BR9810729A - Composição farmacêutica para compostos lipofìlicos ácidos disposta como uma formulação auto-emulsionante - Google Patents
Composição farmacêutica para compostos lipofìlicos ácidos disposta como uma formulação auto-emulsionanteInfo
- Publication number
- BR9810729A BR9810729A BR9810729-1A BR9810729A BR9810729A BR 9810729 A BR9810729 A BR 9810729A BR 9810729 A BR9810729 A BR 9810729A BR 9810729 A BR9810729 A BR 9810729A
- Authority
- BR
- Brazil
- Prior art keywords
- self
- pharmaceutical composition
- emulsifying formulation
- composition
- pharmaceutically acceptable
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000002378 acidificating effect Effects 0.000 title 1
- 150000002634 lipophilic molecules Chemical class 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 2
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 abstract 1
- VOLMSPGWNYJHQQ-UHFFFAOYSA-N Pyranone Natural products CC1=C(O)C(=O)C(O)CO1 VOLMSPGWNYJHQQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 239000008180 pharmaceutical surfactant Substances 0.000 abstract 1
- -1 pyranone compound Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Cosmetics (AREA)
Abstract
<B>COMPOSIçãO FARMACêUTICA PARA COMPOSTOS LIPOFìLICOS áCIDOS DISPOSTA COMO UMA FORMULAçãO AUTO-EMULSIFICANTE A presente invenção provê uma nova composição farmacêutica com base no uso de uma quantidade específica de amina básica que compreende um composto piranona como um agente farmaceuticamente ativo, uma amina básica em uma quantidade de cerca de 0,1% a cerca de 10% em peso da composição total, um ou mais solventes farmaceuticamente aceitáveis e um ou mais tensoativos farmaceuticamente aceitáveis. Além disto, a composição pode compreender, ainda, um ou mais óleos farmaceuticamente aceitáveis. A composição está disposta como uma formulação auto-emulsificante que provê alta concentração e biodisponibilidade oral para compostos piranona lipofílicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5401297P | 1997-07-29 | 1997-07-29 | |
PCT/US1998/014817 WO1999006044A1 (en) | 1997-07-29 | 1998-07-27 | Pharmaceutical composition for acidic lipophilic compounds in a form of a self-emulsifying formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9810729A true BR9810729A (pt) | 2000-08-08 |
BR9810729B1 BR9810729B1 (pt) | 2010-07-13 |
Family
ID=21988155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9810729-1A BR9810729B1 (pt) | 1997-07-29 | 1998-07-27 | composição farmacêutica para compostos lipofìlicos ácidos disposta como uma formulação auto-emulsificante. |
Country Status (25)
Country | Link |
---|---|
US (1) | US6231887B1 (pt) |
EP (1) | EP0989851B1 (pt) |
JP (1) | JP4524367B2 (pt) |
KR (1) | KR100509131B1 (pt) |
CN (1) | CN1112927C (pt) |
AT (1) | ATE225174T1 (pt) |
AU (1) | AU728626B2 (pt) |
BR (1) | BR9810729B1 (pt) |
CA (1) | CA2294033C (pt) |
CY (1) | CY2006002I2 (pt) |
CZ (1) | CZ296957B6 (pt) |
DE (1) | DE69808463T2 (pt) |
DK (1) | DK0989851T3 (pt) |
ES (1) | ES2184310T3 (pt) |
FI (1) | FI20000172A (pt) |
HK (1) | HK1028879A1 (pt) |
HU (1) | HU228923B1 (pt) |
NO (1) | NO323425B1 (pt) |
NZ (1) | NZ502566A (pt) |
PL (1) | PL192865B1 (pt) |
PT (1) | PT989851E (pt) |
RU (1) | RU2202346C2 (pt) |
SI (1) | SI0989851T1 (pt) |
SK (1) | SK284616B6 (pt) |
WO (1) | WO1999006044A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6956048B2 (en) | 1999-03-31 | 2005-10-18 | Pharmacia & Upjohn Company | Pharmaceutical emulsions for retroviral protease inhibitors |
ES2234582T3 (es) * | 1999-03-31 | 2005-07-01 | PHARMACIA & UPJOHN COMPANY LLC | Emulsiones farmaceuticas para inhibidores de proteasas retrovirales. |
SE0000773D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
SE0000774D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
ATE381922T1 (de) | 2000-10-31 | 2008-01-15 | Boehringer Ingelheim Pharma | Perorale, selbst-emulgierende darreichungsformen von pyranon-proteaseinhibitoren |
SE0102993D0 (sv) * | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
US20030165545A1 (en) * | 2002-01-30 | 2003-09-04 | Allergan, Inc. | Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same |
JP2005523262A (ja) | 2002-02-01 | 2005-08-04 | ファイザー・プロダクツ・インク | 薬物及び親油性ミクロ相形成物質の非晶質分散物の医薬組成物 |
US6828301B2 (en) | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
US20040191332A1 (en) * | 2003-03-27 | 2004-09-30 | Allergan, Inc. | Preserved ophthalmic compositions |
NZ543250A (en) * | 2003-04-02 | 2008-12-24 | Boehringer Ingelheim Int | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
BRPI0413277A (pt) | 2003-08-04 | 2006-10-10 | Pfizer Prod Inc | composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas |
CA2541398C (en) * | 2003-10-07 | 2012-08-21 | Eli Lilly And Company | Liquid formulations of ractopamine |
CA2583195A1 (en) * | 2004-11-19 | 2006-05-26 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and reverset |
US20060122220A1 (en) * | 2004-11-19 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and UK-427,857 |
WO2006060159A1 (en) * | 2004-12-01 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and gw695634 |
JP5028885B2 (ja) * | 2006-07-04 | 2012-09-19 | 大正製薬株式会社 | ユビデカレノン含有自己乳化組成物 |
JP5448854B2 (ja) | 2007-03-12 | 2014-03-19 | ウェルズ ファーゴ バンク ナショナル アソシエイション | オリゴマー−プロテアーゼ阻害剤複合体 |
US9095620B2 (en) * | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
US20120108501A1 (en) | 2009-06-12 | 2012-05-03 | Nektar Therapeutics | Protease Inhibitors |
ES2464367T3 (es) * | 2009-07-07 | 2014-06-02 | Boehringer Ingelheim International Gmbh | Composición Farmacéutica para un Inhibidor de Proteasa del Virus de la Hepatitis C |
WO2011047259A1 (en) | 2009-10-16 | 2011-04-21 | Glaxosmithkline Llc | Compositions |
RU2419426C1 (ru) * | 2010-04-26 | 2011-05-27 | Всеволод Иванович Киселев | Лекарственное средство на основе дииндолилметана (dim) с повышенной биодоступностью и его использование в лечении гиперпластических и воспалительных заболеваний человека |
CN109745287A (zh) | 2010-05-03 | 2019-05-14 | 帝国制药美国公司 | 非水性紫杉烷前-乳剂制剂以及制备和使用该制剂的方法 |
JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
AU2014204739B2 (en) * | 2013-01-14 | 2016-08-11 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4230702A (en) | 1978-01-09 | 1980-10-28 | Kali-Chemie Pharma Gmbh | Readily enterally absorbable pharmaceutical compositions of per se poorly enterally absorbable pharmacologically active agents |
DE3300793A1 (de) * | 1983-01-12 | 1984-07-12 | Bayer Ag, 5090 Leverkusen | Coccidiosemittel |
GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5071643A (en) | 1986-10-17 | 1991-12-10 | R. P. Scherer Corporation | Solvent system enhancing the solubility of pharmaceuticals for encapsulation |
GB2222770B (en) | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
GB9113872D0 (en) | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
IL102236A0 (en) * | 1991-06-27 | 1993-01-14 | Ltt Inst Co Ltd | Topical preparations containing cyclosporin |
GB9208712D0 (en) * | 1992-04-22 | 1992-06-10 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporin derivates |
US5376688A (en) | 1992-12-18 | 1994-12-27 | R. P. Scherer Corporation | Enhanced solubility pharmaceutical solutions |
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
WO1996003113A1 (en) * | 1994-07-22 | 1996-02-08 | G.D. Searle & Co. | Self-emulsifying drug delivery system |
WO1996033697A1 (fr) * | 1995-04-24 | 1996-10-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Formulation auto-emulsionnable formant une emulsion huile dans l'eau |
NZ311646A (en) | 1995-06-06 | 2000-02-28 | Hoffmann La Roche | Pharmaceutical composition comprising a proteinase inhibitor and a monoglyceride |
ZA9710071B (en) * | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
-
1998
- 1998-07-27 BR BRPI9810729-1A patent/BR9810729B1/pt not_active IP Right Cessation
- 1998-07-27 PT PT98936888T patent/PT989851E/pt unknown
- 1998-07-27 JP JP51097399A patent/JP4524367B2/ja not_active Expired - Lifetime
- 1998-07-27 NZ NZ502566A patent/NZ502566A/en not_active IP Right Cessation
- 1998-07-27 RU RU2000104861/14A patent/RU2202346C2/ru active
- 1998-07-27 AU AU85738/98A patent/AU728626B2/en not_active Expired
- 1998-07-27 CN CN98806771A patent/CN1112927C/zh not_active Expired - Lifetime
- 1998-07-27 EP EP98936888A patent/EP0989851B1/en not_active Expired - Lifetime
- 1998-07-27 CZ CZ20000156A patent/CZ296957B6/cs not_active IP Right Cessation
- 1998-07-27 HU HU0002440A patent/HU228923B1/hu unknown
- 1998-07-27 KR KR10-2000-7000948A patent/KR100509131B1/ko not_active IP Right Cessation
- 1998-07-27 CA CA002294033A patent/CA2294033C/en not_active Expired - Lifetime
- 1998-07-27 DK DK98936888T patent/DK0989851T3/da active
- 1998-07-27 AT AT98936888T patent/ATE225174T1/de active
- 1998-07-27 US US09/122,927 patent/US6231887B1/en not_active Expired - Lifetime
- 1998-07-27 SK SK16-2000A patent/SK284616B6/sk not_active IP Right Cessation
- 1998-07-27 DE DE69808463T patent/DE69808463T2/de not_active Expired - Lifetime
- 1998-07-27 PL PL338335A patent/PL192865B1/pl unknown
- 1998-07-27 SI SI9830303T patent/SI0989851T1/xx unknown
- 1998-07-27 WO PCT/US1998/014817 patent/WO1999006044A1/en active IP Right Grant
- 1998-07-27 ES ES98936888T patent/ES2184310T3/es not_active Expired - Lifetime
-
2000
- 2000-01-28 FI FI20000172A patent/FI20000172A/fi unknown
- 2000-01-28 NO NO20000466A patent/NO323425B1/no not_active IP Right Cessation
- 2000-12-21 HK HK00108284A patent/HK1028879A1/xx not_active IP Right Cessation
-
2006
- 2006-02-28 CY CY2006002C patent/CY2006002I2/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/07/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
B25D | Requested change of name of applicant approved |
Owner name: PHARMACIA AND UPJOHN COMPANY LLC (US) Free format text: NOME ALTERADO DE: PHARMACIA AND UPJOHN COMPANY |
|
B25G | Requested change of headquarter approved |
Owner name: PHARMACIA AND UPJOHN COMPANY LLC (US) Free format text: ENDERECO ALTERADO CONFORME SOLICITADO NA PETICAO NO 020120005559/RJ DE 23/01/2012. |
|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 13.07.2020 |