JP4005637B2 - カルボキシドテルムス ヒドロゲノホルマンス由来の熱安定ｄｎａポリメラーゼ - Google Patents
カルボキシドテルムス ヒドロゲノホルマンス由来の熱安定ｄｎａポリメラーゼ Download PDFInfo
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- JP4005637B2 JP4005637B2 JP51624298A JP51624298A JP4005637B2 JP 4005637 B2 JP4005637 B2 JP 4005637B2 JP 51624298 A JP51624298 A JP 51624298A JP 51624298 A JP51624298 A JP 51624298A JP 4005637 B2 JP4005637 B2 JP 4005637B2
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- C—CHEMISTRY; METALLURGY
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP96115873A EP0834569A1 (en) | 1996-10-03 | 1996-10-03 | Thermostable DNA polymerase from carboxydothermus hydrogenoformans |
| EP96115873.0 | 1996-10-03 | ||
| PCT/EP1997/005391 WO1998014589A1 (en) | 1996-10-03 | 1997-10-01 | Thermostable dna polymerase from carboxydothermus hydrogenoformans |
Publications (3)
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| JP2001502170A JP2001502170A (ja) | 2001-02-20 |
| JP2001502170A5 JP2001502170A5 (enExample) | 2005-05-12 |
| JP4005637B2 true JP4005637B2 (ja) | 2007-11-07 |
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| JP51624298A Expired - Fee Related JP4005637B2 (ja) | 1996-10-03 | 1997-10-01 | カルボキシドテルムス ヒドロゲノホルマンス由来の熱安定ｄｎａポリメラーゼ |
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| EP (2) | EP0834569A1 (enExample) |
| JP (1) | JP4005637B2 (enExample) |
| AT (1) | ATE357527T1 (enExample) |
| AU (1) | AU717009B2 (enExample) |
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| DE (1) | DE69737502T2 (enExample) |
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| NZ (1) | NZ334652A (enExample) |
| RU (1) | RU2197524C2 (enExample) |
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Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0921196A1 (en) * | 1997-12-02 | 1999-06-09 | Roche Diagnostics GmbH | Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction |
| EP0922765B1 (en) * | 1997-12-02 | 2005-11-23 | Roche Diagnostics GmbH | Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction |
| US20030228616A1 (en) * | 1999-10-29 | 2003-12-11 | Stratagene | DNA polymerase mutants with reverse transcriptase activity |
| US20040009486A1 (en) * | 1999-10-29 | 2004-01-15 | Sorge Joseph A. | Compositions and methods utilizing DNA polymerases |
| US20050123940A1 (en) * | 1999-10-29 | 2005-06-09 | Stratagene California | Compositions and methods for synthesizing cDNA |
| WO2006033665A1 (en) | 2004-03-16 | 2006-03-30 | Inist Inc. | Tat-based vaccine compositions and methods of making and using same |
| ATE427992T1 (de) * | 2001-11-14 | 2009-04-15 | Toyo Boseki | Dna-synthesepromotoren, mit dna-polymerase assoziierte faktoren und nutzung davon |
| BRPI0408967B8 (pt) | 2003-03-31 | 2021-07-27 | Hoffmann La Roche | kit e métodos para detecção de um ácido nucléico de vários membros do sorogrupo do vírus da encefalite japonesa em uma amostra biológica sob condições de hibridização rigorosas |
| US8962293B2 (en) | 2006-10-18 | 2015-02-24 | Roche Molecular Systems, Inc. | DNA polymerases and related methods |
| ES2432863T3 (es) | 2009-03-23 | 2013-12-05 | Pin Pharma, Inc. | Tratamiento del cáncer con polipéptidos inmunoestimuladores derivados de Tat del VIH |
| CN103025867B (zh) | 2010-06-18 | 2015-05-20 | 霍夫曼-拉罗奇有限公司 | 具有增强的3’-错配辨别力的dna聚合酶 |
| EP2582806B1 (en) | 2010-06-18 | 2015-12-16 | Roche Diagnostics GmbH | Dna polymerases with increased 3'-mismatch discrimination |
| EP2582807B1 (en) | 2010-06-18 | 2015-03-18 | Roche Diagnostics GmbH | Dna polymerases with increased 3'-mismatch discrimination |
| CA2802304C (en) | 2010-06-18 | 2016-01-12 | F.Hoffman-La Roche Ag | Dna polymerases with increased 3'-mismatch discrimination |
| WO2011157436A1 (en) | 2010-06-18 | 2011-12-22 | Roche Diagnostics Gmbh | Dna polymerases with increased 3'-mismatch discrimination |
| WO2011157432A1 (en) | 2010-06-18 | 2011-12-22 | Roche Diagnostics Gmbh | Dna polymerases with increased 3'-mismatch discrimination |
| EP2582802B1 (en) | 2010-06-18 | 2016-01-13 | Roche Diagnostics GmbH | Dna polymerases with increased 3'-mismatch discrimination |
| US8759062B2 (en) | 2010-06-18 | 2014-06-24 | Roche Molecular Systems, Inc. | DNA polymerases with increased 3′- mismatch discrimination |
| EP2675897B1 (en) | 2011-02-15 | 2016-05-11 | Roche Diagnostics GmbH | Dna polymerases with increased 3'-mismatch discrimination |
| EP2697372B1 (en) | 2011-04-11 | 2015-12-16 | Roche Diagnostics GmbH | Dna polymerases with improved activity |
| US9090883B2 (en) | 2011-07-28 | 2015-07-28 | Roche Molecular Systems, Inc. | DNA polymerases with improved activity |
| WO2013083262A1 (en) | 2011-12-08 | 2013-06-13 | Roche Diagnostics Gmbh | Dna polymerases with improved activity |
| JP6144697B2 (ja) | 2011-12-08 | 2017-06-07 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 改善された活性を有するｄｎａポリメラーゼ |
| ES2569723T3 (es) | 2011-12-08 | 2016-05-12 | F. Hoffmann-La Roche Ag | Polimerasas de DNA con actividad mejorada |
| US9663556B2 (en) | 2013-10-04 | 2017-05-30 | Pin Pharma, Inc. | Treatment of cancers with immunostimulatory HIV tat derivative polypeptides |
| WO2019180137A1 (en) | 2018-03-21 | 2019-09-26 | F. Hoffmann-La Roche Ag | Dna polymerases for efficient and effective incorporation of methylated-dntps |
| CN112703248B (zh) | 2018-09-13 | 2025-03-25 | 豪夫迈·罗氏有限公司 | 具有改良链置换能力的突变型dna聚合酶 |
| CN111733145A (zh) * | 2020-07-01 | 2020-10-02 | 济南国科医工科技发展有限公司 | 重组酶的纯化方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5374553A (en) * | 1986-08-22 | 1994-12-20 | Hoffmann-La Roche Inc. | DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima |
| US5912155A (en) * | 1994-09-30 | 1999-06-15 | Life Technologies, Inc. | Cloned DNA polymerases from Thermotoga neapolitana |
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1996
- 1996-10-03 EP EP96115873A patent/EP0834569A1/en not_active Withdrawn
-
1997
- 1997-10-01 NZ NZ334652A patent/NZ334652A/xx not_active IP Right Cessation
- 1997-10-01 DE DE69737502T patent/DE69737502T2/de not_active Expired - Lifetime
- 1997-10-01 AT AT97913133T patent/ATE357527T1/de active
- 1997-10-01 EP EP97913133A patent/EP0929680B1/en not_active Expired - Lifetime
- 1997-10-01 AU AU50495/98A patent/AU717009B2/en not_active Ceased
- 1997-10-01 WO PCT/EP1997/005391 patent/WO1998014589A1/en not_active Ceased
- 1997-10-01 JP JP51624298A patent/JP4005637B2/ja not_active Expired - Fee Related
- 1997-10-01 CA CA002268014A patent/CA2268014C/en not_active Expired - Fee Related
- 1997-10-01 US US09/269,861 patent/US6468775B1/en not_active Expired - Lifetime
- 1997-10-01 IL IL129085A patent/IL129085A/en not_active IP Right Cessation
- 1997-10-01 RU RU99109121/13A patent/RU2197524C2/ru not_active IP Right Cessation
-
1999
- 1999-03-30 NO NO19991568A patent/NO323846B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6468775B1 (en) | 2002-10-22 |
| CA2268014C (en) | 2008-01-15 |
| DE69737502D1 (en) | 2007-05-03 |
| NO991568L (no) | 1999-06-02 |
| NZ334652A (en) | 2000-03-27 |
| AU5049598A (en) | 1998-04-24 |
| CA2268014A1 (en) | 1998-04-09 |
| EP0929680A1 (en) | 1999-07-21 |
| AU717009B2 (en) | 2000-03-16 |
| RU2197524C2 (ru) | 2003-01-27 |
| ATE357527T1 (de) | 2007-04-15 |
| JP2001502170A (ja) | 2001-02-20 |
| WO1998014589A1 (en) | 1998-04-09 |
| EP0834569A1 (en) | 1998-04-08 |
| IL129085A0 (en) | 2000-02-17 |
| NO991568D0 (no) | 1999-03-30 |
| EP0929680B1 (en) | 2007-03-21 |
| DE69737502T2 (de) | 2007-10-31 |
| IL129085A (en) | 2006-12-10 |
| NO323846B1 (no) | 2007-07-09 |
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