JP4465148B2 - Ｎｏｇｏレセプターホモログ - Google Patents

Ｎｏｇｏレセプターホモログ Download PDF

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Publication number
JP4465148B2
JP4465148B2 JP2002532629A JP2002532629A JP4465148B2 JP 4465148 B2 JP4465148 B2 JP 4465148B2 JP 2002532629 A JP2002532629 A JP 2002532629A JP 2002532629 A JP2002532629 A JP 2002532629A JP 4465148 B2 JP4465148 B2 JP 4465148B2
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JP
Japan
Prior art keywords
ngr
polypeptide
seq
protein
amino acids
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Expired - Fee Related
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JP2002532629A
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English (en)
Japanese (ja)
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JP2004528809A5 (enExample
JP2004528809A (ja
Inventor
スティーブン エム． ストリットマター，
リチャード エル． ケイト，
ディナー ダブリュー． ワイ． サー，
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Yale University
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Yale University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002532629A 2000-10-06 2001-10-06 Ｎｏｇｏレセプターホモログ Expired - Fee Related JP4465148B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23836100P 2000-10-06 2000-10-06
PCT/US2001/031488 WO2002029059A2 (en) 2000-10-06 2001-10-06 Nogo receptor homologs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009022063A Division JP2009100767A (ja) 2000-10-06 2009-02-02 Ｎｏｇｏレセプターホモログ

Publications (3)

Publication Number Publication Date
JP2004528809A JP2004528809A (ja) 2004-09-24
JP2004528809A5 JP2004528809A5 (enExample) 2005-03-03
JP4465148B2 true JP4465148B2 (ja) 2010-05-19

Family

ID=22897532

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002532629A Expired - Fee Related JP4465148B2 (ja) 2000-10-06 2001-10-06 Ｎｏｇｏレセプターホモログ
JP2009022063A Withdrawn JP2009100767A (ja) 2000-10-06 2009-02-02 Ｎｏｇｏレセプターホモログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009022063A Withdrawn JP2009100767A (ja) 2000-10-06 2009-02-02 Ｎｏｇｏレセプターホモログ

Country Status (12)

Country Link
US (5) US20030124704A1 (enExample)
EP (1) EP1325130B1 (enExample)
JP (2) JP4465148B2 (enExample)
AT (1) ATE458815T1 (enExample)
AU (2) AU2002211539B2 (enExample)
CA (1) CA2424834A1 (enExample)
DE (1) DE60141409D1 (enExample)
DK (1) DK1325130T3 (enExample)
ES (1) ES2341608T3 (enExample)
NZ (1) NZ525422A (enExample)
PT (1) PT1325130E (enExample)
WO (1) WO2002029059A2 (enExample)

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US7119165B2 (en) 2000-01-12 2006-10-10 Yale University Nogo receptor-mediated blockade of axonal growth
ATE458815T1 (de) * 2000-10-06 2010-03-15 Univ Yale Homologe des nogo rezeptors
JP2005507246A (ja) * 2001-08-27 2005-03-17 ノバルティス アクチエンゲゼルシャフト Ｎｏｇｏレセプターホモログおよびそれらの使用
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US7309485B2 (en) * 2001-12-03 2007-12-18 Children's Medical Center Corporation Reducing myelin-mediated inhibition of axon regeneration
AU2003246254A1 (en) * 2002-07-05 2004-01-23 Shionogi And Co., Ltd. NOVEL Nogo RECEPTOR-LIKE POLYPEPTIDE AND DNA THEREOF
DK1534736T3 (da) 2002-08-10 2010-09-20 Biogen Idec Inc Nogo-receptorantagonister
PL2248899T3 (pl) 2003-03-19 2015-10-30 Biogen Ma Inc Białko wiążące receptor nogo
CA2521469A1 (en) 2003-04-04 2004-10-21 University Of Rochester Identification of novel nogo-receptors and methods related thereto
CA2522649A1 (en) * 2003-04-16 2004-11-04 Biogen Idec Ma Inc. Treatment of conditions involving amyloid plaques
EA008253B1 (ru) * 2003-08-07 2007-04-27 Байоджен Айдек Ма Инк. Антагонисты nogo-рецептора
US8912144B2 (en) * 2003-12-16 2014-12-16 Children's Medical Center Corporation Method for treating stroke via administration of NEP1-40 and inosine
EP1695061A4 (en) * 2003-12-16 2008-02-20 Childrens Medical Center METHOD OF TREATING NEUROLOGICAL DISORDERS
WO2005074972A2 (en) * 2004-01-30 2005-08-18 Biogen Idec Ma Inc. Treatment of conditions involving dopaminergic neuronal degeneration using nogo receptor antagonists
DK1776136T3 (da) 2004-06-24 2012-12-03 Biogen Idec Inc Behandling af tilstande, der involverer demyelinisering
CN101035803A (zh) * 2004-10-01 2007-09-12 耶鲁大学 Nogo－a多肽片段、变异nogo受体－1多肽、及其应用
US7893032B2 (en) 2005-07-07 2011-02-22 Yale University NgR variants and compositions thereof for suppressing axonal growth inhibition
CA2902070A1 (en) 2005-07-08 2007-01-18 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
EP1940446A4 (en) * 2005-08-25 2009-08-05 Biogen Idec Inc NOGO RECEPTOR POLYPEPTIDE POLYPEPTIDES AND FRAGMENTS AND USES THEREOF
CN103215293B (zh) 2006-01-27 2015-10-28 比奥根Ma公司 Nogo受体拮抗剂
WO2007133746A2 (en) * 2006-05-15 2007-11-22 Biogen Idec Ma Inc. Use of nogo receptor-1 (ngr1) antagonists for promoting oligodendrocyte survival
EP2037945A4 (en) * 2006-05-24 2012-07-04 Myelin Repair Foundation Inc PERMEABILITY OF THE HEMATO-ENCEPHALIC BARRIER
ES2437110T3 (es) 2006-11-14 2014-01-08 Genentech, Inc. Moduladores de la regeneración neuronal
US20100047232A1 (en) * 2006-11-14 2010-02-25 Jasvinder Atwal Modulators of neuronal regeneration
WO2009009743A2 (en) * 2007-07-12 2009-01-15 Institute For Advance Study Sequence optimization for expression of a foreign gene
AU2008335245A1 (en) * 2007-12-11 2009-06-18 Genentech, Inc. Modulators of neuronal regeneration
EP2276500A4 (en) 2008-03-13 2015-03-04 Univ Yale REACTIVATION OF AXON GROWTH AND AXON RECOVERY IN CHRONIC REVERSE MARKET INJURIES
US20090285803A1 (en) * 2008-05-13 2009-11-19 Jasvinder Atwal ANTI-PirB ANTIBODIES
US8058406B2 (en) 2008-07-09 2011-11-15 Biogen Idec Ma Inc. Composition comprising antibodies to LINGO or fragments thereof
EP2392208B1 (en) * 2010-06-07 2016-05-04 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use
US9120111B2 (en) 2012-02-24 2015-09-01 Rain Bird Corporation Arc adjustable rotary sprinkler having full-circle operation and automatic matched precipitation
US9796780B2 (en) 2012-05-14 2017-10-24 Biogen Ma Inc. LINGO-2 antagonists for treatment of conditions involving motor neurons
US9156043B2 (en) 2012-07-13 2015-10-13 Rain Bird Corporation Arc adjustable rotary sprinkler with automatic matched precipitation
EP3242893A1 (en) 2015-01-08 2017-11-15 Biogen MA Inc. Lingo-1 antagonists and uses for treatment of demyelinating disorders
US12343748B2 (en) 2021-03-16 2025-07-01 Rain Bird Corporation Multi-mode rotor sprinkler apparatus and method
US12434252B2 (en) 2022-04-20 2025-10-07 Rain Bird Corporation Full-circle and part-circle rotor sprinkler
US12440855B2 (en) 2022-10-27 2025-10-14 Rain Bird Corporation Multi-mode rotor sprinkler apparatus and method

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JPH07509002A (ja) 1993-02-11 1995-10-05 エルツィーヒュングスディレクション　オブ　ザ　キャントン　チューリッヒ ニューロトロフィンとミエリン−関連の軸索成長阻害タンパク質に対する抗体との組み合わせが中枢神経系の再生を促進する
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US5858708A (en) * 1996-08-12 1999-01-12 Bandman; Olga Polynucleotides encoding two novel human neuroendocrine-specific proteins
WO2000070050A1 (en) 1999-05-14 2000-11-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
JP2003521216A (ja) * 1997-08-05 2003-07-15 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ９０個のヒト分泌タンパク質
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ATE458050T1 (de) 1998-12-01 2010-03-15 Genentech Inc Promotion oder inhibition von angiogenese und kardiovaskularisation
PT1484338E (pt) 1998-12-22 2007-05-31 Genentech Inc Métodos e composições para inibição do crescimento de células neoplásicas.
AU3514400A (en) 1999-03-08 2000-09-28 Genentech Inc. Compositions and methods for the treatment of immune related diseases
JP2004513602A (ja) 1999-03-08 2004-05-13 ジェネンテック・インコーポレーテッド 分泌及び膜貫通ポリペプチドとそれをコードしている核酸
JP2004507202A (ja) 1999-03-31 2004-03-11 キュラジェン　コーポレイション ポリペプチドをコードするオープンリーディングフレームを含む核酸；「ｏｒｆｘ」
AU6394400A (en) 1999-07-30 2001-02-19 Millennium Pharmaceuticals, Inc. Secreted proteins and uses thereof
WO2001042286A2 (en) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Human leucine rich repeat-containing polypeptide and uses therefor
US7119165B2 (en) * 2000-01-12 2006-10-10 Yale University Nogo receptor-mediated blockade of axonal growth
CN100354307C (zh) * 2000-01-12 2007-12-12 耶鲁大学 Nogo受体介导的对轴突生长的阻断
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ATE458815T1 (de) * 2000-10-06 2010-03-15 Univ Yale Homologe des nogo rezeptors
JP2005507246A (ja) 2001-08-27 2005-03-17 ノバルティス アクチエンゲゼルシャフト Ｎｏｇｏレセプターホモログおよびそれらの使用
WO2003035687A1 (en) 2001-10-22 2003-05-01 Novartis Ag Nogo receptor homologues and their use
DK1534736T3 (da) * 2002-08-10 2010-09-20 Biogen Idec Inc Nogo-receptorantagonister

Also Published As

Publication number Publication date
WO2002029059A3 (en) 2003-01-23
US7456255B2 (en) 2008-11-25
US20090175850A1 (en) 2009-07-09
US20110129477A1 (en) 2011-06-02
AU2002211539B2 (en) 2007-01-25
PT1325130E (pt) 2010-05-31
CA2424834A1 (en) 2002-04-11
DK1325130T3 (da) 2010-05-25
ATE458815T1 (de) 2010-03-15
DE60141409D1 (de) 2010-04-08
WO2002029059A2 (en) 2002-04-11
EP1325130A2 (en) 2003-07-09
US20050048520A1 (en) 2005-03-03
US7173118B2 (en) 2007-02-06
JP2009100767A (ja) 2009-05-14
WO2002029059A9 (en) 2003-05-15
US20030124704A1 (en) 2003-07-03
ES2341608T3 (es) 2010-06-23
JP2004528809A (ja) 2004-09-24
AU1153902A (en) 2002-04-15
US20070104713A1 (en) 2007-05-10
NZ525422A (en) 2006-09-29
EP1325130B1 (en) 2010-02-24

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