JP4014645B2 - 軟骨細胞への剪断流れ応力の印加 - Google Patents

軟骨細胞への剪断流れ応力の印加 Download PDF

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Publication number
JP4014645B2
JP4014645B2 JP52382798A JP52382798A JP4014645B2 JP 4014645 B2 JP4014645 B2 JP 4014645B2 JP 52382798 A JP52382798 A JP 52382798A JP 52382798 A JP52382798 A JP 52382798A JP 4014645 B2 JP4014645 B2 JP 4014645B2
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cells
substrate
shear flow
cartilage
chondrocytes
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Expired - Fee Related
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Japanese (ja)
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JP2001504697A5 (enExample
JP2001504697A (ja
Inventor
セリクター，ドロール
ダンケルマン，ヌーシン
イー． ピーターソン，アルビン
イー． シュライバー，ロンダ
ウィラビ，ジェイン
ケー． ノートン，ゲイル
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ティージェイ スミス アンド ネフュー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Mechanical Engineering (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Excavating Of Shafts Or Tunnels (AREA)
  • Lubricants (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP52382798A 1996-11-20 1997-11-18 軟骨細胞への剪断流れ応力の印加 Expired - Fee Related JP4014645B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/753,104 1996-11-20
US08/753,104 US5928945A (en) 1996-11-20 1996-11-20 Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
PCT/US1997/021088 WO1998022573A1 (en) 1996-11-20 1997-11-18 Application of shear flow stress to chondrocytes

Publications (3)

Publication Number Publication Date
JP2001504697A JP2001504697A (ja) 2001-04-10
JP2001504697A5 JP2001504697A5 (enExample) 2005-07-14
JP4014645B2 true JP4014645B2 (ja) 2007-11-28

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JP52382798A Expired - Fee Related JP4014645B2 (ja) 1996-11-20 1997-11-18 軟骨細胞への剪断流れ応力の印加

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Country Link
US (1) US5928945A (enExample)
EP (1) EP1019489B1 (enExample)
JP (1) JP4014645B2 (enExample)
KR (1) KR20000057136A (enExample)
AT (1) ATE273382T1 (enExample)
AU (1) AU744686B2 (enExample)
CA (1) CA2272547A1 (enExample)
DE (1) DE69730251T2 (enExample)
ES (1) ES2225999T3 (enExample)
NZ (1) NZ335991A (enExample)
WO (1) WO1998022573A1 (enExample)

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Also Published As

Publication number Publication date
ES2225999T3 (es) 2005-03-16
WO1998022573A1 (en) 1998-05-28
AU5445198A (en) 1998-06-10
EP1019489A4 (en) 2002-08-28
DE69730251T2 (de) 2005-09-15
CA2272547A1 (en) 1998-05-28
EP1019489B1 (en) 2004-08-11
US5928945A (en) 1999-07-27
KR20000057136A (ko) 2000-09-15
ATE273382T1 (de) 2004-08-15
DE69730251D1 (de) 2004-09-16
NZ335991A (en) 2000-07-28
AU744686B2 (en) 2002-02-28
JP2001504697A (ja) 2001-04-10
EP1019489A1 (en) 2000-07-19

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