DK0822182T3 - Substituerede indanylidenacetylguanidiner som Na+/H+-udveks-lingsinhibitorer, fremgangsmåde til deres fremstilling, deres anvendelse om lægemidler eller diagnostiske midler samt lægemidler indeholdende dem - Google Patents

Substituerede indanylidenacetylguanidiner som Na+/H+-udveks-lingsinhibitorer, fremgangsmåde til deres fremstilling, deres anvendelse om lægemidler eller diagnostiske midler samt lægemidler indeholdende dem

Info

Publication number
DK0822182T3
DK0822182T3 DK97112674T DK97112674T DK0822182T3 DK 0822182 T3 DK0822182 T3 DK 0822182T3 DK 97112674 T DK97112674 T DK 97112674T DK 97112674 T DK97112674 T DK 97112674T DK 0822182 T3 DK0822182 T3 DK 0822182T3
Authority
DK
Denmark
Prior art keywords
drugs
acetylguanidines
indanylidene
substituted
preparation
Prior art date
Application number
DK97112674T
Other languages
English (en)
Inventor
Ravindra Dattatraya Gupte
Andreas Weichert
Jan-Robert Schwark
Anil Vasantrao Ghate
Rao Venkata Satya Ve Vadlamudi
Nirogi Venkata Sat Ramakrishna
Arun Kumar Jain
Bansi Lal
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0822182T3 publication Critical patent/DK0822182T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C327/54—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK97112674T 1996-07-30 1997-07-24 Substituerede indanylidenacetylguanidiner som Na+/H+-udveks-lingsinhibitorer, fremgangsmåde til deres fremstilling, deres anvendelse om lægemidler eller diagnostiske midler samt lægemidler indeholdende dem DK0822182T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96112275A EP0837055A1 (en) 1996-07-30 1996-07-30 Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them

Publications (1)

Publication Number Publication Date
DK0822182T3 true DK0822182T3 (da) 2002-02-25

Family

ID=8223055

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97112674T DK0822182T3 (da) 1996-07-30 1997-07-24 Substituerede indanylidenacetylguanidiner som Na+/H+-udveks-lingsinhibitorer, fremgangsmåde til deres fremstilling, deres anvendelse om lægemidler eller diagnostiske midler samt lægemidler indeholdende dem

Country Status (29)

Country Link
US (1) US5900436A (da)
EP (2) EP0837055A1 (da)
JP (1) JP4039589B2 (da)
KR (1) KR980009236A (da)
CN (1) CN1064351C (da)
AR (1) AR008095A1 (da)
AT (1) ATE207888T1 (da)
AU (1) AU715187B2 (da)
BR (1) BR9704131A (da)
CA (1) CA2211982C (da)
CZ (1) CZ241197A3 (da)
DE (1) DE69707777T2 (da)
DK (1) DK0822182T3 (da)
ES (1) ES2164283T3 (da)
HR (1) HRP970424B1 (da)
HU (1) HUP9701316A3 (da)
ID (1) ID17565A (da)
IL (1) IL121407A0 (da)
MX (1) MX9705737A (da)
NO (1) NO308213B1 (da)
NZ (1) NZ328440A (da)
PL (1) PL321392A1 (da)
PT (1) PT822182E (da)
RU (1) RU2176638C2 (da)
SI (1) SI0822182T1 (da)
SK (1) SK282128B6 (da)
TR (1) TR199700704A2 (da)
TW (1) TW445251B (da)
ZA (1) ZA976735B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2010078449A2 (en) 2008-12-31 2010-07-08 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine
BR112015025805A2 (pt) 2013-04-12 2017-07-25 Ardelyx Inc compostos de ligação de nh3 e métodos para inibir o transporte de fosfato
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
CN110267944B (zh) 2017-01-09 2024-03-08 阿德利克斯股份有限公司 可用于治疗胃肠道病症的化合物
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
ID17565A (id) 1998-01-08
SK282128B6 (sk) 2001-11-06
ES2164283T3 (es) 2002-02-16
PT822182E (pt) 2002-03-28
HUP9701316A3 (en) 1998-07-28
MX9705737A (es) 1998-02-28
RU2176638C2 (ru) 2001-12-10
PL321392A1 (en) 1998-02-02
DE69707777T2 (de) 2003-01-16
SI0822182T1 (en) 2002-04-30
TW445251B (en) 2001-07-11
ZA976735B (en) 1998-01-30
CN1064351C (zh) 2001-04-11
HRP970424B1 (en) 2002-06-30
CA2211982A1 (en) 1998-01-30
KR980009236A (ko) 1998-04-30
US5900436A (en) 1999-05-04
CZ241197A3 (cs) 1998-02-18
NO973486D0 (no) 1997-07-29
NO973486L (no) 1998-02-02
HRP970424A2 (en) 1998-06-30
IL121407A0 (en) 1998-01-04
HUP9701316A2 (hu) 1998-03-02
JPH1129545A (ja) 1999-02-02
CN1172104A (zh) 1998-02-04
NZ328440A (en) 1997-11-24
DE69707777D1 (de) 2001-12-06
NO308213B1 (no) 2000-08-14
HU9701316D0 (en) 1997-09-29
EP0822182B1 (en) 2001-10-31
BR9704131A (pt) 1998-12-29
EP0822182A1 (en) 1998-02-04
SK103497A3 (en) 1998-02-04
EP0837055A1 (en) 1998-04-22
JP4039589B2 (ja) 2008-01-30
AU715187B2 (en) 2000-01-20
CA2211982C (en) 2007-09-18
ATE207888T1 (de) 2001-11-15
AR008095A1 (es) 1999-12-09
AU3155497A (en) 1998-02-05
TR199700704A2 (xx) 1998-02-21

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