JP4836280B2 - 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物 - Google Patents

癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物 Download PDF

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JP4836280B2
JP4836280B2 JP2007516842A JP2007516842A JP4836280B2 JP 4836280 B2 JP4836280 B2 JP 4836280B2 JP 2007516842 A JP2007516842 A JP 2007516842A JP 2007516842 A JP2007516842 A JP 2007516842A JP 4836280 B2 JP4836280 B2 JP 4836280B2
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Prior art keywords
imidazol
benzyl
phenyl
dimethylpropyl
propyl
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Expired - Fee Related
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Japanese (ja)
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JP2008503501A5 (OSRAM
JP2008503501A (ja
Inventor
ウェイボ ワン，
ポール エー． バルサンティ，
イ シー，
ラストン エス． ボイス，
サビナ ペチ，
ナタン ブラマイヤー，
メガン フィリップ，
クリス メンデンホール，
ケリー ウェイマン，
リアナ マリー ラニトン，
ライアン コンスタンティン，
ホン ヤン，
エリザベス ミエウリ，
ザビズリ ラムルズィー，
エリサ ジャザン，
アヌ シャルマ，
ジェーン ラマ，
シャラダ サブラマニアン，
ポール レンハウエ，
ケネス ウォルター ベア，
デーヴィッド ドゥル，
アネット ウォルター，
ティニア エイブラムズ，
ケイ ハ，
エリック マーティン，
マーク クナップ，
ビンセント レー，
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ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド
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    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2007516842A 2004-06-18 2005-06-20 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物 Expired - Fee Related JP4836280B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58092704P 2004-06-18 2004-06-18
US60/580,927 2004-06-18
PCT/US2005/022062 WO2006002236A1 (en) 2004-06-18 2005-06-20 N- (1- (1-benzyl -4-phenyl-1h-imidazol-2-yl) -2,2-dymethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer

Related Child Applications (1)

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JP2011179247A Division JP2011256197A (ja) 2004-06-18 2011-08-18 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物

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JP2008503501A JP2008503501A (ja) 2008-02-07
JP2008503501A5 JP2008503501A5 (OSRAM) 2008-08-14
JP4836280B2 true JP4836280B2 (ja) 2011-12-14

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JP2007516842A Expired - Fee Related JP4836280B2 (ja) 2004-06-18 2005-06-20 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物
JP2011179247A Withdrawn JP2011256197A (ja) 2004-06-18 2011-08-18 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物

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JP2011179247A Withdrawn JP2011256197A (ja) 2004-06-18 2011-08-18 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物

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US (3) US7576221B2 (OSRAM)
EP (1) EP1765789B1 (OSRAM)
JP (2) JP4836280B2 (OSRAM)
KR (1) KR101170925B1 (OSRAM)
CN (1) CN1993331A (OSRAM)
AU (1) AU2005258135B2 (OSRAM)
BR (1) BRPI0510929A (OSRAM)
CA (1) CA2571002A1 (OSRAM)
EC (1) ECSP077183A (OSRAM)
ES (1) ES2409345T3 (OSRAM)
IL (1) IL180147A0 (OSRAM)
MA (1) MA28739B1 (OSRAM)
MX (1) MXPA06014909A (OSRAM)
NO (1) NO20070343L (OSRAM)
NZ (1) NZ552510A (OSRAM)
RU (1) RU2427572C2 (OSRAM)
SG (1) SG153851A1 (OSRAM)
TN (1) TNSN06419A1 (OSRAM)
TW (1) TW200612958A (OSRAM)
WO (1) WO2006002236A1 (OSRAM)
ZA (1) ZA200700481B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011256197A (ja) * 2004-06-18 2011-12-22 Novartis Vaccines & Diagnostics Inc 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物

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KR20070046176A (ko) 2004-08-18 2007-05-02 아스트라제네카 아베 특정 융합 피리미돈의 거울상이성질체 및 이의 암 치료 및예방에 있어서의 용도
WO2007011647A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin ksp
MY147188A (en) * 2005-08-09 2012-11-14 Novartis Ag Substituted imidazole compounds as ksp inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
DK2010528T3 (en) 2006-04-19 2018-01-15 Novartis Ag 6-O-Substituted Benzoxazole and Benzothiazole Compounds and Methods for Inhibiting CSF-1R Signaling
ATE532770T1 (de) 2006-09-05 2011-11-15 Kyowa Hakko Kirin Co Ltd Imidazolderivat
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
KR20090081020A (ko) * 2006-11-13 2009-07-27 노파르티스 아게 Ｋｓｐ 억제제로서의 치환된 피라졸 및 트리아졸 화합물
KR20090097210A (ko) * 2007-01-05 2009-09-15 노파르티스 아게 키네신 방추체 단백질 (ｅｇ－５) 억제제로서의 이미다졸 유도체
US8252832B2 (en) * 2007-12-14 2012-08-28 Novartis Ag Kinesin inhibitors as cancer therapeutics
US20110275685A1 (en) 2009-01-26 2011-11-10 Michael Mutz Salt and polymorphs of a kinesin inhibitor compound
MX2012011910A (es) 2010-04-15 2012-11-29 Novartis Ag Compuestos de triazol como inhibidores de ksp.
JP2013525290A (ja) * 2010-04-15 2013-06-20 ノバルティス アーゲー Ｋｓｐ阻害剤としてのオキサゾールおよびチアゾール化合物
DE102010025663A1 (de) 2010-06-30 2012-01-05 Karl-Heinz Glüsenkamp Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
CN105451773A (zh) * 2013-03-15 2016-03-30 诺华股份有限公司 细胞增殖抑制剂及其缀合物
PE20160996A1 (es) * 2013-12-23 2016-11-09 Bayer Pharma AG Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
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