BR112023006262A2 - Métodos de diagnóstico de tuberculose e de diferenciação entre tuberculose ativa e latente - Google Patents
Métodos de diagnóstico de tuberculose e de diferenciação entre tuberculose ativa e latenteInfo
- Publication number
- BR112023006262A2 BR112023006262A2 BR112023006262A BR112023006262A BR112023006262A2 BR 112023006262 A2 BR112023006262 A2 BR 112023006262A2 BR 112023006262 A BR112023006262 A BR 112023006262A BR 112023006262 A BR112023006262 A BR 112023006262A BR 112023006262 A2 BR112023006262 A2 BR 112023006262A2
- Authority
- BR
- Brazil
- Prior art keywords
- tuberculosis
- methods
- active
- diagnosis
- differentiation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
- C12Q2531/113—PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/521—Chemokines
- G01N2333/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4 or KC
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/55—IL-2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9723—Urokinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
MÉTODOS DE DIAGNÓSTICO DE TUBERCULOSE E DE DIFERENCIAÇÃO ENTRE TUBERCULOSE ATIVA E LATENTE. São fornecidos composições e métodos para detectar infecção por Mycobacterium tuberculosis (MTB) em um paciente suspeito de estar infectado com Mycobacterium tuberculosis e para distinguir entre infecção por tuberculose ativa e latente. Os métodos também podem ser usados para monitorar a progressão da infecção por MTB ou para monitorar o tratamento de pacientes infectados por MTB. São utilizadas alterações no nível de expressão de genes para auxiliar no diagnóstico, prognóstico e tratamento da tuberculose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063088077P | 2020-10-06 | 2020-10-06 | |
US202063104187P | 2020-10-22 | 2020-10-22 | |
PCT/US2021/053594 WO2022076428A1 (en) | 2020-10-06 | 2021-10-05 | Methods of diagnosing tuberculosis and differentiating between active and latent tuberculosis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023006262A2 true BR112023006262A2 (pt) | 2023-05-09 |
Family
ID=78500726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023006262A BR112023006262A2 (pt) | 2020-10-06 | 2021-10-05 | Métodos de diagnóstico de tuberculose e de diferenciação entre tuberculose ativa e latente |
Country Status (6)
Country | Link |
---|---|
US (1) | US20220106627A1 (pt) |
EP (1) | EP4226158A1 (pt) |
KR (1) | KR20230080458A (pt) |
CN (1) | CN116348767A (pt) |
BR (1) | BR112023006262A2 (pt) |
WO (1) | WO2022076428A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108368551B (zh) * | 2015-10-14 | 2022-12-23 | 斯坦福大学托管董事会 | 用于诊断结核病的方法 |
BR112023006262A2 (pt) * | 2020-10-06 | 2023-05-09 | Cepheid | Métodos de diagnóstico de tuberculose e de diferenciação entre tuberculose ativa e latente |
CN114736276B (zh) * | 2022-05-24 | 2023-08-01 | 中国人民解放军总医院第八医学中心 | 结核分枝杆菌ltbi-rd相关蛋白抗原的ctl表位肽及其应用 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5449602A (en) | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
EP0920440B1 (en) | 1996-02-09 | 2012-08-22 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
EP2369007B1 (en) | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
US6312892B1 (en) | 1996-07-19 | 2001-11-06 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
US5958349A (en) | 1997-02-28 | 1999-09-28 | Cepheid | Reaction vessel for heat-exchanging chemical processes |
US6027998A (en) | 1997-12-17 | 2000-02-22 | Advanced Micro Devices, Inc. | Method for fully planarized conductive line for a stack gate |
ES2309022T3 (es) | 1997-12-24 | 2008-12-16 | Cepheid | Dispositivo y procedimiento para lisis. |
EP1144447B1 (en) | 1998-11-04 | 2009-10-14 | Isis Innovation Limited | Tuberculosis diagnostic test |
US6506594B1 (en) | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US6818185B1 (en) | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
DE60014676T2 (de) | 1999-05-28 | 2005-11-17 | Cepheid, Sunnyvale | Vorrichtung und verfahren zur analyse flüssiger proben |
US6403037B1 (en) | 2000-02-04 | 2002-06-11 | Cepheid | Reaction vessel and temperature control system |
AU2001265121A1 (en) | 2000-05-30 | 2001-12-11 | Applera Corporation | Methods for detecting target nucleic acids using coupled ligation and amplification |
US6605451B1 (en) | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
GB0722105D0 (en) | 2007-11-10 | 2007-12-19 | Sec Dep For Environment Food A | Antigens |
ZA200905156B (en) * | 2008-06-25 | 2010-05-26 | South African Medical Res Council | Marker for the rapid differentiation of active TB disease from latent tuberculosis infection |
EP2791679A1 (en) * | 2011-12-15 | 2014-10-22 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and kits for diagnosing latent tuberculosis infection |
WO2013175459A2 (en) * | 2012-05-25 | 2013-11-28 | Stellenbosch University | Method for diagnosing tuberculosis disease |
GB201211158D0 (en) * | 2012-06-22 | 2012-08-08 | Univ Nottingham Trent | Biomarkers and uses thereof |
GB201213567D0 (en) * | 2012-07-31 | 2012-09-12 | Proteinlogic Ltd | Biomarkers |
US20150315643A1 (en) * | 2012-12-13 | 2015-11-05 | Baylor Research Institute | Blood transcriptional signatures of active pulmonary tuberculosis and sarcoidosis |
GB201401603D0 (en) * | 2014-01-30 | 2014-03-19 | Proteinlogic Ltd | Biomarkers |
US10295538B2 (en) | 2014-08-15 | 2019-05-21 | Oxford Immunotec Limited | Mycobacterium tuberculosis proteins |
CN108368551B (zh) * | 2015-10-14 | 2022-12-23 | 斯坦福大学托管董事会 | 用于诊断结核病的方法 |
WO2017179008A1 (en) * | 2016-04-15 | 2017-10-19 | Stellenbosch University | Host biomarkers for immunodiagnosis and monitoring of tuberculosis disease |
BR112023006262A2 (pt) * | 2020-10-06 | 2023-05-09 | Cepheid | Métodos de diagnóstico de tuberculose e de diferenciação entre tuberculose ativa e latente |
CN116635538A (zh) * | 2021-10-22 | 2023-08-22 | 塞弗德公司 | 诊断和治疗结核病的组合物和方法 |
-
2021
- 2021-10-05 BR BR112023006262A patent/BR112023006262A2/pt unknown
- 2021-10-05 US US17/494,427 patent/US20220106627A1/en active Pending
- 2021-10-05 CN CN202180068320.9A patent/CN116348767A/zh active Pending
- 2021-10-05 EP EP21802074.1A patent/EP4226158A1/en active Pending
- 2021-10-05 KR KR1020237014928A patent/KR20230080458A/ko unknown
- 2021-10-05 WO PCT/US2021/053594 patent/WO2022076428A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2022076428A1 (en) | 2022-04-14 |
EP4226158A1 (en) | 2023-08-16 |
US20220106627A1 (en) | 2022-04-07 |
CN116348767A (zh) | 2023-06-27 |
KR20230080458A (ko) | 2023-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112023006262A2 (pt) | Métodos de diagnóstico de tuberculose e de diferenciação entre tuberculose ativa e latente | |
Jia et al. | Human infection with Candidatus Rickettsia tarasevichiae | |
Sharma et al. | Multidrug-resistant tuberculosis | |
Phillips et al. | Clinical and bacteriological efficacy of rifampin-streptomycin combination for two weeks followed by rifampin and clarithromycin for six weeks for treatment of Mycobacterium ulcerans disease | |
Bradley et al. | Clinical efficacy of the amplified Mycobacterium tuberculosis direct test for the diagnosis of pulmonary tuberculosis. | |
Day et al. | Screening for tuberculosis prior to isoniazid preventive therapy among HIV-infected gold miners in South Africa | |
Doern et al. | A comprehensive update on the problem of blood culture contamination and a discussion of methods for addressing the problem | |
Bayona et al. | Contact investigations as a means of detection and timely treatment of persons with infectious multidrug-resistant tuberculosis | |
Castro et al. | Detection of Treponema pallidum sp. pallidum DNA in cerebrospinal fluid (CSF) by two PCR techniques | |
Eells et al. | Non-suppurative cellulitis: risk factors and its association with Staphylococcus aureus colonization in an area of endemic community-associated methicillin-resistant S. aureus infections | |
Boggild et al. | Diagnostic performance of filter paper lesion impression PCR for secondarily infected ulcers and nonulcerative lesions caused by cutaneous leishmaniasis | |
Takahashi et al. | Pneumocystis carinii carriage in immunocompromised patients with and without human immunodeficiency virus infection | |
Hargreaves et al. | Pneumocystis carinii pneumonia in patients being registered for smear-negative pulmonary tuberculosis in Malawi | |
Farhat et al. | Concordance of Mycobacterium tuberculosis fluoroquinolone resistance testing: implications for treatment | |
Ogawa et al. | Rat-bite fever in human with Streptobacillus notomytis infection, Japan | |
Khawcharoenporn et al. | Isoniazid preventive therapy and 4-year incidence of pulmonary tuberculosis among HIV-infected Thai patients | |
Supsrisunjai et al. | Case report: Disseminated autochthonous dermal leishmaniasis caused by Leishmania siamensis (PCM2 Trang) in a patient from central Thailand infected with human immunodeficiency virus | |
Limmathurotsakul et al. | Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis | |
van der Heijden et al. | Fluoroquinolone exposure prior to tuberculosis diagnosis is associated with an increased risk of death | |
Toh et al. | A 5-year retrospective study of melioidosis cases treated in a district specialist hospital | |
Singh et al. | Detecting aerobic bacterial diversity in patients with diabetic foot wounds using ERIC-PCR: a preliminary communication | |
Sauzullo et al. | Interferon-γ release assay in HIV-infected patients with active tuberculosis: impact of antituberculous drugs on host immune response | |
Kano | Carbapenem-Resistant Enterobacteriaceae (CRE) in Intensive Care Units and surgical wards of hospitals with no history of carbapenem usage in Kano, North West Nigeria | |
Abu Raya et al. | The laboratory diagnosis of Bordetella pertussis infection: a comparison of semi-nested PCR and real-time PCR with culture | |
Rabahi et al. | Characterization of Mycobacterium tuberculosis var. africanum isolated from a patient with pulmonary tuberculosis in Brazil |