AU722217B2 - Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability - Google Patents

Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability Download PDF

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Publication number
AU722217B2
AU722217B2 AU24339/97A AU2433997A AU722217B2 AU 722217 B2 AU722217 B2 AU 722217B2 AU 24339/97 A AU24339/97 A AU 24339/97A AU 2433997 A AU2433997 A AU 2433997A AU 722217 B2 AU722217 B2 AU 722217B2
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AU
Australia
Prior art keywords
composition
lipid
dry
solid
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU24339/97A
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English (en)
Other versions
AU2433997A (en
Inventor
Shimon Amselem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmos Corp
Original Assignee
Pharmos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmos Corp filed Critical Pharmos Corp
Publication of AU2433997A publication Critical patent/AU2433997A/en
Application granted granted Critical
Publication of AU722217B2 publication Critical patent/AU722217B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
AU24339/97A 1996-04-02 1997-04-02 Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability Ceased AU722217B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11777396A IL117773A (en) 1996-04-02 1996-04-02 Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
IL117773 1996-04-02
PCT/US1997/005453 WO1997036577A1 (en) 1996-04-02 1997-04-02 Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability

Publications (2)

Publication Number Publication Date
AU2433997A AU2433997A (en) 1997-10-22
AU722217B2 true AU722217B2 (en) 2000-07-27

Family

ID=11068733

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24339/97A Ceased AU722217B2 (en) 1996-04-02 1997-04-02 Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability

Country Status (10)

Country Link
US (1) US5989583A (enExample)
EP (1) EP0954284B1 (enExample)
JP (1) JP4219403B2 (enExample)
AT (1) ATE301454T1 (enExample)
AU (1) AU722217B2 (enExample)
BR (1) BR9708423A (enExample)
DE (1) DE69733966T2 (enExample)
ES (1) ES2249797T3 (enExample)
IL (1) IL117773A (enExample)
WO (1) WO1997036577A1 (enExample)

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US5989583A (en) 1999-11-23
JP2000507594A (ja) 2000-06-20
EP0954284A4 (en) 2000-01-26
JP4219403B2 (ja) 2009-02-04
EP0954284B1 (en) 2005-08-10
DE69733966D1 (de) 2005-09-15
ES2249797T3 (es) 2006-04-01
ATE301454T1 (de) 2005-08-15
AU2433997A (en) 1997-10-22
IL117773A0 (en) 1996-08-04
EP0954284A1 (en) 1999-11-10
IL117773A (en) 2000-10-31
BR9708423A (pt) 2000-01-04
WO1997036577A1 (en) 1997-10-09
DE69733966T2 (de) 2006-05-18

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