JP3429338B2 - 新規なアリールグリシンアミド誘導体及びその製造法 - Google Patents

新規なアリールグリシンアミド誘導体及びその製造法

Info

Publication number
JP3429338B2
JP3429338B2 JP19688293A JP19688293A JP3429338B2 JP 3429338 B2 JP3429338 B2 JP 3429338B2 JP 19688293 A JP19688293 A JP 19688293A JP 19688293 A JP19688293 A JP 19688293A JP 3429338 B2 JP3429338 B2 JP 3429338B2
Authority
JP
Japan
Prior art keywords
group
carbon atoms
lower alkyl
alkyl group
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP19688293A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0692921A (ja
Inventor
弘幸 宮地
満 瀬川
恵美子 田上
秀夫 大久保
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP19688293A priority Critical patent/JP3429338B2/ja
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to US08/093,854 priority patent/US5439919A/en
Priority to HUP9302090A priority patent/HU215846B/hu
Priority to DE69305276T priority patent/DE69305276T2/de
Priority to ES93111592T priority patent/ES2093332T3/es
Priority to AT93111592T priority patent/ATE143943T1/de
Priority to EP93111592A priority patent/EP0581167B1/en
Priority to AU42169/93A priority patent/AU658316B2/en
Priority to TW082105885A priority patent/TW271435B/zh
Priority to KR1019930014143A priority patent/KR100295027B1/ko
Priority to CA002101310A priority patent/CA2101310C/en
Publication of JPH0692921A publication Critical patent/JPH0692921A/ja
Application granted granted Critical
Publication of JP3429338B2 publication Critical patent/JP3429338B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP19688293A 1992-07-27 1993-07-14 新規なアリールグリシンアミド誘導体及びその製造法 Expired - Fee Related JP3429338B2 (ja)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP19688293A JP3429338B2 (ja) 1992-07-27 1993-07-14 新規なアリールグリシンアミド誘導体及びその製造法
HUP9302090A HU215846B (hu) 1992-07-27 1993-07-20 Eljárás aril-glicin-amid-származékok előállítására
DE69305276T DE69305276T2 (de) 1992-07-27 1993-07-20 Arylglycinamidderivate, Verfahren zur deren Herstellung und deren Verwendung zur Therapie der Dysurie
ES93111592T ES2093332T3 (es) 1992-07-27 1993-07-20 Nuevos derivados arilglicinamidicos, su procedimiento de preparacion y su uso para el tratamiento de la disuria.
AT93111592T ATE143943T1 (de) 1992-07-27 1993-07-20 Arylglycinamidderivate, verfahren zur deren herstellung und deren verwendung zur therapie der dysurie
EP93111592A EP0581167B1 (en) 1992-07-27 1993-07-20 Novel arylglycinamide derivatives and preparative processes therefor and their use for treatment of dysuria
US08/093,854 US5439919A (en) 1992-07-27 1993-07-20 Arylglycinamide derivatives and preparative processes therefor
AU42169/93A AU658316B2 (en) 1992-07-27 1993-07-23 Novel arylglycinamide derivatives and preparative processes therefor
TW082105885A TW271435B (en:Method) 1992-07-27 1993-07-23
KR1019930014143A KR100295027B1 (ko) 1992-07-27 1993-07-26 아릴글리신아미드유도체,이의제조방법및활성성분으로서이를함유하는배뇨장해치료제
CA002101310A CA2101310C (en) 1992-07-27 1993-07-26 Novel arylglycinamide derivatives and preparative processes therefor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4-219699 1992-07-27
JP21969992 1992-07-27
JP19688293A JP3429338B2 (ja) 1992-07-27 1993-07-14 新規なアリールグリシンアミド誘導体及びその製造法

Publications (2)

Publication Number Publication Date
JPH0692921A JPH0692921A (ja) 1994-04-05
JP3429338B2 true JP3429338B2 (ja) 2003-07-22

Family

ID=26510045

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19688293A Expired - Fee Related JP3429338B2 (ja) 1992-07-27 1993-07-14 新規なアリールグリシンアミド誘導体及びその製造法

Country Status (11)

Country Link
US (1) US5439919A (en:Method)
EP (1) EP0581167B1 (en:Method)
JP (1) JP3429338B2 (en:Method)
KR (1) KR100295027B1 (en:Method)
AT (1) ATE143943T1 (en:Method)
AU (1) AU658316B2 (en:Method)
CA (1) CA2101310C (en:Method)
DE (1) DE69305276T2 (en:Method)
ES (1) ES2093332T3 (en:Method)
HU (1) HU215846B (en:Method)
TW (1) TW271435B (en:Method)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5706027A (en) * 1985-12-18 1998-01-06 Spacetec Imc Corporation Force and torque converter for use in a computer input device
DE4344648A1 (de) * 1993-12-24 1995-06-29 Dresden Arzneimittel Neue Aminocarbonsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2179574A1 (en) * 1995-06-26 1996-12-27 Tomomi Okada Substituted piperidine derivative and medicine comprising the same
EP0882699A4 (en) * 1996-08-06 2001-03-21 Taisho Pharmaceutical Co Ltd AMINO CONNECTIONS AND ANGIOTENSIN IV RECEPTOR AGONISTS
DE10111058A1 (de) * 2001-03-08 2002-09-12 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und NK¶1¶-Rezeptor-Antagonisten
US6620438B2 (en) 2001-03-08 2003-09-16 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics and NK1-receptor antagonists
DE10143009A1 (de) * 2001-09-03 2003-03-20 Molecular And Clinical Drug Re Präparat zur Behandlung weiblicher Inkontinenz
JP4589007B2 (ja) * 2002-04-12 2010-12-01 ヘンリー ケイ． オバーマイヤー， 多軸ジョイスティックおよびそのためのトランスデューサー手段
JP2006502985A (ja) 2002-07-08 2006-01-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体拮抗剤として有用な３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体
EP1546098B1 (en) 2002-07-31 2008-05-28 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
EP1545508A4 (en) 2002-08-09 2009-11-25 Ranbaxy Lab Ltd 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS
WO2004018422A1 (en) 2002-08-23 2004-03-04 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
EP2177511A2 (en) 2002-12-10 2010-04-21 Ranbaxy Laboratories Limited Process for preparing 3,6-disubstituted azabicyclo derivatives
EP1583741A1 (en) 2002-12-23 2005-10-12 Ranbaxy Laboratories, Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
ATE386738T1 (de) 2002-12-23 2008-03-15 Ranbaxy Lab Ltd Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1618091A1 (en) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP2006514978A (ja) 2003-04-10 2006-05-18 ランバクシー ラボラトリーズ リミテッド ムスカリン受容体アンタゴニストである置換アザビシクロヘキサン誘導体
EP1615887A1 (en) 2003-04-10 2006-01-18 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EA009387B1 (ru) 2003-04-11 2007-12-28 Рэнбакси Лабораториз Лимитед Азабициклические производные в качестве антагонистов мускаринового рецептора
US20070203139A1 (en) * 2004-04-14 2007-08-30 Astrazeneca Ab Aryl Glycinamide Derivatives And Their Use As Nk1 Antagonists And Serotonin Reuptake Inhibitors
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
EP1889612A3 (en) * 2006-07-24 2008-03-19 Jan Kees Piet Bruinstroop Method for controlling micturition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1269556A (fr) * 1956-05-14 1961-08-18 Upjohn Co Procédé de préparation de nu-mono-substituées-alpha-(tertio-aminoalcoyl)-alphaphénylacétamides
US4783537A (en) * 1985-11-13 1988-11-08 Pennwalt Corporation α-(aminoalkyl)-arylacetic acid derivatives
JPH0783006B2 (ja) * 1987-12-23 1995-09-06 株式会社半導体エネルギー研究所 薄膜加工方法
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia

Also Published As

Publication number Publication date
JPH0692921A (ja) 1994-04-05
DE69305276T2 (de) 1997-04-30
HU9302090D0 (en) 1993-10-28
TW271435B (en:Method) 1996-03-01
EP0581167A1 (en) 1994-02-02
KR940005534A (ko) 1994-03-21
ES2093332T3 (es) 1996-12-16
CA2101310C (en) 2001-07-03
AU658316B2 (en) 1995-04-06
US5439919A (en) 1995-08-08
HUT64944A (en) 1994-03-28
KR100295027B1 (ko) 2001-09-17
AU4216993A (en) 1994-02-03
EP0581167B1 (en) 1996-10-09
HU215846B (hu) 1999-04-28
CA2101310A1 (en) 1994-01-28
DE69305276D1 (de) 1996-11-14
ATE143943T1 (de) 1996-10-15

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