JP4190586B2 - 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 - Google Patents
抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 Download PDFInfo
- Publication number
- JP4190586B2 JP4190586B2 JP51087698A JP51087698A JP4190586B2 JP 4190586 B2 JP4190586 B2 JP 4190586B2 JP 51087698 A JP51087698 A JP 51087698A JP 51087698 A JP51087698 A JP 51087698A JP 4190586 B2 JP4190586 B2 JP 4190586B2
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- phosphate
- dental composition
- gel
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000499 gel Substances 0.000 title claims abstract description 62
- 239000000606 toothpaste Substances 0.000 title claims abstract description 47
- 239000000551 dentifrice Substances 0.000 title claims abstract description 43
- 229940034610 toothpaste Drugs 0.000 title claims description 34
- 235000009508 confectionery Nutrition 0.000 title abstract description 91
- 235000015218 chewing gum Nutrition 0.000 title abstract description 37
- 230000000675 anti-caries Effects 0.000 title abstract 2
- 229940112822 chewing gum Drugs 0.000 title description 28
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 82
- 239000011575 calcium Substances 0.000 claims abstract description 65
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 53
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 53
- 239000000203 mixture Substances 0.000 claims abstract description 51
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 12
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 52
- 229940043430 calcium compound Drugs 0.000 claims description 50
- 239000010452 phosphate Substances 0.000 claims description 50
- 150000001674 calcium compounds Chemical class 0.000 claims description 49
- 150000001875 compounds Chemical class 0.000 claims description 28
- 210000003296 saliva Anatomy 0.000 claims description 27
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 25
- 229910001424 calcium ion Inorganic materials 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 19
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 18
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 18
- 230000007935 neutral effect Effects 0.000 claims description 18
- 159000000007 calcium salts Chemical class 0.000 claims description 14
- 239000011734 sodium Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Chemical class OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 9
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 9
- 239000011737 fluorine Substances 0.000 claims description 9
- 229910052731 fluorine Inorganic materials 0.000 claims description 9
- 239000001530 fumaric acid Chemical class 0.000 claims description 9
- 235000011087 fumaric acid Nutrition 0.000 claims description 9
- 239000000174 gluconic acid Chemical class 0.000 claims description 9
- 235000012208 gluconic acid Nutrition 0.000 claims description 9
- 239000004310 lactic acid Chemical class 0.000 claims description 9
- 235000014655 lactic acid Nutrition 0.000 claims description 9
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical class OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 9
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Chemical class OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 9
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 8
- 239000013078 crystal Substances 0.000 claims description 7
- 239000003966 growth inhibitor Substances 0.000 claims description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 3
- 235000010980 cellulose Nutrition 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 238000013268 sustained release Methods 0.000 claims description 3
- 239000012730 sustained-release form Substances 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 2
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229910004261 CaF 2 Inorganic materials 0.000 claims 1
- 229910008449 SnF 2 Inorganic materials 0.000 claims 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract description 76
- 239000001506 calcium phosphate Substances 0.000 abstract description 56
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract description 48
- 235000011010 calcium phosphates Nutrition 0.000 abstract description 48
- 208000002925 dental caries Diseases 0.000 abstract description 29
- 239000000654 additive Substances 0.000 abstract description 22
- 238000009472 formulation Methods 0.000 abstract description 13
- 239000003795 chemical substances by application Substances 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 9
- 210000000214 mouth Anatomy 0.000 abstract description 9
- 229930006000 Sucrose Natural products 0.000 abstract description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 7
- 230000003902 lesion Effects 0.000 abstract description 7
- 239000005720 sucrose Substances 0.000 abstract description 7
- 210000004268 dentin Anatomy 0.000 abstract description 6
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract description 4
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 3
- 210000003298 dental enamel Anatomy 0.000 abstract description 3
- 210000005239 tubule Anatomy 0.000 abstract description 3
- 230000008439 repair process Effects 0.000 abstract description 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 230000001013 cariogenic effect Effects 0.000 abstract 1
- 229920000591 gum Polymers 0.000 description 62
- 229960005069 calcium Drugs 0.000 description 49
- 235000021317 phosphate Nutrition 0.000 description 43
- 229910052500 inorganic mineral Inorganic materials 0.000 description 32
- 235000010755 mineral Nutrition 0.000 description 32
- 239000011707 mineral Substances 0.000 description 32
- 230000002378 acidificating effect Effects 0.000 description 18
- ZBZJARSYCHAEND-UHFFFAOYSA-L calcium;dihydrogen phosphate;hydrate Chemical compound O.[Ca+2].OP(O)([O-])=O.OP(O)([O-])=O ZBZJARSYCHAEND-UHFFFAOYSA-L 0.000 description 16
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 14
- 230000000694 effects Effects 0.000 description 12
- -1 calcium phosphate compound Chemical class 0.000 description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 9
- 230000000996 additive effect Effects 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 7
- 230000001055 chewing effect Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000003449 preventive effect Effects 0.000 description 7
- LFULEKSKNZEWOE-UHFFFAOYSA-N propanil Chemical compound CCC(=O)NC1=CC=C(Cl)C(Cl)=C1 LFULEKSKNZEWOE-UHFFFAOYSA-N 0.000 description 7
- 230000009469 supplementation Effects 0.000 description 7
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 235000003599 food sweetener Nutrition 0.000 description 6
- 239000003349 gelling agent Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
- 239000003765 sweetening agent Substances 0.000 description 6
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 5
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 5
- 229940095618 calcium glycerophosphate Drugs 0.000 description 5
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 5
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 5
- 238000000151 deposition Methods 0.000 description 5
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium phosphate dihydrate Substances O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 5
- 239000006072 paste Substances 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 4
- 101000801619 Homo sapiens Long-chain-fatty-acid-CoA ligase ACSBG1 Proteins 0.000 description 4
- 102100033564 Long-chain-fatty-acid-CoA ligase ACSBG1 Human genes 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 235000010634 bubble gum Nutrition 0.000 description 4
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 4
- 239000001639 calcium acetate Substances 0.000 description 4
- 235000011092 calcium acetate Nutrition 0.000 description 4
- 229960005147 calcium acetate Drugs 0.000 description 4
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 4
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 4
- 229940038472 dicalcium phosphate Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 238000005755 formation reaction Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 235000019691 monocalcium phosphate Nutrition 0.000 description 4
- 229910000150 monocalcium phosphate Inorganic materials 0.000 description 4
- 229940085991 phosphate ion Drugs 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 244000246386 Mentha pulegium Species 0.000 description 3
- 235000016257 Mentha pulegium Nutrition 0.000 description 3
- 235000004357 Mentha x piperita Nutrition 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 235000010216 calcium carbonate Nutrition 0.000 description 3
- 239000004227 calcium gluconate Substances 0.000 description 3
- 235000013927 calcium gluconate Nutrition 0.000 description 3
- 229960004494 calcium gluconate Drugs 0.000 description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229940091249 fluoride supplement Drugs 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000001050 hortel pimenta Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229940029985 mineral supplement Drugs 0.000 description 3
- 235000020786 mineral supplement Nutrition 0.000 description 3
- 229910000392 octacalcium phosphate Inorganic materials 0.000 description 3
- 239000011775 sodium fluoride Substances 0.000 description 3
- 235000013024 sodium fluoride Nutrition 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- 235000011008 sodium phosphates Nutrition 0.000 description 3
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- 244000215068 Acacia senegal Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 2
- 229910001634 calcium fluoride Inorganic materials 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- 235000006491 Acacia senegal Nutrition 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229910004883 Na2SiF6 Inorganic materials 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 230000000170 anti-cariogenic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 229940041131 calcium lactate gluconate Drugs 0.000 description 1
- 235000011035 calcium tartrate Nutrition 0.000 description 1
- 239000001427 calcium tartrate Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000037123 dental health Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- XVNVFKZODWAQKN-UHFFFAOYSA-N phosphoric acid;heptahydrate Chemical group O.O.O.O.O.O.O.OP(O)(O)=O XVNVFKZODWAQKN-UHFFFAOYSA-N 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 235000015260 sugar-free gum Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/362—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Cosmetics (AREA)
- Confectionery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/704,420 US5833954A (en) | 1996-08-20 | 1996-08-20 | Anti-carious chewing gums, candies, gels, toothpastes and dentifrices |
| US08/704,420 | 1996-08-20 | ||
| PCT/US1997/014519 WO1998007448A1 (en) | 1996-08-20 | 1997-08-19 | Anti-carious chewing gums, candies, gels, toothpastes and dentifrices |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006334369A Division JP2007145847A (ja) | 1996-08-20 | 2006-12-12 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002500504A JP2002500504A (ja) | 2002-01-08 |
| JP2002500504A5 JP2002500504A5 (OSRAM) | 2005-05-12 |
| JP4190586B2 true JP4190586B2 (ja) | 2008-12-03 |
Family
ID=24829402
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51087698A Expired - Lifetime JP4190586B2 (ja) | 1996-08-20 | 1997-08-19 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
| JP2006334369A Pending JP2007145847A (ja) | 1996-08-20 | 2006-12-12 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
| JP2009215669A Expired - Lifetime JP5121800B2 (ja) | 1996-08-20 | 2009-09-17 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006334369A Pending JP2007145847A (ja) | 1996-08-20 | 2006-12-12 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
| JP2009215669A Expired - Lifetime JP5121800B2 (ja) | 1996-08-20 | 2009-09-17 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5833954A (OSRAM) |
| EP (1) | EP0952851B1 (OSRAM) |
| JP (3) | JP4190586B2 (OSRAM) |
| CN (1) | CN1137728C (OSRAM) |
| AT (1) | ATE507843T1 (OSRAM) |
| AU (1) | AU735193B2 (OSRAM) |
| BR (1) | BR9711339A (OSRAM) |
| DE (1) | DE69740186D1 (OSRAM) |
| WO (1) | WO1998007448A1 (OSRAM) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8648529B2 (en) | 2009-10-29 | 2014-02-11 | Lintec Corporation | Light-emitting composition, electroluminescent sheet, and method for producing same |
| US8723410B2 (en) | 2008-05-22 | 2014-05-13 | Lintec Corporation | Luminescent composition, electroluminescent sheet using the luminescent composition, and process for producing the electroluminescent sheet |
| US8764505B2 (en) | 2008-05-22 | 2014-07-01 | Lintec Corporation | Process for producing an inorganic electroluminescent sheet |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6036944A (en) * | 1995-08-08 | 2000-03-14 | Enamelon, Inc. | Processes for the remineralization and mineralization of teeth |
| US6491900B2 (en) * | 1996-08-20 | 2002-12-10 | American Dental Association Health Foundation | Anti-carious candies and confections |
| WO1998013013A1 (en) * | 1996-09-27 | 1998-04-02 | Enamelon, Inc. | Improved products and methods for the remineralization and prevention of demineralization of teeth |
| US6673380B2 (en) | 1998-11-17 | 2004-01-06 | Mcneil-Ppc, Inc. | Fortified confectionery delivery systems and methods of preparation thereof |
| AUPP494798A0 (en) * | 1998-07-29 | 1998-08-20 | Pacific Biolink Pty Limited | Protective protein formulation |
| US6582731B1 (en) * | 1998-11-25 | 2003-06-24 | Konrad Kaufmann | Hard candy with plaque-neutralizing effect comprising alkali metal monophosphate |
| AU2626700A (en) * | 1999-01-26 | 2000-08-07 | Wm. Wrigley Jr. Company | Chewing gum with dental health benefits employing calcium lactate |
| AU2004201045B2 (en) * | 1999-01-26 | 2005-12-15 | Wm. Wrigley Jr. Company | Chewing Gum with Dental Health Benefits Employing Calcium Lactate |
| WO2000062762A1 (en) * | 1999-04-15 | 2000-10-26 | Wm. Wrigley Jr. Company | Chewing gum with dental benefits including calcium in a food grade acid |
| US6440394B2 (en) * | 1999-06-01 | 2002-08-27 | Church & Dwight, Co., Inc. | Remineralizing-mineralizing oral products containing discrete cationic and anionic agglomerate components and method of use |
| US6482395B1 (en) * | 1999-06-01 | 2002-11-19 | Church & Dwight Co. Inc. | Remineralizing-mineralizing oral products containing discrete cationic and anionic agglomerate components and method of use |
| JP4109797B2 (ja) * | 1999-06-07 | 2008-07-02 | 株式会社ロッテ | チューインガム |
| US6926916B1 (en) * | 1999-11-12 | 2005-08-09 | The Procter & Gamble Company | Chewing gum compositions |
| WO2001039606A1 (en) * | 1999-11-12 | 2001-06-07 | The Procter & Gamble Company | Chewing gum compositions |
| US6447754B1 (en) | 2000-01-24 | 2002-09-10 | Akpharma Inc. | Oral rinse methods and compositions |
| AU3478001A (en) * | 2000-02-04 | 2001-08-14 | Procter & Gamble Company, The | Chewing gum compositions |
| WO2001065189A1 (fr) * | 2000-02-28 | 2001-09-07 | Promotionbobsleigh S.A.R.L. | Segment de piste de glisse |
| WO2002019833A2 (en) * | 2000-09-07 | 2002-03-14 | Akpharma Inc. | Edible candy compositions and methods of using the same |
| US6526993B1 (en) * | 2000-09-12 | 2003-03-04 | Eugene C. Wagner | Dental implement with comfit grip |
| US6372198B1 (en) | 2000-09-14 | 2002-04-16 | Joseph M. Abbate | Dentifrice for the mineralization and remineralization of teeth |
| US6607387B2 (en) | 2000-10-30 | 2003-08-19 | Healthetech, Inc. | Sensor system for diagnosing dental conditions |
| US20020099037A1 (en) * | 2001-01-19 | 2002-07-25 | Akpharma, Inc. | Method for alleviating syndromes and conditions of discomfort of the mammalian intestinal and genito-urinary tracts |
| CA2442771C (en) * | 2001-05-15 | 2007-11-06 | The Procter & Gamble Company | Confectionery compositions |
| US20060076295A1 (en) | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| US20040225249A1 (en) | 2003-03-14 | 2004-11-11 | Leonard Edward F. | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| CN1856258A (zh) * | 2003-09-26 | 2006-11-01 | 罗迪亚公司 | 钙类膳食补充剂 |
| US7309232B2 (en) | 2003-10-10 | 2007-12-18 | Dentigenix Inc. | Methods for treating dental conditions using tissue scaffolds |
| DE10349050A1 (de) * | 2003-10-17 | 2005-05-12 | Nova Dentalia Zahnpflege Gmbh | Kaumasse zur Remineralisation von Zahnschmelz |
| CA2587275A1 (en) | 2004-11-16 | 2006-05-26 | 3M Innovative Properties Company | Dental fillers and compositions including phosphate salts |
| CA2587278A1 (en) | 2004-11-16 | 2006-05-26 | 3M Innovative Properties Company | Dental fillers, methods, compositions including a caseinate |
| US20080050408A1 (en) * | 2004-11-26 | 2008-02-28 | Discus Dental, Llc | Dental Whitening Compositions |
| US20060115437A1 (en) * | 2004-11-26 | 2006-06-01 | Robert Hayman | Dental whitening compositions |
| US20060134020A1 (en) * | 2004-12-21 | 2006-06-22 | Robinson Richard S | Anti-caries oral care composition with a chelating agent |
| US8858920B2 (en) * | 2004-12-21 | 2014-10-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| US20060292090A1 (en) * | 2005-06-22 | 2006-12-28 | Deepak Sharma | Oral care compositions, devices, and methods of using the same |
| RU2404737C2 (ru) * | 2005-12-21 | 2010-11-27 | Колгейт-Палмолив Компани | Чистящие и/или полирующие составы и методы их применения |
| CZ301206B6 (cs) * | 2006-01-19 | 2009-12-09 | Ceská hlava s.r.o. | Prípravek pro prevenci a lécbu iniciálního zubního kazu |
| WO2007089894A2 (en) * | 2006-01-31 | 2007-08-09 | Indiana University Research & Technology Corporation | Materials and methods for manufacturing amorphous tricalcium phosphate and metal oxide alloys of amorphous tricalcium phosphate and methods of using the same |
| US10130561B2 (en) * | 2006-01-31 | 2018-11-20 | Robert L. Karlinsey | Functionalized calcium phosphate hybrid systems for confectionery and foodstuff applications |
| WO2007092763A2 (en) * | 2006-02-03 | 2007-08-16 | Wm. Wrigley Jr. Company | Calcium phosphate salts in oral compositions suitable as a tooth remineralizing agent |
| US8518383B2 (en) * | 2006-02-03 | 2013-08-27 | Wm. Wrigley Jr. Company | Oral care products comprising buffer systems for improved mineralization/remineralization benefits |
| DE102006009799A1 (de) * | 2006-03-01 | 2007-09-06 | Henkel Kgaa | Vorwiegend plättchenförmige schwer wasserlösliche Calciumsalze und/oder deren Kompositmaterialien, umfassend diese |
| US10092488B1 (en) | 2006-03-30 | 2018-10-09 | Janet M. Wehrli | System and method for reducing plaque on teeth |
| US9833386B2 (en) | 2006-03-30 | 2017-12-05 | James D. Welch | Method of, and system for smoothing teeth |
| US9498414B1 (en) | 2006-03-30 | 2016-11-22 | Janet M. Wehrli | System and method for reducing plaque on teeth |
| AU2011202746B2 (en) * | 2006-04-05 | 2011-10-13 | Intercontinental Great Brands Llc | Calcium phosphate complex and salts in oral delivery systems |
| WO2007117627A2 (en) * | 2006-04-05 | 2007-10-18 | Cadbury Adams Usa Llc | Calcium phosphate complex and salts in oral delivery systems |
| US20070237856A1 (en) * | 2006-04-05 | 2007-10-11 | Cadbury Adams Usa, Llc. | Impact of calcium phosphate complex on dental caries |
| EP2026745A4 (en) * | 2006-04-05 | 2013-11-20 | Kraft Foods Global Brands Llc | CALCIUM PHOSPHATE COMPLEX IN CONFECTIONERY CONTAINING ACID |
| AU2007253702A1 (en) | 2006-05-22 | 2007-11-29 | The Trustees Of Columbia University In The City Of New York | Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams |
| JP2009538602A (ja) * | 2006-05-26 | 2009-11-12 | キャドバリー アダムス ユーエスエー エルエルシー | 反応性成分を含有する菓子組成物 |
| US9682256B2 (en) * | 2006-07-14 | 2017-06-20 | Colgate-Palmolive Company | Methods of making compositions comprising films |
| WO2008011126A2 (en) | 2006-07-21 | 2008-01-24 | Lyne Laboratories | Liquid compositions of calcium acetate |
| WO2008068149A1 (en) | 2006-12-05 | 2008-06-12 | Unilever Plc | Oral care product |
| US9023373B2 (en) | 2007-01-31 | 2015-05-05 | Indiana Nanotech | Functionalized calcium phosphate hybrid systems for the remineralization of teeth and a method for producing the same |
| EP2120842B1 (en) * | 2007-02-06 | 2019-08-21 | Indiana Nanotech Division of Therametric Technologies, INC. | Hybrid organic/inorganic chemical hybrid systems, including functionalized calcium phosphate hybrid systems, and a solid-state method of producing the same |
| US9320692B2 (en) | 2007-05-24 | 2016-04-26 | Ada Foundation | Tooth fluoridating and remineralizing compositions and methods, based on nanoaggregate formation |
| JP4755145B2 (ja) * | 2007-06-25 | 2011-08-24 | 花王株式会社 | 口腔用剤 |
| BRPI0907473A2 (pt) | 2008-02-04 | 2019-09-24 | Univ Columbia | métodos, sistemas e dispositivos de separação de fluidos |
| RU2480198C2 (ru) * | 2008-02-15 | 2013-04-27 | Вм. Ригли Дж. Компани | Жевательная резинка (варианты) и способ выделения гидрофильных добавок из композиции жевательной резинки |
| US8568696B2 (en) * | 2008-08-06 | 2013-10-29 | Indiana Nanotech Llc | Grinding method for the manipulation or preservation of calcium phosphate hybrid properties |
| US8603441B2 (en) * | 2008-09-12 | 2013-12-10 | Indiana Nanotech Llc | Functionalized calcium phosphate hybrid systems for confectionery and foodstuff applications |
| GB0817369D0 (en) * | 2008-09-23 | 2008-10-29 | Cadbury Uk Ltd | Confectionery and methods of production thereof |
| WO2010068359A1 (en) | 2008-12-11 | 2010-06-17 | 3M Innovative Properties Company | Surface-treated calcium phosphate particles suitable for oral care and dental compositions |
| JP5501346B2 (ja) * | 2009-03-30 | 2014-05-21 | クラレノリタケデンタル株式会社 | 歯牙石灰化剤の製造方法 |
| WO2010113800A1 (ja) * | 2009-03-30 | 2010-10-07 | クラレメディカル株式会社 | 象牙質石灰化剤及びその製造方法 |
| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
| RU2403007C1 (ru) * | 2009-10-22 | 2010-11-10 | Государственное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации" | Гель для реминерализации эмали зубов |
| AR079639A1 (es) * | 2009-12-17 | 2012-02-08 | Colgate Palmolive Co | Composicion de pasta de dientes anti-erosiva |
| GB201004900D0 (en) * | 2010-03-23 | 2010-05-05 | Cadbury Uk Ltd | Confectionery product and methods of production thereof |
| US8715625B1 (en) | 2010-05-10 | 2014-05-06 | The Clorox Company | Natural oral care compositions |
| US9901755B2 (en) | 2011-09-23 | 2018-02-27 | Sancastle Worldwide Corporation | Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same |
| US20140242005A1 (en) * | 2011-10-05 | 2014-08-28 | Multi Oral Bv | Method For Oral Care |
| WO2014124950A1 (en) | 2013-02-14 | 2014-08-21 | Glaxo Group Limited | Novel composition |
| CN105377218B (zh) | 2013-07-19 | 2019-06-11 | 荷兰联合利华有限公司 | 再矿化口腔护理产品 |
| CN105722844B (zh) * | 2013-11-22 | 2020-04-17 | 宝洁公司 | 用于控制或减轻牙质超敏的方案 |
| ITMI20132003A1 (it) * | 2013-11-29 | 2015-05-30 | Perfetti Van Melle Spa | Prodotti di confetteria con calcio fosfato |
| CN107743386A (zh) | 2015-06-05 | 2018-02-27 | 荷兰联合利华有限公司 | 口腔护理装置 |
| CN107995865A (zh) * | 2015-06-26 | 2018-05-04 | 影像研发有限责任公司 | 用于预防微生物生长的组合物 |
| US11103732B1 (en) | 2015-10-17 | 2021-08-31 | James D. Welch | Method of improving the condition of teeth |
| US10342646B2 (en) | 2015-10-17 | 2019-07-09 | James D. Welch | Method of, and system for smoothing teeth |
| US10383807B2 (en) | 2016-05-20 | 2019-08-20 | The Procter & Gamble Company | Regimen for providing smooth tooth feel |
| CN109640928B (zh) * | 2016-08-19 | 2022-02-11 | 联合利华知识产权控股有限公司 | 口腔护理组合物 |
| EA038664B1 (ru) * | 2016-09-23 | 2021-09-30 | ЮНИЛЕВЕР АйПи ХОЛДИНГС Б.В. | Композиция для ухода за полостью рта |
| RU2677231C1 (ru) * | 2017-10-10 | 2019-01-16 | Федеральное государственное бюджетное учреждение науки Институт химии твердого тела Уральского отделения Российской академии наук | Стоматологический гель для реминерализации твердых тканей зубов и способ реминерализации твердых тканей зубов |
| US11617711B2 (en) | 2018-08-30 | 2023-04-04 | University Of Washington | Compositions and methods for dental care |
| EP3984517A1 (en) * | 2020-10-19 | 2022-04-20 | Credentis AG | Accelerating tooth remineralisation and bone regeneration with self-assembling peptides and amorphous calcium phosphate |
| CN113100323A (zh) * | 2021-04-07 | 2021-07-13 | 佛山市安齿生物科技有限公司 | 一种可变色、护齿的口香糖及其制备方法 |
| CN116023679B (zh) * | 2022-12-01 | 2024-04-23 | 中山大学附属口腔医院 | 一种温敏性缓释钙磷抗菌纳米水凝胶及其制备方法与应用 |
| WO2025259826A1 (en) * | 2024-06-14 | 2025-12-18 | Wm. Wrigley Jr. Company | Chewing gum rolling compounds |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1492247A1 (de) * | 1964-03-20 | 1969-11-06 | Warner Lambert Pharmaceutical | Verfahren zum Wiederverhaerten von Zahnschmelz und dafuer geeignetes Zahnpflegemittel |
| GR36380B (el) * | 1966-12-09 | 1969-02-05 | Colgate - Palmolive Company | Αρωματικη οδοντοπαστα. |
| US3655866A (en) * | 1970-01-26 | 1972-04-11 | Warner Lambert Co | Sugarless gum containing dicalcium phosphate dihydrate |
| GB1408922A (en) * | 1972-02-02 | 1975-10-08 | Blendax Werke Schneider Co | Process and composition for the remineralisation and prevention of demineralisation of human teeth |
| US4472437A (en) * | 1983-03-01 | 1984-09-18 | Warner-Lambert Company | Dicalcium phosphate as gum base filler |
| US4765984A (en) * | 1986-01-22 | 1988-08-23 | Colgate-Palmolive Company | Stable single unit dose oral product |
| JPH0825860B2 (ja) * | 1987-05-14 | 1996-03-13 | サンスタ−株式会社 | う蝕予防ガム |
| US5460803A (en) * | 1989-05-24 | 1995-10-24 | American Dental Association Health Foundation | Methods and compositions for mineralizing and fluoridating calcified tissues |
| US5037639A (en) * | 1989-05-24 | 1991-08-06 | American Dental Association Health Foundation | Methods and compositions for mineralizing calcified tissues |
| AU660691B2 (en) | 1991-09-13 | 1995-07-06 | Colgate-Palmolive Company, The | Abrasive tooth whitening dentifrice of improved stability |
| JP2979446B2 (ja) * | 1991-11-06 | 1999-11-15 | ライオン株式会社 | 口腔用組成物 |
| DE4221054A1 (de) * | 1992-06-30 | 1994-01-05 | Herbst Bremer Goldschlaegerei | Präparat zur prophylaktischen und therapeutischen Behandlung von Karies sowie Verfahren zum Herstellen desselben |
| US5378131A (en) * | 1993-02-18 | 1995-01-03 | The Wm. Wrigley Jr. Company | Chewing gum with dental health benefits employing calcium glycerophosphate |
| US5427768A (en) * | 1993-06-23 | 1995-06-27 | American Dental Association Health Foundation | Carbonated solutions for treating, mineralizing and fluoridating calcified tissues and methods for their use |
| JPH07223930A (ja) * | 1994-02-10 | 1995-08-22 | Sumitomo Osaka Cement Co Ltd | 歯磨組成物 |
| US5500206A (en) * | 1994-04-29 | 1996-03-19 | The Procter & Gamble Company | Oral compositions comprising actinomyces viscosus fimbriae |
| US5605675A (en) * | 1995-06-06 | 1997-02-25 | Enamelon Inc. | Processes and compositions for remineralization and prevention of demineralization of dental enamel |
| US5603922A (en) * | 1995-08-08 | 1997-02-18 | Enamelon Inc. | Processes and compositions for the remineralization of teeth |
| US5571502A (en) * | 1995-08-08 | 1996-11-05 | Enamelon Research | Stable single-part compositions and the use thereof for remineralization of lesions in teeth |
| US5645853A (en) * | 1995-08-08 | 1997-07-08 | Enamelon Inc. | Chewing gum compositions and the use thereof for remineralization of lesions in teeth |
| JPH09122658A (ja) * | 1995-10-30 | 1997-05-13 | Tateho Chem Ind Co Ltd | ミネラル添加剤及びその製造方法 |
-
1996
- 1996-08-20 US US08/704,420 patent/US5833954A/en not_active Expired - Lifetime
-
1997
- 1997-08-19 BR BR9711339-5A patent/BR9711339A/pt not_active IP Right Cessation
- 1997-08-19 JP JP51087698A patent/JP4190586B2/ja not_active Expired - Lifetime
- 1997-08-19 AU AU40730/97A patent/AU735193B2/en not_active Expired
- 1997-08-19 AT AT97938396T patent/ATE507843T1/de not_active IP Right Cessation
- 1997-08-19 EP EP97938396A patent/EP0952851B1/en not_active Expired - Lifetime
- 1997-08-19 WO PCT/US1997/014519 patent/WO1998007448A1/en not_active Ceased
- 1997-08-19 DE DE69740186T patent/DE69740186D1/de not_active Expired - Lifetime
- 1997-08-19 CN CNB971988986A patent/CN1137728C/zh not_active Expired - Lifetime
-
1998
- 1998-06-02 US US09/088,869 patent/US5993786A/en not_active Expired - Lifetime
-
2006
- 2006-12-12 JP JP2006334369A patent/JP2007145847A/ja active Pending
-
2009
- 2009-09-17 JP JP2009215669A patent/JP5121800B2/ja not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8723410B2 (en) | 2008-05-22 | 2014-05-13 | Lintec Corporation | Luminescent composition, electroluminescent sheet using the luminescent composition, and process for producing the electroluminescent sheet |
| US8764505B2 (en) | 2008-05-22 | 2014-07-01 | Lintec Corporation | Process for producing an inorganic electroluminescent sheet |
| US8648529B2 (en) | 2009-10-29 | 2014-02-11 | Lintec Corporation | Light-emitting composition, electroluminescent sheet, and method for producing same |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE507843T1 (de) | 2011-05-15 |
| EP0952851B1 (en) | 2011-05-04 |
| US5993786A (en) | 1999-11-30 |
| WO1998007448A1 (en) | 1998-02-26 |
| BR9711339A (pt) | 2000-10-24 |
| EP0952851A1 (en) | 1999-11-03 |
| JP5121800B2 (ja) | 2013-01-16 |
| CN1137728C (zh) | 2004-02-11 |
| JP2002500504A (ja) | 2002-01-08 |
| JP2007145847A (ja) | 2007-06-14 |
| US5833954A (en) | 1998-11-10 |
| AU4073097A (en) | 1998-03-06 |
| DE69740186D1 (de) | 2011-06-16 |
| AU735193B2 (en) | 2001-07-05 |
| CN1233964A (zh) | 1999-11-03 |
| EP0952851A4 (en) | 2002-11-13 |
| JP2010047575A (ja) | 2010-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4190586B2 (ja) | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 | |
| CA2228091C (en) | Preparation used in dental care | |
| US6491900B2 (en) | Anti-carious candies and confections | |
| JP3895388B2 (ja) | 過飽和溶液中のカルシウムおよびリン酸イオンからなるうがい薬 | |
| JP3528181B2 (ja) | 歯の病変部の再石灰用の改善された製品および方法 | |
| WO2009158564A1 (en) | Composition and method for enhancing flouride uptake using bioactive glass | |
| US20150209249A1 (en) | Enhanced Anti-Carious Dentifrices, Rinses, Lozenges, Candies and Chewing Gums and Methods of Using Same | |
| JPH09143043A (ja) | 歯石軟化・溶解用組成物 | |
| JPH07108851B2 (ja) | 固形のむしば予防用口内組成物 | |
| JP2000154127A (ja) | 口腔用組成物 | |
| US20060088480A1 (en) | Oral composition for stabilization, (re)calcification and (re)mineralization of tooth enamel and dentine | |
| JPH09295924A (ja) | 歯垢の酸中和剤及び口腔用組成物 | |
| JPH1017447A (ja) | 抗歯石剤及び口腔用組成物 | |
| Soni et al. | Remineralizing agents in paediatric dentistry | |
| Kaur et al. | Neoteric Non-Fluoride Enamel Remineralization Systems: A Review | |
| MXPA99001686A (en) | Anti-carious chewing gums, candies, gels, toothpastes and dentifrices | |
| JP2008507480A (ja) | 唾液中における浸食可能性のない酸性固形口腔用組成物および唾液中の浸食可能性を測定する方法 | |
| JP2960176B2 (ja) | 口腔用組成物 | |
| Naji | Materials Used in Remineralization of Initial Caries | |
| WO2014124950A1 (en) | Novel composition | |
| EP2956112B1 (en) | Dental composition | |
| Uppala | A review of the literature on non-fluoridated remineralizing agents for dental caries | |
| HK1114574B (en) | Acidic solid oral compositions without erosive potential in saliva and method for determining erosive potential in saliva | |
| JPH11171749A (ja) | 口腔用組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A72 | Notification of change in name of applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A721 Effective date: 20040708 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040720 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040720 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060613 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20060906 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20061023 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20061213 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070320 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070619 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070806 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070920 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080826 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080917 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110926 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110926 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120926 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130926 Year of fee payment: 5 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |