CN101460156B - 抗痴呆药的经皮吸收制剂 - Google Patents

抗痴呆药的经皮吸收制剂 Download PDF

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Publication number
CN101460156B
CN101460156B CN200680054495XA CN200680054495A CN101460156B CN 101460156 B CN101460156 B CN 101460156B CN 200680054495X A CN200680054495X A CN 200680054495XA CN 200680054495 A CN200680054495 A CN 200680054495A CN 101460156 B CN101460156 B CN 101460156B
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drug
meth
acrylate
absorption preparation
alkyl
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Chinese (zh)
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CN101460156A (zh
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伊东健
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Teikoku Seiyaku Co Ltd
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Teikoku Seiyaku Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200680054495XA 2006-05-08 2006-12-25 抗痴呆药的经皮吸收制剂 Active CN101460156B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79829606P 2006-05-08 2006-05-08
US60/798,296 2006-05-08
PCT/JP2006/325813 WO2007129427A1 (ja) 2006-05-08 2006-12-25 抗認知症薬物の経皮吸収製剤

Publications (2)

Publication Number Publication Date
CN101460156A CN101460156A (zh) 2009-06-17
CN101460156B true CN101460156B (zh) 2011-06-08

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CN200680054495XA Active CN101460156B (zh) 2006-05-08 2006-12-25 抗痴呆药的经皮吸收制剂

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US (2) US7858114B2 (https=)
EP (1) EP2016939B1 (https=)
JP (1) JP5122445B2 (https=)
KR (1) KR20090009951A (https=)
CN (1) CN101460156B (https=)
AU (1) AU2006343077B2 (https=)
BR (1) BRPI0621655A2 (https=)
CA (1) CA2651596C (https=)
ES (1) ES2466647T3 (https=)
IL (1) IL195174A0 (https=)
IN (1) IN266817B (https=)
MY (1) MY149152A (https=)
NO (1) NO20084614L (https=)
NZ (1) NZ572809A (https=)
RU (1) RU2428179C2 (https=)
WO (1) WO2007129427A1 (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100048628A1 (en) * 2006-12-01 2010-02-25 Sumiyo Nishi Method for suppressing discoloration over time of adhesive preparation containing donepezil
JP5237112B2 (ja) * 2006-12-01 2013-07-17 日東電工株式会社 経皮吸収製剤
EP2269653A4 (en) * 2008-03-25 2013-10-23 Teikoku Seiyaku Kk COMPOSITION FOR THE STABILIZATION OF BLOCKER AND THE COMPOSITION COMPRISING TRANSDERMAL ABSORBABLE PREPARATION
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
WO2009145177A1 (ja) * 2008-05-30 2009-12-03 日東電工株式会社 ドネペジル含有貼付製剤およびその包装体
KR20110020788A (ko) * 2008-05-30 2011-03-03 에자이 알앤드디 매니지먼트 가부시키가이샤 경피 흡수 제제
CA2733265A1 (en) * 2008-09-30 2010-04-08 Teikoku Pharma Usa, Inc. Transdermal extended-delivery donepezil compositions and methods for using the same
US20100278895A1 (en) 2009-04-30 2010-11-04 Medtronic, Inc. Antioxidants and antimicrobial accessories including antioxidants
CN102630160B (zh) 2009-09-16 2014-05-07 株式会社三养生物制药 透皮递送系统、其制备方法以及使用所述系统的透皮递送方法
EP2514414A4 (en) * 2009-12-16 2013-05-29 Goto Takeshi TRANSDERMAL ABSORBED PREPARATION OF ANTI-DENSITY ACTIVE SUBSTANCE
CN102834092A (zh) * 2009-12-16 2012-12-19 后藤武 抗痴呆药物的经皮吸收制剂
JP2012236773A (ja) * 2009-12-16 2012-12-06 Goto Takeshi 抗認知症薬物の経皮吸収製剤
ES2670227T3 (es) * 2009-12-22 2018-05-29 Luye Pharma Ag Sistema terapéutico transdérmico para la administración de rivastigmina o sus derivados
US10076502B2 (en) 2009-12-22 2018-09-18 Luye Pharma Ag Transdermal therapeutic system for administering rivastigmine or derivatives thereof
US20100178307A1 (en) * 2010-01-13 2010-07-15 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
NZ605352A (en) * 2010-06-30 2013-10-25 Nal Pharmaceuticals Ltd Process for producing glycosaminoglycans
DK2468274T3 (en) 2010-12-14 2015-08-31 Acino Ag Transdermal therapeutic system for administration of an active substance
US8911427B2 (en) 2010-12-28 2014-12-16 Medtronic, Inc. Therapeutic agent reservoir delivery system
TWI433904B (zh) * 2011-01-12 2014-04-11 Taiwan Biotech Co Ltd 多奈哌齊經皮貼片
KR101054317B1 (ko) 2011-01-28 2011-08-08 신신제약 주식회사 리바스티그민을 함유하는 경피흡수제제
KR101317158B1 (ko) * 2011-02-18 2013-10-15 조선대학교산학협력단 갈란타민 또는 그의 염을 함유하는 경피흡수제제
BR112013029945A2 (pt) 2011-05-20 2017-01-31 Sk Chemicals Co Ltd emplastro contendo rivastigmina
KR101395557B1 (ko) * 2011-08-25 2014-05-16 아이큐어 주식회사 경피 흡수 제제 및 그 제조방법
KR101239150B1 (ko) 2012-02-28 2013-03-06 에스케이케미칼주식회사 도네페질-함유 경피흡수제제 및 그의 제조방법
KR101964295B1 (ko) * 2012-09-05 2019-04-01 주식회사 한독 피부 자극이 감소된 메만틴 경피전달 시스템
GEP201706739B (en) * 2012-12-13 2017-09-25 H Lundbeck As Compositions comprising vortioxetine and donepezil
JP6151935B2 (ja) * 2013-03-11 2017-06-21 日東電工株式会社 経皮吸収促進用組成物および貼付製剤
KR20160120778A (ko) 2014-02-20 2016-10-18 날 파마슈티칼 그룹 리미티드 도네페질을 함유하는 경피흡수제제
CN108135860A (zh) 2015-06-22 2018-06-08 考里安国际公司 包含难溶性治疗剂的透皮粘合剂组合物
WO2017002865A1 (ja) 2015-06-29 2017-01-05 積水化学工業株式会社 コアシェル構造体及び外用剤
WO2017117554A1 (en) 2015-12-30 2017-07-06 Corium International, Inc. Systems and methods for long term transdermal administration
AU2017281789B2 (en) 2016-06-23 2023-04-13 Corium, LLC. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
US10300025B2 (en) * 2016-07-27 2019-05-28 Corium, Inc. Donepezil transdermal delivery system
EP3490559A1 (en) 2016-07-27 2019-06-05 Corium International, Inc. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
WO2018022818A1 (en) * 2016-07-27 2018-02-01 Corium International, Inc. Memantine transdermal delivery systems
MX389431B (es) * 2017-02-28 2025-03-20 Kimberly Clark Co Composicion sinergica para el mantenimiento del equilibrio saludable de la microflora.
CN108096690B (zh) * 2017-04-07 2019-08-20 杭州多泰科技有限公司 一种诱导循环肿瘤细胞转移的可移植支架的制备方法
KR102033686B1 (ko) * 2017-05-19 2019-10-18 보령제약 주식회사 도네페질을 함유하는 마이크로니들 경피 패치
AU2018307792B2 (en) * 2017-07-26 2024-08-08 Corium, LLC. Transdermal delivery system with a microporous membrane having solvent-filled pores
JP2021506783A (ja) 2017-12-13 2021-02-22 コリウム， インコーポレイテッド 経皮薬物送達の間にデポを作成するための方法
US11173132B2 (en) 2017-12-20 2021-11-16 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
CN108926549A (zh) * 2018-09-27 2018-12-04 安徽安科余良卿药业有限公司 卡巴拉汀凝胶贴膏及其制备方法
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
WO2022216977A1 (en) 2021-04-07 2022-10-13 Batelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
KR102489860B1 (ko) * 2021-09-02 2023-01-19 동아에스티 주식회사 메만틴 에난트산염을 포함하는 치매 치료용 경피흡수 제제
CN115957200A (zh) * 2023-02-23 2023-04-14 广州新济药业科技有限公司 一种美金刚透皮贴剂及制备方法
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650851B2 (en) 1989-09-14 1994-07-07 Cygnus, Inc. Transdermal delivery device having delayed onset
JP2977254B2 (ja) 1990-09-04 1999-11-15 積水化学工業株式会社 経皮吸収貼付剤
US5273756A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset
JPH06199659A (ja) * 1992-10-28 1994-07-19 Hisamitsu Pharmaceut Co Inc 経皮治療用装置
US5919478A (en) * 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
FR2717689B1 (fr) * 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base de copolymère styrène-isoprène-styrène.
US5635203A (en) 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
DE19533772C1 (de) * 1995-09-12 1998-01-02 Hexal Ag Tacrin/Selegilin-Pflaster
DE19653605C2 (de) 1996-12-20 2002-11-28 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems
JPH10315016A (ja) 1997-05-15 1998-12-02 Nissan Diesel Motor Co Ltd チャック装置
JP3987655B2 (ja) * 1998-03-03 2007-10-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗痴呆薬を含有した経皮適用製剤又は坐剤
DE19918106A1 (de) * 1999-04-22 2000-10-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern
GB9917290D0 (en) * 1999-07-22 1999-09-22 Glaxo Wellcome Spa Pharmaceutical composition
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
FR2814368B1 (fr) * 2000-09-26 2004-05-07 Pf Medicament Preparation pharmaceutique a base d'oxans
EP1340496A4 (en) * 2000-11-07 2004-04-14 Hisamitsu Pharmaceutical Co PHARMACEUTICAL PREPARATION OF THE PERCUTANEOUS ABSORPTION TYPE
DE10060550C1 (de) 2000-12-06 2002-04-18 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten
KR20050037405A (ko) * 2001-10-17 2005-04-21 히사미쯔 제약 주식회사 경피 흡수형 제제
DE10220230A1 (de) * 2002-05-06 2003-11-27 Sanol Arznei Schwarz Gmbh Verwendung von Rotigotine zur Behandlung des Restless Leg Syndroms
JP4274951B2 (ja) * 2004-01-07 2009-06-10 久光製薬株式会社 異型断面繊維を使用した支持体を有するテーピング型貼付剤
WO2005115355A1 (ja) * 2004-05-28 2005-12-08 Hisamitsu Pharmaceutical Co., Inc. 貼付製剤

Also Published As

Publication number Publication date
IL195174A0 (en) 2009-08-03
US20110059141A1 (en) 2011-03-10
US7858114B2 (en) 2010-12-28
EP2016939A1 (en) 2009-01-21
JP5122445B2 (ja) 2013-01-16
EP2016939A4 (en) 2013-01-09
US20070259028A1 (en) 2007-11-08
CA2651596A1 (en) 2007-11-15
AU2006343077B2 (en) 2012-11-08
BRPI0621655A2 (pt) 2011-12-20
IN266817B (https=) 2015-06-03
MY149152A (en) 2013-07-15
RU2428179C2 (ru) 2011-09-10
KR20090009951A (ko) 2009-01-23
RU2008148131A (ru) 2010-06-20
WO2007129427A1 (ja) 2007-11-15
EP2016939B1 (en) 2014-03-19
AU2006343077A1 (en) 2007-11-15
ES2466647T3 (es) 2014-06-10
NO20084614L (no) 2009-02-06
CN101460156A (zh) 2009-06-17
CA2651596C (en) 2014-03-25
JPWO2007129427A1 (ja) 2009-09-17
HK1130175A1 (en) 2009-12-24
NZ572809A (en) 2011-02-25

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