JP3657008B2 - １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン - Google Patents

１−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン Download PDF

Info

Publication number
JP3657008B2
JP3657008B2 JP52839997A JP52839997A JP3657008B2 JP 3657008 B2 JP3657008 B2 JP 3657008B2 JP 52839997 A JP52839997 A JP 52839997A JP 52839997 A JP52839997 A JP 52839997A JP 3657008 B2 JP3657008 B2 JP 3657008B2
Authority
JP
Japan
Prior art keywords
formula
compound
group
fluoro
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP52839997A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO1997038001A1 (ja
Inventor
祐一 吉村
健司 北濃
信仕 三浦
治彦 町田
美華理 渡辺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Corp
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of JPWO1997038001A1 publication Critical patent/JPWO1997038001A1/ja
Application granted granted Critical
Publication of JP3657008B2 publication Critical patent/JP3657008B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP52839997A 1996-04-09 1997-04-09 １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン Expired - Lifetime JP3657008B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP11196896 1996-04-09
JP8-111968 1996-04-09
JP21508296 1996-07-26
JP8-215082 1996-07-26
JP27863196 1996-09-30
JP8-278631 1996-09-30
PCT/JP1997/001206 WO1997038001A1 (en) 1996-04-09 1997-04-09 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005000222A Division JP4202327B2 (ja) 1996-04-09 2005-01-04 １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン

Publications (2)

Publication Number Publication Date
JPWO1997038001A1 JPWO1997038001A1 (ja) 1998-09-08
JP3657008B2 true JP3657008B2 (ja) 2005-06-08

Family

ID=27312140

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52839997A Expired - Lifetime JP3657008B2 (ja) 1996-04-09 1997-04-09 １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン

Country Status (10)

Country Link
US (1) US6147058A (ref)
EP (1) EP0841344B1 (ref)
JP (1) JP3657008B2 (ref)
AT (1) ATE224909T1 (ref)
CA (1) CA2224155C (ref)
DE (1) DE69715774T2 (ref)
DK (1) DK0841344T3 (ref)
ES (1) ES2182061T3 (ref)
PT (1) PT841344E (ref)
WO (1) WO1997038001A1 (ref)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
EP1058686B1 (en) * 1998-02-25 2006-11-02 Emory University 2'-fluoronucleosides
JP5379347B2 (ja) * 2003-09-18 2013-12-25 アイシス ファーマシューティカルズ， インコーポレーテッド ４’−チオヌクレオシドおよびオリゴマー化合物
US7524831B2 (en) * 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
PH12012501205A1 (en) 2009-12-18 2016-07-15 Libramedicina Inc Process for preparing substituted 1-o-acyl-2-deoxy-2-fluoro-4-thio-ãŸ-d-arabinofuranoses
EP2388257A1 (en) 2010-05-20 2011-11-23 LibraMedicina, Inc. Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses
SG10201603288XA (en) 2012-03-28 2016-05-30 Fujifilm Corp Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine
KR20170001722A (ko) 2012-08-13 2017-01-04 후지필름 가부시키가이샤 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6175553B2 (ja) * 2014-02-18 2017-08-09 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) * 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
CN109553651B (zh) * 2015-04-03 2021-08-06 四川科伦博泰生物医药股份有限公司 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
BR112019003946A2 (pt) * 2016-08-31 2019-05-21 Fujifilm Corporation agente antitumoral, reforçador do efeito antitumoral e kit antitumoral
EA201990780A1 (ru) 2016-12-22 2019-11-29 Твердая форма соединения 4'-тио-2'-фторнуклеозид фосфамида и способ его получения и применения
CN110831604B (zh) * 2017-09-01 2023-05-02 四川科伦博泰生物医药股份有限公司 用于肿瘤治疗或预防的药物组合物、方法及其用途
WO2019146129A1 (ja) * 2018-01-29 2019-08-01 富士フイルム株式会社 イソクエン酸デヒドロゲナーゼ変異を有する腫瘍に対する医薬組成物および抗腫瘍剤ならびにその利用
MX2018002611A (es) 2018-01-29 2019-07-30 Fujifilm Corp Agente antitumoral para cancer del tracto biliar y metodo para tratar cancer del tracto biliar.
TW202000207A (zh) * 2018-02-26 2020-01-01 日商富士軟片股份有限公司 膀胱癌用抗腫瘤劑及膀胱癌的處置方法
JP6974585B2 (ja) 2018-03-13 2021-12-01 富士フイルム株式会社 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット
EP3856754A1 (en) * 2018-09-25 2021-08-04 The United States of America, as represented by the Secretary, Department of Health and Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
WO2020108343A1 (zh) * 2018-11-28 2020-06-04 四川科伦博泰生物医药股份有限公司 以4'-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
EP4004013A4 (en) * 2019-07-30 2023-08-09 Pinotbio, Inc. DINUCLEOTIDE COMPOUNDS FOR THE TREATMENT OF CANCER AND THEIR MEDICAL USES
WO2023008511A1 (ja) 2021-07-29 2023-02-02 富士フイルム株式会社 Ｂａｐ１およびｐｂｒｍ１の少なくとも１つの機能低下を有する腫瘍に対する医薬組成物および抗腫瘍剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
EP0770621A4 (en) * 1994-07-12 1998-01-28 Yamasa Corp 2'-DEOXY-2 '(SUBSTITUTED OR Unsubstituted METHYLIDENE) -4-THIONUCLEOSIDE
JPH0853490A (ja) * 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

Also Published As

Publication number Publication date
DE69715774D1 (de) 2002-10-31
EP0841344A4 (ref) 1998-05-13
DK0841344T3 (da) 2002-12-23
DE69715774T2 (de) 2003-05-15
EP0841344A1 (en) 1998-05-13
CA2224155A1 (en) 1997-10-16
ATE224909T1 (de) 2002-10-15
CA2224155C (en) 2004-10-26
US6147058A (en) 2000-11-14
PT841344E (pt) 2003-02-28
EP0841344B1 (en) 2002-09-25
ES2182061T3 (es) 2003-03-01
WO1997038001A1 (en) 1997-10-16

Similar Documents

Publication Publication Date Title
EP0841344B1 (en) 1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)cytosines
JPWO1997038001A1 (ja) １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン
JP5213194B2 (ja) ４’−ｃ−置換−２−ハロアデノシン誘導体
US8058424B2 (en) Synthesis of 5-azacytidine
EP0193903B1 (en) Production of cytosine nucleosides
JP2008069182A (ja) ４’−ｃ−置換−２−ハロアデノシン誘導体
US6103707A (en) 9-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)purine derivatives
JPH06228186A (ja) ２’−デオキシ−（２’ｓ）−アルキルピリミジンヌクレオシド誘導体
JP4202327B2 (ja) １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン
EP1373288B1 (en) Process for the preparation of 2'-halo-beta-l-arabinofuranosyl nucleosides
JPH09328497A (ja) ４’−フルオロメチルヌクレオシド
US5811408A (en) 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
JPH0853490A (ja) ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド
EP0500610A1 (en) Nucleoside derivatives
JPH06211890A (ja) ２’−デオキシ−２’（ｓ）−置換アルキルシチジン誘導体
JP4211901B2 (ja) ４’−メチルヌクレオシド化合物
JP2665527B2 (ja) ２’−デオキシ−２’−メチリデンピリミジンヌクレオチド化合物
JPH09249690A (ja) ４’−チオアラビノプリンヌクレオシド
JPH1087687A (ja) ５−置換−１−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）ウラシル
WO2003068796A1 (en) 4’-c-cyano-2’-deoxypurine nucleosides
JPWO1996001834A1 (ja) ２′−デオキシ−２′−（置換または非置換）メチリデン−４′−チオヌクレオシド
JPH11217396A (ja) ヌクレオシド誘導体の製造方法
JPWO1997037993A1 (ja) ９−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）プリン誘導体
JPH0987295A (ja) ２’−デオキシ−２’−メチリデン−４’−チオピリミジンヌクレオシド及び抗ウイルス剤
JPH10168096A (ja) ２’−アジド−２’−デオキシ−４’−チオリボヌクレオシド

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20041116

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050104

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20050301

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20050308

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20170318

Year of fee payment: 12

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20170318

Year of fee payment: 12

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20180318

Year of fee payment: 13

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20180318

Year of fee payment: 13

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20180318

Year of fee payment: 13

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

EXPY Cancellation because of completion of term