JP5053635B2 - 医療用定量噴霧式吸入器及びそれに関連する方法 - Google Patents
医療用定量噴霧式吸入器及びそれに関連する方法 Download PDFInfo
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- JP5053635B2 JP5053635B2 JP2006524809A JP2006524809A JP5053635B2 JP 5053635 B2 JP5053635 B2 JP 5053635B2 JP 2006524809 A JP2006524809 A JP 2006524809A JP 2006524809 A JP2006524809 A JP 2006524809A JP 5053635 B2 JP5053635 B2 JP 5053635B2
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- elastic material
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- valve
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/46—Tilt valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/54—Metering valves ; Metering valve assemblies
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
- C09K3/10—Materials in mouldable or extrudable form for sealing or packing joints or covers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
- C09K3/10—Materials in mouldable or extrudable form for sealing or packing joints or covers
- C09K2003/1034—Materials or components characterised by specific properties
- C09K2003/1053—Elastomeric materials
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2200/00—Chemical nature of materials in mouldable or extrudable form for sealing or packing joints or covers
- C09K2200/06—Macromolecular organic compounds, e.g. prepolymers
- C09K2200/0607—Rubber or rubber derivatives
- C09K2200/0612—Butadiene-acrylonitrile rubber
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2200/00—Chemical nature of materials in mouldable or extrudable form for sealing or packing joints or covers
- C09K2200/06—Macromolecular organic compounds, e.g. prepolymers
- C09K2200/0642—Copolymers containing at least three different monomers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Mechanical Engineering (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
バージニア州ハリソンバーグに所在のCCL Containerより供給されたPTFE-PESコーティングを施した(ノースカロライナ州ケアリーに所在のPresspart Inc.製)8mlアルミニウムキャニスター、ネック(または、キャップ)シール、キャップ(または、フェルール)、及び下部軸シール及び上部軸シールを有する(フランスのLe Vaudreuilに所在のValois Pharm製)DF60 Mk42計量弁(部品番号803309)を含む密封容器を、当技術分野で知られた従来の技術を用いて組み立てた。密封容器の各々におけるネックシール、下部軸シール及び上部軸シールについて使用した材料は以下の表に従って変化させた。
弁を、(フランスのLe Vaudreuilに所在のValois Pharm製)DF60 Mk42計量弁(部品番号10002715)とした以外は、実施例1に使用したものと同一の医薬製剤及び実施例1に使用したものと同一の密封容器を用いて、上記実施例1で行った手順を繰り返した。相対FPM結果(変動を伴う)を以下のチャート2(図6)に示す。
2 キャップ
3 キャップシール
4 計量チャンバ
5 サンプリングチャンバ
6 リターンスプリング
7 弁軸
8 弁軸の一部
9 下部軸シール
10 出口管
11 通路
12 上部軸シール
13 ステップ
14 スリーブ
15 通路
17 肩部
18 リング
20 容器
26 オリフィス
30 オリフィス
31 オリフィス
32 肩部
210 密封容器
Claims (1)
- エアゾール医薬製剤が収容されている密封容器を含む薬物ディスペンサーを備え、
前記密封容器は開口を有する容器を含み、該容器の該開口を覆うキャップと該キャップに隣接する弁胴を有し、該弁胴はその下部部分が計量チャンバを画定し、その上部がサンプリングチャンバを画定しており、さらに、該弁胴の上部のサンプリングチャンバに近接した位置にある上部軸シールと該弁胴の下部の計量チャンバに近接した位置にある下部軸シールを有し、該弁胴はさらにその内側に弁軸を配置しており、該弁軸は該下部軸シールおよび該上部軸シールを通って摺動可能な直径を有しており、該下部軸シールおよび該上部軸シールはニトリルポリマーから形成されており、
キャップシールが容器とキャップの間に位置して、エアゾール医薬製剤を含むように構成された密封容器を提供し、該キャップシールがエチレンプロピレンジエンモノマー(EPDM)のポリマーからなり、
前記エアゾール医薬製剤は、キシナホ酸サルメテロールおよびプロピオン酸フルチカゾンからなる薬物と、噴射剤としての1,1,1,2-テトラフルオロエタン(HFA134a)と、からなり、且つ、界面活性剤およびアルコールを含んでいない定量噴霧式吸入器。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49925003P | 2003-08-29 | 2003-08-29 | |
US60/499,250 | 2003-08-29 | ||
PCT/US2004/027539 WO2005023330A2 (en) | 2003-08-29 | 2004-08-25 | Pharmaceutical metered dose inhaler and methods relating thereto |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007503873A JP2007503873A (ja) | 2007-03-01 |
JP2007503873A5 JP2007503873A5 (ja) | 2007-10-04 |
JP5053635B2 true JP5053635B2 (ja) | 2012-10-17 |
Family
ID=34272792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006524809A Active JP5053635B2 (ja) | 2003-08-29 | 2004-08-25 | 医療用定量噴霧式吸入器及びそれに関連する方法 |
Country Status (10)
Country | Link |
---|---|
US (2) | US20080190418A1 (ja) |
EP (1) | EP1658105B1 (ja) |
JP (1) | JP5053635B2 (ja) |
CN (1) | CN1874756B (ja) |
AU (2) | AU2004270171A1 (ja) |
CA (1) | CA2536876A1 (ja) |
ES (1) | ES2668780T3 (ja) |
MX (1) | MXPA06002075A (ja) |
WO (1) | WO2005023330A2 (ja) |
ZA (1) | ZA200601483B (ja) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0425518D0 (en) * | 2004-11-19 | 2004-12-22 | Clinical Designs Ltd | Substance source |
US7611816B2 (en) * | 2005-07-29 | 2009-11-03 | Canon Kabushiki Kaisha | Process for producing toner particles |
GB201210580D0 (en) * | 2012-06-14 | 2012-08-01 | 3M Innovative Properties Co | Metered dose dispensing valve |
WO2014043487A2 (en) | 2012-09-14 | 2014-03-20 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
FR2996827B1 (fr) * | 2012-10-12 | 2014-10-31 | Rexam Healthcare La Verpillier | Valve doseuse de distribution d'un aerosol |
US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
DE102013104549B4 (de) * | 2013-05-03 | 2015-08-13 | Chv Pharma Gmbh & Co. Kg | Inhalator für ein Dosieraerosol |
US9579265B2 (en) | 2014-03-13 | 2017-02-28 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
US9662285B2 (en) | 2014-03-13 | 2017-05-30 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
CA2953207A1 (en) * | 2014-06-25 | 2015-12-30 | Optinose As | Nasal administration |
CN106620976B (zh) * | 2016-12-28 | 2020-01-07 | 四川普锐特医药科技有限责任公司 | 一种丙酸氟替卡松定量吸入气雾剂 |
GB201702407D0 (en) | 2017-02-14 | 2017-03-29 | Norton (Waterford) Ltd | Inhalers and related methods |
GB201702406D0 (en) | 2017-02-14 | 2017-03-29 | Norton (Waterford) Ltd | Inhalers and related methods |
GB201702408D0 (en) | 2017-02-14 | 2017-03-29 | Norton (Waterford) Ltd | Inhalers and related methods |
WO2019094432A1 (en) * | 2017-11-07 | 2019-05-16 | Cheu Dwight | Respiratory therapy device and system with integrated gaming capabilities and method of using the same |
CA3160440A1 (en) * | 2019-11-22 | 2021-05-27 | Kindeva Drug Delivery L.P. | Carbon dioxide based metered dose inhaler |
CN111138699A (zh) * | 2020-01-14 | 2020-05-12 | 烟台鑫汇包装有限公司 | 一种气雾剂阀门用三元乙丙橡胶密封垫片后处理工艺 |
GB202001537D0 (en) * | 2020-02-05 | 2020-03-18 | Consort Medical Plc | Pressurised dispensing container |
FR3107039B1 (fr) * | 2020-02-07 | 2022-03-18 | Aptar France Sas | Valve doseuse avec chambre de dosage améliorée |
EP4106722A1 (en) * | 2020-02-20 | 2022-12-28 | Chiesi Farmaceutici S.p.A. | Pressurised metered dose inhalers comprising a buffered pharmaceutical formulation |
GB202207610D0 (en) * | 2022-05-24 | 2022-07-06 | Kindeva Drug Delivery Lp | Metered dose inhaler canister with improved sealing arrangement |
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-
2004
- 2004-08-25 AU AU2004270171A patent/AU2004270171A1/en not_active Abandoned
- 2004-08-25 CA CA002536876A patent/CA2536876A1/en not_active Abandoned
- 2004-08-25 US US10/570,033 patent/US20080190418A1/en not_active Abandoned
- 2004-08-25 ES ES04782101.2T patent/ES2668780T3/es active Active
- 2004-08-25 CN CN2004800320131A patent/CN1874756B/zh active Active
- 2004-08-25 JP JP2006524809A patent/JP5053635B2/ja active Active
- 2004-08-25 WO PCT/US2004/027539 patent/WO2005023330A2/en active Application Filing
- 2004-08-25 MX MXPA06002075A patent/MXPA06002075A/es unknown
- 2004-08-25 EP EP04782101.2A patent/EP1658105B1/en active Active
-
2006
- 2006-02-20 ZA ZA200601483A patent/ZA200601483B/en unknown
-
2009
- 2009-03-13 AU AU2009201034A patent/AU2009201034B2/en active Active
-
2016
- 2016-02-05 US US15/016,421 patent/US20160151588A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1658105A4 (en) | 2012-11-07 |
CA2536876A1 (en) | 2005-03-17 |
AU2009201034B2 (en) | 2011-05-12 |
AU2004270171A1 (en) | 2005-03-17 |
WO2005023330A3 (en) | 2006-07-13 |
MXPA06002075A (es) | 2006-05-19 |
AU2009201034A1 (en) | 2009-04-02 |
CN1874756A (zh) | 2006-12-06 |
US20080190418A1 (en) | 2008-08-14 |
ES2668780T3 (es) | 2018-05-22 |
EP1658105A2 (en) | 2006-05-24 |
EP1658105B1 (en) | 2018-03-14 |
US20160151588A1 (en) | 2016-06-02 |
WO2005023330A2 (en) | 2005-03-17 |
CN1874756B (zh) | 2012-02-29 |
ZA200601483B (en) | 2007-05-30 |
JP2007503873A (ja) | 2007-03-01 |
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