JP4668616B2 - オオアワガエリからの主要アレルゲンＰｈｌｐ１の変異体 - Google Patents

オオアワガエリからの主要アレルゲンＰｈｌｐ１の変異体 Download PDF

Info

Publication number
JP4668616B2
JP4668616B2 JP2004533298A JP2004533298A JP4668616B2 JP 4668616 B2 JP4668616 B2 JP 4668616B2 JP 2004533298 A JP2004533298 A JP 2004533298A JP 2004533298 A JP2004533298 A JP 2004533298A JP 4668616 B2 JP4668616 B2 JP 4668616B2
Authority
JP
Japan
Prior art keywords
allergen
rphl
variant
tag
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004533298A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006516382A5 (https=
JP2006516382A (ja
Inventor
ローラント ズック，
ヘルムート フィービック，
オリバー クロムウェル，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2006516382A publication Critical patent/JP2006516382A/ja
Publication of JP2006516382A5 publication Critical patent/JP2006516382A5/ja
Application granted granted Critical
Publication of JP4668616B2 publication Critical patent/JP4668616B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2004533298A 2002-08-19 2003-07-31 オオアワガエリからの主要アレルゲンＰｈｌｐ１の変異体 Expired - Fee Related JP4668616B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02018157 2002-08-19
PCT/EP2003/008471 WO2004022588A1 (de) 2002-08-19 2003-07-31 Varianten des majorallergens phl p 1 aus lieschgras

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010249581A Division JP5868587B2 (ja) 2002-08-19 2010-11-08 オオアワガエリからの主要アレルゲンＰｈｌｐ１の変異体

Publications (3)

Publication Number Publication Date
JP2006516382A JP2006516382A (ja) 2006-07-06
JP2006516382A5 JP2006516382A5 (https=) 2006-09-14
JP4668616B2 true JP4668616B2 (ja) 2011-04-13

Family

ID=31970262

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004533298A Expired - Fee Related JP4668616B2 (ja) 2002-08-19 2003-07-31 オオアワガエリからの主要アレルゲンＰｈｌｐ１の変異体
JP2010249581A Expired - Fee Related JP5868587B2 (ja) 2002-08-19 2010-11-08 オオアワガエリからの主要アレルゲンＰｈｌｐ１の変異体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010249581A Expired - Fee Related JP5868587B2 (ja) 2002-08-19 2010-11-08 オオアワガエリからの主要アレルゲンＰｈｌｐ１の変異体

Country Status (12)

Country Link
US (2) US7731970B2 (https=)
EP (1) EP1532169B1 (https=)
JP (2) JP4668616B2 (https=)
CN (1) CN100509844C (https=)
AU (1) AU2003251674B2 (https=)
BR (1) BRPI0313613B1 (https=)
CA (1) CA2495825C (https=)
ES (1) ES2400181T3 (https=)
PL (1) PL212891B1 (https=)
PT (1) PT1532169E (https=)
RU (1) RU2323942C2 (https=)
WO (1) WO2004022588A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2323942C2 (ru) * 2002-08-19 2008-05-10 Мерк Патент Гмбх ВАРИАНТЫ ОСНОВНОГО АЛЛЕРГЕНА Phl p 1 ИЗ ТИМОФЕЕВКИ ЛУГОВОЙ
DE102004035337A1 (de) * 2004-07-21 2006-03-16 Merck Patent Gmbh Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität
MX2014009285A (es) * 2012-02-07 2015-02-04 Jolla Inst Allergy Immunolog Alergenos del fleo de los prados y metodos y usos para la modulacion de respuesta inmune.
JP6102442B2 (ja) * 2013-04-04 2017-03-29 日産自動車株式会社 リチウムイオン二次電池
CN113825518A (zh) 2019-01-17 2021-12-21 莱蒂生物制药公司 纯化过敏原提取物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05509230A (ja) * 1990-08-17 1993-12-22 ザ・ユニバーシテイ・オブ・メルボルン ライグラスの花粉のアレルゲン
IL115177A0 (en) * 1994-09-16 1995-12-31 Immunomedics Inc Phosphorus-32 labeling of antibodies for cancer therapy
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
CA2267106A1 (en) * 1996-10-07 1998-07-16 The Johns Hopkins University School Of Medicine Novel hedgehog-derived polypeptides
GB2348808B (en) * 1998-01-09 2003-03-19 Circassia Ltd Methods and compositions for desensitisation
DE19918682A1 (de) * 1999-04-23 2000-10-26 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens
US20070011783A1 (en) * 1999-05-06 2007-01-11 Jingdong Liu Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US20100293669A2 (en) * 1999-05-06 2010-11-18 Jingdong Liu Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
IT1318692B1 (it) 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.
AU2002256276A1 (en) * 2001-04-19 2002-11-05 Penn State Research Foundation Novel expansin polynucleotides, related polypeptides and methods of use
RU2323942C2 (ru) * 2002-08-19 2008-05-10 Мерк Патент Гмбх ВАРИАНТЫ ОСНОВНОГО АЛЛЕРГЕНА Phl p 1 ИЗ ТИМОФЕЕВКИ ЛУГОВОЙ

Also Published As

Publication number Publication date
CA2495825A1 (en) 2004-03-18
AU2003251674B2 (en) 2009-09-03
RU2323942C2 (ru) 2008-05-10
JP5868587B2 (ja) 2016-02-24
US9453058B2 (en) 2016-09-27
ES2400181T3 (es) 2013-04-08
PL373069A1 (en) 2005-08-08
PT1532169E (pt) 2013-03-18
CN100509844C (zh) 2009-07-08
US20060251682A1 (en) 2006-11-09
JP2006516382A (ja) 2006-07-06
CN1675240A (zh) 2005-09-28
BRPI0313613B1 (pt) 2016-06-07
WO2004022588A1 (de) 2004-03-18
RU2005107782A (ru) 2005-11-20
EP1532169A1 (de) 2005-05-25
CA2495825C (en) 2015-03-17
US20120263741A1 (en) 2012-10-18
AU2003251674A1 (en) 2004-03-29
JP2011097940A (ja) 2011-05-19
EP1532169B1 (de) 2012-12-19
PL212891B1 (pl) 2012-12-31
US7731970B2 (en) 2010-06-08
BR0313613A (pt) 2005-06-21

Similar Documents

Publication Publication Date Title
JP5868587B2 (ja) オオアワガエリからの主要アレルゲンＰｈｌｐ１の変異体
EP2699681B1 (en) Hypoallergen
Wallner et al. Lab scale and medium scale production of recombinant allergens in Escherichia coli
JP3316535B2 (ja) ダニアレルゲンの改変体およびその製造法
TWI467017B (zh) 蟎過敏原之變體及其用途
JP2011041566A (ja) 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体
AU2004205160B2 (en) Hypoallergenic polypeptides based on fish parvalbumin
AU2006331005B2 (en) Hypoallergenic variants of the major allergen from Betula verrucosa pollen
JP2002542783A (ja) イネ科アレルゲンのｄｎａ配列および組換え体産生
CN117187222A (zh) 一种低细胞毒性的幽门螺杆菌尿素酶b蛋白突变体的疫苗组合物
CA2558660C (en) Fusion proteins comprising modified allergens of the ns-ltps family, use thereof and pharmaceutical compositions comprising the same
JP2006510346A (ja) 組換え方法による花粉アレルゲンＰｈｌｐ４のＤＮＡ配列および製造
EP1509606B1 (en) Allergen from mugwort pollen
CN120888003B (zh) 一种嵌合蛋白pa5o8及其应用
JP2007536893A5 (https=)
EP2794644B1 (en) Hypoallergenic variants of phl p 5, the major allergen from phleum pratense
JP2008504004A (ja) 穀物からの４群主要アレルゲンのｄｎａ配列および組換え製剤
EP2281836B9 (en) Hybrid proteins from Parietaria judaica major allergens and uses thereof
NZ616746B2 (en) Hypoallergen
JP2014514312A (ja) 新規な低刺激性アレルゲン

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060728

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060728

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090804

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091102

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091110

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091204

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091211

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091225

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100204

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100706

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101108

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20101119

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20101214

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110113

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140121

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees