CN100509844C - 来自梯牧草的主要过敏原Phl p1的变异体 - Google Patents

来自梯牧草的主要过敏原Phl p1的变异体 Download PDF

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Publication number
CN100509844C
CN100509844C CNB038198231A CN03819823A CN100509844C CN 100509844 C CN100509844 C CN 100509844C CN B038198231 A CNB038198231 A CN B038198231A CN 03819823 A CN03819823 A CN 03819823A CN 100509844 C CN100509844 C CN 100509844C
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CN
China
Prior art keywords
variant
allergen
rphl
phl
tag
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Expired - Fee Related
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CNB038198231A
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English (en)
Chinese (zh)
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CN1675240A (zh
Inventor
R·萨克
H·菲比希
O·克洛姆维尔
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CNB038198231A 2002-08-19 2003-07-31 来自梯牧草的主要过敏原Phl p1的变异体 Expired - Fee Related CN100509844C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02018157 2002-08-19
EP02018157.4 2002-08-19

Publications (2)

Publication Number Publication Date
CN1675240A CN1675240A (zh) 2005-09-28
CN100509844C true CN100509844C (zh) 2009-07-08

Family

ID=31970262

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038198231A Expired - Fee Related CN100509844C (zh) 2002-08-19 2003-07-31 来自梯牧草的主要过敏原Phl p1的变异体

Country Status (12)

Country Link
US (2) US7731970B2 (https=)
EP (1) EP1532169B1 (https=)
JP (2) JP4668616B2 (https=)
CN (1) CN100509844C (https=)
AU (1) AU2003251674B2 (https=)
BR (1) BRPI0313613B1 (https=)
CA (1) CA2495825C (https=)
ES (1) ES2400181T3 (https=)
PL (1) PL212891B1 (https=)
PT (1) PT1532169E (https=)
RU (1) RU2323942C2 (https=)
WO (1) WO2004022588A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2323942C2 (ru) * 2002-08-19 2008-05-10 Мерк Патент Гмбх ВАРИАНТЫ ОСНОВНОГО АЛЛЕРГЕНА Phl p 1 ИЗ ТИМОФЕЕВКИ ЛУГОВОЙ
DE102004035337A1 (de) * 2004-07-21 2006-03-16 Merck Patent Gmbh Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität
MX2014009285A (es) * 2012-02-07 2015-02-04 Jolla Inst Allergy Immunolog Alergenos del fleo de los prados y metodos y usos para la modulacion de respuesta inmune.
JP6102442B2 (ja) * 2013-04-04 2017-03-29 日産自動車株式会社 リチウムイオン二次電池
CN113825518A (zh) 2019-01-17 2021-12-21 莱蒂生物制药公司 纯化过敏原提取物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05509230A (ja) * 1990-08-17 1993-12-22 ザ・ユニバーシテイ・オブ・メルボルン ライグラスの花粉のアレルゲン
IL115177A0 (en) * 1994-09-16 1995-12-31 Immunomedics Inc Phosphorus-32 labeling of antibodies for cancer therapy
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
CA2267106A1 (en) * 1996-10-07 1998-07-16 The Johns Hopkins University School Of Medicine Novel hedgehog-derived polypeptides
GB2348808B (en) * 1998-01-09 2003-03-19 Circassia Ltd Methods and compositions for desensitisation
DE19918682A1 (de) * 1999-04-23 2000-10-26 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens
US20070011783A1 (en) * 1999-05-06 2007-01-11 Jingdong Liu Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US20100293669A2 (en) * 1999-05-06 2010-11-18 Jingdong Liu Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
IT1318692B1 (it) 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.
AU2002256276A1 (en) * 2001-04-19 2002-11-05 Penn State Research Foundation Novel expansin polynucleotides, related polypeptides and methods of use
RU2323942C2 (ru) * 2002-08-19 2008-05-10 Мерк Патент Гмбх ВАРИАНТЫ ОСНОВНОГО АЛЛЕРГЕНА Phl p 1 ИЗ ТИМОФЕЕВКИ ЛУГОВОЙ

Also Published As

Publication number Publication date
CA2495825A1 (en) 2004-03-18
AU2003251674B2 (en) 2009-09-03
RU2323942C2 (ru) 2008-05-10
JP5868587B2 (ja) 2016-02-24
US9453058B2 (en) 2016-09-27
ES2400181T3 (es) 2013-04-08
JP4668616B2 (ja) 2011-04-13
PL373069A1 (en) 2005-08-08
PT1532169E (pt) 2013-03-18
US20060251682A1 (en) 2006-11-09
JP2006516382A (ja) 2006-07-06
CN1675240A (zh) 2005-09-28
BRPI0313613B1 (pt) 2016-06-07
WO2004022588A1 (de) 2004-03-18
RU2005107782A (ru) 2005-11-20
EP1532169A1 (de) 2005-05-25
CA2495825C (en) 2015-03-17
US20120263741A1 (en) 2012-10-18
AU2003251674A1 (en) 2004-03-29
JP2011097940A (ja) 2011-05-19
EP1532169B1 (de) 2012-12-19
PL212891B1 (pl) 2012-12-31
US7731970B2 (en) 2010-06-08
BR0313613A (pt) 2005-06-21

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090708

Termination date: 20170731