JP5122445B2 - 抗認知症薬物の経皮吸収製剤 - Google Patents

抗認知症薬物の経皮吸収製剤 Download PDF

Info

Publication number
JP5122445B2
JP5122445B2 JP2008514366A JP2008514366A JP5122445B2 JP 5122445 B2 JP5122445 B2 JP 5122445B2 JP 2008514366 A JP2008514366 A JP 2008514366A JP 2008514366 A JP2008514366 A JP 2008514366A JP 5122445 B2 JP5122445 B2 JP 5122445B2
Authority
JP
Japan
Prior art keywords
drug
meth
acrylate
ester
containing layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2008514366A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2007129427A1 (ja
Inventor
東 健 伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teikoku Seiyaku Co Ltd
Original Assignee
Teikoku Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Seiyaku Co Ltd filed Critical Teikoku Seiyaku Co Ltd
Publication of JPWO2007129427A1 publication Critical patent/JPWO2007129427A1/ja
Application granted granted Critical
Publication of JP5122445B2 publication Critical patent/JP5122445B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2008514366A 2006-05-08 2006-12-25 抗認知症薬物の経皮吸収製剤 Active JP5122445B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79829606P 2006-05-08 2006-05-08
US60/798,296 2006-05-08
PCT/JP2006/325813 WO2007129427A1 (ja) 2006-05-08 2006-12-25 抗認知症薬物の経皮吸収製剤

Publications (2)

Publication Number Publication Date
JPWO2007129427A1 JPWO2007129427A1 (ja) 2009-09-17
JP5122445B2 true JP5122445B2 (ja) 2013-01-16

Family

ID=38667540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008514366A Active JP5122445B2 (ja) 2006-05-08 2006-12-25 抗認知症薬物の経皮吸収製剤

Country Status (16)

Country Link
US (2) US7858114B2 (https=)
EP (1) EP2016939B1 (https=)
JP (1) JP5122445B2 (https=)
KR (1) KR20090009951A (https=)
CN (1) CN101460156B (https=)
AU (1) AU2006343077B2 (https=)
BR (1) BRPI0621655A2 (https=)
CA (1) CA2651596C (https=)
ES (1) ES2466647T3 (https=)
IL (1) IL195174A0 (https=)
IN (1) IN266817B (https=)
MY (1) MY149152A (https=)
NO (1) NO20084614L (https=)
NZ (1) NZ572809A (https=)
RU (1) RU2428179C2 (https=)
WO (1) WO2007129427A1 (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2452474C2 (ru) * 2006-12-01 2012-06-10 Нитто Денко Корпорейшн Стабилизированная адгезивная композиция, содержащая донепезил
US20100062045A1 (en) * 2006-12-01 2010-03-11 Nitto Denko Corporation Method for suppressing coloring of adhesive prepartion containing donepezil and method for reducing amounts of donepezil-related substances formed
AU2009229994B2 (en) * 2008-03-25 2015-04-16 Teikoku Seiyaku Co., Ltd. Transdermally absorbable preparation
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
CN102046171B (zh) * 2008-05-30 2013-06-19 日东电工株式会社 经皮吸收制剂
RU2481826C2 (ru) * 2008-05-30 2013-05-20 Нитто Денко Корпорейшн Содержащий донепезил адгезивный препарат и упаковка для него
JP2012504163A (ja) * 2008-09-30 2012-02-16 テイコク ファーマ ユーエスエー インコーポレーテッド 経皮持続送達ドネペジル組成物および該組成物を使用する方法
US8858983B2 (en) 2009-04-30 2014-10-14 Medtronic, Inc. Antioxidants and antimicrobial accessories including antioxidants
KR101325104B1 (ko) 2009-09-16 2013-11-07 주식회사 삼양바이오팜 경피 투여 제형 및 그 제조 방법
JP2012236773A (ja) * 2009-12-16 2012-12-06 Goto Takeshi 抗認知症薬物の経皮吸収製剤
JPWO2011074637A1 (ja) * 2009-12-16 2013-04-25 後藤　武 抗認知症薬物の経皮吸収製剤
KR20120101704A (ko) * 2009-12-16 2012-09-14 고토 다케시 항인지증 약물의 경피흡수제제
US10076502B2 (en) 2009-12-22 2018-09-18 Luye Pharma Ag Transdermal therapeutic system for administering rivastigmine or derivatives thereof
BR112012017168B1 (pt) * 2009-12-22 2022-03-15 Luye Pharma Ag Sistemas terapêuticos transdérmicos, seu processo de preparação, e usos de um polímero ou copolímero
US20100178307A1 (en) * 2010-01-13 2010-07-15 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
NZ605352A (en) 2010-06-30 2013-10-25 Nal Pharmaceuticals Ltd Process for producing glycosaminoglycans
RS54173B1 (sr) * 2010-12-14 2015-12-31 Acino Ag Transdermalni terapijski sistem za davanje aktivne supstance
US8911427B2 (en) 2010-12-28 2014-12-16 Medtronic, Inc. Therapeutic agent reservoir delivery system
TWI433904B (zh) * 2011-01-12 2014-04-11 Taiwan Biotech Co Ltd 多奈哌齊經皮貼片
KR101054317B1 (ko) 2011-01-28 2011-08-08 신신제약 주식회사 리바스티그민을 함유하는 경피흡수제제
KR101317158B1 (ko) 2011-02-18 2013-10-15 조선대학교산학협력단 갈란타민 또는 그의 염을 함유하는 경피흡수제제
WO2012161489A2 (ko) * 2011-05-20 2012-11-29 에스케이케미칼 주식회사 리바스티그민 함유 패취
KR101395557B1 (ko) * 2011-08-25 2014-05-16 아이큐어 주식회사 경피 흡수 제제 및 그 제조방법
KR101239150B1 (ko) 2012-02-28 2013-03-06 에스케이케미칼주식회사 도네페질-함유 경피흡수제제 및 그의 제조방법
KR101964295B1 (ko) * 2012-09-05 2019-04-01 주식회사 한독 피부 자극이 감소된 메만틴 경피전달 시스템
PL2931276T3 (pl) * 2012-12-13 2018-06-29 H. Lundbeck A/S Kompozycje zawierające wortioksetynę i donepezil
JP6151935B2 (ja) * 2013-03-11 2017-06-21 日東電工株式会社 経皮吸収促進用組成物および貼付製剤
KR20160120778A (ko) 2014-02-20 2016-10-18 날 파마슈티칼 그룹 리미티드 도네페질을 함유하는 경피흡수제제
WO2016209982A1 (en) 2015-06-22 2016-12-29 Corium International, Inc. Transdermal adhesive composition comprising a poorly soluble therapeutic agent
US10561603B2 (en) 2015-06-29 2020-02-18 Sekisui Chemical Co., Ltd. Core-shell structure and topical agent
US10966936B2 (en) 2015-12-30 2021-04-06 Corium, Inc. Systems comprising a composite backing and methods for long term transdermal administration
WO2017223402A1 (en) 2016-06-23 2017-12-28 Corium International, Inc. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
EP3490544A1 (en) * 2016-07-27 2019-06-05 Corium International, Inc. Memantine transdermal delivery systems
WO2018022814A1 (en) * 2016-07-27 2018-02-01 Corium International, Inc. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
CN116270551A (zh) 2016-07-27 2023-06-23 考里安有限责任公司 通过盐至中性药物原位转化的组合物、透皮贴剂及应用
KR102769558B1 (ko) * 2017-02-28 2025-02-19 킴벌리-클라크 월드와이드, 인크. 미생물총의 건강한 균형을 유지하기 위한 상승적 조성물
CN108096690B (zh) * 2017-04-07 2019-08-20 杭州多泰科技有限公司 一种诱导循环肿瘤细胞转移的可移植支架的制备方法
KR102033686B1 (ko) 2017-05-19 2019-10-18 보령제약 주식회사 도네페질을 함유하는 마이크로니들 경피 패치
US20190029971A1 (en) * 2017-07-26 2019-01-31 Corium International, Inc. Transdermal delivery system with a microporous membrane having solvent-filled pores
CA3085342A1 (en) 2017-12-13 2019-06-20 Corium, Inc. Method for depot creation during transdermal drug delivery
US11173132B2 (en) 2017-12-20 2021-11-16 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
CN108926549A (zh) * 2018-09-27 2018-12-04 安徽安科余良卿药业有限公司 卡巴拉汀凝胶贴膏及其制备方法
CA3203975A1 (en) 2020-12-03 2022-06-09 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
CA3216359A1 (en) 2021-04-07 2022-10-13 Battelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
KR102489860B1 (ko) * 2021-09-02 2023-01-19 동아에스티 주식회사 메만틴 에난트산염을 포함하는 치매 치료용 경피흡수 제제
CN115957200A (zh) * 2023-02-23 2023-04-14 广州新济药业科技有限公司 一种美金刚透皮贴剂及制备方法
AU2024353375A1 (en) 2023-09-29 2026-04-09 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
WO2025122954A1 (en) 2023-12-08 2025-06-12 Battelle Memorial Institute Use of dna origami nanostructures for molecular information based data storage systems

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04117323A (ja) * 1990-09-04 1992-04-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
JPH05500511A (ja) * 1989-09-14 1993-02-04 シグナス，インコーポレイテッド 送達開始を遅延させた経皮送達装置
JPH06199659A (ja) * 1992-10-28 1994-07-19 Hisamitsu Pharmaceut Co Inc 経皮治療用装置
JPH06510043A (ja) * 1991-08-23 1994-11-10 シグナス，インコーポレイテッド 薬効遅延を達成するために膜で保護された微細孔膜を用いる経皮ドラッグデリバリーデバイス
JPH10182439A (ja) * 1996-12-20 1998-07-07 Roehm Gmbh 皮膚もしくは経皮の治療系のための付着−及び接合剤
JPH11501527A (ja) * 1994-09-29 1999-02-09 アルザ・コーポレーション 離層の少ない改良された経皮デバイス
JPH11315016A (ja) * 1998-03-03 1999-11-16 Eisai Co Ltd 抗痴呆薬を含有した経皮適用製剤又は坐剤
WO2002038139A1 (en) * 2000-11-07 2002-05-16 Hisamitsu Pharmaceutical Co., Inc. Pharmaceutical preparation of percutaneous absorption type
JP2003505411A (ja) * 1999-07-22 2003-02-12 エルテーエス ローマン テラピー−ジステーメ アーゲー カルシウムアンタゴニストを投与するための経皮治療系
WO2003032960A1 (en) * 2001-10-17 2003-04-24 Hisamitsu Pharmaceutical Co., Inc. Percutaneous absorption preparations
WO2003092677A1 (de) * 2002-05-06 2003-11-13 Schwarz Pharma Ag Transepikutane darreichungsform zur behandlung des restless leg syndroms
JP2004502725A (ja) * 2000-07-12 2004-01-29 ヘクサル・アクチェンゲゼルシャフト 高分散シリカを用いた経皮治療システム
JP2004509916A (ja) * 2000-09-26 2004-04-02 ピエール、ファーブル、メディカマン オキサンに基づく薬剤
JP2004514738A (ja) * 2000-12-06 2004-05-20 エルテーエス　ローマン　テラピー−ジステーメ　アーゲー 活性物質としてオキシブチニンで構成される経皮治療システム
JP2005194230A (ja) * 2004-01-07 2005-07-21 Hisamitsu Pharmaceut Co Inc 異型断面繊維を使用した支持体を有するテーピング型貼付剤
WO2005115355A1 (ja) * 2004-05-28 2005-12-08 Hisamitsu Pharmaceutical Co., Inc. 貼付製剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919478A (en) * 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
FR2717689B1 (fr) * 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base de copolymère styrène-isoprène-styrène.
DE19533772C1 (de) * 1995-09-12 1998-01-02 Hexal Ag Tacrin/Selegilin-Pflaster
JPH10315016A (ja) 1997-05-15 1998-12-02 Nissan Diesel Motor Co Ltd チャック装置
DE19918106A1 (de) * 1999-04-22 2000-10-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05500511A (ja) * 1989-09-14 1993-02-04 シグナス，インコーポレイテッド 送達開始を遅延させた経皮送達装置
JPH04117323A (ja) * 1990-09-04 1992-04-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
JPH06510043A (ja) * 1991-08-23 1994-11-10 シグナス，インコーポレイテッド 薬効遅延を達成するために膜で保護された微細孔膜を用いる経皮ドラッグデリバリーデバイス
JPH06199659A (ja) * 1992-10-28 1994-07-19 Hisamitsu Pharmaceut Co Inc 経皮治療用装置
JPH11501527A (ja) * 1994-09-29 1999-02-09 アルザ・コーポレーション 離層の少ない改良された経皮デバイス
JPH10182439A (ja) * 1996-12-20 1998-07-07 Roehm Gmbh 皮膚もしくは経皮の治療系のための付着−及び接合剤
JPH11315016A (ja) * 1998-03-03 1999-11-16 Eisai Co Ltd 抗痴呆薬を含有した経皮適用製剤又は坐剤
JP2003505411A (ja) * 1999-07-22 2003-02-12 エルテーエス ローマン テラピー−ジステーメ アーゲー カルシウムアンタゴニストを投与するための経皮治療系
JP2004502725A (ja) * 2000-07-12 2004-01-29 ヘクサル・アクチェンゲゼルシャフト 高分散シリカを用いた経皮治療システム
JP2004509916A (ja) * 2000-09-26 2004-04-02 ピエール、ファーブル、メディカマン オキサンに基づく薬剤
WO2002038139A1 (en) * 2000-11-07 2002-05-16 Hisamitsu Pharmaceutical Co., Inc. Pharmaceutical preparation of percutaneous absorption type
JP2004514738A (ja) * 2000-12-06 2004-05-20 エルテーエス　ローマン　テラピー−ジステーメ　アーゲー 活性物質としてオキシブチニンで構成される経皮治療システム
WO2003032960A1 (en) * 2001-10-17 2003-04-24 Hisamitsu Pharmaceutical Co., Inc. Percutaneous absorption preparations
WO2003092677A1 (de) * 2002-05-06 2003-11-13 Schwarz Pharma Ag Transepikutane darreichungsform zur behandlung des restless leg syndroms
JP2005194230A (ja) * 2004-01-07 2005-07-21 Hisamitsu Pharmaceut Co Inc 異型断面繊維を使用した支持体を有するテーピング型貼付剤
WO2005115355A1 (ja) * 2004-05-28 2005-12-08 Hisamitsu Pharmaceutical Co., Inc. 貼付製剤

Also Published As

Publication number Publication date
RU2008148131A (ru) 2010-06-20
US20110059141A1 (en) 2011-03-10
RU2428179C2 (ru) 2011-09-10
IL195174A0 (en) 2009-08-03
AU2006343077A1 (en) 2007-11-15
EP2016939A4 (en) 2013-01-09
KR20090009951A (ko) 2009-01-23
JPWO2007129427A1 (ja) 2009-09-17
US7858114B2 (en) 2010-12-28
BRPI0621655A2 (pt) 2011-12-20
US20070259028A1 (en) 2007-11-08
CN101460156B (zh) 2011-06-08
HK1130175A1 (en) 2009-12-24
EP2016939A1 (en) 2009-01-21
NZ572809A (en) 2011-02-25
CA2651596C (en) 2014-03-25
MY149152A (en) 2013-07-15
CN101460156A (zh) 2009-06-17
IN266817B (https=) 2015-06-03
NO20084614L (no) 2009-02-06
EP2016939B1 (en) 2014-03-19
AU2006343077B2 (en) 2012-11-08
CA2651596A1 (en) 2007-11-15
WO2007129427A1 (ja) 2007-11-15
ES2466647T3 (es) 2014-06-10

Similar Documents

Publication Publication Date Title
JP5122445B2 (ja) 抗認知症薬物の経皮吸収製剤
JP5800715B2 (ja) 抗認知症薬物の経皮吸収製剤
JP5795264B2 (ja) 抗認知症薬物の経皮吸収製剤
JP5615697B2 (ja) β遮断剤の安定化組成物およびそれを用いた経皮吸収製剤
KR20120102747A (ko) 항인지증 약물의 경피흡수제제
US20230218538A1 (en) Transdermal patch
HK1130175B (en) Tansdermally absorbable preparation comprising anti-dementia agent
MX2008014151A (es) Preparaciones de absorcion percutanea de drogas contra demencia.
HK1179184B (en) Transdermally absorbed preparation of anti-dementia drug
HK1179184A (en) Transdermally absorbed preparation of anti-dementia drug

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091118

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120703

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120903

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120925

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20121024

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20151102

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 5122445

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250