JP4039589B2 - 置換インダニリジンアセチルグアニジン類、それらの製造方法、医薬または診断剤としてのそれらの使用およびそれらを含有する医薬 - Google Patents
置換インダニリジンアセチルグアニジン類、それらの製造方法、医薬または診断剤としてのそれらの使用およびそれらを含有する医薬 Download PDFInfo
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- JP4039589B2 JP4039589B2 JP20275697A JP20275697A JP4039589B2 JP 4039589 B2 JP4039589 B2 JP 4039589B2 JP 20275697 A JP20275697 A JP 20275697A JP 20275697 A JP20275697 A JP 20275697A JP 4039589 B2 JP4039589 B2 JP 4039589B2
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- indanilysin
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C327/54—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE96112275:1 | 1996-07-30 | ||
| EP96112275A EP0837055A1 (en) | 1996-07-30 | 1996-07-30 | Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH1129545A JPH1129545A (ja) | 1999-02-02 |
| JPH1129545A5 JPH1129545A5 (https=) | 2005-05-26 |
| JP4039589B2 true JP4039589B2 (ja) | 2008-01-30 |
Family
ID=8223055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20275697A Expired - Fee Related JP4039589B2 (ja) | 1996-07-30 | 1997-07-29 | 置換インダニリジンアセチルグアニジン類、それらの製造方法、医薬または診断剤としてのそれらの使用およびそれらを含有する医薬 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5900436A (https=) |
| EP (2) | EP0837055A1 (https=) |
| JP (1) | JP4039589B2 (https=) |
| KR (1) | KR980009236A (https=) |
| CN (1) | CN1064351C (https=) |
| AR (1) | AR008095A1 (https=) |
| AT (1) | ATE207888T1 (https=) |
| AU (1) | AU715187B2 (https=) |
| BR (1) | BR9704131A (https=) |
| CA (1) | CA2211982C (https=) |
| CZ (1) | CZ241197A3 (https=) |
| DE (1) | DE69707777T2 (https=) |
| DK (1) | DK0822182T3 (https=) |
| ES (1) | ES2164283T3 (https=) |
| HR (1) | HRP970424B1 (https=) |
| HU (1) | HUP9701316A3 (https=) |
| ID (1) | ID17565A (https=) |
| IL (1) | IL121407A0 (https=) |
| MX (1) | MX9705737A (https=) |
| NO (1) | NO308213B1 (https=) |
| NZ (1) | NZ328440A (https=) |
| PL (1) | PL321392A1 (https=) |
| PT (1) | PT822182E (https=) |
| RU (1) | RU2176638C2 (https=) |
| SI (1) | SI0822182T1 (https=) |
| SK (1) | SK282128B6 (https=) |
| TR (1) | TR199700704A2 (https=) |
| TW (1) | TW445251B (https=) |
| ZA (1) | ZA976735B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2384318T1 (en) | 2008-12-31 | 2018-03-30 | Ardelyx, Inc. | MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| GB0916163D0 (en) * | 2009-09-15 | 2009-10-28 | Shire Llc | Prodrugs of guanfacine |
| LT2983667T (lt) | 2013-04-12 | 2019-07-10 | Ardelyx, Inc. | Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai |
| CA3049678A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| CN116492469A (zh) * | 2023-05-22 | 2023-07-28 | 遵义医科大学附属医院 | 一种通道阻滞剂在制备治疗和/或预防肝纤维疾病药物中的应用 |
| CN119118881B (zh) * | 2024-07-25 | 2026-01-02 | 中国农业大学 | 含胍基的5-氯茚满化合物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| DE4421536A1 (de) * | 1994-06-20 | 1995-12-21 | Hoechst Ag | Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DK0738712T3 (da) * | 1995-04-18 | 2000-03-06 | Hoechst Ag | Substituerede indenoylguanidiner med antiarytmetisk kardioprotektiv virkning |
-
1996
- 1996-07-30 EP EP96112275A patent/EP0837055A1/en not_active Withdrawn
-
1997
- 1997-05-23 TW TW086106928A patent/TW445251B/zh active
- 1997-07-14 ID IDP972422A patent/ID17565A/id unknown
- 1997-07-24 DE DE69707777T patent/DE69707777T2/de not_active Expired - Lifetime
- 1997-07-24 PT PT97112674T patent/PT822182E/pt unknown
- 1997-07-24 DK DK97112674T patent/DK0822182T3/da active
- 1997-07-24 SI SI9730260T patent/SI0822182T1/xx unknown
- 1997-07-24 ES ES97112674T patent/ES2164283T3/es not_active Expired - Lifetime
- 1997-07-24 EP EP97112674A patent/EP0822182B1/en not_active Expired - Lifetime
- 1997-07-24 AT AT97112674T patent/ATE207888T1/de not_active IP Right Cessation
- 1997-07-28 NZ NZ328440A patent/NZ328440A/en unknown
- 1997-07-28 CN CN97114777A patent/CN1064351C/zh not_active Expired - Fee Related
- 1997-07-28 KR KR1019970035527A patent/KR980009236A/ko not_active Ceased
- 1997-07-28 SK SK1034-97A patent/SK282128B6/sk unknown
- 1997-07-28 IL IL12140797A patent/IL121407A0/xx unknown
- 1997-07-28 AR ARP970103414A patent/AR008095A1/es unknown
- 1997-07-28 CZ CZ972411A patent/CZ241197A3/cs unknown
- 1997-07-28 AU AU31554/97A patent/AU715187B2/en not_active Ceased
- 1997-07-28 TR TR97/00704A patent/TR199700704A2/xx unknown
- 1997-07-28 US US08/901,099 patent/US5900436A/en not_active Expired - Lifetime
- 1997-07-29 HU HU9701316A patent/HUP9701316A3/hu unknown
- 1997-07-29 CA CA002211982A patent/CA2211982C/en not_active Expired - Fee Related
- 1997-07-29 BR BR9704131A patent/BR9704131A/pt active Search and Examination
- 1997-07-29 RU RU97113146/04A patent/RU2176638C2/ru not_active IP Right Cessation
- 1997-07-29 ZA ZA9706735A patent/ZA976735B/xx unknown
- 1997-07-29 JP JP20275697A patent/JP4039589B2/ja not_active Expired - Fee Related
- 1997-07-29 HR HR970424A patent/HRP970424B1/xx not_active IP Right Cessation
- 1997-07-29 MX MX9705737A patent/MX9705737A/es not_active IP Right Cessation
- 1997-07-29 PL PL97321392A patent/PL321392A1/xx unknown
- 1997-07-29 NO NO973486A patent/NO308213B1/no not_active IP Right Cessation
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