CN1856258A - 钙类膳食补充剂 - Google Patents
钙类膳食补充剂 Download PDFInfo
- Publication number
- CN1856258A CN1856258A CNA2004800278948A CN200480027894A CN1856258A CN 1856258 A CN1856258 A CN 1856258A CN A2004800278948 A CNA2004800278948 A CN A2004800278948A CN 200480027894 A CN200480027894 A CN 200480027894A CN 1856258 A CN1856258 A CN 1856258A
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- China
- Prior art keywords
- dietary supplements
- calcium
- weight
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- supplements according
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- 239000011575 calcium Substances 0.000 title claims abstract description 35
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 35
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 claims abstract description 23
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 19
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- 239000002552 dosage form Substances 0.000 claims abstract description 3
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- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 14
- 239000011574 phosphorus Substances 0.000 claims description 14
- 229910052698 phosphorus Inorganic materials 0.000 claims description 14
- 239000001506 calcium phosphate Substances 0.000 claims description 8
- 239000000796 flavoring agent Substances 0.000 claims description 7
- 235000019634 flavors Nutrition 0.000 claims description 7
- 235000013736 caramel Nutrition 0.000 claims description 5
- 238000010411 cooking Methods 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
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- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 4
- 125000003147 glycosyl group Chemical group 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 4
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 2
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- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/362—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
本发明提供一种可咀嚼剂型钙类膳食补充剂，并且该钙类膳食补充剂包含粒状磷酸钙类盐与可咀嚼型糖基形成的混合物。
Description
技术领域
本发明涉及膳食补充剂，更具体地讲，涉及含钙的膳食补充剂。
背景技术
矿物质和维生素组合物通常被用作膳食补充剂，或者作为一般的营养膳食补充剂或者作为针对性地治疗特定医学问题的治疗剂。
钙是重要的营养物质，对于正在生长的儿童来说，其有助于骨形成，对于成人来说，其有助于预防骨丧失。过度的骨丧失可能导致被称为“骨质疏松症”的病况，即，骨质减少会引起骨骼易碎并从而更易骨折。被广泛认可的观点是：膳食钙的长期不足是导致骨质疏松症的一个因素，参见1987年由位于美国马里兰州的美国国家卫生院公共卫生局的美国卫生与人类服务部出版的“Osteoporosis，Cause，Treatment，Prevention”。钙类膳食补充剂似乎对帮助预防骨质疏松症是有价值的。
最近的研究表明，除了摄取补充量的钙之外，摄取补充量的其它矿物质如磷似乎可以提供其它的益处，例如，参见Shapiro，R.和Heaney，R.P.的“Co-dependence of calcium and phosphorus for growthand bone development under conditions of varying deficiency”，Bone2003May；32(5)：532-40。
为促进健康骨生长并延缓或预防骨丧失，提供除包含钙之外还包含其它组分(如磷)的改进的钙类膳食补充剂一直令人很感兴趣。
发明概述
本发明涉及可咀嚼剂型钙类膳食补充剂，其包含粒状磷酸钙类盐与可咀嚼型糖基形成的混合物。
发明详述及优选实施方案
合适的磷酸钙类盐包括(例如)磷酸三钙、二水磷酸二钙、无水磷酸二钙和磷酸一钙。
在一个实施方案中，相对于每重量份(pbw)的磷来说，本发明的补充剂组合物包含约1.4重量份到约2.1重量份的钙，更通常包含约1.5重量份到约2.0重量份的钙。
可任选的是，例如，通过加入包含比上述钙磷盐更低量的磷或不含显著量磷的钙来源或者加入包含比上述钙磷盐相对更低量的钙或不含显著量的钙的磷来源，可以在所需范围内调节剂型中钙和磷的相对含量。
不含显著量的磷的合适的钙来源包括(例如)：钙螯合物，例如氨基酸螯合物；和钙盐，例如碳酸钙、葡萄糖酸钙、柠檬酸钙、柠檬酸苹果酸钙。
不含显著量的钙的合适的磷酸盐来源包括(例如)：磷酸盐，例如磷酸钠；和蛋白质，例如大豆蛋白、乳清蛋白。
控制本发明的钙类膳食补充剂中的粒状磷酸钙类盐组分的粒径分布，使得生产的钙类膳食补充剂通常表现出更具吸引力的感官性质，例如，在咀嚼时感觉更加顺滑和更少砂砾感。
在一个实施方案中，本发明的钙类膳食补充剂中的粒状磷酸钙类盐组分具有这样的粒径分布，即：其中粒径小于约10微米(μm)的盐的量大于或等于约50重量％(“重量百分比”)、更通常大于或等于约75重量％、甚至更通常大于或等于约90重量％。
在一个实施方案中，本发明的钙类膳食补充剂的粒状磷酸钙类盐组分具有这样的粒径分布，即：其中粒径大于约20μm的盐的量小于或等于约10重量％、更通常小于或等于约5重量％、甚至更通常小于或等于约1重量％。
本发明的膳食补充剂组合物还包含可咀嚼型糖基。合适的可咀嚼型糖基是本领域中公知的。
在一个实施方案中，可咀嚼型糖基为包含调味剂与经烹制的糖形成的混合物的太妃糖糖基。在一个实施方案中，太妃糖基的制备为将糖加热到约250-255的温度，使该混合物稍微冷却，然后加入调味剂。
在另一个实施方案中，可咀嚼型糖基为包含混合物的焦糖糖基，该混合物包含糖与脂类形成的经烹制的混合物以及调味剂。在一个实施方案中，焦糖糖基的制备为将糖与脂类形成的混合物加热到约240-255的温度，使该混合物稍微冷却，然后加入调味剂。
合适的糖是已知的，并且包括(例如)玉米糖浆、蔗糖、甜菜糖、葡萄糖。合适的脂类是已知的，并且包括黄油、奶油、炼乳和植物油(例如部分氢化的大豆油)。合适的调味剂是已知的，并且包括：天然调味剂，例如香荚兰浸剂、可可粉、天然巧克力调味剂和浓缩果汁；和人工调味剂，例如香草醛和人工果味剂。
在一个实施方案中，可咀嚼型糖基为软质可咀嚼型糖基，并且包含有效量的软化剂，例如甘油、甘油单硬脂酸酯或脂类成分。
糖基可任选地包含通常被认为作为食品添加剂使用是安全的其它组分，这些组分包括(例如)：淀粉，例如小麦粉和玉米淀粉；防腐剂，例如丁羟甲苯和叔丁对甲氧酚；食品级乳化剂，例如卵磷脂、丙二醇酯和乙二醇酯；调味品，例如食盐；和食品级着色剂，例如，已经被美国食品药物管理局(“US FDA”)认证或可由其认证用于食品的着色添加剂诸如FD&C Blue No.1(亮蓝FCF)、FD&C Blue No.2(靛蓝)、FD&C Green No.3(固绿FCF)、FD&C Red No.40(诱惑红AC)、FD&C Red No.(赤藓红)、FD&C Yellow No.5(柠檬黄)、和FD&C Yellow No.6(日落黄)，以及免US FDA认证的着色添加剂诸如胭脂树橙提取物、β-阿朴-8′-胡萝卜素醛、β-胡萝卜素、甜菜粉、角黄素、焦糖色、胡萝卜油、胭脂虫提取物(胭脂虫红)、棉籽粉(经烘烤部分脱脂，经烹制)、葡萄糖酸铁、果汁、葡萄色素提取物、葡萄皮提取物(葡萄皮色素(enocianina))、辣椒色素、辣椒油树脂、核黄素、藏红花、二氧化钛、姜黄、姜黄油树脂和蔬菜汁。
本发明的软质咀嚼物如下制备：将钙磷组分以及任何可任选的组分与可咀嚼型糖基按所需的相对量组合，根据已知的方法混合各个组分以生产基本上均质的混合物并将所得到的混合物形成单个的软质咀嚼物。
在一个实施方案中，选择各个组分的相对量和软质咀嚼物的尺寸以提供这样的剂量，即：每个独立的软质咀嚼物包含约100毫克(“mg”)到约1200mg、更通常约500mg到约600mg的钙，每个独立的软质咀嚼物包含约100mg到约1000mg、更通常约200mg到约400mg的磷。
本发明的钙类膳食补充剂提供一种用于补钙和补磷的便携和方便的来源。
例1和例2
通过如下方法来制备例1的软质咀嚼物：将具有如下表所示粒径分布的磷酸三钙和可咀嚼型巧克力焦糖糖基按照每100重量份可咀嚼型焦糖糖基对应于约21.9重量份磷酸三钙的量混合，并将该混合物形成为每个约6克(“g”)重、尺寸约0.8英寸×0.7英寸×0.4英寸的截角立方体。就例1的软质咀嚼物而言，标称上每个咀嚼物包含500mg钙和260mg磷。
| 粒径(μm) | 重量％ |
| ＜19.6 | 99 |
| ＜12 | 90 |
| ＜3 | 50 |
| ＜1.2 | 10 |
除了使用具有如下表所示粒径分布的磷酸三钙之外，根据上述例1中所述的步骤制备例2的软质咀嚼物：
| 粒径(μm) | 重量％ |
| ＜100 | 99 |
| ＜45 | 95 |
| ＜20 | 50 |
| ＜2 | 10 |
在盲品时，感觉例1的软质咀嚼物比例2的那些具有更少的粉质感(chalky)、更少的嘎吱嘎吱感、更少的砂砾感而且更顺滑。
Claims (12)
1.一种可咀嚼剂型钙类膳食补充剂，该钙类膳食补充剂包含粒状磷酸钙类盐与可咀嚼型糖基形成的混合物。
2.根据权利要求1所述的膳食补充剂，其中，所述磷酸钙类盐包含磷酸三钙、二水磷酸二钙、无水磷酸二钙和磷酸一钙中的一种或多种。
3.根据权利要求1所述的膳食补充剂，其中，相对于每重量份的磷来说，所述膳食补充剂包含约1.4重量份到约2.1重量份的钙，更通常包含约1.5重量份到约2.0重量份的钙。
4.根据权利要求1所述的膳食补充剂，其中，大于或等于约50重量％的所述粒状磷酸钙类盐的粒径小于约10微米。
5.根据权利要求1所述的膳食补充剂，其中，大于或等于约75重量％的所述粒状磷酸钙类盐的粒径小于约10微米。
6.根据权利要求1所述的膳食补充剂，其中，大于或等于约90重量％的所述粒状磷酸钙类盐的粒径小于约10微米。
7.根据权利要求1所述的膳食补充剂，其中，小于或等于约10重量％的所述粒状磷酸钙类盐的粒径大于约20微米。
8.根据权利要求1所述的膳食补充剂，其中，小于或等于约5重量％的所述粒状磷酸钙类盐的粒径大于约20微米。
9.根据权利要求1所述的膳食补充剂，其中，小于或等于约1重量％的所述粒状磷酸钙类盐的粒径大于约20微米。
10.根据权利要求1所述的膳食补充剂，其中，所述可咀嚼型糖基为太妃糖糖基，所述太妃糖糖基包含调味剂与经烹制的糖形成的混合物。
11.根据权利要求1所述的膳食补充剂，其中，所述可咀嚼型糖基为包含混合物的焦糖糖基，该混合物包含糖与脂类形成的经烹制的混合物以及调味剂。
12.根据权利要求1所述的膳食补充剂，其中，所述膳食补充剂中的每个独立的软质咀嚼物包含约100毫克到约1200毫克的钙，并且所述膳食补充剂中的每个独立的软质咀嚼物包含约100毫克到约1000毫克的磷。
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| US8263137B2 (en) * | 2005-08-04 | 2012-09-11 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for women |
| US8202546B2 (en) | 2005-08-04 | 2012-06-19 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for use under physiologically stressful conditions |
| US7998500B2 (en) * | 2005-08-04 | 2011-08-16 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for women |
| US7901710B2 (en) * | 2005-08-04 | 2011-03-08 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for use under physiologically stressful conditions |
| US7968131B2 (en) * | 2006-01-11 | 2011-06-28 | Mission Pharmacal Co. | Calcium-enriched food product |
| US7968130B2 (en) * | 2006-01-11 | 2011-06-28 | Mission Pharmacal Co. | Calcium-enriched food product |
| US7767248B2 (en) * | 2007-02-02 | 2010-08-03 | Overly Iii Harry J | Soft chew confectionary with high fiber and sugar content and method for making same |
| US20090011079A1 (en) * | 2007-07-02 | 2009-01-08 | Bestsweet, Inc. | Hard Coated Confectionary Having A Consumable Soft Chewing Core With An Active And Method For Making Same |
| FR2919191B1 (fr) * | 2007-07-25 | 2010-01-01 | Teknimed Sas | Composition adhesive pour comblement osseux a base de phosphatede calcium. |
| JP5275079B2 (ja) * | 2009-02-17 | 2013-08-28 | ユーハ味覚糖株式会社 | 柔軟性を有するハードキャンディおよびその製造方法 |
| US20140248394A1 (en) * | 2011-10-14 | 2014-09-04 | Compagnie Gervais Danone | Composition Comprising a Calcium Salt, Preparation Process and Use in Food Products |
| ITMI20132003A1 (it) | 2013-11-29 | 2015-05-30 | Perfetti Van Melle Spa | Prodotti di confetteria con calcio fosfato |
| US10463691B2 (en) * | 2017-04-27 | 2019-11-05 | Jargalsaikhan Shagdar | Natural compositions containing eggshell calcium, organic honey and lemon |
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| US4582709A (en) * | 1985-02-08 | 1986-04-15 | Warner-Lambert Company | Chewable mineral supplement |
| US4867989A (en) * | 1986-09-09 | 1989-09-19 | Warner-Lambert Company | Chewing gum mineral supplement |
| US5833954A (en) * | 1996-08-20 | 1998-11-10 | American Dental Association Health Foundation | Anti-carious chewing gums, candies, gels, toothpastes and dentifrices |
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| WO2005030146A2 (en) | 2005-04-07 |
| EP1686864A4 (en) | 2009-09-23 |
| MXPA06003367A (es) | 2006-06-23 |
| EP1686864A2 (en) | 2006-08-09 |
| RU2362338C2 (ru) | 2009-07-27 |
| WO2005030146A3 (en) | 2006-01-26 |
| NO20061834L (no) | 2006-06-22 |
| SG132689A1 (en) | 2007-06-28 |
| NZ546113A (en) | 2009-03-31 |
| US20050069608A1 (en) | 2005-03-31 |
| BRPI0414790A (pt) | 2006-11-21 |
| IL174535A0 (en) | 2006-08-01 |
| RU2006114041A (ru) | 2007-11-10 |
| KR20060115369A (ko) | 2006-11-08 |
| CA2550722A1 (en) | 2005-04-07 |
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