JP5128274B2 - 長時間放出特性を有する生分解性眼インプラント - Google Patents

長時間放出特性を有する生分解性眼インプラント Download PDF

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Publication number
JP5128274B2
JP5128274B2 JP2007510790A JP2007510790A JP5128274B2 JP 5128274 B2 JP5128274 B2 JP 5128274B2 JP 2007510790 A JP2007510790 A JP 2007510790A JP 2007510790 A JP2007510790 A JP 2007510790A JP 5128274 B2 JP5128274 B2 JP 5128274B2
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Prior art keywords
implant
dexamethasone
release
polymer
active agent
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Expired - Fee Related
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JP2007510790A
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Japanese (ja)
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JP2007535535A (ja
JP2007535535A5 (https=
Inventor
ティエリー・ニバジョリ
シアー・ジェーン・グオ
キン・リン
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Allergan Inc
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Allergan Inc
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Publication of JP2007535535A5 publication Critical patent/JP2007535535A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2007510790A 2004-04-30 2005-04-14 長時間放出特性を有する生分解性眼インプラント Expired - Fee Related JP5128274B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/837,355 2004-04-30
US10/837,355 US8685435B2 (en) 2004-04-30 2004-04-30 Extended release biodegradable ocular implants
PCT/US2005/013143 WO2005110362A1 (en) 2004-04-30 2005-04-14 Biodegradable ocular implants with long-term release characteristics

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011216499A Division JP5552102B2 (ja) 2004-04-30 2011-09-30 長時間放出特性を有する生分解性眼インプラント
JP2012144950A Division JP2012207028A (ja) 2004-04-30 2012-06-28 長時間放出特性を有する生分解性眼インプラント

Publications (3)

Publication Number Publication Date
JP2007535535A JP2007535535A (ja) 2007-12-06
JP2007535535A5 JP2007535535A5 (https=) 2008-05-29
JP5128274B2 true JP5128274B2 (ja) 2013-01-23

Family

ID=34966124

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007510790A Expired - Fee Related JP5128274B2 (ja) 2004-04-30 2005-04-14 長時間放出特性を有する生分解性眼インプラント
JP2011216499A Expired - Lifetime JP5552102B2 (ja) 2004-04-30 2011-09-30 長時間放出特性を有する生分解性眼インプラント
JP2012144950A Pending JP2012207028A (ja) 2004-04-30 2012-06-28 長時間放出特性を有する生分解性眼インプラント
JP2014091044A Expired - Fee Related JP5706020B2 (ja) 2004-04-30 2014-04-25 生分解性眼インプラントの製造方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2011216499A Expired - Lifetime JP5552102B2 (ja) 2004-04-30 2011-09-30 長時間放出特性を有する生分解性眼インプラント
JP2012144950A Pending JP2012207028A (ja) 2004-04-30 2012-06-28 長時間放出特性を有する生分解性眼インプラント
JP2014091044A Expired - Fee Related JP5706020B2 (ja) 2004-04-30 2014-04-25 生分解性眼インプラントの製造方法

Country Status (10)

Country Link
US (6) US8685435B2 (https=)
EP (2) EP2777693A1 (https=)
JP (4) JP5128274B2 (https=)
AR (1) AR048773A1 (https=)
AU (1) AU2005244195B2 (https=)
BR (1) BRPI0509332A (https=)
CA (1) CA2565329C (https=)
ES (1) ES2501942T3 (https=)
TW (1) TW200603838A (https=)
WO (1) WO2005110362A1 (https=)

Families Citing this family (212)

* Cited by examiner, † Cited by third party
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