CA2101310C - Novel arylglycinamide derivatives and preparative processes therefor - Google Patents
Novel arylglycinamide derivatives and preparative processes therefor Download PDFInfo
- Publication number
- CA2101310C CA2101310C CA002101310A CA2101310A CA2101310C CA 2101310 C CA2101310 C CA 2101310C CA 002101310 A CA002101310 A CA 002101310A CA 2101310 A CA2101310 A CA 2101310A CA 2101310 C CA2101310 C CA 2101310C
- Authority
- CA
- Canada
- Prior art keywords
- group
- carbon atoms
- lower alkyl
- denotes
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPHEI4-219699 | 1992-07-27 | ||
JP21969992 | 1992-07-27 | ||
JP19688293A JP3429338B2 (ja) | 1992-07-27 | 1993-07-14 | 新規なアリールグリシンアミド誘導体及びその製造法 |
JPHEI5-196882 | 1993-07-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2101310A1 CA2101310A1 (en) | 1994-01-28 |
CA2101310C true CA2101310C (en) | 2001-07-03 |
Family
ID=26510045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002101310A Expired - Fee Related CA2101310C (en) | 1992-07-27 | 1993-07-26 | Novel arylglycinamide derivatives and preparative processes therefor |
Country Status (11)
Country | Link |
---|---|
US (1) | US5439919A (es) |
EP (1) | EP0581167B1 (es) |
JP (1) | JP3429338B2 (es) |
KR (1) | KR100295027B1 (es) |
AT (1) | ATE143943T1 (es) |
AU (1) | AU658316B2 (es) |
CA (1) | CA2101310C (es) |
DE (1) | DE69305276T2 (es) |
ES (1) | ES2093332T3 (es) |
HU (1) | HU215846B (es) |
TW (1) | TW271435B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5706027A (en) * | 1985-12-18 | 1998-01-06 | Spacetec Imc Corporation | Force and torque converter for use in a computer input device |
CA2179574A1 (en) * | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
CA2242571C (en) * | 1996-08-06 | 2006-05-16 | Taisho Pharmaceutical Co., Ltd. | Amino compounds and angiotensin iv receptor agonists |
US6620438B2 (en) | 2001-03-08 | 2003-09-16 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics and NK1-receptor antagonists |
DE10111058A1 (de) * | 2001-03-08 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und NK¶1¶-Rezeptor-Antagonisten |
DE10143009A1 (de) * | 2001-09-03 | 2003-03-20 | Molecular And Clinical Drug Re | Präparat zur Behandlung weiblicher Inkontinenz |
CN1692401B (zh) * | 2002-04-12 | 2011-11-16 | 雷斯里·R·奥柏梅尔 | 多轴输入转换器装置和摇杆 |
MXPA05000434A (es) | 2002-07-08 | 2005-04-19 | Ranbaxy Lab Ltd | Derivados de hexano [3.1.0] azabiciclo 3,6-disustituido utiles como antagonistas de receptor muscarinico. |
US7265147B2 (en) | 2002-07-31 | 2007-09-04 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
AU2002321711A1 (en) | 2002-08-09 | 2004-02-25 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist |
DE60231341D1 (de) | 2002-08-23 | 2009-04-09 | Ranbaxy Lab Ltd | Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten |
EP1572648B1 (en) | 2002-12-10 | 2008-07-09 | Ranbaxy Laboratories, Ltd. | 3,6-disubstituted azabicyclo (3.1.0)-hexane derivatives as muscarinic receptor antagonists |
WO2004056767A1 (en) | 2002-12-23 | 2004-07-08 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
US7501443B2 (en) | 2002-12-23 | 2009-03-10 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
BR0318242A (pt) | 2003-04-10 | 2006-04-04 | Ranbaxy Lab Ltd | derivados de azabiciclo hexano substituìdo como antagonistas de receptores muscarìnicos e processo para sua preparação |
EP1615887A1 (en) | 2003-04-10 | 2006-01-18 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
CN100436414C (zh) | 2003-04-11 | 2008-11-26 | 兰贝克赛实验室有限公司 | 作为毒蕈碱受体拮抗剂的氮杂双环衍生物 |
WO2005100325A1 (en) * | 2004-04-14 | 2005-10-27 | Astrazeneca Ab | Aryl glycinamide derivatives and their use as nk1 antagonists and serotonin reuptake inhibithors |
US20090221664A1 (en) | 2005-10-19 | 2009-09-03 | Abhijit Ray | Pharmaceutical compositions of muscarinic receptor antagonists |
EP1889612A3 (en) * | 2006-07-24 | 2008-03-19 | Jan Kees Piet Bruinstroop | Method for controlling micturition |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1269556A (fr) * | 1956-05-14 | 1961-08-18 | Upjohn Co | Procédé de préparation de nu-mono-substituées-alpha-(tertio-aminoalcoyl)-alphaphénylacétamides |
US4783537A (en) * | 1985-11-13 | 1988-11-08 | Pennwalt Corporation | α-(aminoalkyl)-arylacetic acid derivatives |
JPH0783006B2 (ja) * | 1987-12-23 | 1995-09-06 | 株式会社半導体エネルギー研究所 | 薄膜加工方法 |
US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
-
1993
- 1993-07-14 JP JP19688293A patent/JP3429338B2/ja not_active Expired - Fee Related
- 1993-07-20 DE DE69305276T patent/DE69305276T2/de not_active Expired - Fee Related
- 1993-07-20 EP EP93111592A patent/EP0581167B1/en not_active Expired - Lifetime
- 1993-07-20 US US08/093,854 patent/US5439919A/en not_active Expired - Fee Related
- 1993-07-20 ES ES93111592T patent/ES2093332T3/es not_active Expired - Lifetime
- 1993-07-20 AT AT93111592T patent/ATE143943T1/de not_active IP Right Cessation
- 1993-07-20 HU HUP9302090A patent/HU215846B/hu not_active IP Right Cessation
- 1993-07-23 AU AU42169/93A patent/AU658316B2/en not_active Ceased
- 1993-07-23 TW TW082105885A patent/TW271435B/zh active
- 1993-07-26 CA CA002101310A patent/CA2101310C/en not_active Expired - Fee Related
- 1993-07-26 KR KR1019930014143A patent/KR100295027B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUT64944A (en) | 1994-03-28 |
HU215846B (hu) | 1999-04-28 |
DE69305276D1 (de) | 1996-11-14 |
EP0581167A1 (en) | 1994-02-02 |
DE69305276T2 (de) | 1997-04-30 |
JP3429338B2 (ja) | 2003-07-22 |
ATE143943T1 (de) | 1996-10-15 |
EP0581167B1 (en) | 1996-10-09 |
KR940005534A (ko) | 1994-03-21 |
TW271435B (es) | 1996-03-01 |
US5439919A (en) | 1995-08-08 |
KR100295027B1 (ko) | 2001-09-17 |
ES2093332T3 (es) | 1996-12-16 |
HU9302090D0 (en) | 1993-10-28 |
AU4216993A (en) | 1994-02-03 |
AU658316B2 (en) | 1995-04-06 |
CA2101310A1 (en) | 1994-01-28 |
JPH0692921A (ja) | 1994-04-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2101310C (en) | Novel arylglycinamide derivatives and preparative processes therefor | |
US9771376B2 (en) | N-substituted benzamides and methods of use thereof | |
EP1192122B1 (fr) | Derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant | |
WO2003084943A9 (fr) | Derives de terphenyle, leur preparation, les compositions pharmaceutiques en contenant | |
AU603137B2 (en) | Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same | |
US20040106611A1 (en) | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase | |
MXPA03006597A (es) | Derivados de glutaramida sustituida con n-fenpropilciclopentilo como inhibidores de nep para fsad. | |
WO1996014297A1 (fr) | Nouveaux derives de lactame | |
JP2009007258A (ja) | Pai−1産生抑制作用を有する3−アニリノ−2−シクロアルケノン誘導体 | |
EP1572648B1 (en) | 3,6-disubstituted azabicyclo (3.1.0)-hexane derivatives as muscarinic receptor antagonists | |
IE47721B1 (en) | New derivatives of 1-azabicyclo(2.2.2)octane,process for their preparation,their use as medicaments and intermediates for their preparation | |
SK9812002A3 (en) | Substituted aminomethyl-phenyl-cyclohexane derivatives | |
EP1196403B1 (fr) | N-aralkyl amines cycliques antipsychotiques | |
FR2876691A1 (fr) | Derives de pyridine, leur preparation, leur application en therapeutique | |
CA2217479C (en) | Derivatives of phenoxyethylamine having a high affinity for 5-ht1a receptor, their preparation procedure, their application as medications and pharmaceutical compounds containing them | |
AU660832B2 (en) | Tetrahydronaphthalene derivatives, their preparation and their application in therapy | |
US6433174B1 (en) | Process for producing novel naphthyridine derivatives | |
FR2555580A1 (fr) | Nouveaux composes azabicycliques, procede pour les preparer et medicaments les contenant | |
EP0406111B1 (fr) | Arylamines et hétéroarylamines substituées, leur procédé de préparation et composition pharmaceutique les contenant | |
JP6176615B2 (ja) | 新規化合物及び抗がん剤 | |
CN1042728C (zh) | 芳基甘氨酰胺衍生物及其制备方法 | |
WO1994006773A1 (en) | Azepine derivative, production thereof, and use thereof | |
Dixon | Part I: the synthesis of C3 heteroadamantyl cannabinoids Part II: the synthesis of C3 heteroaroyl cannabinoids | |
UA76491C2 (en) | Cyclohexyl sulphones | |
JPS59515B2 (ja) | N− ( 1− アダマンチルメチル ) − ピペラジンノ セイゾウホウ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |