NZ335991A - Application of shear flow stress to chondrocytes with a bioreactor to produce artificial cartilage - Google Patents

Application of shear flow stress to chondrocytes with a bioreactor to produce artificial cartilage

Info

Publication number
NZ335991A
NZ335991A NZ335991A NZ33599197A NZ335991A NZ 335991 A NZ335991 A NZ 335991A NZ 335991 A NZ335991 A NZ 335991A NZ 33599197 A NZ33599197 A NZ 33599197A NZ 335991 A NZ335991 A NZ 335991A
Authority
NZ
New Zealand
Prior art keywords
bioreactor
chondrocytes
application
growth medium
shear flow
Prior art date
Application number
NZ335991A
Other languages
English (en)
Inventor
Dror Seliktar
Noushin Dunkelman
Alvin E Peterson
Rhonda E Schreiber
Jane Willoughby
Gail K Naughton
Original Assignee
Advanced Tissue Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Tissue Sciences Inc filed Critical Advanced Tissue Sciences Inc
Publication of NZ335991A publication Critical patent/NZ335991A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Excavating Of Shafts Or Tunnels (AREA)
  • Lubricants (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
NZ335991A 1996-11-20 1997-11-18 Application of shear flow stress to chondrocytes with a bioreactor to produce artificial cartilage NZ335991A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/753,104 US5928945A (en) 1996-11-20 1996-11-20 Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
PCT/US1997/021088 WO1998022573A1 (en) 1996-11-20 1997-11-18 Application of shear flow stress to chondrocytes

Publications (1)

Publication Number Publication Date
NZ335991A true NZ335991A (en) 2000-07-28

Family

ID=25029173

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ335991A NZ335991A (en) 1996-11-20 1997-11-18 Application of shear flow stress to chondrocytes with a bioreactor to produce artificial cartilage

Country Status (11)

Country Link
US (1) US5928945A (enExample)
EP (1) EP1019489B1 (enExample)
JP (1) JP4014645B2 (enExample)
KR (1) KR20000057136A (enExample)
AT (1) ATE273382T1 (enExample)
AU (1) AU744686B2 (enExample)
CA (1) CA2272547A1 (enExample)
DE (1) DE69730251T2 (enExample)
ES (1) ES2225999T3 (enExample)
NZ (1) NZ335991A (enExample)
WO (1) WO1998022573A1 (enExample)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8617242B2 (en) 2001-05-25 2013-12-31 Conformis, Inc. Implant device and method for manufacture
IL124722A0 (en) 1998-06-02 1999-01-26 Oron Amir Ischemia laser treatment
US6293970B1 (en) 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US8563232B2 (en) * 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US7063726B2 (en) * 1998-06-30 2006-06-20 Lifenet Plasticized bone grafts and methods of making and using same
US20100030340A1 (en) * 1998-06-30 2010-02-04 Wolfinbarger Jr Lloyd Plasticized Grafts and Methods of Making and Using Same
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
CA2354525A1 (en) 1998-09-14 2000-06-22 Stanford University Assessing the condition of a joint and preventing damage
US6287340B1 (en) 1999-05-14 2001-09-11 Trustees Of Tufts College Bioengineered anterior cruciate ligament
WO2000073417A1 (en) 1999-05-27 2000-12-07 The Research Foundation Of State University Of New York In vitro cell culture device including cartilage and methods of using the same
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US6632651B1 (en) 1999-07-06 2003-10-14 Ramot At Tel Aviv University Ltd. Tissue maintenance system that applies rhythmic pulses of pressure
US7005274B1 (en) 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
US7585323B2 (en) * 2000-05-05 2009-09-08 Medlden, Llc In vitro mechanical loading of musculoskeletal tissues
AU2001280164A1 (en) * 2000-08-28 2002-03-13 Osteogenesis Co., Ltd. Medicinal compositions for forming tissue around bone or tooth, process for preparing the same, injections for forming tissue around bone or tooth and process for preparing the same
AU2001290888B8 (en) 2000-09-14 2007-07-26 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
WO2002022013A1 (en) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Assessing condition of a joint and cartilage loss
DE60136549D1 (de) 2000-09-14 2008-12-24 Univ R Verfahren zur manipulation medizinischer bilder
AU3039602A (en) * 2000-10-06 2002-04-29 Michael B Dancu System and method to simulate hemodynamics
US6835390B1 (en) 2000-11-17 2004-12-28 Jon Vein Method for producing tissue engineered meat for consumption
DE10061704A1 (de) * 2000-12-12 2002-06-20 Hans Joerg Bauer Verfahren und Vorrichtung zur Herstellung von biologischem Gewebe in einer Wachstumskammer
US7326564B2 (en) 2001-02-20 2008-02-05 St. Jude Medical, Inc. Flow system for medical device evaluation and production
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
US6949252B2 (en) * 2001-03-23 2005-09-27 Histogenics, Corp. Method for preparing an implantable multilayer tissue construct
JP2002306157A (ja) * 2001-04-17 2002-10-22 Takagi Ind Co Ltd 細胞・組織培養装置
JP2002315566A (ja) 2001-04-24 2002-10-29 Takagi Ind Co Ltd 細胞・組織培養装置
DE60239674D1 (de) 2001-05-25 2011-05-19 Conformis Inc Verfahren und zusammensetzungen zur reparatur der oberfläche von gelenken
DE10130512B4 (de) * 2001-06-25 2007-08-16 Bionethos Holding Gmbh Vorrichtung zur Druckperfusion für das Züchten und/oder für das Behandeln von Zellen
US7534255B1 (en) 2003-01-24 2009-05-19 Photothera, Inc Low level light therapy for enhancement of neurologic function
US9993659B2 (en) * 2001-11-01 2018-06-12 Pthera, Llc Low level light therapy for enhancement of neurologic function by altering axonal transport rate
US10683494B2 (en) * 2001-11-01 2020-06-16 Pthera LLC Enhanced stem cell therapy and stem cell production through the administration of low level light energy
US7303578B2 (en) * 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
US8308784B2 (en) 2006-08-24 2012-11-13 Jackson Streeter Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
WO2003042376A1 (en) * 2001-11-15 2003-05-22 Photothera, Inc. Methods for preparing artificial cartilage
US20030166274A1 (en) * 2001-11-15 2003-09-04 Hewitt Charles W. Three-dimensional matrix for producing living tissue equivalents
US20030144712A1 (en) * 2001-12-20 2003-07-31 Jackson Streeter, M.D. Methods for overcoming organ transplant rejection
US10695577B2 (en) 2001-12-21 2020-06-30 Photothera, Inc. Device and method for providing phototherapy to the heart
JP4451582B2 (ja) * 2001-12-21 2010-04-14 高木産業株式会社 細胞・組織培養装置
US7316922B2 (en) * 2002-01-09 2008-01-08 Photothera Inc. Method for preserving organs for transplant
AU2003201564A1 (en) * 2002-01-15 2003-07-30 Biogentis Inc. Method and apparatus for inducing controlled mechanical constraints in a tissue construct
US8202725B2 (en) * 2004-12-23 2012-06-19 Tissue Genesis Incorporated Cell sodding method and apparatus
US9144583B2 (en) 2002-03-29 2015-09-29 Tissue Genesis, Inc. Cell separation apparatus and methods of use
KR100629392B1 (ko) * 2002-05-10 2006-09-29 주식회사 리젠 바이오텍 스케폴드를 이용한 체외에서의 정자 배양방법
US20040153130A1 (en) * 2002-05-29 2004-08-05 Amir Oron Methods for treating muscular dystrophy
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US20040132002A1 (en) * 2002-09-17 2004-07-08 Jackson Streeter Methods for preserving blood
CA2501041A1 (en) 2002-10-07 2004-04-22 Conformis, Inc. Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces
AU2003290757A1 (en) 2002-11-07 2004-06-03 Conformis, Inc. Methods for determing meniscal size and shape and for devising treatment
US7416884B2 (en) 2003-02-26 2008-08-26 Georgia Tech Research Corporation Bioreactor and methods for tissue growth and conditioning
US7344555B2 (en) * 2003-04-07 2008-03-18 The United States Of America As Represented By The Department Of Health And Human Services Light promotes regeneration and functional recovery after spinal cord injury
SE0301087D0 (sv) 2003-04-14 2003-04-14 Cartela Ab New monoclonal antibody
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
US20050095711A1 (en) * 2003-11-01 2005-05-05 More Robert B. Bioreactor for growing engineered tissue
EP2335650B1 (en) 2003-12-11 2012-10-03 Isto Technologies Inc. Particulate cartilage system
KR100581728B1 (ko) * 2004-03-11 2006-05-22 부산대학교 산학협력단 골세포 배양기
US7482154B2 (en) * 2004-05-15 2009-01-27 Rensselaer Polytechnic Institute Diamagnetic force field bioreactor
WO2006050213A2 (en) * 2004-10-29 2006-05-11 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
US20090228113A1 (en) * 2008-03-05 2009-09-10 Comformis, Inc. Edge-Matched Articular Implant
EP1902128A4 (en) * 2005-07-12 2009-02-25 Tissue Genesis Inc APPARATUS AND METHODS FOR PREPARING TISSUE GRAFT
JP4778746B2 (ja) * 2005-07-29 2011-09-21 株式会社カネカ 細胞培養装置
EP1916964A4 (en) 2005-08-26 2015-11-04 Zimmer Inc IMPLANTS AND METHODS FOR THE REPAIR, REPLACEMENT AND TREATMENT OF JOINT DISEASES
JP4771123B2 (ja) * 2005-08-26 2011-09-14 独立行政法人物質・材料研究機構 二層バイオリアクター
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP1764117A1 (en) * 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
US7575589B2 (en) 2006-01-30 2009-08-18 Photothera, Inc. Light-emitting device and method for providing phototherapy to the brain
US10357662B2 (en) 2009-02-19 2019-07-23 Pthera LLC Apparatus and method for irradiating a surface with light
US20090254154A1 (en) * 2008-03-18 2009-10-08 Luis De Taboada Method and apparatus for irradiating a surface with pulsed light
US8764697B2 (en) * 2006-02-01 2014-07-01 Agathos Holdings Llc Systems and methods for an advanced medical device
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US7790437B2 (en) * 2006-12-14 2010-09-07 Biorep Technologies, Inc. Organ transportation device
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080221211A1 (en) * 2007-02-02 2008-09-11 Jackson Streeter Method of treatment of neurological injury or cancer by administration of dichloroacetate
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US9421304B2 (en) 2007-07-03 2016-08-23 Histogenics Corporation Method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant
US20090024224A1 (en) 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
EP2198303A4 (en) * 2007-09-10 2011-08-03 Cheryl A Nickerson BASED ON THE CULTURE OF MICRO-ORGANISMS UNDER LOW-DIMENT LIQUIDITY CONDITIONS AND METHODS OF COMPOSITION
US8852925B2 (en) * 2007-12-17 2014-10-07 The Charlotte-Mecklenburg Hospital Authority Bioreactor for cell growth and associated methods
US8682052B2 (en) 2008-03-05 2014-03-25 Conformis, Inc. Implants for altering wear patterns of articular surfaces
EP2303193A4 (en) 2008-05-12 2012-03-21 Conformis Inc DEVICES AND METHOD FOR TREATING CRANE AND OTHER JOINTS
AT506826B1 (de) * 2008-05-23 2010-03-15 Greiner Bio One Gmbh Bioreaktor und verfahren zum kultivieren von zellen und geweben
EP2130905A1 (en) 2008-06-04 2009-12-09 Pharmacell B.V. Method for culturing eukaryotic cells
US7848035B2 (en) * 2008-09-18 2010-12-07 Photothera, Inc. Single-use lens assembly
WO2010099231A2 (en) 2009-02-24 2010-09-02 Conformis, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
JP2012147678A (ja) * 2009-05-14 2012-08-09 Otake:Kk 一検体用多重培養装置
US8507263B2 (en) * 2009-08-07 2013-08-13 Maria Adelaide Asnaghi Rotating bioreactor
EP2509539B1 (en) 2009-12-11 2020-07-01 ConforMIS, Inc. Patient-specific and patient-engineered orthopedic implants
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
WO2012112702A2 (en) 2011-02-15 2012-08-23 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
EP2841010B1 (en) 2012-04-24 2023-08-23 Harvard Apparatus Regenerative Technology, Inc. Supports for engineered tissue scaffolds
US10449026B2 (en) 2012-06-26 2019-10-22 Biostage, Inc. Methods and compositions for promoting the structural integrity of scaffolds for tissue engineering
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
JP5913084B2 (ja) * 2012-12-26 2016-04-27 株式会社日立製作所 培養制御方法、細胞培養装置及び細胞特性評価装置
US11284987B2 (en) 2013-01-09 2022-03-29 Biostage, Inc. Synthetic scaffolds
ITFI20130220A1 (it) * 2013-09-20 2015-03-21 Azienda Ospedaliero Universitaria P Isana Apparato e processo per la preparazione di una protesi tissutale biomimetica della membrana timpanica
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10669516B2 (en) 2015-06-23 2020-06-02 The Board Of Regents Of The University Of Texas System Methods and apparatus for conditioning cell populations for cell therapies
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US10927341B2 (en) 2016-03-22 2021-02-23 University Of Maryland, Baltimore Multi-functional fluid flow device
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN115044471B (zh) 2016-08-27 2025-05-27 三维生物科技有限公司 生物反应器
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
WO2022204315A1 (en) 2021-03-23 2022-09-29 Terumo Bct, Inc. Cell capture and expansion
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
US12435312B2 (en) 2022-02-28 2025-10-07 Brown University Quantifying cell-derived changes in collagen synthesis, alignment, and mechanics in a 3D connective tissue model
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
JP2990789B2 (ja) * 1990-11-14 1999-12-13 東レ株式会社 血管内皮細胞の培養方法
GB9116036D0 (en) * 1991-07-25 1991-09-11 Univ Leicester Preparing grafts for implantation
WO1994025584A1 (en) * 1993-04-28 1994-11-10 Johns Hopkins University School Of Medicine Chronic endothelial cell culture under flow
JPH07274994A (ja) * 1994-04-08 1995-10-24 Asahi Chem Ind Co Ltd トロンボモジュリンの製造法
US5792603A (en) * 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts

Also Published As

Publication number Publication date
EP1019489A1 (en) 2000-07-19
DE69730251D1 (de) 2004-09-16
WO1998022573A1 (en) 1998-05-28
ATE273382T1 (de) 2004-08-15
AU5445198A (en) 1998-06-10
ES2225999T3 (es) 2005-03-16
CA2272547A1 (en) 1998-05-28
AU744686B2 (en) 2002-02-28
KR20000057136A (ko) 2000-09-15
EP1019489A4 (en) 2002-08-28
JP4014645B2 (ja) 2007-11-28
JP2001504697A (ja) 2001-04-10
DE69730251T2 (de) 2005-09-15
EP1019489B1 (en) 2004-08-11
US5928945A (en) 1999-07-27

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