ATE325805T1 - Herstellung von kristalliner dihydratform von azithromycin - Google Patents

Herstellung von kristalliner dihydratform von azithromycin

Info

Publication number
ATE325805T1
ATE325805T1 AT01204550T AT01204550T ATE325805T1 AT E325805 T1 ATE325805 T1 AT E325805T1 AT 01204550 T AT01204550 T AT 01204550T AT 01204550 T AT01204550 T AT 01204550T AT E325805 T1 ATE325805 T1 AT E325805T1
Authority
AT
Austria
Prior art keywords
preparation
azithromycin
dihydrate form
crystalline dihydrate
crystalline
Prior art date
Application number
AT01204550T
Other languages
English (en)
Inventor
Jasanada Miguel Santos Bayod
Garcia Isidro Llorente
Mari Felix Fernandez
Original Assignee
Astur Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astur Pharma Sa filed Critical Astur Pharma Sa
Application granted granted Critical
Publication of ATE325805T1 publication Critical patent/ATE325805T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01204550T 1999-11-26 2000-02-23 Herstellung von kristalliner dihydratform von azithromycin ATE325805T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009902620A ES2177373B1 (es) 1999-11-26 1999-11-26 Preparacion de azitromicina en su forma no cristalina

Publications (1)

Publication Number Publication Date
ATE325805T1 true ATE325805T1 (de) 2006-06-15

Family

ID=8310747

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00500028T ATE243704T1 (de) 1999-11-26 2000-02-23 Herstellung von nicht-kristallinen und kristallinen dihydratformen von azithromycin
AT01204550T ATE325805T1 (de) 1999-11-26 2000-02-23 Herstellung von kristalliner dihydratform von azithromycin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00500028T ATE243704T1 (de) 1999-11-26 2000-02-23 Herstellung von nicht-kristallinen und kristallinen dihydratformen von azithromycin

Country Status (9)

Country Link
US (1) US6451990B1 (de)
EP (2) EP1103558B1 (de)
JP (2) JP4260354B2 (de)
AT (2) ATE243704T1 (de)
CA (1) CA2326930C (de)
DE (2) DE60003509T2 (de)
ES (2) ES2177373B1 (de)
PL (1) PL195910B1 (de)
TR (1) TR200003474A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
AU2002221895A1 (en) * 2000-11-27 2002-06-03 Biochemie S.A. Macrolide solvates
IN190080B (de) * 2001-01-29 2003-06-07 Alembic Ltd
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
JP2004530703A (ja) 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン
EP1671978A1 (de) * 2001-05-22 2006-06-21 Pfizer Products Inc. Neue Kristallforme von Azithromycin
CA2469246A1 (en) 2001-12-21 2003-07-03 Pfizer Products Inc. Directly compressible formulations of azithromycin
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
PL374059A1 (en) 2002-02-13 2005-09-19 Teva Gyogyszergyar Reszvenytarsasag Method for extracting a macrolide from biomatter
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
ES2229975T1 (es) * 2003-03-31 2005-05-01 Teva Gyogyszergyar Reszvenytarsasag Cristalizacion y purificacion de macrolidos.
PL1558622T3 (pl) 2003-07-24 2008-06-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania makrolidów
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
WO2006115494A1 (en) * 2005-04-26 2006-11-02 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7683162B2 (en) 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
DE602005021684D1 (de) 2004-12-01 2010-07-15 Teva Gyogyszergyar Zartkoeruen Verfahren zur herstellung von pimecrolimus
JP2009501206A (ja) * 2005-07-14 2009-01-15 ファイザー・プロダクツ・インク 非晶質アジスロマイシン粒子の生成方法
AR058283A1 (es) * 2005-12-07 2008-01-30 Wyeth Corp Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
WO2011015219A1 (en) 2009-08-06 2011-02-10 Shifa Pharmed Industrial Group Co. Process for the purification of azithromycin by separation from its thermal degradation products and/or isomers
WO2011073927A1 (en) * 2009-12-18 2011-06-23 North-West University Composition comprising an amorphous non- crystalline glass form of azithromycin
WO2013088274A1 (en) * 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN106188177A (zh) * 2016-07-12 2016-12-07 浙江亚太药业股份有限公司 一种阿奇霉素化合物的制备方法及其药物制剂
CN108003109A (zh) * 2017-12-18 2018-05-08 南开大学 一种大环内酯化合物的晶型及其制备方法与用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
ECSP951389A (es) 1995-02-21 1996-05-10 Un procedimiento de obtencion de hidrato de azitromicina
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Also Published As

Publication number Publication date
DE60003509T2 (de) 2004-04-15
JP2001187797A (ja) 2001-07-10
ATE243704T1 (de) 2003-07-15
US6451990B1 (en) 2002-09-17
CA2326930C (en) 2005-03-22
ES2207403B1 (es) 2005-03-01
ES2177373B1 (es) 2003-11-01
EP1103558A2 (de) 2001-05-30
EP1234833A2 (de) 2002-08-28
PL344101A1 (en) 2001-06-04
TR200003474A3 (tr) 2001-07-23
CA2326930A1 (en) 2001-05-26
PL195910B1 (pl) 2007-11-30
TR200003474A2 (tr) 2001-07-23
DE60027919D1 (de) 2006-06-14
EP1234833B1 (de) 2006-05-10
ES2207403A1 (es) 2004-05-16
EP1103558A3 (de) 2001-07-04
EP1234833A3 (de) 2003-03-12
JP4260354B2 (ja) 2009-04-30
DE60003509D1 (de) 2003-07-31
EP1103558B1 (de) 2003-06-25
ES2177373A1 (es) 2002-12-01
JP2009007376A (ja) 2009-01-15

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