CN1173637C - 细粉状类胡萝卜素制剂的制备 - Google Patents

细粉状类胡萝卜素制剂的制备 Download PDF

Info

Publication number
CN1173637C
CN1173637C CNB991029003A CN99102900A CN1173637C CN 1173637 C CN1173637 C CN 1173637C CN B991029003 A CNB991029003 A CN B991029003A CN 99102900 A CN99102900 A CN 99102900A CN 1173637 C CN1173637 C CN 1173637C
Authority
CN
China
Prior art keywords
heat exchanger
suspension
carotenoid
preparation
activeconstituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB991029003A
Other languages
English (en)
Chinese (zh)
Other versions
CN1231843A (zh
Inventor
赫尔曼・斯坦
赫尔曼·斯坦
・维尔多特
克劳斯·维尔多特
杨宾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
D Sm I P Asset Co
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN1231843A publication Critical patent/CN1231843A/zh
Application granted granted Critical
Publication of CN1173637C publication Critical patent/CN1173637C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40Colouring or decolouring of foods
    • A23L5/42Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB991029003A 1998-02-23 1999-02-23 细粉状类胡萝卜素制剂的制备 Expired - Fee Related CN1173637C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98103113 1998-02-23
EP98103113.1 1998-02-23

Publications (2)

Publication Number Publication Date
CN1231843A CN1231843A (zh) 1999-10-20
CN1173637C true CN1173637C (zh) 2004-11-03

Family

ID=8231467

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB991029003A Expired - Fee Related CN1173637C (zh) 1998-02-23 1999-02-23 细粉状类胡萝卜素制剂的制备

Country Status (16)

Country Link
US (1) US6406735B2 (enExample)
EP (1) EP0937412B1 (enExample)
JP (1) JP4837812B2 (enExample)
KR (1) KR100695589B1 (enExample)
CN (1) CN1173637C (enExample)
AU (1) AU743535B2 (enExample)
BR (1) BR9900776A8 (enExample)
CA (1) CA2261456A1 (enExample)
DE (1) DE69929641T2 (enExample)
ES (1) ES2257828T3 (enExample)
ID (1) ID23623A (enExample)
IN (1) IN1999CH00212A (enExample)
MX (1) MX224632B (enExample)
NO (1) NO315892B1 (enExample)
PH (1) PH11999000351B1 (enExample)
TW (1) TW565434B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103327827A (zh) * 2010-11-26 2013-09-25 帝斯曼知识产权资产管理有限公司 用于活性成分的保护性水胶体
CN106278976A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法
CN106278978A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法
CN106278977A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60019239T3 (de) * 1999-12-09 2017-03-02 Dsm Ip Assets B.V. Fettlösliche Vitamine enthaltende Zusammensetzungen
JP2004514419A (ja) * 2000-07-13 2004-05-20 ビタテネ、ソシエダッド アノニマ カロチノイドを含有する水分散性配合物の製造方法
ATE358469T1 (de) * 2000-11-29 2007-04-15 Basf Ag Verfahren zur herstellung fester zubereitungen wasserlöslicher, schwer wasserlöslicher oder wasserunlöslicher wirkstoffe
US7105176B2 (en) 2000-11-29 2006-09-12 Basf Aktiengesellschaft Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds
DE10064387A1 (de) 2000-12-21 2002-06-27 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Sauerstoff-haltiger Carotinoide
EP1227082B1 (en) * 2001-01-24 2004-06-16 Kuraray Co., Ltd. Process for producing carotenoid emulsion
DE10104494A1 (de) * 2001-01-31 2002-08-01 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Carotinoide
ATE428310T1 (de) * 2001-08-13 2009-05-15 Dsm Ip Assets Bv Zusammensetzungen enthaltend zuckerrüben pektin und carotinoide
US6811801B2 (en) * 2001-12-12 2004-11-02 Abbott Laboratories Methods and compositions for brightening the color of thermally processed nutritionals
ES2189697B1 (es) * 2001-12-28 2005-02-01 Antibioticos, S.A.U. Procedimiento para obtener nuevas formulaciones a base de luteina.
JP4420675B2 (ja) 2002-02-06 2010-02-24 ディーエスエム アイピー アセッツ ビー.ブイ. アスタキサンチンエステル
US6936279B2 (en) * 2002-06-18 2005-08-30 Zeavision Llc Microcrystalline zeaxanthin with high bioavailability in oily carrier formulations
EP1405572A1 (en) * 2002-10-04 2004-04-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Modified lupin proteins for the preparation of water dispersible product forms of fat soluble compounds
CN1768033A (zh) * 2003-03-28 2006-05-03 株式会社可乐丽 制备类胡萝卜素乳液的方法
KR20040098887A (ko) * 2003-05-16 2004-11-26 주식회사 마린프로덕트테크 지용성 아스타산틴 등의 수용화 조제 방법
CN100383194C (zh) * 2004-02-17 2008-04-23 章浩龙 一种液状分散染料的制造方法
DE102004030072A1 (de) * 2004-06-23 2006-01-19 Basf Ag Wässrige Dispersionen schwer wasserlöslicher oder wasserunlöslicher Wirkstoffe und daraus hergestellte Trockenpulver
US10463061B2 (en) 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
AU2006251391B2 (en) 2005-05-23 2011-10-06 Phares Pharmaceutical Research N.V. Direct dissolution
DE102005030952A1 (de) 2005-06-30 2007-01-18 Basf Ag Verfahren zur Herstellung einer wässrigen Suspension und einer pulverförmigen Zubereitung eines oder mehrerer Carotinoide
JP2009501534A (ja) * 2005-07-20 2009-01-22 ディーエスエム アイピー アセッツ ビー.ブイ. 新規の安定化カロチノイド組成物
ES2279695B1 (es) * 2005-08-01 2008-08-01 Jesus Antas Pharma, S.A. Nuevas formulaciones solidas de carotenoides y procedimiento para su obtencion.
ES2420155T3 (es) * 2005-08-15 2013-08-22 Phares Drug Delivery Ag Formas de cristal de astaxantina
EP1886584A1 (en) * 2006-08-08 2008-02-13 Indena S.P.A. Stable and bioavailable compositions of isomers of lycopene for skin and hair
US7435846B2 (en) * 2006-08-18 2008-10-14 Industrial Organica, S.A. De C.V. Absorption and bioavailability of carotenoids, formulations and applications
DE502008002872D1 (de) 2007-01-16 2011-04-28 Basf Se Flüssige formulierungen enthaltend carotinoide
EP1967081A1 (en) * 2007-03-05 2008-09-10 DSMIP Assets B.V. Process for the manufacture of a powder containing carotenoids
US9707185B2 (en) * 2007-05-07 2017-07-18 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Water-soluble nanoparticles containing water-insoluble compounds
EP2200588B1 (en) 2007-09-25 2019-03-20 Solubest Ltd. Compositions comprising lipophilic active compounds and method for their preparation
CN101396068B (zh) * 2007-09-27 2013-05-01 浙江医药股份有限公司新昌制药厂 类胡萝卜素制剂及其应用和包含该制剂的饲料及其制备方法
CN105077203A (zh) 2007-11-29 2015-11-25 巴斯夫欧洲公司 用于饮料着色的粉状类胡萝卜素制剂
US20100272861A1 (en) * 2007-12-05 2010-10-28 Thomas Lindemann Pulverous formulation of a fat-soluble active ingredient
JP2011505158A (ja) * 2007-12-05 2011-02-24 ディーエスエム アイピー アセッツ ビー.ブイ. 脂溶性活性成分の微粉砕状調合物
CN101297691B (zh) * 2008-06-06 2011-12-14 成都建福化学品有限公司 稳定的水溶性类胡萝卜素干粉的制备方法
US9375387B2 (en) 2008-10-07 2016-06-28 Basf Se Ready-to-use, stable emulsion
EP2210593A3 (en) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettable formulations of vitamin A and derivatives thereof
EP2403361B1 (de) * 2009-03-04 2012-12-26 Basf Se Verfahren zur herstellung von carotinoid-lösungen
DK2403362T3 (da) * 2009-03-05 2013-04-15 Basf Se Pulverformede sammensætninger af astaxanthin-derivater II
EP2411137B1 (en) 2009-03-27 2016-09-07 Bend Research, Inc. Spray-drying process
JP2012521774A (ja) 2009-03-30 2012-09-20 ビーエーエスエフ ソシエタス・ヨーロピア 部分的に非晶質のカロテノイド粒子の即時使用安定性懸濁液
PT2611530T (pt) 2010-09-03 2019-05-09 Bend Res Inc Aparelho de secagem por pulverização e métodos de utilização do mesmo
WO2012031129A2 (en) 2010-09-03 2012-03-08 Bend Research, Inc. Spray-drying apparatus and methods of using the same
WO2012040502A1 (en) 2010-09-24 2012-03-29 Bend Research, Inc. High-temperature spray drying process and apparatus
US20120157547A1 (en) 2010-12-21 2012-06-21 Ricardo Montoya-Olvera Compositions and applications of carotenoids of improved absorption and bioavailability
US20140364512A9 (en) * 2012-04-19 2014-12-11 Epc (Beijing) Natural Products Co., Ltd. Compositions comprising a combination of at least one colorant and at least one polysaccharide
EP3051963A1 (en) * 2013-09-24 2016-08-10 DSM IP Assets B.V. Stable red formulations for the coloration of beverages and food
WO2016044001A1 (en) * 2014-09-15 2016-03-24 Sustainable Aquatics, Inc. Method and apparatus for producing astaxanthin
JP6650933B2 (ja) 2014-10-31 2020-02-19 ベンド リサーチ, インコーポレイテッド マトリックス中に分散された活性薬剤ドメインを形成するためのプロセス
KR101700909B1 (ko) 2015-05-29 2017-02-14 주식회사 마크로케어 장쇄 레티닐 에스테르 제조를 위한 2상 반응 시스템 및 장쇄 레티닐 에스테르 제조방법
US10479906B2 (en) * 2015-09-18 2019-11-19 Oregon State University Use of fungal pigments from wood-staining fungi as colorants in wood finishes and paints
JP7171542B2 (ja) * 2016-07-19 2022-11-15 ビーエーエスエフ ソシエタス・ヨーロピア 没食子酸プロピル含有ビタミン製剤
WO2019068288A1 (de) 2017-10-04 2019-04-11 Berlimed International Research Gmbh Wirkstoff und wirkstoffmatrix enthaltendes produkt zur transdermalen wirkstoffabgabe sowie dessen herstellung und verwendung sowie die wirkstoffmatrix, ihre herstellung und verwendung
WO2019207084A1 (en) 2018-04-27 2019-10-31 Dsm Ip Assets B.V. Method of manufacturing spray-dried powders
US11772007B2 (en) 2018-04-27 2023-10-03 Dsm Ip Assets B.V. Evaporator system
US12059634B2 (en) 2018-04-27 2024-08-13 Dsm Ip Assets B.V. Continuous manufacturing of spray-dried powders
CN111471317B (zh) * 2020-03-26 2021-06-04 广东省农业科学院蚕业与农产品加工研究所 一种稳态化玉米黄色素及其制备方法
CN114287625B (zh) * 2021-12-28 2024-04-05 大连医诺生物股份有限公司 一种类胡萝卜素制剂及其应用
CN119816210A (zh) * 2022-08-05 2025-04-11 帝斯曼知识产权资产管理有限公司 含有β-胡萝卜素的固体制剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2861891A (en) * 1956-12-13 1958-11-25 Hoffmann La Roche Water dispersible carotenoid compositions and process of making the same
DE1211911B (de) * 1959-09-08 1966-03-03 Hoffmann La Roche Verfahren zur Herstellung eines insbesondere zum Faerben von Lebens- und Futtermitteln geeigneten Carotinoidpraeparates
US3110598A (en) * 1959-09-08 1963-11-12 Hoffmann La Roche Process of making a carotenoid preparation
US3316101A (en) * 1965-08-03 1967-04-25 Hoffmann La Roche Stabilizing carotenoid compositions
CH522717A (de) * 1969-02-07 1972-06-30 Hoffmann La Roche Färbepräparat
US3790688A (en) * 1972-03-15 1974-02-05 Us Agriculture Water dispersible beta-carotene
US3998753A (en) * 1974-08-13 1976-12-21 Hoffmann-La Roche Inc. Water dispersible carotenoid preparations and processes thereof
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
DE3610191A1 (de) * 1986-03-26 1987-10-01 Basf Ag Verfahren zur herstellung von feinteiligen, wasserdispergierbaren carotinoid-praeparationen
DE3611229A1 (de) * 1986-04-04 1987-10-08 Basf Ag Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten
DE59003205D1 (de) * 1989-07-25 1993-12-02 Hoffmann La Roche Verfahren zur Herstellung von Carotinoidpräparaten.
DE19609538A1 (de) * 1996-03-11 1997-09-18 Basf Ag Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung
DE19838636A1 (de) * 1998-08-26 2000-03-02 Basf Ag Carotinoid-Formulierungen, enthaltend ein Gemisch aus beta-Carotin, Lycopin und Lutein

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103327827A (zh) * 2010-11-26 2013-09-25 帝斯曼知识产权资产管理有限公司 用于活性成分的保护性水胶体
CN103327827B (zh) * 2010-11-26 2016-02-10 帝斯曼知识产权资产管理有限公司 用于活性成分的保护性水胶体
CN106278976A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法
CN106278978A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法
CN106278977A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法

Also Published As

Publication number Publication date
CN1231843A (zh) 1999-10-20
KR100695589B1 (ko) 2007-03-14
CA2261456A1 (en) 1999-08-23
JP2000186224A (ja) 2000-07-04
AU743535B2 (en) 2002-01-31
EP0937412A1 (en) 1999-08-25
IN1999CH00212A (enExample) 2007-05-18
JP4837812B2 (ja) 2011-12-14
AU1836299A (en) 1999-09-09
BR9900776A (pt) 2000-03-28
MX9901754A (es) 2000-02-28
US6406735B2 (en) 2002-06-18
ID23623A (id) 2000-05-04
NO990852L (no) 1999-08-24
ES2257828T3 (es) 2006-08-01
BR9900776B1 (pt) 2011-05-31
PH11999000351B1 (en) 2004-02-11
DE69929641D1 (de) 2006-04-13
US20010008644A1 (en) 2001-07-19
TW565434B (en) 2003-12-11
NO315892B1 (no) 2003-11-10
DE69929641T2 (de) 2006-12-14
KR19990072792A (ko) 1999-09-27
BR9900776A8 (pt) 2018-03-20
EP0937412B1 (en) 2006-02-01
NO990852D0 (no) 1999-02-23
MX224632B (es) 2004-12-03

Similar Documents

Publication Publication Date Title
CN1173637C (zh) 细粉状类胡萝卜素制剂的制备
AU743477B2 (en) The production of carotenoid preparations in the form of coldwater-dispersible powders, and the use of the novel carotenoid preparations
US5500415A (en) Process for the preparation of spherules of active principles and emulsions containing the spherules
CN1184201C (zh) 一种或多种氧化的类胡萝卜素干粉的制备方法
US5811609A (en) Process for the preparation of a water dispersible carotenoid preparation in powder form
MXPA99001754A (en) Continuous procedure for the preparation of a composition in the form of powder of a carotenoid and preparation in form of dust prepared through such procedimie
CN1239977A (zh) 叶黄素类的稳定水分散液及稳定的水分散性干粉,其制备以及用途
EP1898721B1 (de) Verfahren zur herstellung einer wässrigen suspension und einer pulverförmigen zubereitung eines oder mehrerer carotinoide
CN1374035A (zh) 生产一种或多种类胡萝卜素的干粉的方法
EP1794238A2 (de) Verfahren zur herstellung von trockenpulvern eines oder mehrerer carotinoide
JPS62240364A (ja) 水に分散しうる微粒状カロチノイド製品の製法
JPH09202769A (ja) 乾燥カロテノイド−油粉体及びその製造方法
JPH1046041A (ja) カロチノイド組成物の製造方法
CN1283454A (zh) 制备含脂溶性物质的小珠的方法
CN1775868A (zh) 一种水分散型辣椒红色素微囊及其制备方法
IL196735A (en) A process for making pigments granules by double expense
CN1993060A (zh) 可脂溶物质的新型组合物
CN1942106A (zh) 生产一种或多种类胡萝卜素的干粉的方法
TWI794481B (zh) 製造噴霧乾燥粉末之方法及相關之組合物
CN119138600A (zh) 类胡萝卜素油悬液及其制备方法
WO2004084862A1 (en) Process for the production of cross-linked gelatin beadlets
CN119896312B (zh) 一种负载根皮素的食叶草蛋白乳液的制备方法
TWI899053B (zh) 用於噴霧乾燥分散液之設置、用於生產分散液之中間組合物的方法及其所獲得的中間組合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: DSM IP CAPITAL CO., LTD.

Free format text: FORMER OWNER: HOFFMAN-LALUOAI LTD.

Effective date: 20040611

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20040611

Address after: Holland Heerlen

Applicant after: D Sm I P Asset company

Address before: Basel

Applicant before: F. Hoffmann-La Roche AG

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20041103

Termination date: 20180223

CF01 Termination of patent right due to non-payment of annual fee