JP4294732B2 - アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出 - Google Patents

アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出 Download PDF

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Publication number
JP4294732B2
JP4294732B2 JP53016497A JP53016497A JP4294732B2 JP 4294732 B2 JP4294732 B2 JP 4294732B2 JP 53016497 A JP53016497 A JP 53016497A JP 53016497 A JP53016497 A JP 53016497A JP 4294732 B2 JP4294732 B2 JP 4294732B2
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Prior art keywords
oligonucleotide
oligonucleotide probe
target
sequence
capture
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Expired - Lifetime
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JP53016497A
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Japanese (ja)
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JP2001519648A (ja
JP2001519648A5 (https=
Inventor
バラニー，フランシス
バラニー，ジョージ
ハマー，ロバート・ピー
ケンプ，マリア
ブロック，ヘルマン
ザービ，モニブ
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Cornell Research Foundation Inc
Louisiana State University
University of Minnesota System
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Cornell Research Foundation Inc
University of Minnesota Twin Cities
Louisiana State University
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/02—Identifying library members by their fixed physical location on a support or substrate
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    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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  • General Chemical & Material Sciences (AREA)
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  • Condensed Matter Physics & Semiconductors (AREA)
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  • Microbiology (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP53016497A 1996-02-09 1997-02-05 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出 Expired - Lifetime JP4294732B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1135996P 1996-02-09 1996-02-09
US60/011,359 1996-02-09
PCT/US1997/001535 WO1997031256A2 (en) 1996-02-09 1997-02-05 Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays

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JP2007260054A Division JP4890411B2 (ja) 1996-02-09 2007-10-03 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出

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JP2001519648A JP2001519648A (ja) 2001-10-23
JP2001519648A5 JP2001519648A5 (https=) 2004-11-25
JP4294732B2 true JP4294732B2 (ja) 2009-07-15

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JP53016497A Expired - Lifetime JP4294732B2 (ja) 1996-02-09 1997-02-05 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2007260054A Expired - Lifetime JP4890411B2 (ja) 1996-02-09 2007-10-03 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2011098299A Expired - Lifetime JP5634937B2 (ja) 1996-02-09 2011-04-26 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2014185507A Expired - Lifetime JP5855195B2 (ja) 1996-02-09 2014-09-11 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出

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JP2007260054A Expired - Lifetime JP4890411B2 (ja) 1996-02-09 2007-10-03 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2011098299A Expired - Lifetime JP5634937B2 (ja) 1996-02-09 2011-04-26 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2014185507A Expired - Lifetime JP5855195B2 (ja) 1996-02-09 2014-09-11 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出

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EP (7) EP2332958B1 (https=)
JP (4) JP4294732B2 (https=)
AU (1) AU735440B2 (https=)
CA (1) CA2244891C (https=)
WO (1) WO1997031256A2 (https=)

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US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
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US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6280935B1 (en) 1994-10-13 2001-08-28 Lynx Therapeutics, Inc. Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags
EP0832287B1 (en) * 1995-06-07 2007-10-10 Solexa, Inc Oligonucleotide tags for sorting and identification
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
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EP1736554B1 (en) 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6312892B1 (en) * 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
JP3142879B2 (ja) * 1996-09-13 2001-03-07 株式会社分子バイオホトニクス研究所 標的核酸検出用固相、その製造方法、及び標的核酸検出方法
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
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US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
CA2276462C (en) 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
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