ATE273382T1 - Anwendung von scherflussbeanspruchung auf chondrozyten - Google Patents

Anwendung von scherflussbeanspruchung auf chondrozyten

Info

Publication number
ATE273382T1
ATE273382T1 AT97948366T AT97948366T ATE273382T1 AT E273382 T1 ATE273382 T1 AT E273382T1 AT 97948366 T AT97948366 T AT 97948366T AT 97948366 T AT97948366 T AT 97948366T AT E273382 T1 ATE273382 T1 AT E273382T1
Authority
AT
Austria
Prior art keywords
cells
cartilage
shear flow
substrate
produce
Prior art date
Application number
AT97948366T
Other languages
German (de)
English (en)
Inventor
Dror Seliktar
Noushin Dunkelman
Alvin E Peterson
Rhonda E Schreiber
Jane Willoughby
Gail K Naughton
Original Assignee
Smith & Nephew
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith & Nephew filed Critical Smith & Nephew
Application granted granted Critical
Publication of ATE273382T1 publication Critical patent/ATE273382T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Excavating Of Shafts Or Tunnels (AREA)
  • Lubricants (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
AT97948366T 1996-11-20 1997-11-18 Anwendung von scherflussbeanspruchung auf chondrozyten ATE273382T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/753,104 US5928945A (en) 1996-11-20 1996-11-20 Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
PCT/US1997/021088 WO1998022573A1 (en) 1996-11-20 1997-11-18 Application of shear flow stress to chondrocytes

Publications (1)

Publication Number Publication Date
ATE273382T1 true ATE273382T1 (de) 2004-08-15

Family

ID=25029173

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97948366T ATE273382T1 (de) 1996-11-20 1997-11-18 Anwendung von scherflussbeanspruchung auf chondrozyten

Country Status (11)

Country Link
US (1) US5928945A (enExample)
EP (1) EP1019489B1 (enExample)
JP (1) JP4014645B2 (enExample)
KR (1) KR20000057136A (enExample)
AT (1) ATE273382T1 (enExample)
AU (1) AU744686B2 (enExample)
CA (1) CA2272547A1 (enExample)
DE (1) DE69730251T2 (enExample)
ES (1) ES2225999T3 (enExample)
NZ (1) NZ335991A (enExample)
WO (1) WO1998022573A1 (enExample)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US9020788B2 (en) 1997-01-08 2015-04-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
IL124722A0 (en) 1998-06-02 1999-01-26 Oron Amir Ischemia laser treatment
US7063726B2 (en) * 1998-06-30 2006-06-20 Lifenet Plasticized bone grafts and methods of making and using same
US20100030340A1 (en) * 1998-06-30 2010-02-04 Wolfinbarger Jr Lloyd Plasticized Grafts and Methods of Making and Using Same
US8563232B2 (en) 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US6293970B1 (en) * 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
EP1139872B1 (en) * 1998-09-14 2009-08-19 The Board of Trustees of The Leland Stanford Junior University Assessing the condition of a joint and preventing damage
US6287340B1 (en) 1999-05-14 2001-09-11 Trustees Of Tufts College Bioengineered anterior cruciate ligament
WO2000073417A1 (en) * 1999-05-27 2000-12-07 The Research Foundation Of State University Of New York In vitro cell culture device including cartilage and methods of using the same
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US6632651B1 (en) 1999-07-06 2003-10-14 Ramot At Tel Aviv University Ltd. Tissue maintenance system that applies rhythmic pulses of pressure
US7005274B1 (en) * 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
US7585323B2 (en) * 2000-05-05 2009-09-08 Medlden, Llc In vitro mechanical loading of musculoskeletal tissues
WO2002017983A1 (en) * 2000-08-28 2002-03-07 Osteogenesis Co., Ltd. Medicinal compositions for forming tissue around bone or tooth, process for preparing the same, injections for forming tissue around bone or tooth and process for preparing the same
WO2002022013A1 (en) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Assessing condition of a joint and cartilage loss
US6799066B2 (en) 2000-09-14 2004-09-28 The Board Of Trustees Of The Leland Stanford Junior University Technique for manipulating medical images
EP1322225B1 (en) 2000-09-14 2009-03-25 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
US7063942B2 (en) * 2000-10-06 2006-06-20 Victor Krstec System and method to simulate hemodynamics
US6835390B1 (en) 2000-11-17 2004-12-28 Jon Vein Method for producing tissue engineered meat for consumption
DE10061704A1 (de) * 2000-12-12 2002-06-20 Hans Joerg Bauer Verfahren und Vorrichtung zur Herstellung von biologischem Gewebe in einer Wachstumskammer
US7326564B2 (en) 2001-02-20 2008-02-05 St. Jude Medical, Inc. Flow system for medical device evaluation and production
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
JP4500898B2 (ja) 2001-03-23 2010-07-14 高木産業株式会社 生物学的組織および組織構築物を製造するための組成物および方法
JP2002306157A (ja) * 2001-04-17 2002-10-22 Takagi Ind Co Ltd 細胞・組織培養装置
JP2002315566A (ja) 2001-04-24 2002-10-29 Takagi Ind Co Ltd 細胞・組織培養装置
AU2002310193B8 (en) 2001-05-25 2007-05-17 Conformis, Inc. Methods and compositions for articular resurfacing
DE10130512B4 (de) * 2001-06-25 2007-08-16 Bionethos Holding Gmbh Vorrichtung zur Druckperfusion für das Züchten und/oder für das Behandeln von Zellen
US7534255B1 (en) * 2003-01-24 2009-05-19 Photothera, Inc Low level light therapy for enhancement of neurologic function
US9993659B2 (en) * 2001-11-01 2018-06-12 Pthera, Llc Low level light therapy for enhancement of neurologic function by altering axonal transport rate
US8308784B2 (en) 2006-08-24 2012-11-13 Jackson Streeter Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
US10683494B2 (en) 2001-11-01 2020-06-16 Pthera LLC Enhanced stem cell therapy and stem cell production through the administration of low level light energy
US7303578B2 (en) * 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
WO2003042376A1 (en) * 2001-11-15 2003-05-22 Photothera, Inc. Methods for preparing artificial cartilage
AU2002343738A1 (en) * 2001-11-15 2003-05-26 University Of Medicine And Dentistry Of New Jersey A three-dimensional matrix for producing living tissue equivalents
US20030144712A1 (en) * 2001-12-20 2003-07-31 Jackson Streeter, M.D. Methods for overcoming organ transplant rejection
JP4451582B2 (ja) * 2001-12-21 2010-04-14 高木産業株式会社 細胞・組織培養装置
US10695577B2 (en) 2001-12-21 2020-06-30 Photothera, Inc. Device and method for providing phototherapy to the heart
US7316922B2 (en) * 2002-01-09 2008-01-08 Photothera Inc. Method for preserving organs for transplant
DE60308479T2 (de) * 2002-01-15 2007-06-21 Biogentis Inc., Sainte-Foy Verfahren und anlage zur kontrollierten mechanischen belastung eines gewebekonstrukts
US9144583B2 (en) 2002-03-29 2015-09-29 Tissue Genesis, Inc. Cell separation apparatus and methods of use
US8202725B2 (en) * 2004-12-23 2012-06-19 Tissue Genesis Incorporated Cell sodding method and apparatus
KR100629392B1 (ko) * 2002-05-10 2006-09-29 주식회사 리젠 바이오텍 스케폴드를 이용한 체외에서의 정자 배양방법
US20040153130A1 (en) * 2002-05-29 2004-08-05 Amir Oron Methods for treating muscular dystrophy
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US20040132002A1 (en) * 2002-09-17 2004-07-08 Jackson Streeter Methods for preserving blood
WO2004032806A1 (en) 2002-10-07 2004-04-22 Conformis, Inc. Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces
WO2004043305A1 (en) 2002-11-07 2004-05-27 Conformis, Inc. Methods for determing meniscal size and shape and for devising treatment
US7416884B2 (en) 2003-02-26 2008-08-26 Georgia Tech Research Corporation Bioreactor and methods for tissue growth and conditioning
US7344555B2 (en) * 2003-04-07 2008-03-18 The United States Of America As Represented By The Department Of Health And Human Services Light promotes regeneration and functional recovery after spinal cord injury
SE0301087D0 (sv) * 2003-04-14 2003-04-14 Cartela Ab New monoclonal antibody
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
US20050095711A1 (en) * 2003-11-01 2005-05-05 More Robert B. Bioreactor for growing engineered tissue
EP1691727B1 (en) 2003-12-11 2011-07-06 Isto Technologies Inc. Particulate cartilage system
KR100581728B1 (ko) * 2004-03-11 2006-05-22 부산대학교 산학협력단 골세포 배양기
US7482154B2 (en) * 2004-05-15 2009-01-27 Rensselaer Polytechnic Institute Diamagnetic force field bioreactor
WO2006050213A2 (en) * 2004-10-29 2006-05-11 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
JP2009501562A (ja) * 2005-07-12 2009-01-22 ティシュー・ジェネシス・インコーポレーテッド 組織移植片を前処理する装置および方法
JP4778746B2 (ja) * 2005-07-29 2011-09-21 株式会社カネカ 細胞培養装置
JP4771123B2 (ja) * 2005-08-26 2011-09-14 独立行政法人物質・材料研究機構 二層バイオリアクター
JP5292533B2 (ja) 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド インプラントおよび関節疾患の治療、置換および治療方法
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
EP1764117A1 (en) * 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
US7575589B2 (en) * 2006-01-30 2009-08-18 Photothera, Inc. Light-emitting device and method for providing phototherapy to the brain
US10357662B2 (en) 2009-02-19 2019-07-23 Pthera LLC Apparatus and method for irradiating a surface with light
US20090254154A1 (en) * 2008-03-18 2009-10-08 Luis De Taboada Method and apparatus for irradiating a surface with pulsed light
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US8764697B2 (en) * 2006-02-01 2014-07-01 Agathos Holdings Llc Systems and methods for an advanced medical device
US7790437B2 (en) * 2006-12-14 2010-09-07 Biorep Technologies, Inc. Organ transportation device
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080221211A1 (en) * 2007-02-02 2008-09-11 Jackson Streeter Method of treatment of neurological injury or cancer by administration of dichloroacetate
EP2114312B1 (en) 2007-02-14 2014-01-08 ConforMIS, Inc. Method for manufacture of an implant device
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US9421304B2 (en) 2007-07-03 2016-08-23 Histogenics Corporation Method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US9744043B2 (en) 2007-07-16 2017-08-29 Lifenet Health Crafting of cartilage
WO2009036036A1 (en) * 2007-09-10 2009-03-19 Nickerson Cheryl A Methods and compositions based on culturing microorganisms in low sedimental fluid shear conditions
US8852925B2 (en) * 2007-12-17 2014-10-07 The Charlotte-Mecklenburg Hospital Authority Bioreactor for cell growth and associated methods
WO2009111626A2 (en) 2008-03-05 2009-09-11 Conformis, Inc. Implants for altering wear patterns of articular surfaces
CN102006841A (zh) * 2008-03-05 2011-04-06 肯弗默斯股份有限公司 边缘匹配的关节植入物
JP2011519713A (ja) 2008-05-12 2011-07-14 コンフォーミス・インコーポレイテッド 面関節および他の関節の治療のためのデバイスならびに方法
AT506826B1 (de) * 2008-05-23 2010-03-15 Greiner Bio One Gmbh Bioreaktor und verfahren zum kultivieren von zellen und geweben
EP2130905A1 (en) 2008-06-04 2009-12-09 Pharmacell B.V. Method for culturing eukaryotic cells
US7848035B2 (en) 2008-09-18 2010-12-07 Photothera, Inc. Single-use lens assembly
EP2405865B1 (en) 2009-02-24 2019-04-17 ConforMIS, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
JP2012147678A (ja) * 2009-05-14 2012-08-09 Otake:Kk 一検体用多重培養装置
US8507263B2 (en) * 2009-08-07 2013-08-13 Maria Adelaide Asnaghi Rotating bioreactor
WO2011072235A2 (en) 2009-12-11 2011-06-16 Conformis, Inc. Patient-specific and patient-engineered orthopedic implants
EP2625263B1 (en) 2010-10-08 2020-03-11 Terumo BCT, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
EP2841010B1 (en) 2012-04-24 2023-08-23 Harvard Apparatus Regenerative Technology, Inc. Supports for engineered tissue scaffolds
US10449026B2 (en) 2012-06-26 2019-10-22 Biostage, Inc. Methods and compositions for promoting the structural integrity of scaffolds for tissue engineering
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
JP5913084B2 (ja) 2012-12-26 2016-04-27 株式会社日立製作所 培養制御方法、細胞培養装置及び細胞特性評価装置
HK1217663A1 (zh) 2013-01-09 2017-01-20 Harvard Apparatus Regenerative Technology, Inc. 合成支架
ITFI20130220A1 (it) * 2013-09-20 2015-03-21 Azienda Ospedaliero Universitaria P Isana Apparato e processo per la preparazione di una protesi tissutale biomimetica della membrana timpanica
WO2015073918A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
KR102783045B1 (ko) 2015-06-23 2025-03-19 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 세포 치료를 위해 세포 집단을 조건화하기 위한 방법 및 장치
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US10927341B2 (en) 2016-03-22 2021-02-23 University Of Maryland, Baltimore Multi-functional fluid flow device
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
EP3504315A4 (en) 2016-08-27 2020-04-15 3D Biotek, LLC BIOREACTOR
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion
US12435312B2 (en) 2022-02-28 2025-10-07 Brown University Quantifying cell-derived changes in collagen synthesis, alignment, and mechanics in a 3D connective tissue model
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
JP2990789B2 (ja) * 1990-11-14 1999-12-13 東レ株式会社 血管内皮細胞の培養方法
GB9116036D0 (en) * 1991-07-25 1991-09-11 Univ Leicester Preparing grafts for implantation
WO1994025584A1 (en) * 1993-04-28 1994-11-10 Johns Hopkins University School Of Medicine Chronic endothelial cell culture under flow
JPH07274994A (ja) * 1994-04-08 1995-10-24 Asahi Chem Ind Co Ltd トロンボモジュリンの製造法
US5792603A (en) * 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts

Also Published As

Publication number Publication date
CA2272547A1 (en) 1998-05-28
DE69730251D1 (de) 2004-09-16
EP1019489B1 (en) 2004-08-11
EP1019489A4 (en) 2002-08-28
US5928945A (en) 1999-07-27
NZ335991A (en) 2000-07-28
JP4014645B2 (ja) 2007-11-28
KR20000057136A (ko) 2000-09-15
EP1019489A1 (en) 2000-07-19
WO1998022573A1 (en) 1998-05-28
AU744686B2 (en) 2002-02-28
DE69730251T2 (de) 2005-09-15
JP2001504697A (ja) 2001-04-10
AU5445198A (en) 1998-06-10
ES2225999T3 (es) 2005-03-16

Similar Documents

Publication Publication Date Title
DE69730251D1 (de) Anwendung von scherflussbeanspruchung auf chondrozyten
Vunjak‐Novakovic et al. Bioreactor studies of native and tissue engineered cartilage
Cartmell et al. Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro
Vunjak‐Novakovic et al. Effects of mixing on the composition and morphology of tissue‐engineered cartilage
Sittinger et al. Tissue engineering and autologous transplant formation: practical approaches with resorbable biomaterials and new cell culture techniques
Eisenbarth et al. Cell orientation and cytoskeleton organisation on ground titanium surfaces
Shachar et al. Effects of mechanical stimulation induced by compression and medium perfusion on cardiac tissue engineering
Baker et al. Three-dimensional culture of bovine chondrocytes in rotating-wall vessels
AR000921A1 (es) Composicion como medio de cultivo para soportar el crecimiento de poblaciones celulares. metodo in vitro para sostener el crecimiento in vitro dede celulas eucarioticas, respectivamente para in vitro incrementar las propiedades del tejido submucoso para cultivar celulas islote o analizar in
DE60017875D1 (de) Verwendung von collagenase in der zubereitung von neuralen stammzellkulturen
ATE311437T1 (de) Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung
EA199800835A1 (ru) Среда для культуры клеток млекопитающихся, способ ее получения и смесь компонентов, композиция, способы получения, продуцирования клонального роста, размножения и изменения фенотипа гепатоцитов in vitro, клетки, фармацевтический состав, способы получения рекомбинантной клетки и генного продукта, способы использования клеток, способ трансплантации гепатоцитов, способ испытания лекарственного препарата, способ поддержания жизнеспособности дифференцированных гепатоцитов
CA2123683A1 (en) New cultures of keratinocytes, process for their preparation and their use as wound healing substances
Knedlitschek et al. A tissue-like culture system using microstructures: influence of extracellular matrix material on cell adhesion and aggregation
ATE517176T1 (de) Verfahren zur kultivierung von geschmackszellen aus säugern
ATE258594T1 (de) Verfahren zur steigerung des wachstums von pflanzenzellkulturen
Pisu et al. A novel simulation model for engineered cartilage growth in static systems
CN109402049B (zh) 一种可用于软骨损伤修复的具有软骨分化潜能的组织工程脂肪干细胞片层的制备方法
CN107083355A (zh) 一种饲养层细胞及其制备方法与应用
Desgranges et al. Extracellular matrix covered biomaterials for human endothelial cell growth
Nan-Chang Su et al. In situ collagen gelation: a new method for constructing large tissue in rotary culture vessels
Katoh et al. Establishment of clonal cell lines of hamster chondrocytes maintaining their phenotypic traits
Noyes Culture of human fetal liver
Porter et al. Design of a 3D perfused cell culture system to evaluate bone regeneration technologies
Wezeman et al. Multicellular tumor spheroid interactions with bone cells and bone

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1019489

Country of ref document: EP

REN Ceased due to non-payment of the annual fee