JP4219403B2 - 経口の生物学的利用率増大のための親油性化合物の固形脂質組成物 - Google Patents

経口の生物学的利用率増大のための親油性化合物の固形脂質組成物 Download PDF

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JP4219403B2
JP4219403B2 JP53557397A JP53557397A JP4219403B2 JP 4219403 B2 JP4219403 B2 JP 4219403B2 JP 53557397 A JP53557397 A JP 53557397A JP 53557397 A JP53557397 A JP 53557397A JP 4219403 B2 JP4219403 B2 JP 4219403B2
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lipid
composition
solid
dry
coq10
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Japanese (ja)
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JP2000507594A5 (enExample
JP2000507594A (ja
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シモン アムセレム
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ファーモス コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
JP53557397A 1996-04-02 1997-04-02 経口の生物学的利用率増大のための親油性化合物の固形脂質組成物 Expired - Fee Related JP4219403B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11777396A IL117773A (en) 1996-04-02 1996-04-02 Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
IL117773 1996-04-02
PCT/US1997/005453 WO1997036577A1 (en) 1996-04-02 1997-04-02 Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability

Publications (3)

Publication Number Publication Date
JP2000507594A JP2000507594A (ja) 2000-06-20
JP2000507594A5 JP2000507594A5 (enExample) 2004-12-09
JP4219403B2 true JP4219403B2 (ja) 2009-02-04

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Application Number Title Priority Date Filing Date
JP53557397A Expired - Fee Related JP4219403B2 (ja) 1996-04-02 1997-04-02 経口の生物学的利用率増大のための親油性化合物の固形脂質組成物

Country Status (10)

Country Link
US (1) US5989583A (enExample)
EP (1) EP0954284B1 (enExample)
JP (1) JP4219403B2 (enExample)
AT (1) ATE301454T1 (enExample)
AU (1) AU722217B2 (enExample)
BR (1) BR9708423A (enExample)
DE (1) DE69733966T2 (enExample)
ES (1) ES2249797T3 (enExample)
IL (1) IL117773A (enExample)
WO (1) WO1997036577A1 (enExample)

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EP0954284B1 (en) 2005-08-10
EP0954284A4 (en) 2000-01-26
DE69733966T2 (de) 2006-05-18
ES2249797T3 (es) 2006-04-01
IL117773A0 (en) 1996-08-04
WO1997036577A1 (en) 1997-10-09
BR9708423A (pt) 2000-01-04
IL117773A (en) 2000-10-31
JP2000507594A (ja) 2000-06-20
ATE301454T1 (de) 2005-08-15
DE69733966D1 (de) 2005-09-15
AU2433997A (en) 1997-10-22
EP0954284A1 (en) 1999-11-10
AU722217B2 (en) 2000-07-27
US5989583A (en) 1999-11-23

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