JP4780549B2 - キナーゼ阻害活性を有するピロロピラジン誘導体およびその生物学的用途 - Google Patents
キナーゼ阻害活性を有するピロロピラジン誘導体およびその生物学的用途 Download PDFInfo
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- JP4780549B2 JP4780549B2 JP2004528508A JP2004528508A JP4780549B2 JP 4780549 B2 JP4780549 B2 JP 4780549B2 JP 2004528508 A JP2004528508 A JP 2004528508A JP 2004528508 A JP2004528508 A JP 2004528508A JP 4780549 B2 JP4780549 B2 JP 4780549B2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020292019 EP1388541A1 (en) | 2002-08-09 | 2002-08-09 | Pyrrolopyrazines as kinase inhibitors |
| EP02292019.3 | 2002-08-09 | ||
| PCT/EP2003/009515 WO2004016614A2 (en) | 2002-08-09 | 2003-08-08 | Pyrrolopyrazines as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006502137A JP2006502137A (ja) | 2006-01-19 |
| JP2006502137A5 JP2006502137A5 (https=) | 2006-08-03 |
| JP4780549B2 true JP4780549B2 (ja) | 2011-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2004528508A Expired - Fee Related JP4780549B2 (ja) | 2002-08-09 | 2003-08-08 | キナーゼ阻害活性を有するピロロピラジン誘導体およびその生物学的用途 |
Country Status (6)
| Country | Link |
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| US (1) | US8106050B2 (https=) |
| EP (2) | EP1388541A1 (https=) |
| JP (1) | JP4780549B2 (https=) |
| AU (1) | AU2003271566A1 (https=) |
| CA (1) | CA2495060C (https=) |
| WO (1) | WO2004016614A2 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1388541A1 (en) | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
| FR2876377B1 (fr) * | 2004-10-11 | 2007-03-16 | Univ Claude Bernard Lyon | Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes |
| FR2876582B1 (fr) * | 2004-10-15 | 2007-01-05 | Centre Nat Rech Scient Cnrse | Utilisation de derives de pyrrolo-pyrazines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
| FR2899107B1 (fr) * | 2006-03-30 | 2008-06-13 | Neurokin Entpr Unipersonnelle | Utilisation de la (s)-roscovitine pour la fabrication d'un medicament |
| EP2012822B1 (en) * | 2006-04-28 | 2010-01-20 | The Trustees of the University of Pennsylvania | Modified adenovirus hexon protein and uses thereof |
| EP2057164A1 (en) * | 2006-08-07 | 2009-05-13 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
| CL2007002617A1 (es) | 2006-09-11 | 2008-05-16 | Sanofi Aventis | Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto. |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| FR2918061B1 (fr) * | 2007-06-28 | 2010-10-22 | Sanofi Aventis | Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique. |
| JP5661476B2 (ja) | 2008-03-04 | 2015-01-28 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | サルアデノウイルスＳＡｄＶ−３６、−４２．１、−４２．２および−４４ならびにそれらの用途 |
| US8110576B2 (en) | 2008-06-10 | 2012-02-07 | Plexxikon Inc. | Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications |
| MY172424A (en) | 2009-04-03 | 2019-11-25 | Hoffmann La Roche | Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof |
| CN106220623A (zh) | 2009-11-06 | 2016-12-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| US9624213B2 (en) | 2011-02-07 | 2017-04-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2013028952A2 (en) * | 2011-08-25 | 2013-02-28 | Rutgers, The State University Of New Jersey | Compositions and methods for enhancing lipid production in microalgae via induction of cell cycle arrest |
| SG11201407343XA (en) | 2012-05-18 | 2014-12-30 | Univ Pennsylvania | Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2016190847A1 (en) * | 2015-05-26 | 2016-12-01 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| HRP20241288T1 (hr) | 2018-05-04 | 2024-12-06 | Incyte Corporation | Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju |
| AU2019262579B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Salts of an FGFR inhibitor |
| MX2021003904A (es) * | 2018-10-05 | 2021-10-26 | Annapurna Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj. |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3157361A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| JP7832891B2 (ja) | 2019-12-04 | 2026-03-18 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤の誘導体 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| CA3220155A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
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| EP1388541A1 (en) | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
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-
2002
- 2002-08-09 EP EP20020292019 patent/EP1388541A1/en not_active Withdrawn
-
2003
- 2003-08-08 JP JP2004528508A patent/JP4780549B2/ja not_active Expired - Fee Related
- 2003-08-08 CA CA2495060A patent/CA2495060C/en not_active Expired - Fee Related
- 2003-08-08 US US10/524,044 patent/US8106050B2/en not_active Expired - Fee Related
- 2003-08-08 WO PCT/EP2003/009515 patent/WO2004016614A2/en not_active Ceased
- 2003-08-08 AU AU2003271566A patent/AU2003271566A1/en not_active Abandoned
- 2003-08-08 EP EP03753362A patent/EP1527077A2/en not_active Withdrawn
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| JP2001506980A (ja) * | 1996-11-19 | 2001-05-29 | アムジエン・インコーポレーテツド | アリールおよびヘテロアリール置換縮合ピロール抗炎症剤 |
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| WO2001096336A2 (en) * | 2000-06-14 | 2001-12-20 | Warner-Lambert Company | 6,5-fused bicyclic heterocycles |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1527077A2 (en) | 2005-05-04 |
| WO2004016614A3 (en) | 2004-05-06 |
| US20080161312A1 (en) | 2008-07-03 |
| AU2003271566A1 (en) | 2004-03-03 |
| AU2003271566A8 (en) | 2004-03-03 |
| CA2495060C (en) | 2012-01-03 |
| US8106050B2 (en) | 2012-01-31 |
| JP2006502137A (ja) | 2006-01-19 |
| EP1388541A1 (en) | 2004-02-11 |
| WO2004016614A2 (en) | 2004-02-26 |
| CA2495060A1 (en) | 2004-02-26 |
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