JP4740864B2 - 生分解性ポリ（β−アミノエステル）およびその使用 - Google Patents

生分解性ポリ（β−アミノエステル）およびその使用 Download PDF

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JP4740864B2
JP4740864B2 JP2006533421A JP2006533421A JP4740864B2 JP 4740864 B2 JP4740864 B2 JP 4740864B2 JP 2006533421 A JP2006533421 A JP 2006533421A JP 2006533421 A JP2006533421 A JP 2006533421A JP 4740864 B2 JP4740864 B2 JP 4740864B2
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poly
polymer
group
amine
dna
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JP2007504353A5 (enExample
JP2007504353A (ja
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ロバート ランジャー，
デービット エム． リン，
ダニエル ジー． アンダーソン，
エーキン アキンク，
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
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    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
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    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/40—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds, other than from esters thereof
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    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6854—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C08L77/04—Polyamides derived from alpha-amino carboxylic acids
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    • C08L79/02—Polyamines
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    • C08L99/00—Compositions of natural macromolecular compounds or of derivatives thereof not provided for in groups C08L89/00 - C08L97/00

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  • Medicinal Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nanotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006533421A 2003-05-28 2004-05-26 生分解性ポリ（β−アミノエステル）およびその使用 Expired - Lifetime JP4740864B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/446,444 2003-05-28
US10/446,444 US7427394B2 (en) 2000-10-10 2003-05-28 Biodegradable poly(β-amino esters) and uses thereof
PCT/US2004/016521 WO2004106411A2 (en) 2003-05-28 2004-05-26 Biodegradable poly(beta-amino esters) and uses thereof

Related Child Applications (1)

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JP2010069008A Division JP5558154B2 (ja) 2003-05-28 2010-03-24 生分解性ポリ（β−アミノエステル）およびその使用

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JP2007504353A JP2007504353A (ja) 2007-03-01
JP2007504353A5 JP2007504353A5 (enExample) 2010-05-13
JP4740864B2 true JP4740864B2 (ja) 2011-08-03

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JP2006533421A Expired - Lifetime JP4740864B2 (ja) 2003-05-28 2004-05-26 生分解性ポリ（β−アミノエステル）およびその使用
JP2010069008A Expired - Fee Related JP5558154B2 (ja) 2003-05-28 2010-03-24 生分解性ポリ（β−アミノエステル）およびその使用
JP2014013391A Pending JP2014129536A (ja) 2003-05-28 2014-01-28 生分解性ポリ（β−アミノエステル）およびその使用

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JP2010069008A Expired - Fee Related JP5558154B2 (ja) 2003-05-28 2010-03-24 生分解性ポリ（β−アミノエステル）およびその使用
JP2014013391A Pending JP2014129536A (ja) 2003-05-28 2014-01-28 生分解性ポリ（β−アミノエステル）およびその使用

Country Status (9)

Country Link
US (1) US7427394B2 (enExample)
EP (2) EP1903068B1 (enExample)
JP (3) JP4740864B2 (enExample)
AT (2) ATE366769T1 (enExample)
CA (1) CA2527722C (enExample)
DE (2) DE602004007518T2 (enExample)
ES (2) ES2350055T3 (enExample)
PT (1) PT1639029E (enExample)
WO (1) WO2004106411A2 (enExample)

Families Citing this family (152)

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US20080281041A1 (en) 1999-06-07 2008-11-13 Rozema David B Reversibly Masked Polymers
USRE43612E1 (en) 2000-10-10 2012-08-28 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6998115B2 (en) * 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US7223851B2 (en) * 2003-02-06 2007-05-29 General Dynamics Advanced Information Systems, Inc. Nucleic acid-binding polymers
US7309757B2 (en) 2003-06-20 2007-12-18 Agency For Science, Technology And Research Polymers for the delivery of bioactive agents and methods of their preparation
WO2005007819A2 (en) 2003-07-09 2005-01-27 Wisconsin Alumni Research Foundation Charge-dynamic polymers and delivery of anionic compounds
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US7943179B2 (en) * 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
US20050215507A1 (en) * 2004-03-04 2005-09-29 Massachusetts Institute Of Technology Therapeutic anti-cancer DNA
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EP1903068A1 (en) 2008-03-26
ATE366769T1 (de) 2007-08-15
JP5558154B2 (ja) 2014-07-23
US7427394B2 (en) 2008-09-23
ATE475685T1 (de) 2010-08-15
WO2004106411A2 (en) 2004-12-09
ES2350055T3 (es) 2011-01-17
PT1639029E (pt) 2007-09-26
JP2010180412A (ja) 2010-08-19
EP1639029A2 (en) 2006-03-29
DE602004007518T2 (de) 2008-03-20
DE602004007518D1 (de) 2007-08-23
EP1639029B1 (en) 2007-07-11
ES2290737T3 (es) 2008-02-16
US20040071654A1 (en) 2004-04-15
CA2527722A1 (en) 2004-12-09
JP2014129536A (ja) 2014-07-10
EP1903068B1 (en) 2010-07-28
CA2527722C (en) 2013-04-16
JP2007504353A (ja) 2007-03-01
DE602004028418D1 (de) 2010-09-09
WO2004106411A3 (en) 2005-01-20

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