ES2156327T3 - Obtencion de un epoxido. - Google Patents

Obtencion de un epoxido.

Info

Publication number
ES2156327T3
ES2156327T3 ES97117720T ES97117720T ES2156327T3 ES 2156327 T3 ES2156327 T3 ES 2156327T3 ES 97117720 T ES97117720 T ES 97117720T ES 97117720 T ES97117720 T ES 97117720T ES 2156327 T3 ES2156327 T3 ES 2156327T3
Authority
ES
Spain
Prior art keywords
epoxide
obtaining
trimethyl
formula
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97117720T
Other languages
English (en)
Inventor
Hans Hilpert
Erich Widmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2156327T3 publication Critical patent/ES2156327T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PRODUCCION DE UN 4,8,8 - TRIMETIL 1 - OXASPIRO[2.5]OCT - 4 - EN - 6 - OL (I) OPCIONALMENTE PROTEGIDO A PARTIR DE LA 4 - HIDROXI - 2,6,6 - TRIMETIL - 2 CICLOHEXEN - 1 - ONA (II) PROTEGIDA CONSISTE EN QUE EL COMPUESTO PROTEGIDO II REACCIONA CON METIL - LITIO HALOGENADO Y DESEABLEMENTE SEPARANDO EL GRUPO PROTECTOR DEL 4,8,8 - TRIMETIL 1 - OXASPIRO[2.5]OCT - 4 - EN - 6 - OL PROTEGIDO ASI OBTENIDO. PARA ELLO, EL METIL-LITIO HALOGENADO SE PUEDE PRODUCIR IN SITU HACIENDO REACCIONAR EL COMPUESTO II CON UN METANO DIHALOGENADO, ASI COMO CON UN ALQUILO INFERIOR DE LITIO. PREFERENTEMENTE DE ESTA FORMA LA (S) - 4 - HIDROXI - 2,6,6 - TRIMETIL - 2 CICLOHEXEN 1 - ONA SE CONVIERTE EN EL (3S,6S) - 4,8,8 TRIMETIL - 1 - OXASPIRO[2.5]OCT - 4 - EN - 6 - OL PROTEGIDO. TANTO EL MATERIAL DE PARTIDA II COMO EL PRODUCTO FINAL I DEL PROCEDIMIENTO DE LA INVENCION SON PRODUCTOS INTERMEDIOS CONOCIDOS Y VALIOSOS PARA LA PREPARACION DE CAROTINOIDES.
ES97117720T 1996-10-18 1997-10-11 Obtencion de un epoxido. Expired - Lifetime ES2156327T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96116742 1996-10-18

Publications (1)

Publication Number Publication Date
ES2156327T3 true ES2156327T3 (es) 2001-06-16

Family

ID=8223312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97117720T Expired - Lifetime ES2156327T3 (es) 1996-10-18 1997-10-11 Obtencion de un epoxido.

Country Status (9)

Country Link
US (1) US5919956A (es)
EP (1) EP0837060B1 (es)
JP (1) JPH10120669A (es)
CN (1) CN1103337C (es)
AT (1) ATE200282T1 (es)
BR (1) BR9705086A (es)
DE (1) DE59703279D1 (es)
DK (1) DK0837060T3 (es)
ES (1) ES2156327T3 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000131A (en) * 1974-05-10 1976-12-28 Hoffmann-La Roche Inc. Process for preparing epoxide-cyclohexyl compound and resultant compound
JPH03130291A (ja) * 1989-10-16 1991-06-04 Japan Tobacco Inc ペリプラノン―ｂ類縁体、その製造法、およびその中間体、ならびにゴキブリ類の誘引剤
DK0641333T3 (da) * 1992-05-20 1996-09-02 Monsanto Co Fremgangsmåde til fremstilling af mellemprodukter, som er anvendelige ved syntese af retrovirus- protease-inhibitorer

Also Published As

Publication number Publication date
EP0837060A1 (de) 1998-04-22
JPH10120669A (ja) 1998-05-12
US5919956A (en) 1999-07-06
EP0837060B1 (de) 2001-04-04
DK0837060T3 (da) 2001-07-23
CN1180700A (zh) 1998-05-06
BR9705086A (pt) 1999-07-20
CN1103337C (zh) 2003-03-19
ATE200282T1 (de) 2001-04-15
DE59703279D1 (de) 2001-05-10

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