AU722217B2 - Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability - Google Patents

Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability Download PDF

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Publication number
AU722217B2
AU722217B2 AU24339/97A AU2433997A AU722217B2 AU 722217 B2 AU722217 B2 AU 722217B2 AU 24339/97 A AU24339/97 A AU 24339/97A AU 2433997 A AU2433997 A AU 2433997A AU 722217 B2 AU722217 B2 AU 722217B2
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AU
Australia
Prior art keywords
composition
lipid
dry
solid
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU24339/97A
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English (en)
Other versions
AU2433997A (en
Inventor
Shimon Amselem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmos Corp
Original Assignee
Pharmos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmos Corp filed Critical Pharmos Corp
Publication of AU2433997A publication Critical patent/AU2433997A/en
Application granted granted Critical
Publication of AU722217B2 publication Critical patent/AU722217B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
AU24339/97A 1996-04-02 1997-04-02 Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability Ceased AU722217B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11777396A IL117773A (en) 1996-04-02 1996-04-02 Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
IL117773 1996-04-02
PCT/US1997/005453 WO1997036577A1 (en) 1996-04-02 1997-04-02 Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability

Publications (2)

Publication Number Publication Date
AU2433997A AU2433997A (en) 1997-10-22
AU722217B2 true AU722217B2 (en) 2000-07-27

Family

ID=11068733

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24339/97A Ceased AU722217B2 (en) 1996-04-02 1997-04-02 Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability

Country Status (10)

Country Link
US (1) US5989583A (enExample)
EP (1) EP0954284B1 (enExample)
JP (1) JP4219403B2 (enExample)
AT (1) ATE301454T1 (enExample)
AU (1) AU722217B2 (enExample)
BR (1) BR9708423A (enExample)
DE (1) DE69733966T2 (enExample)
ES (1) ES2249797T3 (enExample)
IL (1) IL117773A (enExample)
WO (1) WO1997036577A1 (enExample)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9726343D0 (en) * 1997-12-13 1998-02-11 Auffret Anthony The use of excipients to accelerate freeze-drying
KR100682154B1 (ko) * 1998-05-07 2007-02-12 코릭사 코포레이션 아쥬번트 조성물 및 그의 사용방법
US6200550B1 (en) * 1998-12-11 2001-03-13 Q-Pharma, Inc. Oral care compositions comprising coenzyme Q10
PT1154759E (pt) 1998-12-30 2008-11-20 Dexcel Ltd Concentrado dispersível para administração de ciclosporina
US6242491B1 (en) * 1999-06-25 2001-06-05 Rima Kaddurah-Daouk Use of creatine or creatine compounds for skin preservation
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
ATE364442T1 (de) 2000-04-27 2007-07-15 Verion Inc Nullte-ordnung-freisetzung und temperatur- kontrollierte mikrokapseln sowie herstellungsverfahren
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
GB0014437D0 (en) * 2000-06-14 2000-08-09 Porter William L Immune response stimulation
AU2001279284A1 (en) * 2000-07-05 2002-01-14 Capricorn Pharma, Inc Rapid-melt semi-solid compositions, methods of making same and methods of using same
US6375982B1 (en) 2000-07-05 2002-04-23 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and method of using same
DE10035513A1 (de) * 2000-07-21 2002-01-31 Beiersdorf Ag Wirkstoffkombinationen bzw. Addukte aus Cyclodextrinen und mindestens einem Chinon und/oder mindestens einem Hydrochinon und Verwendung solcher Wirkstoffkombinationen in kosmetischen Zubereitungen
WO2002026372A2 (en) 2000-09-27 2002-04-04 Verion Inc. Instant water dissolvable encapsulate and process
US6565873B1 (en) 2000-10-25 2003-05-20 Salvona Llc Biodegradable bioadhesive controlled release system of nano-particles for oral care products
US6589562B1 (en) 2000-10-25 2003-07-08 Salvona L.L.C. Multicomponent biodegradable bioadhesive controlled release system for oral care products
US6403116B1 (en) 2000-11-03 2002-06-11 Triarco Inductries, Inc. Coenzyme Q10 formulation
AU1608502A (en) 2000-12-14 2002-06-24 Hoffmann La Roche Self emulsifying lipid matrix (selm)
KR100743404B1 (ko) 2000-12-21 2007-07-30 넥타르 테라퓨틱스 폴리엔 항균제의 폐 전달
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6607784B2 (en) * 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6806069B2 (en) 2001-01-09 2004-10-19 Pharmachem Laboratories, Inc. Ubiquinone composition and methods related thereto
US6864231B2 (en) * 2001-01-09 2005-03-08 Pharmachem Laboratories, Inc. Glycoprotein matrix compositions and methods related thereto
ATE253353T1 (de) * 2001-04-12 2003-11-15 Vesifact Ag Coenzym q10 enthaltende mikroemulsion- prekonzentrate und mikroemulsionen
US6991809B2 (en) 2001-06-23 2006-01-31 Lyotropic Therapeutics, Inc. Particles with improved solubilization capacity
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
WO2003034302A1 (en) * 2001-10-15 2003-04-24 Stark Co., Ltd. Content delivery server and content delivery system having the same
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US7714006B1 (en) 2001-12-03 2010-05-11 King Pharmaceuticals Research & Development, Inc. Methods of modifying the bioavailability of metaxalone
US6407128B1 (en) 2001-12-03 2002-06-18 Elan Pharmaceuticals, Inc. Method for increasing the bioavailability of metaxalone
TW200302054A (en) 2002-01-18 2003-08-01 Kaneka Corp Ubiquinone-enriched foods
SE0200475D0 (sv) * 2002-02-15 2002-02-15 Ltp Lipid Technologies Provide Oral farmaceutisk beredning
AR039194A1 (es) 2002-04-03 2005-02-09 Solvay Pharm Bv Formulacion de cannabinoides naturales estabilizados
ES2316759T3 (es) * 2002-04-03 2009-04-16 Solvay Pharmaceuticals B.V. Formulacion de cannabinoide natural estabilizada.
US20060093661A1 (en) * 2002-05-07 2006-05-04 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
ES2333318T3 (es) 2002-08-12 2010-02-19 Bend Research, Inc. Composiciones farmaceuticas de medicamentos con estructura semiordenada y de polimero.
EP2138190B1 (en) 2002-08-19 2014-02-12 SOHO Flordis International Pty Ltd Compositions comprising dietary fat complexer and methods for their use
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
CA2414763A1 (en) * 2002-12-19 2004-06-19 Aquanova German Solubilisate Technologies (Agt) Gmbh Tocopherol concentrates and method for producing same
US20130085146A1 (en) * 2003-01-14 2013-04-04 Rodney J.Y. Ho Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues
JP2004323444A (ja) * 2003-04-25 2004-11-18 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai 凍結乾燥微粒子製剤およびその製法
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7438903B2 (en) * 2003-06-06 2008-10-21 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
US20050096365A1 (en) * 2003-11-03 2005-05-05 David Fikstad Pharmaceutical compositions with synchronized solubilizer release
US20050196416A1 (en) * 2004-02-05 2005-09-08 Kipp James E. Dispersions prepared by use of self-stabilizing agents
DE602005025313D1 (de) * 2004-02-17 2011-01-27 Matuschka Greiffenclau Markus Zusammensetzung zur veränderung des alkoholstoffwechsels
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US7803366B2 (en) * 2004-05-07 2010-09-28 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
JP5153341B2 (ja) * 2004-12-09 2013-02-27 インシス セラピューティクス，インコーポレーテッド 室温で安定なドロナビノール製剤
JP4877899B2 (ja) * 2005-01-25 2012-02-15 学校法人近畿大学 薬物徐放出性球状微粒子及びその製造方法
WO2006110924A2 (en) * 2005-04-14 2006-10-19 Jarrow Formulas, Inc. Dietary supplement formulations for improved delivery of coenzyme q10 and methods of administration
US8252326B2 (en) * 2005-06-01 2012-08-28 Catalent Australia Pty Ltd. Self-microemulsifying dosage forms of low solubility active ingredients such as co-enzyme Q10
WO2007016435A2 (en) * 2005-07-28 2007-02-08 Isp Investments Inc. Method to improve characteristics of spray dried powders and granulated materials, and the products thereby produced
WO2007014392A2 (en) * 2005-07-28 2007-02-01 Isp Investments Inc. Benzoquinones of enhanced bioavailability
KR101487848B1 (ko) * 2005-07-29 2015-02-03 티마 파운데이션 알콜대사를 완화하고 알콜유도성 질환의 위험을 감소하기 위한 조성물
EP1965762A1 (en) * 2005-12-23 2008-09-10 Alcon, Inc. Pharmaceutical formulation for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye
MX2008013855A (es) * 2006-05-02 2009-01-29 Univ Miami Formulaciones de co-enzima topica q10 y tratamiento de dolor, fatiga y heridas.
US20070264312A1 (en) * 2006-05-12 2007-11-15 Skaggs Crawford B Rheologically Modified Edible Oils
EP2039353B1 (en) * 2006-06-22 2018-12-05 Kaneka Corporation Reduced coenzyme q10-containing composition and method for producing the same
WO2008019146A2 (en) * 2006-08-04 2008-02-14 Insys Therapeutics Inc. Aqueous dronabinol formulations
AU2007295179B2 (en) 2006-09-15 2013-05-30 Echo Pharmaceuticals B.V. Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances
CN101594848B (zh) * 2006-09-15 2014-10-29 艾可制药有限公司 包含药物活性物质和乳化剂的颗粒及其制备方法
WO2008076780A2 (en) * 2006-12-14 2008-06-26 Isp Investments Inc. Amorphous valsartan and the production thereof
US8613946B2 (en) * 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
EP1952803A1 (en) 2007-01-23 2008-08-06 KTB-Tumorforschungs GmbH Solid pharmaceutical dosage form containing hydrogenated phospholipids
WO2008092057A2 (en) 2007-01-26 2008-07-31 Isp Investments Inc. Formulation process method to produce spray dried products
WO2008092046A2 (en) * 2007-01-26 2008-07-31 Isp Investments Inc. Amorphous oxcarbazepine and the production thereof
US20100092560A1 (en) * 2007-04-16 2010-04-15 Kaneka Corporation Reduced coenzyme q10-containing particulate composition and method for producing the same
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
WO2009020666A1 (en) * 2007-08-06 2009-02-12 Insys Therapeutics Inc. Oral cannabinoid liquid formulations and methods of treatment
US9861656B2 (en) * 2007-08-08 2018-01-09 Allergy Research Group, Llc Phospholipid compositions and use thereof to enhance spermatozoa motility and viability
FR2929512B1 (fr) * 2008-04-08 2010-12-31 Roquette Freres Composition pulverulente de maltitol cristallise de grande fluidite et non mottante
WO2010022364A1 (en) * 2008-08-22 2010-02-25 Ackley Donald E Water soluble drugs and supplements
GB0909154D0 (en) * 2008-09-25 2009-07-08 Nanomaterials Tech Pte Ltd A process for making particles for delivery of drug nanoparticles
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
WO2010143199A1 (en) * 2009-06-11 2010-12-16 Suven Nishtaa Pharma Private Limited Solid lipid dispersion for aqueous solubility enhancement of poorly water soluble drugs
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
WO2011038068A1 (en) 2009-09-23 2011-03-31 Formatech, Inc. Methods for the preparation of liposomes
US11224659B2 (en) * 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11202831B2 (en) * 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
WO2012059936A1 (en) 2010-11-03 2012-05-10 Padma Venkitachalam Devarajan Pharmaceutical compositions for colloidal drug delivery
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US9655849B2 (en) 2011-03-18 2017-05-23 Particle Dynamics International, Llc Solid particulate compositions comprising coenzyme Q10
US10421943B2 (en) * 2011-08-11 2019-09-24 Allergy Research Group, Llc Phospholipid compositions and use thereof to enhance spermatozoa motility, viability and resistance to oxydative damage
WO2014078435A1 (en) 2012-11-14 2014-05-22 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide
DE102013004263A1 (de) * 2013-03-13 2014-09-18 Martin Lipsdorf Schnell lösliche orale Darreichungsform und Methode zur Herstellung derselben
US11331279B2 (en) 2014-05-29 2022-05-17 Radius Pharmaceuticals, Inc. Stable cannabinoid formulations
US11911361B2 (en) 2014-05-29 2024-02-27 Radius Pharmaceuticals, Inc. Stable cannabinoid formulations
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
EP4193990A1 (en) * 2015-05-28 2023-06-14 Radius Pharmaceuticals, Inc. Stable cannabinoid formulations
EP3103440A1 (en) * 2015-06-12 2016-12-14 INDENA S.p.A. Solid dispersions of coenzyme q10
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
WO2017045034A1 (en) * 2015-09-17 2017-03-23 Pharmako Biotechnologies Pty Limited Ubiquinone and ubiquinol compositions, and methods relating thereto
RU2605616C1 (ru) * 2015-11-27 2016-12-27 Закрытое акционерное общество "Институт экспериментальной фармакологии" Липосомальное средство на основе убихинола и способ его получения
US11590230B2 (en) 2015-12-07 2023-02-28 Elka Touitou Compositions of therapeutic substances, methods and uses thereof
CA3176596A1 (en) * 2015-12-09 2017-06-15 Poviva Corp. Methods for formulating orally ingestible compositions comprising lipophilic active agents
MA45279A (fr) * 2016-03-02 2019-01-09 Pathway Intermediates Ltd Aliments pour animaux contenant des glycolipides spécifiques
US11166912B2 (en) * 2016-03-03 2021-11-09 Ctt Pharma Inc. Orally administrable composition
US20220079881A1 (en) * 2016-03-03 2022-03-17 Ctt Pharma Inc. Orally Administrable Composition
BE1024442B1 (nl) * 2016-07-27 2018-02-28 Nutrisan Nv Samenstelling en gebruik van een voedingssupplement
WO2018035027A1 (en) * 2016-08-15 2018-02-22 Corr-Jensen Inc. TIME RELEASE OF CoQ10
EP3544614A4 (en) 2016-11-28 2020-08-05 Lipocine Inc. TESTOSTERONE UNDECANOATE ORAL TREATMENT
ES3017696T3 (en) 2017-05-17 2025-05-13 Bpgbio Inc Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa
AU2018307361A1 (en) 2017-07-27 2020-03-12 Locus Ip Company, Llc Compositions for enhancing bioavailability of pharmaceuticals, supplements and ingested substances
MX2020010908A (es) * 2018-04-16 2021-03-25 Poviva Corp Composiciones infundidas con compuestos de nicotina y metodos de uso de las mismas.
CN108379236B (zh) * 2018-04-20 2020-02-18 武汉百纳礼康生物制药有限公司 一种非那雄胺缓释片及其制备方法
WO2020018974A1 (en) 2018-07-20 2020-01-23 Lipocine Inc. Liver disease
CN113382719B (zh) 2018-12-11 2023-10-31 迪斯拉普申实验室公司 用于递送治疗剂的组合物及其使用方法和制备方法
US11298336B2 (en) 2019-05-30 2022-04-12 Soluble Technologies, Inc. Water soluble formulation
WO2021016134A1 (en) * 2019-07-19 2021-01-28 Spi Pharma, Inc. Preparation of lipophilic active ingredients
MX2022001802A (es) * 2019-08-10 2022-03-11 Locus Ip Co Llc Metodos para incrementar la biodisponibilidad de medicamentos farmaceuticos y de venta libre.
US20220322707A1 (en) * 2019-08-14 2022-10-13 Locus Ip Company, Llc Drinkable Supplement Composition for Improved Health and Hydration
US11311559B2 (en) 2020-04-20 2022-04-26 Poviva Corp. Compositions and methods for enhanced delivery of antiviral agents
EP3919046A1 (en) 2020-06-02 2021-12-08 Athenion AG Method for solubilizing natural, endogenous and synthetic cannabinoids
US11786475B2 (en) 2020-07-22 2023-10-17 Soluble Technologies Inc. Film-based dosage form

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55153713A (en) * 1979-05-02 1980-11-29 Kureha Chem Ind Co Ltd Pharmaceutical preparation of ribosome containing active substance
IT8219012A0 (it) * 1982-01-06 1982-01-06 Ausonia Farma Srl Metodo per la somministrazione orale di sostanze sotto forma di liposomi, e relative formulazioni farmaceutiche.
US4687782A (en) * 1984-12-10 1987-08-18 Nutri-Fuels Systems, Inc. Nutritional composition for enhancing skeletal muscle adaptation to exercise training
IT1191608B (it) * 1985-02-01 1988-03-23 Zambon Spa Composizione farmaceutica e forme farmaceutiche che la contengono
DE3919982A1 (de) * 1989-06-19 1990-12-20 Liedtke Pharmed Gmbh Orale lipidarzneiform
US5665379A (en) * 1990-09-28 1997-09-09 Pharmacia & Upjohn Aktiebolag Lipid particle forming matrix, preparation and use thereof
US5179122A (en) * 1991-02-11 1993-01-12 Eastman Kodak Company Nutritional supplement containing vitamin e
US5480865A (en) * 1994-02-25 1996-01-02 Parkinson's Charitable Trust Nutritional composition

Also Published As

Publication number Publication date
ATE301454T1 (de) 2005-08-15
EP0954284B1 (en) 2005-08-10
IL117773A0 (en) 1996-08-04
AU2433997A (en) 1997-10-22
ES2249797T3 (es) 2006-04-01
WO1997036577A1 (en) 1997-10-09
DE69733966D1 (de) 2005-09-15
EP0954284A1 (en) 1999-11-10
US5989583A (en) 1999-11-23
JP4219403B2 (ja) 2009-02-04
EP0954284A4 (en) 2000-01-26
IL117773A (en) 2000-10-31
JP2000507594A (ja) 2000-06-20
DE69733966T2 (de) 2006-05-18
BR9708423A (pt) 2000-01-04

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