CA2424834A1 - Nogo receptor homologs - Google Patents

Nogo receptor homologs Download PDF

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Publication number
CA2424834A1
CA2424834A1 CA002424834A CA2424834A CA2424834A1 CA 2424834 A1 CA2424834 A1 CA 2424834A1 CA 002424834 A CA002424834 A CA 002424834A CA 2424834 A CA2424834 A CA 2424834A CA 2424834 A1 CA2424834 A1 CA 2424834A1
Authority
CA
Canada
Prior art keywords
ngr
polypeptide
seq
protein
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002424834A
Other languages
English (en)
French (fr)
Inventor
Stephen M. Strittmatter
Richard L. Cate
Dinah W. Y. Sah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Biogen MA Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2424834A1 publication Critical patent/CA2424834A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002424834A 2000-10-06 2001-10-06 Nogo receptor homologs Abandoned CA2424834A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23836100P 2000-10-06 2000-10-06
US60/238,361 2000-10-06
PCT/US2001/031488 WO2002029059A2 (en) 2000-10-06 2001-10-06 Nogo receptor homologs

Publications (1)

Publication Number Publication Date
CA2424834A1 true CA2424834A1 (en) 2002-04-11

Family

ID=22897532

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002424834A Abandoned CA2424834A1 (en) 2000-10-06 2001-10-06 Nogo receptor homologs

Country Status (12)

Country Link
US (5) US20030124704A1 (enExample)
EP (1) EP1325130B1 (enExample)
JP (2) JP4465148B2 (enExample)
AT (1) ATE458815T1 (enExample)
AU (2) AU2002211539B2 (enExample)
CA (1) CA2424834A1 (enExample)
DE (1) DE60141409D1 (enExample)
DK (1) DK1325130T3 (enExample)
ES (1) ES2341608T3 (enExample)
NZ (1) NZ525422A (enExample)
PT (1) PT1325130E (enExample)
WO (1) WO2002029059A2 (enExample)

Families Citing this family (37)

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US7119165B2 (en) 2000-01-12 2006-10-10 Yale University Nogo receptor-mediated blockade of axonal growth
ATE458815T1 (de) * 2000-10-06 2010-03-15 Univ Yale Homologe des nogo rezeptors
JP2005507246A (ja) * 2001-08-27 2005-03-17 ノバルティス アクチエンゲゼルシャフト Nogoレセプターホモログおよびそれらの使用
WO2003035687A1 (en) * 2001-10-22 2003-05-01 Novartis Ag Nogo receptor homologues and their use
US7309485B2 (en) * 2001-12-03 2007-12-18 Children's Medical Center Corporation Reducing myelin-mediated inhibition of axon regeneration
AU2003246254A1 (en) * 2002-07-05 2004-01-23 Shionogi And Co., Ltd. NOVEL Nogo RECEPTOR-LIKE POLYPEPTIDE AND DNA THEREOF
DK1534736T3 (da) 2002-08-10 2010-09-20 Biogen Idec Inc Nogo-receptorantagonister
PL2248899T3 (pl) 2003-03-19 2015-10-30 Biogen Ma Inc Białko wiążące receptor nogo
CA2521469A1 (en) 2003-04-04 2004-10-21 University Of Rochester Identification of novel nogo-receptors and methods related thereto
CA2522649A1 (en) * 2003-04-16 2004-11-04 Biogen Idec Ma Inc. Treatment of conditions involving amyloid plaques
EA008253B1 (ru) * 2003-08-07 2007-04-27 Байоджен Айдек Ма Инк. Антагонисты nogo-рецептора
US8912144B2 (en) * 2003-12-16 2014-12-16 Children's Medical Center Corporation Method for treating stroke via administration of NEP1-40 and inosine
EP1695061A4 (en) * 2003-12-16 2008-02-20 Childrens Medical Center METHOD OF TREATING NEUROLOGICAL DISORDERS
WO2005074972A2 (en) * 2004-01-30 2005-08-18 Biogen Idec Ma Inc. Treatment of conditions involving dopaminergic neuronal degeneration using nogo receptor antagonists
DK1776136T3 (da) 2004-06-24 2012-12-03 Biogen Idec Inc Behandling af tilstande, der involverer demyelinisering
CN101035803A (zh) * 2004-10-01 2007-09-12 耶鲁大学 Nogo-a多肽片段、变异nogo受体-1多肽、及其应用
US7893032B2 (en) 2005-07-07 2011-02-22 Yale University NgR variants and compositions thereof for suppressing axonal growth inhibition
CA2902070A1 (en) 2005-07-08 2007-01-18 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
EP1940446A4 (en) * 2005-08-25 2009-08-05 Biogen Idec Inc NOGO RECEPTOR POLYPEPTIDE POLYPEPTIDES AND FRAGMENTS AND USES THEREOF
CN103215293B (zh) 2006-01-27 2015-10-28 比奥根Ma公司 Nogo受体拮抗剂
WO2007133746A2 (en) * 2006-05-15 2007-11-22 Biogen Idec Ma Inc. Use of nogo receptor-1 (ngr1) antagonists for promoting oligodendrocyte survival
EP2037945A4 (en) * 2006-05-24 2012-07-04 Myelin Repair Foundation Inc PERMEABILITY OF THE HEMATO-ENCEPHALIC BARRIER
ES2437110T3 (es) 2006-11-14 2014-01-08 Genentech, Inc. Moduladores de la regeneración neuronal
US20100047232A1 (en) * 2006-11-14 2010-02-25 Jasvinder Atwal Modulators of neuronal regeneration
WO2009009743A2 (en) * 2007-07-12 2009-01-15 Institute For Advance Study Sequence optimization for expression of a foreign gene
AU2008335245A1 (en) * 2007-12-11 2009-06-18 Genentech, Inc. Modulators of neuronal regeneration
EP2276500A4 (en) 2008-03-13 2015-03-04 Univ Yale REACTIVATION OF AXON GROWTH AND AXON RECOVERY IN CHRONIC REVERSE MARKET INJURIES
US20090285803A1 (en) * 2008-05-13 2009-11-19 Jasvinder Atwal ANTI-PirB ANTIBODIES
US8058406B2 (en) 2008-07-09 2011-11-15 Biogen Idec Ma Inc. Composition comprising antibodies to LINGO or fragments thereof
EP2392208B1 (en) * 2010-06-07 2016-05-04 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use
US9120111B2 (en) 2012-02-24 2015-09-01 Rain Bird Corporation Arc adjustable rotary sprinkler having full-circle operation and automatic matched precipitation
US9796780B2 (en) 2012-05-14 2017-10-24 Biogen Ma Inc. LINGO-2 antagonists for treatment of conditions involving motor neurons
US9156043B2 (en) 2012-07-13 2015-10-13 Rain Bird Corporation Arc adjustable rotary sprinkler with automatic matched precipitation
EP3242893A1 (en) 2015-01-08 2017-11-15 Biogen MA Inc. Lingo-1 antagonists and uses for treatment of demyelinating disorders
US12343748B2 (en) 2021-03-16 2025-07-01 Rain Bird Corporation Multi-mode rotor sprinkler apparatus and method
US12434252B2 (en) 2022-04-20 2025-10-07 Rain Bird Corporation Full-circle and part-circle rotor sprinkler
US12440855B2 (en) 2022-10-27 2025-10-14 Rain Bird Corporation Multi-mode rotor sprinkler apparatus and method

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341050C (en) 1988-11-04 2000-07-11 Martin E. Schwab Neurite growth regulatory factors
AU652537B2 (en) 1988-11-04 1994-09-01 Erziehungsdirektion Of The Canton Zurich Neurite growth regulatory factors
US5250414A (en) 1988-11-04 1993-10-05 Erziehungsdirektion Of The Canton Zurich Diagnostic methods using neurite growth regulatory factors
JPH07509002A (ja) 1993-02-11 1995-10-05 エルツィーヒュングスディレクション オブ ザ キャントン チューリッヒ ニューロトロフィンとミエリン−関連の軸索成長阻害タンパク質に対する抗体との組み合わせが中枢神経系の再生を促進する
WO2000073452A2 (en) 1999-06-02 2000-12-07 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US5858708A (en) * 1996-08-12 1999-01-12 Bandman; Olga Polynucleotides encoding two novel human neuroendocrine-specific proteins
WO2000070050A1 (en) 1999-05-14 2000-11-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
JP2003521216A (ja) * 1997-08-05 2003-07-15 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 90個のヒト分泌タンパク質
ES2312205T3 (es) 1998-03-10 2009-02-16 Genentech, Inc. Nuevo polipeptido y acidos nucleicos que lo codifican.
JP2002518010A (ja) 1998-06-16 2002-06-25 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 94個のヒト分泌タンパク質
PT1098972E (pt) 1998-07-22 2010-12-14 Smithkline Beecham Ltd Proteína semelhante a proteína especificamente neuroendócrina e adnc codificante
KR100728405B1 (ko) * 1998-11-06 2007-06-13 더 유니버시티 오브 취리히 Nogo 유전자의 뉴클레오티드와 단백질 서열 및 이들에기초한 방법
ATE458050T1 (de) 1998-12-01 2010-03-15 Genentech Inc Promotion oder inhibition von angiogenese und kardiovaskularisation
PT1484338E (pt) 1998-12-22 2007-05-31 Genentech Inc Métodos e composições para inibição do crescimento de células neoplásicas.
AU3514400A (en) 1999-03-08 2000-09-28 Genentech Inc. Compositions and methods for the treatment of immune related diseases
JP2004513602A (ja) 1999-03-08 2004-05-13 ジェネンテック・インコーポレーテッド 分泌及び膜貫通ポリペプチドとそれをコードしている核酸
JP2004507202A (ja) 1999-03-31 2004-03-11 キュラジェン コーポレイション ポリペプチドをコードするオープンリーディングフレームを含む核酸;「orfx」
AU6394400A (en) 1999-07-30 2001-02-19 Millennium Pharmaceuticals, Inc. Secreted proteins and uses thereof
WO2001042286A2 (en) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Human leucine rich repeat-containing polypeptide and uses therefor
US7119165B2 (en) * 2000-01-12 2006-10-10 Yale University Nogo receptor-mediated blockade of axonal growth
CN100354307C (zh) * 2000-01-12 2007-12-12 耶鲁大学 Nogo受体介导的对轴突生长的阻断
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
CA2376873A1 (en) 2000-04-18 2001-10-25 Teijin Limited Oxygen concentrating apparatus
ATE458815T1 (de) * 2000-10-06 2010-03-15 Univ Yale Homologe des nogo rezeptors
JP2005507246A (ja) 2001-08-27 2005-03-17 ノバルティス アクチエンゲゼルシャフト Nogoレセプターホモログおよびそれらの使用
WO2003035687A1 (en) 2001-10-22 2003-05-01 Novartis Ag Nogo receptor homologues and their use
DK1534736T3 (da) * 2002-08-10 2010-09-20 Biogen Idec Inc Nogo-receptorantagonister

Also Published As

Publication number Publication date
WO2002029059A3 (en) 2003-01-23
US7456255B2 (en) 2008-11-25
US20090175850A1 (en) 2009-07-09
US20110129477A1 (en) 2011-06-02
AU2002211539B2 (en) 2007-01-25
PT1325130E (pt) 2010-05-31
DK1325130T3 (da) 2010-05-25
ATE458815T1 (de) 2010-03-15
DE60141409D1 (de) 2010-04-08
JP4465148B2 (ja) 2010-05-19
WO2002029059A2 (en) 2002-04-11
EP1325130A2 (en) 2003-07-09
US20050048520A1 (en) 2005-03-03
US7173118B2 (en) 2007-02-06
JP2009100767A (ja) 2009-05-14
WO2002029059A9 (en) 2003-05-15
US20030124704A1 (en) 2003-07-03
ES2341608T3 (es) 2010-06-23
JP2004528809A (ja) 2004-09-24
AU1153902A (en) 2002-04-15
US20070104713A1 (en) 2007-05-10
NZ525422A (en) 2006-09-29
EP1325130B1 (en) 2010-02-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued