JP4837812B2 - 微粉砕粉末カロテノイド製剤の製造 - Google Patents

微粉砕粉末カロテノイド製剤の製造 Download PDF

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Publication number
JP4837812B2
JP4837812B2 JP04259499A JP4259499A JP4837812B2 JP 4837812 B2 JP4837812 B2 JP 4837812B2 JP 04259499 A JP04259499 A JP 04259499A JP 4259499 A JP4259499 A JP 4259499A JP 4837812 B2 JP4837812 B2 JP 4837812B2
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Japan
Prior art keywords
heat exchanger
suspension
solution
kettle
carotene
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Expired - Fee Related
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JP04259499A
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English (en)
Japanese (ja)
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JP2000186224A (ja
Inventor
ヘルマン・シュタイン
クラウス・ヴィアドー
ビン・ヤング
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DSM IP Assets BV
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DSM IP Assets BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP04259499A 1998-02-23 1999-02-22 微粉砕粉末カロテノイド製剤の製造 Expired - Fee Related JP4837812B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98103113 1998-02-23
EP98103113.1 1998-02-23

Publications (2)

Publication Number Publication Date
JP2000186224A JP2000186224A (ja) 2000-07-04
JP4837812B2 true JP4837812B2 (ja) 2011-12-14

Family

ID=8231467

Family Applications (1)

Application Number Title Priority Date Filing Date
JP04259499A Expired - Fee Related JP4837812B2 (ja) 1998-02-23 1999-02-22 微粉砕粉末カロテノイド製剤の製造

Country Status (16)

Country Link
US (1) US6406735B2 (enExample)
EP (1) EP0937412B1 (enExample)
JP (1) JP4837812B2 (enExample)
KR (1) KR100695589B1 (enExample)
CN (1) CN1173637C (enExample)
AU (1) AU743535B2 (enExample)
BR (1) BR9900776A8 (enExample)
CA (1) CA2261456A1 (enExample)
DE (1) DE69929641T2 (enExample)
ES (1) ES2257828T3 (enExample)
ID (1) ID23623A (enExample)
IN (1) IN1999CH00212A (enExample)
MX (1) MX224632B (enExample)
NO (1) NO315892B1 (enExample)
PH (1) PH11999000351B1 (enExample)
TW (1) TW565434B (enExample)

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DE10104494A1 (de) 2001-01-31 2002-08-01 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Carotinoide
DE60231985D1 (de) * 2001-08-13 2009-05-28 Dsm Ip Assets Bv Zusammensetzungen enthaltend zuckerrüben pektin und carotinoide
US6811801B2 (en) * 2001-12-12 2004-11-02 Abbott Laboratories Methods and compositions for brightening the color of thermally processed nutritionals
ES2189697B1 (es) † 2001-12-28 2005-02-01 Antibioticos, S.A.U. Procedimiento para obtener nuevas formulaciones a base de luteina.
ES2297125T5 (es) † 2002-02-06 2013-07-03 Dsm Ip Assets B.V. Ésteres de astaxantina
US6936279B2 (en) * 2002-06-18 2005-08-30 Zeavision Llc Microcrystalline zeaxanthin with high bioavailability in oily carrier formulations
EP1405572A1 (en) * 2002-10-04 2004-04-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Modified lupin proteins for the preparation of water dispersible product forms of fat soluble compounds
JPWO2004087645A1 (ja) * 2003-03-28 2006-06-29 株式会社クラレ カロテノイド乳化液の製造方法
KR20040098887A (ko) * 2003-05-16 2004-11-26 주식회사 마린프로덕트테크 지용성 아스타산틴 등의 수용화 조제 방법
CN100383194C (zh) * 2004-02-17 2008-04-23 章浩龙 一种液状分散染料的制造方法
DE102004030072A1 (de) * 2004-06-23 2006-01-19 Basf Ag Wässrige Dispersionen schwer wasserlöslicher oder wasserunlöslicher Wirkstoffe und daraus hergestellte Trockenpulver
US10463061B2 (en) 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
EP2266419A1 (en) 2005-05-23 2010-12-29 Phares Drug Delivery AG Direct dissolution of carotenoids in edible oils and fats
DE102005030952A1 (de) 2005-06-30 2007-01-18 Basf Ag Verfahren zur Herstellung einer wässrigen Suspension und einer pulverförmigen Zubereitung eines oder mehrerer Carotinoide
EP1903887A1 (en) * 2005-07-20 2008-04-02 DSMIP Assets B.V. Novel stabilized carotenoid compositions
ES2279695B1 (es) * 2005-08-01 2008-08-01 Jesus Antas Pharma, S.A. Nuevas formulaciones solidas de carotenoides y procedimiento para su obtencion.
AU2006281638B2 (en) * 2005-08-15 2012-05-03 Phares Pharmaceutical Research N.V. Crystal forms of astaxanthin
EP1886584A1 (en) * 2006-08-08 2008-02-13 Indena S.P.A. Stable and bioavailable compositions of isomers of lycopene for skin and hair
US7435846B2 (en) * 2006-08-18 2008-10-14 Industrial Organica, S.A. De C.V. Absorption and bioavailability of carotenoids, formulations and applications
ES2361276T5 (es) 2007-01-16 2017-06-09 Basf Se Formulaciones líquidas, que contienen carotenoides
EP1967081A1 (en) * 2007-03-05 2008-09-10 DSMIP Assets B.V. Process for the manufacture of a powder containing carotenoids
US9707185B2 (en) * 2007-05-07 2017-07-18 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Water-soluble nanoparticles containing water-insoluble compounds
HRP20191104T1 (hr) 2007-09-25 2019-09-20 Solubest Ltd. Pripravci koji sadrže lipofilne aktivne spojeve i postupak za njihovu pripremu
CN101396068B (zh) * 2007-09-27 2013-05-01 浙江医药股份有限公司新昌制药厂 类胡萝卜素制剂及其应用和包含该制剂的饲料及其制备方法
CN101873804A (zh) 2007-11-29 2010-10-27 巴斯夫欧洲公司 用于饮料着色的粉状类胡萝卜素制剂
US20100247713A1 (en) * 2007-12-05 2010-09-30 Thomas Lindemann Beta + hydrolyzed lecithin
CN101888786A (zh) * 2007-12-05 2010-11-17 帝斯曼知识产权资产管理有限公司 脂溶性活性成分的粉状制剂
CN101297691B (zh) * 2008-06-06 2011-12-14 成都建福化学品有限公司 稳定的水溶性类胡萝卜素干粉的制备方法
ES2563640T5 (es) 2008-10-07 2021-11-22 Basf Se Emulsión estable, lista para usar
EP2210593A3 (en) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettable formulations of vitamin A and derivatives thereof
EP2403361B1 (de) * 2009-03-04 2012-12-26 Basf Se Verfahren zur herstellung von carotinoid-lösungen
DK2403362T3 (da) * 2009-03-05 2013-04-15 Basf Se Pulverformede sammensætninger af astaxanthin-derivater II
PT3130396T (pt) * 2009-03-27 2021-05-12 Bend Res Inc Processo de secagem por pulverização
JP2012521774A (ja) 2009-03-30 2012-09-20 ビーエーエスエフ ソシエタス・ヨーロピア 部分的に非晶質のカロテノイド粒子の即時使用安定性懸濁液
WO2012031133A2 (en) 2010-09-03 2012-03-08 Bench Research, Inc. Spray-drying apparatus and methods of using the same
WO2012031129A2 (en) 2010-09-03 2012-03-08 Bend Research, Inc. Spray-drying apparatus and methods of using the same
US9248584B2 (en) 2010-09-24 2016-02-02 Bend Research, Inc. High-temperature spray drying process and apparatus
AU2011334017B2 (en) * 2010-11-26 2016-03-03 Dsm Ip Assets B.V. Protective hydrocolloid for active ingredients
US20120157547A1 (en) 2010-12-21 2012-06-21 Ricardo Montoya-Olvera Compositions and applications of carotenoids of improved absorption and bioavailability
US20140364512A9 (en) * 2012-04-19 2014-12-11 Epc (Beijing) Natural Products Co., Ltd. Compositions comprising a combination of at least one colorant and at least one polysaccharide
EP3051963A1 (en) * 2013-09-24 2016-08-10 DSM IP Assets B.V. Stable red formulations for the coloration of beverages and food
WO2016044001A1 (en) * 2014-09-15 2016-03-24 Sustainable Aquatics, Inc. Method and apparatus for producing astaxanthin
CA2962719A1 (en) 2014-10-31 2016-05-06 Bend Research Inc. Process for forming active domains dispersed in a matrix
KR101700909B1 (ko) 2015-05-29 2017-02-14 주식회사 마크로케어 장쇄 레티닐 에스테르 제조를 위한 2상 반응 시스템 및 장쇄 레티닐 에스테르 제조방법
US10479906B2 (en) * 2015-09-18 2019-11-19 Oregon State University Use of fungal pigments from wood-staining fungi as colorants in wood finishes and paints
US10835456B2 (en) * 2016-07-19 2020-11-17 Basf Se Propyl gallate-containing vitamin preparations
CN106278978A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术（武汉）股份有限公司 制备β‑胡萝卜素晶体的方法
CN106278976A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术（武汉）股份有限公司 制备β‑胡萝卜素晶体的方法
CN106278977A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术（武汉）股份有限公司 制备β‑胡萝卜素晶体的方法
WO2019068288A1 (de) 2017-10-04 2019-04-11 Berlimed International Research Gmbh Wirkstoff und wirkstoffmatrix enthaltendes produkt zur transdermalen wirkstoffabgabe sowie dessen herstellung und verwendung sowie die wirkstoffmatrix, ihre herstellung und verwendung
EP3784056A1 (en) 2018-04-27 2021-03-03 DSM IP Assets B.V. Method of manufacturing spray-dried powders
EP3784057A1 (en) 2018-04-27 2021-03-03 DSM IP Assets B.V. Continuous manufacturing of spray-dried powders
EP3784055B1 (en) 2018-04-27 2024-05-01 DSM IP Assets B.V. Apparatus and process for manufacturing of powders with a fat-soluble component
CN111471317B (zh) * 2020-03-26 2021-06-04 广东省农业科学院蚕业与农产品加工研究所 一种稳态化玉米黄色素及其制备方法
CN114287625B (zh) * 2021-12-28 2024-04-05 大连医诺生物股份有限公司 一种类胡萝卜素制剂及其应用
CN119816210A (zh) * 2022-08-05 2025-04-11 帝斯曼知识产权资产管理有限公司 含有β-胡萝卜素的固体制剂

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Also Published As

Publication number Publication date
CN1231843A (zh) 1999-10-20
KR19990072792A (ko) 1999-09-27
EP0937412A1 (en) 1999-08-25
JP2000186224A (ja) 2000-07-04
BR9900776A (pt) 2000-03-28
TW565434B (en) 2003-12-11
EP0937412B1 (en) 2006-02-01
AU743535B2 (en) 2002-01-31
DE69929641T2 (de) 2006-12-14
AU1836299A (en) 1999-09-09
CA2261456A1 (en) 1999-08-23
NO315892B1 (no) 2003-11-10
US6406735B2 (en) 2002-06-18
PH11999000351B1 (en) 2004-02-11
NO990852L (no) 1999-08-24
NO990852D0 (no) 1999-02-23
MX224632B (es) 2004-12-03
BR9900776A8 (pt) 2018-03-20
DE69929641D1 (de) 2006-04-13
CN1173637C (zh) 2004-11-03
MX9901754A (es) 2000-02-28
IN1999CH00212A (enExample) 2007-05-18
ES2257828T3 (es) 2006-08-01
BR9900776B1 (pt) 2011-05-31
ID23623A (id) 2000-05-04
US20010008644A1 (en) 2001-07-19
KR100695589B1 (ko) 2007-03-14

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