ES2093332T3 - Nuevos derivados arilglicinamidicos, su procedimiento de preparacion y su uso para el tratamiento de la disuria. - Google Patents

Nuevos derivados arilglicinamidicos, su procedimiento de preparacion y su uso para el tratamiento de la disuria.

Info

Publication number
ES2093332T3
ES2093332T3 ES93111592T ES93111592T ES2093332T3 ES 2093332 T3 ES2093332 T3 ES 2093332T3 ES 93111592 T ES93111592 T ES 93111592T ES 93111592 T ES93111592 T ES 93111592T ES 2093332 T3 ES2093332 T3 ES 2093332T3
Authority
ES
Spain
Prior art keywords
carbon atoms
group
denotes
lower alkyl
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93111592T
Other languages
English (en)
Inventor
Hiroyuki Miyachi
Mitsuru Segawa
Emiko Tagami
Hideo Okubo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2093332T3 publication Critical patent/ES2093332T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Abstract

DERIVADOS DE ARILGLICINAMIDAS REPRESENTADOS POR LA FORMULA GENERAL (1), (EN DONDE AR MUESTRA UN GRUPO FENIL QUE PUEDE TENER DE 1 A 3 SUBSTITUYENTES O UN GRUPO NAFTIL QUE PUEDE TENER DE 1 A 3 SUBSTITUYENTES, R1 Y R4 PRESENTAN IDENTICAMENTE O DE FORMA DIFERENTE ATOMOS DE HIDROGENO O GRUPOS ALQUIL INFERIOR CON 1 A 3 ATOMOS DE CARBONO, R2 MUESTRA UN GRUPO ALQUIL INFERIOR CON 1 A 6 ATOMOS DE CARBONO, UN GRUPO CICLOALQUIL CON 3 A 6 ATOMOS DE CARBONO, UN GRUPO ALQUIL INFERIOR CON 1 A 4 ATOMOS DE CARBONO QUE PUEDE TENER UN GRUPO FENIL QUE A SU VEZ PUEDE TENER DE 1 A 3 SUBSTITUYENTES, UN GRUPO NORBORNIL, UN GRUPO FENIL O UN GRUPO ADAMANTIL QUE PUEDE TENER DE 1 A 3 SUBSTITUYENTES, R3 MUESTRA UN ATOMO DE HIDROGENO O UN GRUPO ALQUIL INFERIOR CON 1 A 6 ATOMOS DE CARBONO O PUEDE FORMAR UN ANILLO CONSTITUYENDO ALQUILENO JUNTO CON R2, R5 MUESTRA UN GRUPO ALQUIL INFERIOR CON 1 A 6 ATOMOS DE CARBONO O UN GRUPO CICLOALQUIL CON 5 O 6 ATOMOS DE CARBONO, R6 MUESTRA UN ATOMO DE HIDROGENO O GRUPO ALQUIL INFERIOR CON 1 A 6 ATOMOS DE CARBONO O PUEDE FORMAR UN ANILLO CONSTITUYENDO ALQUILENO JUNTO CON R5, Y M ES 2 O 3), Y SUS SALES, QUE FUNCIONAN COMO MEDICAMENTOS TERAPEUTICAMENTE EFECTIVOS PARA LAS DISURIAS TAL COMO LA INCONTINENCIA URINARIA Y POLIACURIA, Y LOS PROCESOS DE PREPARACION DE LOS MISMOS.
ES93111592T 1992-07-27 1993-07-20 Nuevos derivados arilglicinamidicos, su procedimiento de preparacion y su uso para el tratamiento de la disuria. Expired - Lifetime ES2093332T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21969992 1992-07-27
JP19688293A JP3429338B2 (ja) 1992-07-27 1993-07-14 新規なアリールグリシンアミド誘導体及びその製造法

Publications (1)

Publication Number Publication Date
ES2093332T3 true ES2093332T3 (es) 1996-12-16

Family

ID=26510045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93111592T Expired - Lifetime ES2093332T3 (es) 1992-07-27 1993-07-20 Nuevos derivados arilglicinamidicos, su procedimiento de preparacion y su uso para el tratamiento de la disuria.

Country Status (11)

Country Link
US (1) US5439919A (es)
EP (1) EP0581167B1 (es)
JP (1) JP3429338B2 (es)
KR (1) KR100295027B1 (es)
AT (1) ATE143943T1 (es)
AU (1) AU658316B2 (es)
CA (1) CA2101310C (es)
DE (1) DE69305276T2 (es)
ES (1) ES2093332T3 (es)
HU (1) HU215846B (es)
TW (1) TW271435B (es)

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US5706027A (en) * 1985-12-18 1998-01-06 Spacetec Imc Corporation Force and torque converter for use in a computer input device
CA2179574A1 (en) 1995-06-26 1996-12-27 Tomomi Okada Substituted piperidine derivative and medicine comprising the same
CA2242571C (en) * 1996-08-06 2006-05-16 Taisho Pharmaceutical Co., Ltd. Amino compounds and angiotensin iv receptor agonists
US6620438B2 (en) 2001-03-08 2003-09-16 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics and NK1-receptor antagonists
DE10111058A1 (de) * 2001-03-08 2002-09-12 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und NK¶1¶-Rezeptor-Antagonisten
DE10143009A1 (de) * 2001-09-03 2003-03-20 Molecular And Clinical Drug Re Präparat zur Behandlung weiblicher Inkontinenz
EP1514257A4 (en) 2002-04-12 2015-12-30 Henry K Obermeyer MANIFOLD WITH MULTIPLE AXES AND MEDIUM TRANSDUCER
CN1668585A (zh) 2002-07-08 2005-09-14 兰贝克赛实验室有限公司 用作蝇蕈碱受体拮抗剂的3,6－二取代氮杂双环[3.1.0]己烷衍生物
DE60226906D1 (de) 2002-07-31 2008-07-10 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen
WO2004014363A1 (en) 2002-08-09 2004-02-19 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist
EP1534675B1 (en) 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists
DE60227576D1 (de) 2002-12-10 2008-08-21 Ranbaxy Lab Ltd 3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS
AU2002347552A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
ATE386738T1 (de) 2002-12-23 2008-03-15 Ranbaxy Lab Ltd Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003214520A1 (en) 2003-04-09 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
ATE362364T1 (de) 2003-04-10 2007-06-15 Ranbaxy Lab Ltd Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
AU2003223010A1 (en) 2003-04-10 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
BRPI0409302A (pt) 2003-04-11 2006-04-11 Ranbaxy Lab Ltd derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
WO2005100325A1 (en) * 2004-04-14 2005-10-27 Astrazeneca Ab Aryl glycinamide derivatives and their use as nk1 antagonists and serotonin reuptake inhibithors
EP1948164A1 (en) 2005-10-19 2008-07-30 Ranbaxy Laboratories, Ltd. Pharmaceutical compositions of muscarinic receptor antagonists
EP1889612A3 (en) * 2006-07-24 2008-03-19 Jan Kees Piet Bruinstroop Method for controlling micturition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1269556A (fr) * 1956-05-14 1961-08-18 Upjohn Co Procédé de préparation de nu-mono-substituées-alpha-(tertio-aminoalcoyl)-alphaphénylacétamides
US4783537A (en) * 1985-11-13 1988-11-08 Pennwalt Corporation α-(aminoalkyl)-arylacetic acid derivatives
JPH0783006B2 (ja) * 1987-12-23 1995-09-06 株式会社半導体エネルギー研究所 薄膜加工方法
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia

Also Published As

Publication number Publication date
AU658316B2 (en) 1995-04-06
JPH0692921A (ja) 1994-04-05
ATE143943T1 (de) 1996-10-15
EP0581167A1 (en) 1994-02-02
JP3429338B2 (ja) 2003-07-22
CA2101310C (en) 2001-07-03
HU215846B (hu) 1999-04-28
TW271435B (es) 1996-03-01
EP0581167B1 (en) 1996-10-09
KR100295027B1 (ko) 2001-09-17
HU9302090D0 (en) 1993-10-28
HUT64944A (en) 1994-03-28
AU4216993A (en) 1994-02-03
DE69305276D1 (de) 1996-11-14
CA2101310A1 (en) 1994-01-28
US5439919A (en) 1995-08-08
KR940005534A (ko) 1994-03-21
DE69305276T2 (de) 1997-04-30

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