JP4988353B2 - 治療用フォーム - Google Patents
治療用フォーム Download PDFInfo
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- JP4988353B2 JP4988353B2 JP2006540586A JP2006540586A JP4988353B2 JP 4988353 B2 JP4988353 B2 JP 4988353B2 JP 2006540586 A JP2006540586 A JP 2006540586A JP 2006540586 A JP2006540586 A JP 2006540586A JP 4988353 B2 JP4988353 B2 JP 4988353B2
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- foam
- gas
- canister
- oxygen
- liquid
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Landscapes
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0326768A GB0326768D0 (en) | 2003-11-17 | 2003-11-17 | Generation of therapeutic microfoam |
| GB0326768.9 | 2003-11-17 | ||
| US54286704P | 2004-02-10 | 2004-02-10 | |
| US54286604P | 2004-02-10 | 2004-02-10 | |
| US60/542,866 | 2004-02-10 | ||
| US60/542,867 | 2004-02-10 | ||
| GB0422307.9 | 2004-10-07 | ||
| GB0422307A GB0422307D0 (en) | 2004-10-07 | 2004-10-07 | Generation and delivery of therapeutic microfoam |
| PCT/GB2004/004848 WO2005048977A2 (en) | 2003-11-17 | 2004-11-17 | Therapeutic foam comprising a sclerosing solution |
Publications (3)
| Publication Number | Publication Date |
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| JP2007511592A JP2007511592A (ja) | 2007-05-10 |
| JP2007511592A5 JP2007511592A5 (enExample) | 2008-01-17 |
| JP4988353B2 true JP4988353B2 (ja) | 2012-08-01 |
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| JP2006540581A Pending JP2007511590A (ja) | 2003-11-17 | 2004-11-17 | 治療用フォーム |
| JP2006540579A Pending JP2007511312A (ja) | 2003-11-17 | 2004-11-17 | 硬化剤を含むフォームを製造する方法 |
| JP2006540586A Expired - Fee Related JP4988353B2 (ja) | 2003-11-17 | 2004-11-17 | 治療用フォーム |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006540585A Pending JP2007511591A (ja) | 2003-11-17 | 2004-11-17 | 硬化剤を含むフォームを調製する方法。 |
| JP2006540581A Pending JP2007511590A (ja) | 2003-11-17 | 2004-11-17 | 治療用フォーム |
| JP2006540579A Pending JP2007511312A (ja) | 2003-11-17 | 2004-11-17 | 硬化剤を含むフォームを製造する方法 |
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| GB9912356D0 (en) * | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
| GB0028692D0 (en) | 2000-11-24 | 2001-01-10 | Btg Int Ltd | Generation of therapeutic microform |
| US8512680B2 (en) * | 2001-08-08 | 2013-08-20 | Btg International Ltd. | Injectables in foam, new pharmaceutical applications |
| WO2005048984A1 (en) * | 2003-11-17 | 2005-06-02 | Btg International Limited | Methods of preparing a foam comprising a sclerosing agent |
| US8048439B2 (en) * | 2003-11-17 | 2011-11-01 | Btg International Ltd. | Therapeutic foam |
| ITMI20041056A1 (it) * | 2004-05-26 | 2004-08-26 | Garrido Antonio Luis Cabrera | Uso in campo medico diagnostico e flebo logico di una kiscela di gas sterili e fisiologicamente accettabili |
| EP1901712B1 (en) * | 2005-05-13 | 2012-06-20 | BTG International Limited | Therapeutic sclerosing foam made preferably from xenon |
| GB0509824D0 (en) * | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
| GB0509819D0 (en) * | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
| GB0509845D0 (en) | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Preparation of therapeutic foam |
| WO2007045897A1 (en) | 2005-10-21 | 2007-04-26 | Btg International Limited | Aerosol valve |
| US20080243068A1 (en) * | 2005-12-29 | 2008-10-02 | Kamal Ramzipoor | Methods and apparatus for treatment of venous insufficiency |
| AU2013213741B2 (en) * | 2006-01-17 | 2016-01-28 | Baxter Healthcare Sa | Device, system and method for mixing |
| US20090038701A1 (en) | 2006-01-17 | 2009-02-12 | Baxter International Inc. | Device, system and method for mixing |
| CN101370433B (zh) * | 2006-01-17 | 2012-08-08 | 巴克斯特国际公司 | 用于混合的装置、系统和方法 |
| US9486594B2 (en) | 2006-11-27 | 2016-11-08 | Frank Levy | Portable medical gas delivery system |
| US8876749B2 (en) | 2006-11-27 | 2014-11-04 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
| US9662435B2 (en) | 2006-01-31 | 2017-05-30 | Frank Levy | System and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid |
| US20100101579A1 (en) * | 2006-11-27 | 2010-04-29 | Frank Levy | Portable Medical Gas Delivery System |
| EP2010249A2 (en) | 2006-04-04 | 2009-01-07 | Vnus Medical Technologies, Inc. | Method and apparatus for generating vascular treatment foam |
| EP2015702A2 (en) * | 2006-05-11 | 2009-01-21 | Dentsply International Inc. | Aerosol delivery system for dispensing dental compositions |
| ES2289947B1 (es) * | 2006-07-25 | 2009-02-16 | Universidade De Santiago De Compostela | Microespuma esclerosante con co2, dispositivo de preparacion y sus aplicaciones. |
| US10350399B2 (en) | 2006-11-27 | 2019-07-16 | Frank Levy | Apparatus and method for producing an enriched medical suspension of carbon dioxide |
| US12377251B2 (en) | 2006-11-27 | 2025-08-05 | Frank Levy | Apparatus and method for producing an enriched medical suspension of carbon dioxide |
| US10322271B2 (en) | 2006-11-27 | 2019-06-18 | Frank Levy | Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid |
| US10155093B2 (en) | 2006-11-27 | 2018-12-18 | Frank Levy | Apparatus and method for producing CO2 enriched medical foam |
| US9427522B2 (en) | 2006-11-27 | 2016-08-30 | Frank Levy | Delivery system for the effective and reliable delivery of controlled amounts of a medical fluid |
| US20190070397A1 (en) * | 2006-11-27 | 2019-03-07 | Frank Levy | Apparatus and method for producing co2 enriched medical foam |
| US10149935B2 (en) | 2006-11-27 | 2018-12-11 | Frank Levy | Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid |
| US11185671B2 (en) | 2006-11-27 | 2021-11-30 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
| US11833320B2 (en) | 2006-11-27 | 2023-12-05 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
| US11712510B2 (en) | 2006-11-27 | 2023-08-01 | Frank Levy | Delivery system and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid |
| US20080140002A1 (en) * | 2006-12-06 | 2008-06-12 | Kamal Ramzipoor | System for delivery of biologically active substances with actuating three dimensional surface |
| DE112007003084T5 (de) | 2006-12-21 | 2009-10-29 | Btg International Ltd. | Vorrichtung und Verfahren zur Herstellung von therapeutischem Schaum |
| CA2673166C (en) * | 2007-01-25 | 2015-09-22 | Hyperbranch Medical Technology, Inc. | Applicators for multiple component formulations and the like, and methods of use thereof |
| KR101562199B1 (ko) * | 2007-11-08 | 2015-10-21 | 넥스메드 홀딩스 인코포레이티드 | 서로 개별적으로 저장된 성분을 혼합하고 분배하기 위한 디바이스 및 시스템 |
| US8512740B2 (en) | 2008-03-26 | 2013-08-20 | Baxter International Inc. | Fibrin foam and process for making |
| US8753670B2 (en) | 2008-03-26 | 2014-06-17 | Baxter International Inc. | Fibrin foam and process |
| US20110139821A1 (en) * | 2008-09-22 | 2011-06-16 | Medmix Systems Ag | Connector having mixing element for discharge arrangement |
| US8560968B1 (en) * | 2009-03-26 | 2013-10-15 | Vinod Nair | Method and apparatus for evaluating a heart patient |
| US8376989B2 (en) * | 2009-03-30 | 2013-02-19 | Covidien Lp | Compartmented syringe |
| EP2475308A1 (en) | 2009-09-08 | 2012-07-18 | Baxter International Inc | Reconstitution and applicator system for wound sealant product |
| US20110082340A1 (en) * | 2009-10-07 | 2011-04-07 | Tyco Healthercare Group LP | Foam collar for surgical access devices |
| US8641661B2 (en) | 2010-01-05 | 2014-02-04 | Baxter International Inc. | Mixing system, kit and mixer adapter |
| EP2384703A1 (en) * | 2010-05-05 | 2011-11-09 | Bioadhesives Meditech Solutions, S.L. | Device for dispensing a two-component tissue adhesive or sealant |
| NZ606713A (en) * | 2010-08-06 | 2015-04-24 | Hospira Australia Pty Ltd | Vial preparation method and system |
| WO2013070692A1 (en) | 2011-11-07 | 2013-05-16 | Battelle Memorial Institute | Processes for delivery of viscous drug therapies |
| US9937317B2 (en) * | 2012-01-30 | 2018-04-10 | Ipsumpro, S.L. | Modified medical syringe with a flow regulator for the administration of local anaesthetic |
| WO2013155009A1 (en) | 2012-04-09 | 2013-10-17 | Becton, Dickinson And Company | Injection mechanism utilizing a vial |
| ES2843482T3 (es) * | 2012-04-24 | 2021-07-19 | Angioclinic Ag | Composición para tratar la insuficiencia venosa y las venas varicosas |
| US10052107B2 (en) * | 2012-06-25 | 2018-08-21 | Arsenal Medical, Inc. | Systems and methods for the treatment of aneurysms |
| US8968449B2 (en) * | 2012-07-04 | 2015-03-03 | Vki Technologies Inc. | Spout, system, and method for producing a foam |
| WO2014031150A1 (en) * | 2012-08-24 | 2014-02-27 | St. Jude Medical Puerto Rico Llc | Sealant storage, preparation, and delivery systems and related methods |
| PL2722008T3 (pl) * | 2012-10-16 | 2018-07-31 | Erbe Elektromedizin Gmbh | Dysza do doprowadzania materiału biologicznego, zwłaszcza komórek, urządzenie medyczne z taką dyszą, zastosowanie dyszy, sposób mieszania płynów i urządzenie |
| EP2925391B1 (en) * | 2012-11-30 | 2017-05-03 | Unitract Syringe Pty Ltd | Combination plunger device for a dual chamber mixing syringe |
| EP3020343B1 (en) * | 2013-07-08 | 2019-06-19 | Terumo Kabushiki Kaisha | Application tool |
| US10111980B2 (en) | 2013-12-11 | 2018-10-30 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
| US10000009B2 (en) * | 2014-02-05 | 2018-06-19 | Nathan Christopher Maier | Sterile environment for additive manufacturing |
| WO2015125736A1 (ja) * | 2014-02-19 | 2015-08-27 | 株式会社モリタ製作所 | 医療用機器要素、医療用機器、医療用機器構成部品、医療用ハンドピース、医療用機器要素の製造方法、及び医療用切削装置 |
| WO2015153828A1 (en) | 2014-04-04 | 2015-10-08 | Hyperbranch Medical Technology, Inc. | Extended tip spray applicator for two-component surgical selant, and methods of use thereof |
| EP3131473B1 (en) | 2014-04-18 | 2019-07-31 | Covidien LP | Mixing nozzle |
| WO2015160871A1 (en) * | 2014-04-18 | 2015-10-22 | Covidien Lp | Mixing syringe |
| CA2950483C (en) | 2014-06-03 | 2022-06-28 | Antoni PUIG DOMENECH | Methods, devices, systems and kits for preparing compositions for care and repair of varicose veins |
| EP2962681A1 (en) * | 2014-07-03 | 2016-01-06 | Swiss VX Venentherapie und Forschung GmbH | Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof |
| PL2982444T3 (pl) * | 2014-08-05 | 2020-05-18 | Goizper, S. Coop. | Ciśnieniowe urządzenie natryskowe |
| US9687455B2 (en) | 2014-08-14 | 2017-06-27 | John Daniel Dobak | Sodium tetradecyl sulfate formulations for treatment of adipose tissue |
| US9351945B1 (en) * | 2015-02-27 | 2016-05-31 | John Daniel Dobak, III | Reduction of adipose tissue |
| WO2017011668A1 (en) * | 2015-07-14 | 2017-01-19 | Boston Scientific Scimed, Inc. | Gel delivery catheters, systems, and methods |
| US11415019B2 (en) | 2015-12-11 | 2022-08-16 | General Electric Company | Meta-stable detergent based foam cleaning system and method for gas turbine engines |
| EP3251654A1 (de) * | 2016-05-30 | 2017-12-06 | Chemische Fabrik Kreussler & Co. Gmbh | Nichtionische tenside zur reduktion von fettgewebe |
| GB201612925D0 (en) * | 2016-07-26 | 2016-09-07 | Provensis Ltd | Method and device for generating injectable foam |
| GB201612948D0 (en) * | 2016-07-26 | 2016-09-07 | Provensis Ltd | syringe for administering foam |
| IL248775A0 (en) * | 2016-11-06 | 2017-02-28 | Technion Res & Dev Foundation | Administering drugs to the lung using foam |
| GB201703299D0 (en) * | 2017-03-01 | 2017-04-12 | Triple Line Tech Ltd | Apparatus and method for generating a microfoam |
| JP2020515592A (ja) * | 2017-03-27 | 2020-05-28 | ドン,ヨンファ | 連鎖薬物構造およびその製造装置と保存装置 |
| RU2659632C1 (ru) * | 2017-04-04 | 2018-07-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Устройство для вспенивания и введения лекарственного препарата |
| AU2018313859B2 (en) * | 2017-08-08 | 2024-08-01 | Tetrous, Inc. | Therapeutic gas infused cosmetic and methods of infusion |
| US10786433B2 (en) * | 2017-09-13 | 2020-09-29 | William J Moore | Buffering agent cartridge |
| JP2019074486A (ja) * | 2017-10-19 | 2019-05-16 | 大陽日酸株式会社 | 二酸化炭素ガス中の窒素ガス分析方法及び装置 |
| US11185643B2 (en) | 2018-04-06 | 2021-11-30 | Frank Levy | Apparatus and method for producing an enriched medical suspension |
| WO2019195723A1 (en) | 2018-04-06 | 2019-10-10 | Frank Levy | Apparatus and method for producing an enriched medical contrast suspension |
| RU2693344C1 (ru) * | 2018-07-05 | 2019-07-02 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский государственный медико-стоматологический университет имени А.И. Евдокимова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО МГМСУ имени А.И. Евдокимова Минздрава России) | Способ склеротерапии микропенной артерио-венозных мальформаций челюстно-лицевой области пациента под ультразвуковым контролем |
| JP7530647B2 (ja) * | 2018-08-21 | 2024-08-08 | バスキュラー バルセロナ デバイシズ,エス.エル. | 静脈瘤のケアおよび修復用の組成物を調製するための方法、装置、システムおよびキット |
| US11517527B2 (en) * | 2018-11-05 | 2022-12-06 | Ethicon, Inc. | Systems, devices and methods for making and expressing foam used in medical procedures |
| WO2020231429A1 (en) * | 2019-05-10 | 2020-11-19 | Coll Mazzei Jose Vicente | New use of a milk frother apparatus and a method for the preparation of a therapeutic foam for the treatment of varicose veins and other medical conditions. |
| CN110123757B (zh) * | 2019-05-28 | 2020-09-01 | 山东大学齐鲁医院 | 一种应用于治疗脉管异常的乙醇泡沫硬化剂及制备方法 |
| EP3756705A1 (de) * | 2019-06-27 | 2020-12-30 | Adhesys Medical GmbH | Applikator für einen zwei-komponenten gewebekleber |
| US11912975B2 (en) | 2019-09-02 | 2024-02-27 | Mirai Medical Limited | Electroporation apparatus and method |
| EP3798138A1 (en) * | 2019-09-30 | 2021-03-31 | SCHOTT Schweiz AG | Device and process for stoppering from below |
| CA3163519A1 (en) | 2019-12-03 | 2021-06-10 | Boston Scientific Scimed, Inc. | Agent delivery devices |
| EP4106773A1 (en) * | 2020-02-18 | 2022-12-28 | Aviation Works Limited | Oxygen/carbon dioxide compositions for medical uses |
| CN111437504B (zh) * | 2020-04-28 | 2022-02-18 | 山东大学齐鲁医院 | 一种用于产生稳定泡沫的三通阀 |
| WO2022152930A1 (en) * | 2021-01-18 | 2022-07-21 | Bonsens Ab | A swirl nozzle and methods of fabricating the same |
| EP4387761A1 (en) * | 2021-08-19 | 2024-06-26 | Nanortopedi Teknoloji Sanayi Ve Ticaret A.S. | Microfluidic injection device and method for use in cartilage repair |
| US12409271B2 (en) | 2022-04-25 | 2025-09-09 | Frank Levy | Apparatus and method for producing an enriched medical suspension |
| CN115708693B (zh) * | 2022-10-24 | 2024-02-27 | 无忧跳动医疗科技(深圳)有限公司 | 一种全自动发泡装置及方法 |
| US20240149020A1 (en) | 2022-11-04 | 2024-05-09 | Controlled Delivery Systems, Inc. | Catheters for the aspiration controlled delivery of closure agents |
| AU2023371657A1 (en) | 2022-11-04 | 2025-05-15 | Solvein Inc. | Catheters and related methods for aspiration and controlled delivery of closure agents |
| KR102744414B1 (ko) * | 2022-11-15 | 2024-12-19 | 원광대학교산학협력단 | 반응 약물이 충전된 시린지 |
| US20240165294A1 (en) * | 2022-11-23 | 2024-05-23 | Case Western Reserve University | Tunable, stable sclerosing foam for vascular interventions |
| DE102023112792A1 (de) * | 2023-05-15 | 2024-11-21 | Santa Isabel International Foundation | Mikroschaum-Generierungssystem mit Reaktionsbehälter, Kartusche und automatisierten System, Verfahren und Computerprogramm zum Erzeugen eines Mikroschaums |
| PL445663A1 (pl) * | 2023-07-24 | 2025-01-27 | Biotreat Vascular Spółka Z Ograniczoną Odpowiedzialnością | Urządzenie do podawania kleju i zastosowanie tego urządzenia w chirurgii naczyniowej, w szczególności do endowaskularnego podawania kleju |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2630183A (en) * | 1950-01-26 | 1953-03-03 | Foutz Clinton Root | Apparatus for forming and projecting a foam mixture |
| US2724383A (en) * | 1951-06-28 | 1955-11-22 | Compule Corp | Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations |
| FR1547768A (fr) | 1967-10-09 | 1968-11-29 | Récipient remplissable à dispositif décompresseur | |
| US3670786A (en) * | 1970-06-02 | 1972-06-20 | American Home Prod | Container filling apparatus |
| FR2105332A5 (enExample) * | 1970-09-01 | 1972-04-28 | Oreal | |
| US3767085A (en) * | 1971-08-02 | 1973-10-23 | J Cannon | Mixing syringe |
| US3763900A (en) * | 1971-09-10 | 1973-10-09 | Milchwirlschaftliche Forschung | Process for sterilizing and filling aerosol containers |
| US3955720A (en) * | 1972-11-15 | 1976-05-11 | Malone David C | Low pressure dispensing apparatus with air pump |
| US3970219A (en) * | 1975-03-03 | 1976-07-20 | Spitzer Joseph G | Aerosol containers for foaming and delivering aerosols and process |
| US4019657A (en) * | 1975-03-03 | 1977-04-26 | Spitzer Joseph G | Aerosol containers for foaming and delivering aerosols |
| US4019357A (en) * | 1975-11-10 | 1977-04-26 | Nippon Concrete Industries Co. Ltd. | Method of making reinforcements for concrete |
| US4040420A (en) * | 1976-04-22 | 1977-08-09 | General Dynamics | Packaging and dispensing kit |
| US4127131A (en) * | 1977-06-20 | 1978-11-28 | Johnson & Johnson | Hub assembly for use in the filtration of fluids and method of making the same |
| FR2445018A1 (fr) | 1978-12-22 | 1980-07-18 | Anvar | Tube multiplicateur d'electrons a champ magnetique axial |
| US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| US4292975A (en) * | 1979-08-20 | 1981-10-06 | Carolyn Champion | Brassiere |
| US4358107A (en) * | 1980-02-19 | 1982-11-09 | Nissen George P | Weight lifting machine |
| US4292972A (en) * | 1980-07-09 | 1981-10-06 | E. R. Squibb & Sons, Inc. | Lyophilized hydrocolloio foam |
| DE3050812C2 (de) | 1980-12-23 | 1985-03-21 | B. Braun Melsungen Ag, 3508 Melsungen | Katheterisierungsvorrichtung |
| DE3048744A1 (de) | 1980-12-23 | 1982-07-22 | Metzeler Kautschuk GmbH, 8000 München | Anordnung zum abdichten einer mehrscheibenverglasung |
| DE3048774C2 (de) | 1980-12-23 | 1984-03-08 | B. Braun Melsungen Ag, 3508 Melsungen | Katheterisierungsvorrichtung |
| DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| US4718433A (en) | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
| US4538920A (en) * | 1983-03-03 | 1985-09-03 | Minnesota Mining And Manufacturing Company | Static mixing device |
| US5141738A (en) * | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
| DE3313947A1 (de) | 1983-04-15 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel |
| DE3324754A1 (de) | 1983-07-06 | 1985-01-17 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ultraschallkontrastmittel sowie dessen herstellung |
| DE3417182A1 (de) | 1984-05-09 | 1985-11-14 | Gerald Dr. 8000 München Hauer | Spritzen-set |
| US4719433A (en) * | 1984-09-14 | 1988-01-12 | Siemens Aktiengesellschaft | Attenuation bead for the suppression of interference radiation |
| GB8522813D0 (en) | 1985-09-16 | 1985-10-23 | Unilever Plc | Package |
| DE8704600U1 (de) | 1987-03-27 | 1987-10-15 | Cocon Kunststoffen B.V., Arkel | Vorrichtung zur gebrauchsfertigen Zubereitung der beiden Komponenten eines zweikomponentigen Montageschaums, insbesondere Polyurethanschaums |
| IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| US5425366A (en) * | 1988-02-05 | 1995-06-20 | Schering Aktiengesellschaft | Ultrasonic contrast agents for color Doppler imaging |
| AU635200B2 (en) | 1988-02-05 | 1993-03-18 | Schering Aktiengesellschaft Berlin Und Bergkamen | Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents |
| CH676456A5 (enExample) * | 1988-04-05 | 1991-01-31 | Supermatic Kunststoff Ag | |
| US4957656A (en) | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
| FR2641202B1 (fr) * | 1989-01-03 | 1991-03-15 | Poizot Francis | Dispositif de production de mousse |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US5084011A (en) * | 1990-01-25 | 1992-01-28 | Grady Daniel J | Method for oxygen therapy using hyperbarically oxygenated liquid |
| US5556610A (en) * | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| US5064103A (en) * | 1990-05-23 | 1991-11-12 | Rjs Industries, Inc. | Foam dispenser having a plurality of sieves |
| JP2910784B2 (ja) * | 1990-09-14 | 1999-06-23 | 大和製罐株式会社 | エアゾール缶詰の製造方法 |
| ES2074725T3 (es) | 1990-10-05 | 1995-09-16 | Bracco Int Bv | Metodo para la preparacion de suspensiones estables de microesferas huecas llenas de gas adecuadas para ecografia ultrasonica. |
| ATE123930T1 (de) | 1990-12-28 | 1995-07-15 | Byk Gulden Lomberg Chem Fab | Darreichungsform für mikrobläschen- echokontrastmittel. |
| US5425580A (en) * | 1990-12-28 | 1995-06-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dosage form for micro-bubble echo contrast agents |
| DE4100470A1 (de) | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
| FR2672038B1 (fr) | 1991-01-25 | 1993-05-14 | Oreal | Dispositif distributeur de mousse a partir d'un recipient pressurise. |
| JP3231768B2 (ja) | 1991-09-17 | 2001-11-26 | ソーナス ファーマシューティカルス,インコーポレイテッド | 気体状超音波造影剤及び超音波造影剤として使用する気体の選定方法 |
| DE4301820C2 (de) * | 1993-01-23 | 1996-04-25 | Henkel Kgaa | Schäumende Emulsionen, Verfahren zu ihrer Herstellung und ihre Verwendung |
| FR2702196B1 (fr) * | 1993-03-05 | 1995-05-12 | Oreal | Distributeur de mousse sous pression. |
| NL9300517A (nl) | 1993-03-23 | 1994-10-17 | Airspray Int Bv | Schuimvormingssamenstel, een daarvoor geschikte spuitkop en een spuitbus die een dergelijk samenstel omvat. |
| US5695740A (en) | 1993-05-12 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide |
| ES2068151B1 (es) * | 1993-06-23 | 1995-11-16 | Cabrera Garrido Juan | Microespuma inyectable para esclerosis. |
| DE69434119T3 (de) | 1993-07-30 | 2011-05-05 | Imcor Pharmaceutical Co., San Diego | Stabilisierte mikrogasbläschen-zusammensetzungen für echographie |
| US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| US5454805A (en) * | 1994-03-14 | 1995-10-03 | Brony; Seth K. | Medicine vial link for needleless syringes |
| DE4432993C1 (de) | 1994-09-16 | 1996-06-20 | Byk Gulden Lomberg Chem Fab | Mischeinrichtung für mittels einer Spritze zu verabreichende Mittel |
| US5623085A (en) * | 1994-09-23 | 1997-04-22 | Rohm And Haas Company | Method for reducing microfoam in a spray-applied waterborne composition |
| WO1996011162A1 (en) * | 1994-10-11 | 1996-04-18 | Monson James A | Dispensing apparatus for foaming compositions and method |
| TW319763B (enExample) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| GB9503119D0 (en) | 1995-02-17 | 1995-04-05 | Durand Ltd | Medication and apparatus and method of applying medication |
| NL1001366C2 (nl) | 1995-10-06 | 1997-04-08 | Airspray Int Bv | Inrichting voor het afgeven van een luchtvloeistofmengsel, in het bijzonder schuim en daarvoor bestemde bedieningseenheid. |
| JP2751899B2 (ja) | 1995-12-15 | 1998-05-18 | ソニー株式会社 | 光学ピックアップ装置 |
| JPH1081895A (ja) | 1996-09-05 | 1998-03-31 | Lion Corp | 漂白洗剤製品 |
| GB9823029D0 (en) | 1998-10-22 | 1998-12-16 | Giltech Ltd | Packaging system |
| FR2775433A1 (fr) | 1998-02-27 | 1999-09-03 | Alain Monfreux | Dispositif pour la production de mousse dans un corps de seringue |
| FR2775436A1 (fr) | 1998-02-27 | 1999-09-03 | Alain Monfreux | Dispositif pour l'administration parenterale d'une composition sous forme d'une mousse |
| FR2784296B1 (fr) * | 1998-09-18 | 2001-01-05 | Imedex Biomateriaux | Dispositif pour la formulation et la delivrance d'un melange, notamment pour l'application chirurgicale de ce melange |
| DE29819174U1 (de) | 1998-10-28 | 1999-01-28 | Kurt Vogelsang GmbH, 74855 Haßmersheim | Schutzkappe für eine Zweikomponenten-Lack-Sprühdose |
| ES1043183Y (es) | 1999-05-03 | 2000-04-01 | Mingo Fco Javier Garcia | Dispositivo para producir esclerosante espumado. |
| GB9912356D0 (en) | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
| NL1012419C2 (nl) * | 1999-06-23 | 2000-12-28 | Airspray Nv | Spuitbus voor het afgeven van een vloeistof. |
| GB0028692D0 (en) * | 2000-11-24 | 2001-01-10 | Btg Int Ltd | Generation of therapeutic microform |
| US6561237B1 (en) * | 2000-11-28 | 2003-05-13 | Brasscorp Ltd. | Apparatus and method for urging fluid into a pressurized system |
| GB2369996B (en) | 2000-12-18 | 2004-06-23 | S T D Pharmaceutical Products | Method and apparatus for producing an injectable foam |
| US6592251B2 (en) | 2001-01-26 | 2003-07-15 | Howmedica Osteonics Corp. | Cement mixing and dispensing device |
| DE60142311D1 (de) | 2001-08-08 | 2010-07-15 | Dominguez Maria Antonia Garcia-Olmedo | Injizierbarer schaum und neue pharmazeutische anwendungen dafür |
| GB0212047D0 (en) * | 2002-05-24 | 2002-07-03 | Btg Int Ltd | Generation of therapeutic microfoam |
| DE20218493U1 (de) | 2002-11-28 | 2004-04-08 | Chemische Fabrik Kreussler & Co. Gmbh | Vorrichtung zur Erzeugung von medizinischem Schaum |
| GB0300586D0 (en) * | 2003-01-10 | 2003-02-12 | Btg Int Ltd | Therapeutic microfoam |
| JP4333186B2 (ja) * | 2003-04-07 | 2009-09-16 | ソニー株式会社 | 通信システム及び通信照明装置 |
| US8048439B2 (en) * | 2003-11-17 | 2011-11-01 | Btg International Ltd. | Therapeutic foam |
| WO2005048984A1 (en) * | 2003-11-17 | 2005-06-02 | Btg International Limited | Methods of preparing a foam comprising a sclerosing agent |
| GB0509819D0 (en) * | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
-
2004
- 2004-11-17 WO PCT/GB2004/004846 patent/WO2005048984A1/en not_active Ceased
- 2004-11-17 PL PL380484A patent/PL223344B1/pl unknown
- 2004-11-17 DK DK04798564.3T patent/DK1701701T3/da active
- 2004-11-17 US US10/522,528 patent/US7763269B2/en active Active
- 2004-11-17 CZ CZ20060315A patent/CZ2006315A3/cs unknown
- 2004-11-17 AU AU2004290959A patent/AU2004290959A1/en not_active Abandoned
- 2004-11-17 JP JP2006540585A patent/JP2007511591A/ja active Pending
- 2004-11-17 BR BRPI0416611A patent/BRPI0416611B8/pt not_active IP Right Cessation
- 2004-11-17 EP EP04798550.2A patent/EP1791519B1/en not_active Expired - Lifetime
- 2004-11-17 EP EP04798564.3A patent/EP1701701B2/en not_active Expired - Lifetime
- 2004-11-17 IN IN7569DEN2014 patent/IN2014DN07569A/en unknown
- 2004-11-17 AU AU2004290963A patent/AU2004290963A1/en not_active Abandoned
- 2004-11-17 SI SI200431374T patent/SI1701701T1/sl unknown
- 2004-11-17 CN CN2004800339138A patent/CN1960705B/zh not_active Expired - Lifetime
- 2004-11-17 KR KR1020067012049A patent/KR20060127001A/ko not_active Withdrawn
- 2004-11-17 JP JP2006540581A patent/JP2007511590A/ja active Pending
- 2004-11-17 WO PCT/GB2004/004824 patent/WO2005048983A1/en not_active Ceased
- 2004-11-17 EP EP04798543A patent/EP1684718A1/en not_active Withdrawn
- 2004-11-17 ES ES04798566.8T patent/ES2330341T5/es not_active Expired - Lifetime
- 2004-11-17 DE DE602004024925T patent/DE602004024925D1/de not_active Expired - Lifetime
- 2004-11-17 PL PL04798564T patent/PL1701701T5/pl unknown
- 2004-11-17 AU AU2004290965A patent/AU2004290965B2/en not_active Expired
- 2004-11-17 WO PCT/GB2004/004831 patent/WO2005048976A2/en not_active Ceased
- 2004-11-17 WO PCT/GB2004/004848 patent/WO2005048977A2/en not_active Ceased
- 2004-11-17 EP EP04798566.8A patent/EP1694292B2/en not_active Expired - Lifetime
- 2004-11-17 MX MXPA06005526A patent/MXPA06005526A/es active IP Right Grant
- 2004-11-17 US US10/522,529 patent/US20060280690A1/en not_active Abandoned
- 2004-11-17 NZ NZ547265A patent/NZ547265A/en not_active IP Right Cessation
- 2004-11-17 CA CA002546227A patent/CA2546227A1/en not_active Abandoned
- 2004-11-17 PL PL04798566T patent/PL1694292T5/pl unknown
- 2004-11-17 JP JP2006540579A patent/JP2007511312A/ja active Pending
- 2004-11-17 SI SI200431254A patent/SI1694292T2/sl unknown
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