JP4172883B2 - 薬物徐放用担体および薬物徐放用担体の製造方法 - Google Patents
薬物徐放用担体および薬物徐放用担体の製造方法 Download PDFInfo
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- JP4172883B2 JP4172883B2 JP25447099A JP25447099A JP4172883B2 JP 4172883 B2 JP4172883 B2 JP 4172883B2 JP 25447099 A JP25447099 A JP 25447099A JP 25447099 A JP25447099 A JP 25447099A JP 4172883 B2 JP4172883 B2 JP 4172883B2
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- Prior art keywords
- ceramic
- drug
- sustained
- carrier
- release
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 238000013268 sustained release Methods 0.000 title claims description 87
- 239000012730 sustained-release form Substances 0.000 title claims description 87
- 238000004519 manufacturing process Methods 0.000 title claims description 22
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- 238000005245 sintering Methods 0.000 claims description 23
- 238000013269 sustained drug release Methods 0.000 claims description 22
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- 239000001506 calcium phosphate Substances 0.000 claims description 16
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 16
- -1 calcium phosphate compound Chemical class 0.000 claims description 16
- 235000011010 calcium phosphates Nutrition 0.000 claims description 16
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- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 14
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 14
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- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 5
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- HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/026—Ceramic or ceramic-like structures, e.g. glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Ceramic Engineering (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Ceramic Products (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25447099A JP4172883B2 (ja) | 1999-09-08 | 1999-09-08 | 薬物徐放用担体および薬物徐放用担体の製造方法 |
| US09/658,021 US6719989B1 (en) | 1999-09-08 | 2000-09-08 | Sustained release drug carrier, and method of manufacturing sustained release drug carrier |
| GB0022086A GB2356140B (en) | 1999-09-08 | 2000-09-08 | Sustained release chemical substance carrier and method for manufacturing therefor |
| DE10044420A DE10044420A1 (de) | 1999-09-08 | 2000-09-08 | Wirkstoffträger zur anhaltenden Wirkstofffreisetzung und Verfahren zu dessen Herstellung |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25447099A JP4172883B2 (ja) | 1999-09-08 | 1999-09-08 | 薬物徐放用担体および薬物徐放用担体の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001072577A JP2001072577A (ja) | 2001-03-21 |
| JP2001072577A5 JP2001072577A5 (enExample) | 2004-12-16 |
| JP4172883B2 true JP4172883B2 (ja) | 2008-10-29 |
Family
ID=17265495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25447099A Expired - Fee Related JP4172883B2 (ja) | 1999-09-08 | 1999-09-08 | 薬物徐放用担体および薬物徐放用担体の製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6719989B1 (enExample) |
| JP (1) | JP4172883B2 (enExample) |
| DE (1) | DE10044420A1 (enExample) |
| GB (1) | GB2356140B (enExample) |
Families Citing this family (116)
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|---|---|---|---|---|
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| US7270705B2 (en) * | 1999-07-14 | 2007-09-18 | Jiin-Huey Chern Lin | Method of increasing working time of tetracalcium phosphate cement paste |
| US7169373B2 (en) * | 1999-07-14 | 2007-01-30 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same |
| US6960249B2 (en) * | 1999-07-14 | 2005-11-01 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface |
| US7094282B2 (en) * | 2000-07-13 | 2006-08-22 | Calcitec, Inc. | Calcium phosphate cement, use and preparation thereof |
| AUPQ573300A0 (en) * | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
| ITVI20000025U1 (it) * | 2000-04-07 | 2001-10-07 | Tecres Spa | Dispositivo distanziatore temporaneo per il trattamento chirurgico del ginocchio |
| US7156915B2 (en) * | 2000-07-13 | 2007-01-02 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same |
| US7204876B2 (en) * | 2000-07-13 | 2007-04-17 | Calcitec, Inc. | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
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| WO2004026111A2 (en) | 2000-11-16 | 2004-04-01 | Microspherix Llc | Flexible and/or elastic brachytherapy seed or strand |
| JP4070951B2 (ja) * | 2000-12-07 | 2008-04-02 | ペンタックス株式会社 | 多孔質リン酸カルシウム系セラミックス焼結体の製造方法 |
| US20030078660A1 (en) * | 2001-02-15 | 2003-04-24 | Dale Clifford | Orthopedic implant and method for orthopedic treatment |
| US6565659B1 (en) | 2001-06-28 | 2003-05-20 | Advanced Cardiovascular Systems, Inc. | Stent mounting assembly and a method of using the same to coat a stent |
| US7989018B2 (en) | 2001-09-17 | 2011-08-02 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
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| US6863683B2 (en) | 2001-09-19 | 2005-03-08 | Abbott Laboratoris Vascular Entities Limited | Cold-molding process for loading a stent onto a stent delivery system |
| US20030216777A1 (en) * | 2002-05-16 | 2003-11-20 | Yin-Chun Tien | Method of enhancing healing of interfacial gap between bone and tendon or ligament |
| US8435550B2 (en) | 2002-12-16 | 2013-05-07 | Abbot Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
| US7758881B2 (en) | 2004-06-30 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
| DE10320772A1 (de) * | 2003-05-09 | 2004-12-09 | B. Braun Meisungen Ag | Verfahren zur Abgabe von an einem Stent angebrachten Wirkstoff an einen menschlichen oder tierischen Körper und Stent hierfür |
| DE10320773A1 (de) * | 2003-05-09 | 2004-12-16 | B. Braun Melsungen Ag | Verfahren zur Abgabe von an einem Stent angebrachten Wirkstoffen an einen menschlichen oder tierischen Körper und Stent hierfür |
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| US5919473A (en) | 1997-05-12 | 1999-07-06 | Elkhoury; George F. | Methods and devices for delivering opioid analgesics to wounds via a subdermal implant |
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- 2000-09-08 GB GB0022086A patent/GB2356140B/en not_active Expired - Fee Related
- 2000-09-08 DE DE10044420A patent/DE10044420A1/de not_active Withdrawn
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| GB2356140B (en) | 2004-03-17 |
| US6719989B1 (en) | 2004-04-13 |
| JP2001072577A (ja) | 2001-03-21 |
| GB0022086D0 (en) | 2000-10-25 |
| DE10044420A1 (de) | 2001-03-15 |
| GB2356140A (en) | 2001-05-16 |
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