JP4472928B2 - ４位がピペリジン含有部分によって置換されたキノリンおよびその窒素化誘導体および抗菌薬としてのその使用 - Google Patents

４位がピペリジン含有部分によって置換されたキノリンおよびその窒素化誘導体および抗菌薬としてのその使用 Download PDF

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Publication number
JP4472928B2
JP4472928B2 JP2002557390A JP2002557390A JP4472928B2 JP 4472928 B2 JP4472928 B2 JP 4472928B2 JP 2002557390 A JP2002557390 A JP 2002557390A JP 2002557390 A JP2002557390 A JP 2002557390A JP 4472928 B2 JP4472928 B2 JP 4472928B2
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Prior art keywords
dihydro
benzo
methyl
methoxy
piperidin
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Expired - Lifetime
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Japanese (ja)
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JP2004520360A5 (cg-RX-API-DMAC7.html
JP2004520360A (ja
Inventor
デイビッド・トーマス・デイビーズ
グラハム・エルジン・ジョーンズ
ロジャー・エドワード・マークウェル
ウィリアム・ミラー
ニール・デイビッド・ピアソン
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SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2002557390A 2001-01-22 2002-01-22 ４位がピペリジン含有部分によって置換されたキノリンおよびその窒素化誘導体および抗菌薬としてのその使用 Expired - Lifetime JP4472928B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0101577.5A GB0101577D0 (en) 2001-01-22 2001-01-22 Compounds
PCT/EP2002/000587 WO2002056882A1 (en) 2001-01-22 2002-01-22 Quinolines and nitrogenated derivaive thereof substituted in 4-position by a piperidine-containing moiety and their use as antibacterial agents

Related Child Applications (1)

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JP2009251653A Division JP2010024246A (ja) 2001-01-22 2009-11-02 ４位がピペリジン含有部分によって置換されたキノリンおよびその窒素化誘導体および抗菌薬としてのその使用

Publications (3)

Publication Number Publication Date
JP2004520360A JP2004520360A (ja) 2004-07-08
JP2004520360A5 JP2004520360A5 (cg-RX-API-DMAC7.html) 2005-12-22
JP4472928B2 true JP4472928B2 (ja) 2010-06-02

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JP2002557390A Expired - Lifetime JP4472928B2 (ja) 2001-01-22 2002-01-22 ４位がピペリジン含有部分によって置換されたキノリンおよびその窒素化誘導体および抗菌薬としてのその使用
JP2009251653A Pending JP2010024246A (ja) 2001-01-22 2009-11-02 ４位がピペリジン含有部分によって置換されたキノリンおよびその窒素化誘導体および抗菌薬としてのその使用

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Country Status (8)

Country Link
US (1) US7205408B2 (cg-RX-API-DMAC7.html)
EP (1) EP1359908B1 (cg-RX-API-DMAC7.html)
JP (2) JP4472928B2 (cg-RX-API-DMAC7.html)
AT (1) ATE370731T1 (cg-RX-API-DMAC7.html)
DE (1) DE60221969T2 (cg-RX-API-DMAC7.html)
ES (1) ES2292716T3 (cg-RX-API-DMAC7.html)
GB (1) GB0101577D0 (cg-RX-API-DMAC7.html)
WO (1) WO2002056882A1 (cg-RX-API-DMAC7.html)

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ATE370731T1 (de) 2007-09-15
DE60221969D1 (de) 2007-10-04
GB0101577D0 (en) 2001-03-07
JP2004520360A (ja) 2004-07-08
WO2002056882A1 (en) 2002-07-25
EP1359908A1 (en) 2003-11-12
ES2292716T3 (es) 2008-03-16
JP2010024246A (ja) 2010-02-04
EP1359908B1 (en) 2007-08-22
US20040138219A1 (en) 2004-07-15
US7205408B2 (en) 2007-04-17

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