BR9810866A - Composição farmacêutica em uma forma de formulação auto-emulsificante para compostos lipofìlicos - Google Patents

Composição farmacêutica em uma forma de formulação auto-emulsificante para compostos lipofìlicos

Info

Publication number
BR9810866A
BR9810866A BR9810866-2A BR9810866A BR9810866A BR 9810866 A BR9810866 A BR 9810866A BR 9810866 A BR9810866 A BR 9810866A BR 9810866 A BR9810866 A BR 9810866A
Authority
BR
Brazil
Prior art keywords
self
pharmaceutical composition
diglyceride
monoglyceride
emulsifying formulation
Prior art date
Application number
BR9810866-2A
Other languages
English (en)
Other versions
BR9810866B1 (pt
Inventor
Walter Morozowich
Ping Gao
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR9810866A publication Critical patent/BR9810866A/pt
Publication of BR9810866B1 publication Critical patent/BR9810866B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

<B>COMPOSIçãO FARMACêUTICA EM UMA FORMA DE FORMULAçãO AUTO-EMULSIFICANTE PARA COMPOSTOS LIPOFìLICOS<D> A presente invenção fornece uma composição farmacêutica nova com base no uso de uma fase de óleo específica que compreende um composto de piranona como um agente farmaceuticamente ativo, uma mistura de diglicerídeo e monoglicerídeo em uma razão de aproximadamente 9:1 a aproximadamente 6:4 (diglicerídeo:monoglicerídeo) em que o diglicerídeo e monoglicerídeo são ésteres de ácido graxo mono- ou di-insaturados de glicerol com comprimento de cadeia de dezesseis a vinte e dois carbonos, um ou mais solventes farmaceuticamente aceitáveis e um ou mais agentes tensoativos farmaceuticamente aceitáveis. A composição está em uma forma de uma formulação auto-emulsificante que fornece elevada concentração e elevada biodisponibilidade oral para compostos de piranona lipofílicos.
BRPI9810866-2A 1997-07-29 1998-07-27 composição farmacêutica em uma forma de formulação auto-emulsificante para compostos lipofìlicos. BR9810866B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5407897P 1997-07-29 1997-07-29
PCT/US1998/014816 WO1999006043A1 (en) 1997-07-29 1998-07-27 Self-emulsifying formulation for lipophilic compounds

Publications (2)

Publication Number Publication Date
BR9810866A true BR9810866A (pt) 2000-09-26
BR9810866B1 BR9810866B1 (pt) 2010-07-13

Family

ID=21988649

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9810866-2A BR9810866B1 (pt) 1997-07-29 1998-07-27 composição farmacêutica em uma forma de formulação auto-emulsificante para compostos lipofìlicos.

Country Status (23)

Country Link
US (2) US6121313A (pt)
EP (1) EP0999838B1 (pt)
JP (1) JP5005847B2 (pt)
KR (1) KR100509130B1 (pt)
CN (1) CN1113650C (pt)
AT (1) ATE215370T1 (pt)
AU (1) AU728695B2 (pt)
BR (1) BR9810866B1 (pt)
CA (1) CA2294032A1 (pt)
DE (1) DE69804624T2 (pt)
DK (1) DK0999838T3 (pt)
ES (1) ES2174462T3 (pt)
FI (1) FI20000171A (pt)
HK (1) HK1028877A1 (pt)
HU (1) HU225160B1 (pt)
NO (1) NO323773B1 (pt)
NZ (1) NZ502567A (pt)
PL (1) PL192080B1 (pt)
PT (1) PT999838E (pt)
RU (1) RU2203648C2 (pt)
SI (1) SI0999838T1 (pt)
SK (1) SK284579B6 (pt)
WO (1) WO1999006043A1 (pt)

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Also Published As

Publication number Publication date
DE69804624D1 (de) 2002-05-08
JP2002510329A (ja) 2002-04-02
PL192080B1 (pl) 2006-08-31
SK284579B6 (sk) 2005-07-01
US6531139B1 (en) 2003-03-11
HU225160B1 (en) 2006-07-28
SI0999838T1 (en) 2002-08-31
CN1261797A (zh) 2000-08-02
DE69804624T2 (de) 2002-09-19
NO20000465L (no) 2000-03-28
NO323773B1 (no) 2007-07-02
JP5005847B2 (ja) 2012-08-22
RU2203648C2 (ru) 2003-05-10
NO20000465D0 (no) 2000-01-28
PT999838E (pt) 2002-07-31
AU8573798A (en) 1999-02-22
CA2294032A1 (en) 1999-02-11
KR100509130B1 (ko) 2005-08-18
BR9810866B1 (pt) 2010-07-13
HK1028877A1 (en) 2001-03-09
US6121313A (en) 2000-09-19
PL338334A1 (en) 2000-10-23
AU728695B2 (en) 2001-01-18
CN1113650C (zh) 2003-07-09
FI20000171A (fi) 2000-01-28
DK0999838T3 (da) 2002-07-08
ES2174462T3 (es) 2002-11-01
EP0999838A1 (en) 2000-05-17
HUP0003292A1 (hu) 2002-01-28
HUP0003292A3 (en) 2002-02-28
KR20010022364A (ko) 2001-03-15
SK182000A3 (en) 2000-12-11
NZ502567A (en) 2002-03-28
ATE215370T1 (de) 2002-04-15
WO1999006043A1 (en) 1999-02-11
EP0999838B1 (en) 2002-04-03

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