ATE301454T1 - Feste lipidzusammensetzungen von lipophilen verbindungen zur verbesserten oralen bioverfügbarkeit - Google Patents

Feste lipidzusammensetzungen von lipophilen verbindungen zur verbesserten oralen bioverfügbarkeit

Info

Publication number
ATE301454T1
ATE301454T1 AT97920049T AT97920049T ATE301454T1 AT E301454 T1 ATE301454 T1 AT E301454T1 AT 97920049 T AT97920049 T AT 97920049T AT 97920049 T AT97920049 T AT 97920049T AT E301454 T1 ATE301454 T1 AT E301454T1
Authority
AT
Austria
Prior art keywords
oral bioavailability
lipid compositions
solid lipid
dexanabinol
coenzyme
Prior art date
Application number
AT97920049T
Other languages
English (en)
Inventor
Shimon Amselem
Original Assignee
Pharmos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmos Corp filed Critical Pharmos Corp
Application granted granted Critical
Publication of ATE301454T1 publication Critical patent/ATE301454T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
AT97920049T 1996-04-02 1997-04-02 Feste lipidzusammensetzungen von lipophilen verbindungen zur verbesserten oralen bioverfügbarkeit ATE301454T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11777396A IL117773A (en) 1996-04-02 1996-04-02 Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
PCT/US1997/005453 WO1997036577A1 (en) 1996-04-02 1997-04-02 Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability

Publications (1)

Publication Number Publication Date
ATE301454T1 true ATE301454T1 (de) 2005-08-15

Family

ID=11068733

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97920049T ATE301454T1 (de) 1996-04-02 1997-04-02 Feste lipidzusammensetzungen von lipophilen verbindungen zur verbesserten oralen bioverfügbarkeit

Country Status (10)

Country Link
US (1) US5989583A (de)
EP (1) EP0954284B1 (de)
JP (1) JP4219403B2 (de)
AT (1) ATE301454T1 (de)
AU (1) AU722217B2 (de)
BR (1) BR9708423A (de)
DE (1) DE69733966T2 (de)
ES (1) ES2249797T3 (de)
IL (1) IL117773A (de)
WO (1) WO1997036577A1 (de)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9726343D0 (en) * 1997-12-13 1998-02-11 Auffret Anthony The use of excipients to accelerate freeze-drying
CN101219217A (zh) * 1998-05-07 2008-07-16 科里克萨有限公司 佐剂组合物及其使用方法
US6200550B1 (en) * 1998-12-11 2001-03-13 Q-Pharma, Inc. Oral care compositions comprising coenzyme Q10
AU769429C (en) 1998-12-30 2004-10-28 Dexcel Limited Dispersible concentrate for the delivery of cyclosporin
US6242491B1 (en) * 1999-06-25 2001-06-05 Rima Kaddurah-Daouk Use of creatine or creatine compounds for skin preservation
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
CA2407154A1 (en) 2000-04-27 2001-11-01 Verion, Inc Zero order release and temperature-controlled microcapsules and process for the preparation thereof
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
GB0014437D0 (en) * 2000-06-14 2000-08-09 Porter William L Immune response stimulation
US6375982B1 (en) 2000-07-05 2002-04-23 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and method of using same
WO2002002081A1 (en) * 2000-07-05 2002-01-10 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and methods of using same
DE10035513A1 (de) * 2000-07-21 2002-01-31 Beiersdorf Ag Wirkstoffkombinationen bzw. Addukte aus Cyclodextrinen und mindestens einem Chinon und/oder mindestens einem Hydrochinon und Verwendung solcher Wirkstoffkombinationen in kosmetischen Zubereitungen
AU2001291243A1 (en) 2000-09-27 2002-04-08 Verion Inc. Instant water dissolvable encapsulate and process
US6565873B1 (en) * 2000-10-25 2003-05-20 Salvona Llc Biodegradable bioadhesive controlled release system of nano-particles for oral care products
US6589562B1 (en) 2000-10-25 2003-07-08 Salvona L.L.C. Multicomponent biodegradable bioadhesive controlled release system for oral care products
US6403116B1 (en) 2000-11-03 2002-06-11 Triarco Inductries, Inc. Coenzyme Q10 formulation
DE60123661T2 (de) * 2000-12-14 2007-08-16 F. Hoffmann-La Roche Ag Selbstemulgierende lipidmatrix (selm)
WO2002054868A2 (en) 2000-12-21 2002-07-18 Inhale Therapeutic Syst Pulmonary delivery of polyene antifungal agents
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US7037528B2 (en) * 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6806069B2 (en) 2001-01-09 2004-10-19 Pharmachem Laboratories, Inc. Ubiquinone composition and methods related thereto
US6864231B2 (en) * 2001-01-09 2005-03-08 Pharmachem Laboratories, Inc. Glycoprotein matrix compositions and methods related thereto
DK1249230T3 (da) * 2001-04-12 2004-03-15 Vesifact Ag Mikroemulsion-prækoncentrater og mikroemulsioner indeholdende coenzym Q10
CA2451432A1 (en) 2001-06-23 2003-01-03 Lyotropic Therapeutics, Inc. Particles with improved solubilization capacity
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
WO2003034302A1 (fr) * 2001-10-15 2003-04-24 Stark Co., Ltd. Serveur de fourniture de contenu et systeme de fourniture de contenu dote d'un tel serveur
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US6407128B1 (en) 2001-12-03 2002-06-18 Elan Pharmaceuticals, Inc. Method for increasing the bioavailability of metaxalone
US7714006B1 (en) 2001-12-03 2010-05-11 King Pharmaceuticals Research & Development, Inc. Methods of modifying the bioavailability of metaxalone
TW200302054A (en) * 2002-01-18 2003-08-01 Kaneka Corp Ubiquinone-enriched foods
SE0200475D0 (sv) * 2002-02-15 2002-02-15 Ltp Lipid Technologies Provide Oral farmaceutisk beredning
AR039194A1 (es) 2002-04-03 2005-02-09 Solvay Pharm Bv Formulacion de cannabinoides naturales estabilizados
MXPA04009673A (es) * 2002-04-03 2005-01-11 Solvay Pharm Bv Formulacion de cannabinoide natural estabilizado.
US20060093661A1 (en) * 2002-05-07 2006-05-04 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
ES2333318T3 (es) * 2002-08-12 2010-02-19 Bend Research, Inc. Composiciones farmaceuticas de medicamentos con estructura semiordenada y de polimero.
MXPA04012880A (es) 2002-08-19 2005-07-05 Art Jen Complexus Inc Composiciones que comprenden complejante de grasa alimentaria y metodos para su uso.
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
CA2414763A1 (en) * 2002-12-19 2004-06-19 Aquanova German Solubilisate Technologies (Agt) Gmbh Tocopherol concentrates and method for producing same
US20130085146A1 (en) * 2003-01-14 2013-04-04 Rodney J.Y. Ho Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues
JP2004323444A (ja) * 2003-04-25 2004-11-18 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai 凍結乾燥微粒子製剤およびその製法
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7438903B2 (en) * 2003-06-06 2008-10-21 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
US20050096365A1 (en) * 2003-11-03 2005-05-05 David Fikstad Pharmaceutical compositions with synchronized solubilizer release
EP1711163A2 (de) * 2004-02-05 2006-10-18 Baxter International Inc. Unter verwendung von selbststabilisierenden mitteln hergestellte dispersionen
DE602005025313D1 (de) * 2004-02-17 2011-01-27 Matuschka Greiffenclau Markus Zusammensetzung zur veränderung des alkoholstoffwechsels
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US7803366B2 (en) * 2004-05-07 2010-09-28 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
US8628796B2 (en) 2004-12-09 2014-01-14 Insys Therapeutics, Inc. Room-temperature stable dronabinol formulations
JP4877899B2 (ja) * 2005-01-25 2012-02-15 学校法人近畿大学 薬物徐放出性球状微粒子及びその製造方法
CN101500599A (zh) * 2005-04-14 2009-08-05 杰诺营养保健品公司 用于改善的辅酶q10的递送的营养增补剂制剂及其给予方法
US8252326B2 (en) 2005-06-01 2012-08-28 Catalent Australia Pty Ltd. Self-microemulsifying dosage forms of low solubility active ingredients such as co-enzyme Q10
EP1909763A2 (de) * 2005-07-28 2008-04-16 Isp Investments Inc. Benzochinone mit erhöhter bioverfügbarkeit
CN101272769B (zh) * 2005-07-28 2013-04-24 Isp投资有限公司 生物利用度提高的苯醌类化合物
SI1909600T1 (sl) * 2005-07-29 2012-07-31 Tima Foundation Zmes za nadzor metabolizma alkohola in za zmanjšanje nevarnosti z alkoholom induciranih bolezni
JP2009521510A (ja) * 2005-12-23 2009-06-04 アルコン，インコーポレイテッド 眼への受容体チロシンキナーゼ阻害（ｒｔｋｉ）化合物の送達のための医薬製剤
JP2009536215A (ja) * 2006-05-02 2009-10-08 ユニバーシティ オブ マイアミ 局所コエンザイムｑ１０製剤、及び疼痛、疲労、並びに創傷の治療
US20070264312A1 (en) * 2006-05-12 2007-11-15 Skaggs Crawford B Rheologically Modified Edible Oils
CA2666688C (en) * 2006-06-22 2016-01-19 Kaneka Corporation Reduced coenzyme q10-containing composition and method for producing the same
CN101516333A (zh) * 2006-08-04 2009-08-26 英西斯治疗学股份有限公司 水性屈大麻酚制剂
AU2007295178B2 (en) * 2006-09-15 2013-04-18 Echo Pharmaceuticals B.V. Granulate containing a pharmaceutically active substance and anemulsifier and method for its manufacture
ES2536922T3 (es) 2006-09-15 2015-05-29 Echo Pharmaceuticals B.V. Unidad de dosificación para administración sublingual, bucal u oral de sustancias farmacéuticamente activas insolubles en agua
WO2008076780A2 (en) * 2006-12-14 2008-06-26 Isp Investments Inc. Amorphous valsartan and the production thereof
WO2008080037A2 (en) * 2006-12-21 2008-07-03 Isp Investments Inc. Carotenoids of enhanced bioavailability
EP1952803A1 (de) 2007-01-23 2008-08-06 KTB-Tumorforschungs GmbH Feste pharmazeutische Darreichungsform mit hydrierten Phospholipiden
JP5508859B2 (ja) * 2007-01-26 2014-06-04 アイエスピー インヴェストメンツ インコーポレイテッド 噴霧乾燥製品を製造するための調剤処理方法
US20080181961A1 (en) * 2007-01-26 2008-07-31 Isp Investments, Inc. Amorphous oxcarbazepine and the production thereof
US20100092560A1 (en) * 2007-04-16 2010-04-15 Kaneka Corporation Reduced coenzyme q10-containing particulate composition and method for producing the same
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
WO2009020666A1 (en) * 2007-08-06 2009-02-12 Insys Therapeutics Inc. Oral cannabinoid liquid formulations and methods of treatment
US9861656B2 (en) * 2007-08-08 2018-01-09 Allergy Research Group, Llc Phospholipid compositions and use thereof to enhance spermatozoa motility and viability
FR2929512B1 (fr) * 2008-04-08 2010-12-31 Roquette Freres Composition pulverulente de maltitol cristallise de grande fluidite et non mottante
WO2010022364A1 (en) * 2008-08-22 2010-02-25 Ackley Donald E Water soluble drugs and supplements
GB0909154D0 (en) * 2008-09-25 2009-07-08 Nanomaterials Tech Pte Ltd A process for making particles for delivery of drug nanoparticles
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
WO2010143199A1 (en) * 2009-06-11 2010-12-16 Suven Nishtaa Pharma Private Limited Solid lipid dispersion for aqueous solubility enhancement of poorly water soluble drugs
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
WO2011038068A1 (en) 2009-09-23 2011-03-31 Formatech, Inc. Methods for the preparation of liposomes
US11202831B2 (en) * 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US11224659B2 (en) * 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
WO2012059936A1 (en) 2010-11-03 2012-05-10 Padma Venkitachalam Devarajan Pharmaceutical compositions for colloidal drug delivery
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US9655849B2 (en) 2011-03-18 2017-05-23 Particle Dynamics International, Llc Solid particulate compositions comprising coenzyme Q10
US10421943B2 (en) * 2011-08-11 2019-09-24 Allergy Research Group, Llc Phospholipid compositions and use thereof to enhance spermatozoa motility, viability and resistance to oxydative damage
HUE051406T2 (hu) 2012-11-14 2021-03-01 Grace W R & Co Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók
DE102013004263A1 (de) * 2013-03-13 2014-09-18 Martin Lipsdorf Schnell lösliche orale Darreichungsform und Methode zur Herstellung derselben
US11911361B2 (en) 2014-05-29 2024-02-27 Radius Pharmaceuticals, Inc. Stable cannabinoid formulations
US11331279B2 (en) 2014-05-29 2022-05-17 Radius Pharmaceuticals, Inc. Stable cannabinoid formulations
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
AU2016267585C1 (en) * 2015-05-28 2023-02-16 Radius Pharmaceuticals, Inc. Stable cannabinoid formulations
EP3103440A1 (de) 2015-06-12 2016-12-14 INDENA S.p.A. Feste dispersionen von coenzym q10
WO2017045034A1 (en) * 2015-09-17 2017-03-23 Pharmako Biotechnologies Pty Limited Ubiquinone and ubiquinol compositions, and methods relating thereto
RU2605616C1 (ru) * 2015-11-27 2016-12-27 Закрытое акционерное общество "Институт экспериментальной фармакологии" Липосомальное средство на основе убихинола и способ его получения
AU2016367543A1 (en) 2015-12-07 2018-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Compositions of therapeutic substances, methods and uses thereof
AU2016367036B2 (en) * 2015-12-09 2019-04-18 Poviva Corp. Methods for formulating orally ingestible compositions comprising lipophilic active agents
MA45279A (fr) * 2016-03-02 2019-01-09 Pathway Intermediates Ltd Aliments pour animaux contenant des glycolipides spécifiques
US20220079881A1 (en) * 2016-03-03 2022-03-17 Ctt Pharma Inc. Orally Administrable Composition
US11166912B2 (en) * 2016-03-03 2021-11-09 Ctt Pharma Inc. Orally administrable composition
BE1024442B1 (nl) * 2016-07-27 2018-02-28 Nutrisan Nv Samenstelling en gebruik van een voedingssupplement
US20190183815A1 (en) * 2016-08-15 2019-06-20 Corr-Jensen Inc. TIME RELEASE OF CoQ10
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
CN110769818A (zh) 2017-05-17 2020-02-07 博格有限责任公司 辅酶q10制剂在治疗和预防大疱性表皮松解症中的用途
EP3658124A4 (de) 2017-07-27 2021-04-21 Locus IP Company, LLC Zusammensetzungen zur erhöhung der bioverfügbarkeit von arzneimitteln, supplementen und eingenommenen substanzen
MX2020010908A (es) * 2018-04-16 2021-03-25 Poviva Corp Composiciones infundidas con compuestos de nicotina y metodos de uso de las mismas.
CN108379236B (zh) * 2018-04-20 2020-02-18 武汉百纳礼康生物制药有限公司 一种非那雄胺缓释片及其制备方法
WO2020123407A1 (en) 2018-12-11 2020-06-18 Disruption Labs Inc. Compositions for the delivery of therapeutic agents and methods of use and making thereof
US11298336B2 (en) 2019-05-30 2022-04-12 Soluble Technologies, Inc. Water soluble formulation
US20220257772A1 (en) * 2019-07-19 2022-08-18 Spi Pharma, Inc. Preparation of lipophilic active ingredients
EP4009954A4 (de) * 2019-08-10 2023-07-26 Locus IP Company, LLC Verfahren zur erhöhung der bioverfügbarkeit von otc- und pharmazeutischen arzneimitteln
MX2022001806A (es) * 2019-08-14 2022-03-11 Locus Ip Co Llc Composicion de suplemento bebible para mejorar la salud y la hidratacion.
AU2021261261B2 (en) 2020-04-20 2022-12-08 Poviva Corp. Compositions and methods for enhanced delivery of antiviral agents
EP3919046A1 (de) 2020-06-02 2021-12-08 Athenion AG Verfahren zur solubilisierung von natürlichen, endogenen und synthetischen cannabinoiden
US11786475B2 (en) 2020-07-22 2023-10-17 Soluble Technologies Inc. Film-based dosage form

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55153713A (en) * 1979-05-02 1980-11-29 Kureha Chem Ind Co Ltd Pharmaceutical preparation of ribosome containing active substance
IT8219012A0 (it) * 1982-01-06 1982-01-06 Ausonia Farma Srl Metodo per la somministrazione orale di sostanze sotto forma di liposomi, e relative formulazioni farmaceutiche.
US4687782A (en) * 1984-12-10 1987-08-18 Nutri-Fuels Systems, Inc. Nutritional composition for enhancing skeletal muscle adaptation to exercise training
IT1191608B (it) * 1985-02-01 1988-03-23 Zambon Spa Composizione farmaceutica e forme farmaceutiche che la contengono
DE3919982A1 (de) * 1989-06-19 1990-12-20 Liedtke Pharmed Gmbh Orale lipidarzneiform
US5665379A (en) * 1990-09-28 1997-09-09 Pharmacia & Upjohn Aktiebolag Lipid particle forming matrix, preparation and use thereof
US5179122A (en) * 1991-02-11 1993-01-12 Eastman Kodak Company Nutritional supplement containing vitamin e
US5480865A (en) * 1994-02-25 1996-01-02 Parkinson's Charitable Trust Nutritional composition

Also Published As

Publication number Publication date
ES2249797T3 (es) 2006-04-01
WO1997036577A1 (en) 1997-10-09
AU722217B2 (en) 2000-07-27
IL117773A0 (en) 1996-08-04
EP0954284A4 (de) 2000-01-26
IL117773A (en) 2000-10-31
JP2000507594A (ja) 2000-06-20
JP4219403B2 (ja) 2009-02-04
BR9708423A (pt) 2000-01-04
EP0954284B1 (de) 2005-08-10
DE69733966T2 (de) 2006-05-18
DE69733966D1 (de) 2005-09-15
AU2433997A (en) 1997-10-22
US5989583A (en) 1999-11-23
EP0954284A1 (de) 1999-11-10

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