JP3672575B2 - 薬剤の結晶変形 - Google Patents

薬剤の結晶変形 Download PDF

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Publication number
JP3672575B2
JP3672575B2 JP53628998A JP53628998A JP3672575B2 JP 3672575 B2 JP3672575 B2 JP 3672575B2 JP 53628998 A JP53628998 A JP 53628998A JP 53628998 A JP53628998 A JP 53628998A JP 3672575 B2 JP3672575 B2 JP 3672575B2
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Japan
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weak
strong
crystal
deformation
crystal deformation
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JP53628998A
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Japanese (ja)
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JP2000516259A (ja
Inventor
ポルトマン，ローベルト
ホフマイヤー，ウーアス・クリストフ
ブルクハルト，アンドレーアス
シェラー，ヴァルター
スツェラギーヴィックツ，マルティーン
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ノバルティス アクチエンゲゼルシャフト
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Application filed by ノバルティス アクチエンゲゼルシャフト filed Critical ノバルティス アクチエンゲゼルシャフト
Publication of JP2000516259A publication Critical patent/JP2000516259A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP53628998A 1997-06-10 1998-06-08 薬剤の結晶変形 Expired - Lifetime JP3672575B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1404/97 1997-06-10
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (2)

Publication Number Publication Date
JP2000516259A JP2000516259A (ja) 2000-12-05
JP3672575B2 true JP3672575B2 (ja) 2005-07-20

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ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
JP53628998A Expired - Lifetime JP3672575B2 (ja) 1997-06-10 1998-06-08 薬剤の結晶変形
JP53628898A Expired - Lifetime JP3672574B2 (ja) 1997-06-10 1998-06-08 薬剤の結晶変形

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP53628898A Expired - Lifetime JP3672574B2 (ja) 1997-06-10 1998-06-08 薬剤の結晶変形

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
WO2003101991A1 (en) * 2002-05-31 2003-12-11 Schering Corporation Xanthine phosphodiesterase v inhibitor polymorphs
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
US8183269B2 (en) 2008-10-13 2012-05-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
AU2010290049B2 (en) * 2009-09-04 2013-09-19 Tactical Therapeutics, Inc Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
JP2013525413A (ja) * 2010-04-30 2013-06-20 ラボラトリオス レスヴィ，エス．エル． ルフィナマイド中間体の改良された製造方法
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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US4156734A (en) 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
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US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A7 (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
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CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
JPH04506967A (ja) 1989-07-27 1992-12-03 ジー．ディー．サール　アンド　カンパニー 高血圧症治療用腎選択性生成物
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
AU656154B2 (en) 1990-11-06 1995-01-27 Astellas Pharma Inc. Fused pyrazine derivative
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
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US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
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Publication number Publication date
US20010037029A1 (en) 2001-11-01
CY2007014I1 (el) 2009-11-04
WO1998056772A1 (en) 1998-12-17
IL125732A (en) 2002-12-01
TR199801630T1 (xx) 1999-06-21
CN1259127A (zh) 2000-07-05
PL191943B1 (pl) 2006-07-31
JP3672574B2 (ja) 2005-07-20
US20040167186A1 (en) 2004-08-26
CO4940448A1 (es) 2000-07-24
CY2007014I2 (el) 2009-11-04
ID27660A (id) 2001-04-19
ZA984966B (en) 1999-01-11
SI0994864T1 (en) 2003-10-31
CN1132820C (zh) 2003-12-31
PL330798A1 (en) 1999-06-07
US6740669B1 (en) 2004-05-25
NO983667L (no) 1998-12-17
KR100409168B1 (ko) 2004-01-31
ZA984967B (en) 1999-01-11
RU2194041C2 (ru) 2002-12-10
ID21014A (id) 1999-04-08
LU91345I2 (fr) 2007-09-04
KR19990087836A (ko) 1999-12-27
MY120156A (en) 2005-09-30
DE69813560D1 (de) 2003-05-22
CN1159300C (zh) 2004-07-28
AU8437198A (en) 1998-12-30
DE122007000051I2 (de) 2009-02-19
MY125854A (en) 2006-08-30
CZ253398A3 (cs) 1999-04-14
PE80999A1 (es) 1999-09-06
DE122007000051I1 (de) 2007-11-08
US20100310655A1 (en) 2010-12-09
DK0994864T3 (da) 2003-07-21
US20030125568A1 (en) 2003-07-03
ATE237599T1 (de) 2003-05-15
US20060116520A1 (en) 2006-06-01
ES2192779T3 (es) 2003-10-16
HU226107B1 (en) 2008-04-28
RU2198167C2 (ru) 2003-02-10
TW526195B (en) 2003-04-01
DE69811500T2 (de) 2004-04-01
DE69811500D1 (de) 2003-03-27
EP0994864B1 (en) 2003-04-16
HK1028242A1 (en) 2001-02-09
CZ292481B6 (cs) 2003-09-17
HU225153B1 (en) 2006-07-28
DK0994863T3 (da) 2003-05-26
NZ331370A (en) 2000-08-25
ES2197485T3 (es) 2004-01-01
KR100425656B1 (ko) 2004-05-17
NO329314B1 (no) 2010-09-27
CZ292260B6 (cs) 2003-08-13
US7750028B2 (en) 2010-07-06
LU91345I9 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2018-12-31
AR012945A1 (es) 2000-11-22
NO983666L (no) 1998-12-17
HUP0002113A3 (en) 2002-09-30
JP2000516259A (ja) 2000-12-05
HUP0000798A2 (hu) 2000-10-30
AU8437298A (en) 1998-12-30
SK109498A3 (en) 1998-12-02
HK1028031A1 (en) 2001-02-02
ATE232852T1 (de) 2003-03-15
PT994864E (pt) 2003-07-31
TW403740B (en) 2000-09-01
EP0994864A1 (en) 2000-04-26
PL330764A1 (en) 1999-05-24
NZ331371A (en) 2000-08-25
CN1572789A (zh) 2005-02-02
NL300284I2 (nl) 2007-11-01
KR19990087835A (ko) 1999-12-27
CA2614926A1 (en) 1998-12-17
US8076362B2 (en) 2011-12-13
AU725517B2 (en) 2000-10-12
CA2256013A1 (en) 1998-12-17
UY25844A1 (es) 2001-08-27
NO329315B1 (no) 2010-09-27
AR061004A2 (es) 2008-07-30
HUP0000798A3 (en) 2000-10-30
IL125732A0 (en) 1999-04-11
BR9804946A (pt) 1999-08-24
US6455556B2 (en) 2002-09-24
HUP0002113A2 (hu) 2001-02-28
EP0994863B1 (en) 2003-02-19
IL125733A0 (en) 1999-04-11
SK283685B6 (sk) 2003-12-02
BR9804947A (pt) 1999-08-24
AR012946A1 (es) 2000-11-22
CZ253498A3 (cs) 1999-04-14
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
NO983666D0 (no) 1998-08-11
FR07C0037I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2007-08-17
CN1298708C (zh) 2007-02-07
CA2256015A1 (en) 1998-12-17
PE79799A1 (es) 1999-09-03
AU725528B2 (en) 2000-10-12
IL125733A (en) 2002-12-01
SK109398A3 (en) 1998-12-02
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
TR199801631T1 (xx) 1999-06-21
CA2614926C (en) 2010-02-09
AR061005A2 (es) 2008-07-30
CA2256013C (en) 2007-10-16
HK1028241A1 (en) 2001-02-09
CN1217716A (zh) 1999-05-26
FR07C0037I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2008-05-16
SI0994863T1 (en) 2003-08-31
CO4940452A1 (es) 2000-07-24
DE69813560T2 (de) 2004-02-05
PL192114B1 (pl) 2006-08-31
EP0994863A1 (en) 2000-04-26
JP2000516258A (ja) 2000-12-05
CA2256015C (en) 2008-06-03

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