JP4355779B2 - マトリックス制御放出デバイス - Google Patents

マトリックス制御放出デバイス Download PDF

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Publication number
JP4355779B2
JP4355779B2 JP2000033446A JP2000033446A JP4355779B2 JP 4355779 B2 JP4355779 B2 JP 4355779B2 JP 2000033446 A JP2000033446 A JP 2000033446A JP 2000033446 A JP2000033446 A JP 2000033446A JP 4355779 B2 JP4355779 B2 JP 4355779B2
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Prior art keywords
drug
cellulose
phthalate
polymer
dispersion
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Expired - Fee Related
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JP2000033446A
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English (en)
Japanese (ja)
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JP2000229888A (ja
Inventor
レア・エリザベス・アッペル
ウィリアム・ジョン・キュラトロ
ドウェイン・トーマス・フリーセン
ジェームズ・アラン・シュライヴァー・ナイチンゲール
アヴィナシュ・ゴーヴィンド・ソンブレ
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Bend Research incorporated
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Bend Research incorporated
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
JP2000033446A 1999-02-10 2000-02-10 マトリックス制御放出デバイス Expired - Fee Related JP4355779B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11940099P 1999-02-10 1999-02-10
US60/119400 1999-02-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005226695A Division JP4694298B2 (ja) 1999-02-10 2005-08-04 マトリックス制御放出デバイス

Publications (2)

Publication Number Publication Date
JP2000229888A JP2000229888A (ja) 2000-08-22
JP4355779B2 true JP4355779B2 (ja) 2009-11-04

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ID=22384221

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JP2000033446A Expired - Fee Related JP4355779B2 (ja) 1999-02-10 2000-02-10 マトリックス制御放出デバイス
JP2005226695A Expired - Lifetime JP4694298B2 (ja) 1999-02-10 2005-08-04 マトリックス制御放出デバイス

Family Applications After (1)

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JP2005226695A Expired - Lifetime JP4694298B2 (ja) 1999-02-10 2005-08-04 マトリックス制御放出デバイス

Country Status (7)

Country Link
EP (1) EP1027887B1 (enExample)
JP (2) JP4355779B2 (enExample)
AT (1) ATE404178T1 (enExample)
BR (1) BR0000359A (enExample)
CA (1) CA2298245C (enExample)
DE (1) DE60039802D1 (enExample)
ES (1) ES2310164T3 (enExample)

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EP1027887A3 (en) 2001-02-28
JP2000229888A (ja) 2000-08-22
BR0000359A (pt) 2001-08-14
DE60039802D1 (de) 2008-09-25
JP2005320354A (ja) 2005-11-17
CA2298245A1 (en) 2000-08-10
JP4694298B2 (ja) 2011-06-08
EP1027887A2 (en) 2000-08-16
ATE404178T1 (de) 2008-08-15
EP1027887B1 (en) 2008-08-13

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