JP5137572B2 - 第四級塩であるccr2アンタゴニスト - Google Patents
第四級塩であるccr2アンタゴニスト Download PDFInfo
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- JP5137572B2 JP5137572B2 JP2007518228A JP2007518228A JP5137572B2 JP 5137572 B2 JP5137572 B2 JP 5137572B2 JP 2007518228 A JP2007518228 A JP 2007518228A JP 2007518228 A JP2007518228 A JP 2007518228A JP 5137572 B2 JP5137572 B2 JP 5137572B2
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- 229910052698 phosphorus Inorganic materials 0.000 description 1
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- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- DVWOYOSIEJRHKW-UIRZNSHLSA-M sodium (2S)-2-[[(2S)-2-[[(4,4-difluorocyclohexyl)-phenylmethoxy]carbonylamino]-4-methylpentanoyl]amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonate Chemical compound FC1(CCC(CC1)C(OC(=O)N[C@H](C(=O)N[C@H](C(S(=O)(=O)[O-])O)C[C@H]1C(NCC1)=O)CC(C)C)C1=CC=CC=C1)F.[Na+] DVWOYOSIEJRHKW-UIRZNSHLSA-M 0.000 description 1
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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| PCT/US2005/022034 WO2006012135A1 (en) | 2004-06-24 | 2005-06-22 | Quaternary salt ccr2 antagonists |
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| JP2008512348A JP2008512348A (ja) | 2008-04-24 |
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| US8168829B2 (en) * | 2007-10-26 | 2012-05-01 | Janssen Pharmaceutica N.V. | Synthesis of quaternary salt compounds |
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| BR112020020930A2 (pt) | 2018-04-11 | 2021-03-02 | Ohio State Innovation Foundation | composição de liberação de fármaco, método para tratar um distúrbio oftalmológico e kit |
| EP3833762A4 (en) | 2018-08-09 | 2022-09-28 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
| JP7413363B2 (ja) | 2018-09-07 | 2024-01-15 | サノフイ | メチル6-(2,4-ジクロロフェニル)-5-[4-[(3s)-1-(3-フルオロプロピル)ピロリジン-3-イル]オキシフェニル]-8,9-ジヒドロ-7h-ベンゾ[7]アヌレン-2-カルボキシレートの調製方法 |
| WO2021063967A1 (en) | 2019-10-01 | 2021-04-08 | Sanofi | Novel substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof |
| KR20220113695A (ko) | 2019-12-09 | 2022-08-16 | 사노피 | 7h-벤조[7]아눌렌-2-카르복실산 유도체의 결정질 형태 |
| TW202146007A (zh) | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司(alpelisib)與6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯啶-3-基]氧苯基]-8,9-二氫-7h-苯并[7]輪烯-2-羧酸之組合 |
| CN111808062B (zh) * | 2020-07-28 | 2022-09-13 | 遵义医科大学 | 一种蛇床子素磺酸酯类化合物及其应用 |
| WO2022084280A1 (en) | 2020-10-19 | 2022-04-28 | Sanofi | Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof |
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| JPH0873476A (ja) * | 1994-07-04 | 1996-03-19 | Takeda Chem Ind Ltd | ホスホン酸誘導体およびそれを含んでなる医薬 |
| JP4416198B2 (ja) * | 1997-12-19 | 2010-02-17 | 武田薬品工業株式会社 | アニリド誘導体、その製造法および用途 |
| US6166006A (en) * | 1997-12-19 | 2000-12-26 | Takeda Chemical Industries, Ltd. | Anilide derivative, production and use thereof |
| US6172061B1 (en) * | 1997-12-19 | 2001-01-09 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative |
| AU5301599A (en) | 1998-08-20 | 2000-03-14 | Takeda Chemical Industries Ltd. | Quaternary ammonium salts and their use |
| US6235771B1 (en) * | 1998-12-21 | 2001-05-22 | Takeda Chemical Industries, Ltd. | Anilide derivative, production and use thereof |
| JP2001058988A (ja) * | 1998-12-21 | 2001-03-06 | Takeda Chem Ind Ltd | アニリド誘導体、その製造法および用途 |
| JP2001026586A (ja) * | 1999-05-07 | 2001-01-30 | Takeda Chem Ind Ltd | 環状化合物およびその用途 |
| AU4145200A (en) * | 1999-05-07 | 2000-11-21 | Takeda Chemical Industries Ltd. | Cyclic compounds and uses thereof |
| AU1734401A (en) | 1999-12-09 | 2001-06-18 | Mitsubishi Pharma Corporation | Carboxyamido derivatives |
| EP1498138A1 (en) * | 2002-04-19 | 2005-01-19 | Takeda Pharmaceutical Company Limited | Preventives for hiv infection |
| JP2004043432A (ja) * | 2002-04-19 | 2004-02-12 | Takeda Chem Ind Ltd | Hiv感染予防剤 |
| JP4145230B2 (ja) * | 2002-11-01 | 2008-09-03 | 武田薬品工業株式会社 | 神経障害の予防・治療剤 |
| WO2006012135A1 (en) | 2004-06-24 | 2006-02-02 | Janssen Pharmaceutica, N. V. | Quaternary salt ccr2 antagonists |
| KR20070024646A (ko) | 2004-06-25 | 2007-03-02 | 바스프 악티엔게젤샤프트 | 트리아졸로피리미딘 화합물 및 그의 병원성 진균류 방제를위한 용도 |
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- 2005-06-22 AU AU2005267385A patent/AU2005267385B2/en not_active Ceased
- 2005-06-22 KR KR1020077001484A patent/KR101229416B1/ko not_active Expired - Fee Related
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- 2005-06-22 US US11/159,018 patent/US7799824B2/en active Active
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Also Published As
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|---|---|
| CA2571587A1 (en) | 2006-02-02 |
| EA012784B1 (ru) | 2009-12-30 |
| AU2005267385B2 (en) | 2011-11-10 |
| KR101229416B1 (ko) | 2013-02-05 |
| TW200612934A (en) | 2006-05-01 |
| BRPI0512623A (pt) | 2008-03-25 |
| ES2573845T3 (es) | 2016-06-10 |
| KR20070039062A (ko) | 2007-04-11 |
| CA2571587C (en) | 2013-02-12 |
| MX2007000036A (es) | 2007-05-18 |
| JP2008512348A (ja) | 2008-04-24 |
| NZ552173A (en) | 2010-07-30 |
| TWI407957B (zh) | 2013-09-11 |
| AU2005267385A1 (en) | 2006-02-02 |
| EA200700116A1 (ru) | 2007-06-29 |
| CN101010312A (zh) | 2007-08-01 |
| ZA200700677B (en) | 2008-09-25 |
| WO2006012135A1 (en) | 2006-02-02 |
| AR049652A1 (es) | 2006-08-23 |
| EP1765803A1 (en) | 2007-03-28 |
| NI200600319A (es) | 2007-08-22 |
| CN101010312B (zh) | 2011-04-20 |
| EP1765803B1 (en) | 2016-03-09 |
| US7799824B2 (en) | 2010-09-21 |
| IL180197A0 (en) | 2007-06-03 |
| ECSP067116A (es) | 2007-01-26 |
| NO20070387L (no) | 2007-03-20 |
| UA85597C2 (ru) | 2009-02-10 |
| US20060293379A1 (en) | 2006-12-28 |
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