
| CN115595809A (zh) * | 2022-10-25 | 2023-01-13 | 东莞市伊时针织印花有限公司（Cn） | 一种用于蛋白质纤维织物的酸性染料及其制备方法 |
| AU2023420130A1 (en) * | 2022-12-30 | 2025-08-14 | Cornell University | Acid cyclodextrins for the treatment of lipofuscin buildups and ocular diseases |
| CN116515147A (zh) * | 2023-05-24 | 2023-08-01 | 江南大学 | 一种拓扑型环糊精/壳聚糖复合膜及其制备方法与应用 |
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| IT1246188B (it) | 1990-07-27 | 1994-11-16 | Resa Farma | Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute. |
| CN1037232C (zh) * | 1992-09-04 | 1998-02-04 | 付伟 | β-常温保鲜剂 |
| NZ262679A (en) | 1993-02-22 | 1997-08-22 | Vivorx Pharmaceuticals Inc | Compositions for in vivo delivery of pharmaceutical agents where the agents are contained in a polymeric shell |
| US5843347A (en) * | 1993-03-23 | 1998-12-01 | Laboratoire L. Lafon | Extrusion and freeze-drying method for preparing particles containing an active ingredient |
| US5849327A (en) * | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
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| US5686113A (en) * | 1995-03-21 | 1997-11-11 | Temple University Of The Commonwealth System Of Higher Education | Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses |
| WO1997004747A1 (en) | 1995-07-27 | 1997-02-13 | Dunn James M | Drug delivery systems for macromolecular drugs |
| ES2114502B1 (es) * | 1996-07-29 | 1999-07-01 | Univ Santiago Compostela | Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas. |
| US6649192B2 (en) | 1996-07-29 | 2003-11-18 | Universidade De Santiago De Compostela | Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms |
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| DE69921773D1 (de) * | 1998-01-16 | 2004-12-16 | Univ Johns Hopkins | Orale verabreichung von nukleinsäure-impstoffen durch partikelkomplexe |
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| US7030097B1 (en) * | 1999-07-14 | 2006-04-18 | Cornell Research Foundation, Inc. | Controlled nucleic acid delivery systems |
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| JP3908969B2 (ja) * | 2002-03-18 | 2007-04-25 | ピアス株式会社 | 化粧料 |
| FR2841137B1 (fr) * | 2002-06-20 | 2004-08-13 | Bioalliance Pharma | Systeme de vectorisation comprenant des nanoparticules de taille homogene d'au moins un polymere et d'au moins un polysaccharide charge positivement |
| FR2842106B1 (fr) * | 2002-07-11 | 2006-07-14 | Centre Nat Rech Scient | Dispersions aqueuses de particules nanometriques ou micrometriques pour l'encapsulation de composes chimiques |
| CN1255433C (zh) * | 2002-10-15 | 2006-05-10 | 浙江大学 | 壳聚糖－β－环糊精树脂的制备方法 |
| WO2004096998A2 (en) * | 2003-04-29 | 2004-11-11 | Vanderbilt University | Nanoparticular tumor targeting and therapy |
| JP4747256B2 (ja) * | 2003-11-04 | 2011-08-17 | Ｊｎｃ株式会社 | 複合刺激応答材料 |
-
2005
- 2005-06-02 ES ES200501331A patent/ES2277743B2/es not_active Expired - Fee Related
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2006
- 2006-06-01 JP JP2008514129A patent/JP5191884B2/ja not_active Expired - Fee Related
- 2006-06-01 BR BRPI0613234-0A patent/BRPI0613234A2/pt not_active IP Right Cessation
- 2006-06-01 CN CN2006800208889A patent/CN101217947B/zh not_active Expired - Fee Related
- 2006-06-01 KR KR1020077029819A patent/KR20080019014A/ko not_active Ceased
- 2006-06-01 EP EP06778444A patent/EP1891943A2/en not_active Withdrawn
- 2006-06-01 AU AU2006254128A patent/AU2006254128A1/en not_active Abandoned
- 2006-06-01 WO PCT/ES2006/000322 patent/WO2006128937A2/es not_active Ceased
- 2006-06-01 US US11/916,283 patent/US20080220030A1/en not_active Abandoned
- 2006-06-01 CA CA002610403A patent/CA2610403A1/en not_active Abandoned
-
2007
- 2007-11-27 IL IL187696A patent/IL187696A0/en unknown
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