JP4559230B2 - セロトニン受容体に対する親和性を有する新規ｎ−アリールスルホニル−３−置換されたインドール、その調製方法、それを含有する医薬組成物 - Google Patents

セロトニン受容体に対する親和性を有する新規ｎ−アリールスルホニル−３−置換されたインドール、その調製方法、それを含有する医薬組成物 Download PDF

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JP4559230B2
JP4559230B2 JP2004554900A JP2004554900A JP4559230B2 JP 4559230 B2 JP4559230 B2 JP 4559230B2 JP 2004554900 A JP2004554900 A JP 2004554900A JP 2004554900 A JP2004554900 A JP 2004554900A JP 4559230 B2 JP4559230 B2 JP 4559230B2
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indole
ylmethyl
methylpiperazin
bromo
methoxybenzenesulfonyl
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JP2006514011A (ja
JP2006514011A5 (https=
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サチャ ニロギ ラマクリシュナ，ベンカタ
シュリークリシュナ シャーサス，ビカス
サストリ カンバンパティ，ラマ
サチャ ベラブハドラ バドラムディ ラオ，ベンカタ
ジャスティ，ベンカテスワル
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スベン ライフ サイエンシズ リミティド
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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JP2004554900A 2002-11-28 2003-06-05 セロトニン受容体に対する親和性を有する新規ｎ−アリールスルホニル−３−置換されたインドール、その調製方法、それを含有する医薬組成物 Expired - Lifetime JP4559230B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN884MA2002 2002-11-28
PCT/IN2003/000209 WO2004048330A1 (en) 2002-11-28 2003-06-05 N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them

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JP2006514011A JP2006514011A (ja) 2006-04-27
JP2006514011A5 JP2006514011A5 (https=) 2009-03-05
JP4559230B2 true JP4559230B2 (ja) 2010-10-06

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US (1) US7875605B2 (https=)
EP (1) EP1581492B1 (https=)
JP (1) JP4559230B2 (https=)
KR (1) KR100818508B1 (https=)
CN (2) CN101544592B (https=)
AT (1) ATE401307T1 (https=)
AU (1) AU2003237599B2 (https=)
BR (2) BRPI0315959C1 (https=)
CA (1) CA2509982C (https=)
CY (1) CY1108786T1 (https=)
DE (1) DE60322266D1 (https=)
DK (1) DK1581492T3 (https=)
EA (1) EA011320B1 (https=)
ES (1) ES2310243T3 (https=)
MX (1) MXPA05005701A (https=)
NO (2) NO330341B1 (https=)
NZ (2) NZ540840A (https=)
PT (1) PT1581492E (https=)
SI (1) SI1581492T1 (https=)
WO (1) WO2004048330A1 (https=)
ZA (1) ZA200504043B (https=)

Cited By (1)

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JP2017525762A (ja) * 2014-08-16 2017-09-07 スヴェン・ライフ・サイエンシズ・リミテッド １−［（２−ブロモフェニル）スルフォニル］−５−メトキシ−３−［（４−メチル−１−ピペラジニル）メチル］−１ｈ−インドールジメシレート一水和物の活性代謝産物及びその活性代謝産物のジメシレート二水和物の塩

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WO2005005439A1 (en) * 2003-07-09 2005-01-20 Suven Life Sciences Limited Benzothiazino indoles
HRP20090419T1 (hr) 2004-01-02 2009-09-30 Suven Life Sciences Limited Novi indeno[2,1a]indeni i izoindol[2,1-a]indoli
BRPI0614692A2 (pt) 2005-07-29 2009-05-19 Hoffmann La Roche derivados de indol-3-il-carbonil-piperidina e piperazina
EA013875B1 (ru) 2005-08-12 2010-08-30 Сувен Лайф Сайенсиз Лимитед Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды
WO2007020653A1 (en) * 2005-08-12 2007-02-22 Suven Life Sciences Limited Thioether derivatives as functional 5-ht6 ligands
WO2007020654A1 (en) 2005-08-16 2007-02-22 Suven Life Sciences An improved process for the preparation of losartan
AU2007343063B2 (en) * 2007-01-08 2011-02-17 Suven Life Sciences Limited 5-(Heterocyclyl)alkyl-N-(arylsulfonyl)indole compounds and their use as 5-HT6 ligands
MX2009006757A (es) * 2007-01-08 2009-06-30 Suven Life Sciences Ltd Compuestos de 4-(heterociclil)alquil-n-(arilsulfonil) indol y su uso como ligandos de la 5-hidroxitriptamina6.
BRPI0809873A2 (pt) 2007-05-03 2018-11-13 Suven Life Sciences Ltd "composto, processo para a preparação do composto, método para o tratamento de uma desordem do sistema nervoso central, composição farmacêutica, uso do composto, método para testar antagonistas e antagonistas com seletividade para o receptor 5-th6 e método de tratamento"
WO2008144263A1 (en) * 2007-05-18 2008-11-27 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
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CA2786072C (en) 2010-01-05 2014-10-28 Suven Life Sciences Limited Sulfone compounds as 5-ht6 receptor ligands
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US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
KR101534136B1 (ko) * 2013-06-11 2015-07-07 이화여자대학교 산학협력단 인돌 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 5-ht6 수용체 관련 질환의 예방 또는 치료용 약학적 조성물
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