JP4260354B2 - 非結晶および結晶二水和物形態のアジスロマイシンの調製 - Google Patents

非結晶および結晶二水和物形態のアジスロマイシンの調製 Download PDF

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JP4260354B2
JP4260354B2 JP2000359948A JP2000359948A JP4260354B2 JP 4260354 B2 JP4260354 B2 JP 4260354B2 JP 2000359948 A JP2000359948 A JP 2000359948A JP 2000359948 A JP2000359948 A JP 2000359948A JP 4260354 B2 JP4260354 B2 JP 4260354B2
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azithromycin
homoerythromycin
deoxo
aza
methyl
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Japanese (ja)
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JP2001187797A5 (https=
JP2001187797A (ja
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ミゲル、サントス、バヨッド、ヤサナーダ
イジドロ、ロレンテ、ガルシア
フェリックス、フェルナンデス、マリ
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AsturPharma SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000359948A 1999-11-26 2000-11-27 非結晶および結晶二水和物形態のアジスロマイシンの調製 Expired - Fee Related JP4260354B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009902620A ES2177373B1 (es) 1999-11-26 1999-11-26 Preparacion de azitromicina en su forma no cristalina
ES9902620 1999-11-26

Related Child Applications (1)

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JP2008217072A Division JP2009007376A (ja) 1999-11-26 2008-08-26 非結晶および結晶二水和物形態のアジスロマイシンの調製

Publications (3)

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JP2001187797A JP2001187797A (ja) 2001-07-10
JP2001187797A5 JP2001187797A5 (https=) 2005-03-17
JP4260354B2 true JP4260354B2 (ja) 2009-04-30

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ID=8310747

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JP2000359948A Expired - Fee Related JP4260354B2 (ja) 1999-11-26 2000-11-27 非結晶および結晶二水和物形態のアジスロマイシンの調製
JP2008217072A Pending JP2009007376A (ja) 1999-11-26 2008-08-26 非結晶および結晶二水和物形態のアジスロマイシンの調製

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JP2008217072A Pending JP2009007376A (ja) 1999-11-26 2008-08-26 非結晶および結晶二水和物形態のアジスロマイシンの調製

Country Status (9)

Country Link
US (1) US6451990B1 (https=)
EP (2) EP1103558B1 (https=)
JP (2) JP4260354B2 (https=)
AT (2) ATE325805T1 (https=)
CA (1) CA2326930C (https=)
DE (2) DE60003509T2 (https=)
ES (2) ES2177373B1 (https=)
PL (1) PL195910B1 (https=)
TR (1) TR200003474A3 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
HRP20030430B1 (hr) * 2000-11-27 2011-11-30 Biochemie S.A. Makrolidni solvati
IN190080B (https=) * 2001-01-29 2003-06-07 Alembic Ltd
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
SI1390377T1 (sl) * 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
ES2258142T3 (es) 2001-05-22 2006-08-16 Pfizer Products Inc. Nueva forma cristalina.
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
PL371259A1 (pl) 2001-12-21 2005-06-13 Pfizer Products Inc. Bezpośrednio sprasowywalne preparaty azytromycyny
MXPA04007847A (es) 2002-02-13 2005-02-24 Biogal Gyogyszergyar Metodo para extraer un macrolido de biomateria.
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
WO2004089958A2 (en) * 2003-03-31 2004-10-21 TEVA Gyógyszergyár Részvénytársaság Crystallization and purification of macrolides
PL1558622T3 (pl) 2003-07-24 2008-06-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania makrolidów
KR100844628B1 (ko) * 2003-12-04 2008-07-07 화이자 프로덕츠 인크. 제약상 다입자의 제조 방법
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
WO2006115494A1 (en) * 2005-04-26 2006-11-02 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
CA2584430A1 (en) 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods for preparing pimecrolimus
JP2009501206A (ja) * 2005-07-14 2009-01-15 ファイザー・プロダクツ・インク 非晶質アジスロマイシン粒子の生成方法
WO2007067566A2 (en) * 2005-12-07 2007-06-14 Wyeth Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
WO2011015219A1 (en) 2009-08-06 2011-02-10 Shifa Pharmed Industrial Group Co. Process for the purification of azithromycin by separation from its thermal degradation products and/or isomers
CA2784494C (en) * 2009-12-18 2019-03-12 North-West University Composition comprising an amorphous non-crystalline glass form of roxithromycin
WO2013088274A1 (en) * 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN106188177A (zh) * 2016-07-12 2016-12-07 浙江亚太药业股份有限公司 一种阿奇霉素化合物的制备方法及其药物制剂
CN108003109A (zh) * 2017-12-18 2018-05-08 南开大学 一种大环内酯化合物的晶型及其制备方法与用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
WO1989000576A1 (en) * 1987-07-09 1989-01-26 Pfizer Inc. Azithromycin dihydrate
US5686587A (en) 1993-05-19 1997-11-11 Pfizer Inc. Intermediate for azithromycin
ECSP951389A (es) 1995-02-21 1996-05-10 Un procedimiento de obtencion de hidrato de azitromicina
ES2122905B1 (es) 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Also Published As

Publication number Publication date
ATE243704T1 (de) 2003-07-15
EP1103558A3 (en) 2001-07-04
EP1234833A3 (en) 2003-03-12
PL344101A1 (en) 2001-06-04
JP2009007376A (ja) 2009-01-15
DE60003509D1 (de) 2003-07-31
ATE325805T1 (de) 2006-06-15
EP1103558A2 (en) 2001-05-30
EP1234833B1 (en) 2006-05-10
ES2177373A1 (es) 2002-12-01
US6451990B1 (en) 2002-09-17
PL195910B1 (pl) 2007-11-30
TR200003474A2 (tr) 2001-07-23
TR200003474A3 (tr) 2001-07-23
ES2207403B1 (es) 2005-03-01
EP1103558B1 (en) 2003-06-25
DE60027919D1 (de) 2006-06-14
JP2001187797A (ja) 2001-07-10
ES2177373B1 (es) 2003-11-01
DE60003509T2 (de) 2004-04-15
EP1234833A2 (en) 2002-08-28
ES2207403A1 (es) 2004-05-16
CA2326930A1 (en) 2001-05-26
CA2326930C (en) 2005-03-22

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