DE60027919D1 - Herstellung von kristalliner Dihydratform von Azithromycin - Google Patents

Herstellung von kristalliner Dihydratform von Azithromycin

Info

Publication number
DE60027919D1
DE60027919D1 DE60027919T DE60027919T DE60027919D1 DE 60027919 D1 DE60027919 D1 DE 60027919D1 DE 60027919 T DE60027919 T DE 60027919T DE 60027919 T DE60027919 T DE 60027919T DE 60027919 D1 DE60027919 D1 DE 60027919D1
Authority
DE
Germany
Prior art keywords
preparation
azithromycin
dihydrate form
crystalline dihydrate
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60027919T
Other languages
English (en)
Inventor
Jasanada Miguel Santos Bayod
Garcia Isidro Llorente
Mari Felix Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Application granted granted Critical
Publication of DE60027919D1 publication Critical patent/DE60027919D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60027919T 1999-11-26 2000-02-23 Herstellung von kristalliner Dihydratform von Azithromycin Expired - Lifetime DE60027919D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009902620A ES2177373B1 (es) 1999-11-26 1999-11-26 Preparacion de azitromicina en su forma no cristalina

Publications (1)

Publication Number Publication Date
DE60027919D1 true DE60027919D1 (de) 2006-06-14

Family

ID=8310747

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60003509T Expired - Fee Related DE60003509T2 (de) 1999-11-26 2000-02-23 Herstellung von nicht-kristallinen und kristallinen Dihydratformen von Azithromycin
DE60027919T Expired - Lifetime DE60027919D1 (de) 1999-11-26 2000-02-23 Herstellung von kristalliner Dihydratform von Azithromycin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60003509T Expired - Fee Related DE60003509T2 (de) 1999-11-26 2000-02-23 Herstellung von nicht-kristallinen und kristallinen Dihydratformen von Azithromycin

Country Status (9)

Country Link
US (1) US6451990B1 (de)
EP (2) EP1234833B1 (de)
JP (2) JP4260354B2 (de)
AT (2) ATE243704T1 (de)
CA (1) CA2326930C (de)
DE (2) DE60003509T2 (de)
ES (2) ES2177373B1 (de)
PL (1) PL195910B1 (de)
TR (1) TR200003474A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
HU229488B1 (hu) * 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
IN190080B (de) * 2001-01-29 2003-06-07 Alembic Ltd
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
JP2004530703A (ja) * 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン
SI1390377T1 (sl) * 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
EP1455758A1 (de) 2001-12-21 2004-09-15 Pfizer Products Inc. Direktkomprimierbare formulierungen von azithromycin
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
JP4261365B2 (ja) 2002-02-13 2009-04-30 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 生物学的物質からのマクロライドの抽出方法
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US7232486B2 (en) 2003-03-31 2007-06-19 TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság Crystallization and purification of macrolides
DK1558622T3 (da) 2003-07-24 2008-02-25 Teva Gyogyszergyar Zartkoeruee Fremgangsmåde til oprensning af macrolider
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
WO2006115494A1 (en) * 2005-04-26 2006-11-02 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
EP1817314A1 (de) 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Nichthygroskopisches und pulverförmiges amorphes pimecrolimus
WO2007007148A1 (en) * 2005-07-14 2007-01-18 Pfizer Products Inc. Process for forming amorphous azithromycin particles
EP1957964A2 (de) * 2005-12-07 2008-08-20 Wyeth Pharmaceuticals Verfahren zur herstellung von kristallinem rapamycin und zur messung der kristallinität von rapamycin-verbindungen über differenzscanning-kalorimetrie
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
WO2011015219A1 (en) 2009-08-06 2011-02-10 Shifa Pharmed Industrial Group Co. Process for the purification of azithromycin by separation from its thermal degradation products and/or isomers
AP2012006312A0 (en) * 2009-12-18 2012-06-30 Univ Northwest Composition comprising an amorphous non-crystalline glass form of azithromycin.
WO2013088274A1 (en) * 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN106188177A (zh) * 2016-07-12 2016-12-07 浙江亚太药业股份有限公司 一种阿奇霉素化合物的制备方法及其药物制剂
CN108003109A (zh) * 2017-12-18 2018-05-08 南开大学 一种大环内酯化合物的晶型及其制备方法与用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
RU2066324C1 (ru) 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
CA2162401C (en) 1993-05-19 1998-11-03 Bingwei V. Yang Intermediate for azithromycin
ECSP951389A (es) 1995-02-21 1996-05-10 Un procedimiento de obtencion de hidrato de azitromicina
ES2122905B1 (es) 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Also Published As

Publication number Publication date
DE60003509T2 (de) 2004-04-15
ES2207403A1 (es) 2004-05-16
TR200003474A3 (tr) 2001-07-23
ES2177373A1 (es) 2002-12-01
CA2326930C (en) 2005-03-22
JP4260354B2 (ja) 2009-04-30
ES2177373B1 (es) 2003-11-01
CA2326930A1 (en) 2001-05-26
ATE243704T1 (de) 2003-07-15
EP1103558A2 (de) 2001-05-30
JP2001187797A (ja) 2001-07-10
PL344101A1 (en) 2001-06-04
EP1103558B1 (de) 2003-06-25
EP1234833A2 (de) 2002-08-28
TR200003474A2 (tr) 2001-07-23
PL195910B1 (pl) 2007-11-30
ATE325805T1 (de) 2006-06-15
US6451990B1 (en) 2002-09-17
ES2207403B1 (es) 2005-03-01
DE60003509D1 (de) 2003-07-31
JP2009007376A (ja) 2009-01-15
EP1103558A3 (de) 2001-07-04
EP1234833A3 (de) 2003-03-12
EP1234833B1 (de) 2006-05-10

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8332 No legal effect for de