JP3088461B2 - 新規医薬組成物 - Google Patents

新規医薬組成物

Info

Publication number
JP3088461B2
JP3088461B2 JP06503950A JP50395094A JP3088461B2 JP 3088461 B2 JP3088461 B2 JP 3088461B2 JP 06503950 A JP06503950 A JP 06503950A JP 50395094 A JP50395094 A JP 50395094A JP 3088461 B2 JP3088461 B2 JP 3088461B2
Authority
JP
Japan
Prior art keywords
galactopyranosyloxy
integer
formula
represented
galactosylceramide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP06503950A
Other languages
English (en)
Japanese (ja)
Inventor
靖彦 肥塚
浩司 蒲谷
一宏 元木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Brewery Co Ltd
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Application granted granted Critical
Publication of JP3088461B2 publication Critical patent/JP3088461B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP06503950A 1992-07-16 1993-07-15 新規医薬組成物 Expired - Fee Related JP3088461B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP21201592 1992-07-16
JP5-85219 1993-03-19
JP4-212015 1993-03-19
JP8521993 1993-03-19
PCT/JP1993/000984 WO1994002168A1 (fr) 1992-07-16 1993-07-15 Nouvelle composition medicamenteuse

Publications (1)

Publication Number Publication Date
JP3088461B2 true JP3088461B2 (ja) 2000-09-18

Family

ID=26426239

Family Applications (1)

Application Number Title Priority Date Filing Date
JP06503950A Expired - Fee Related JP3088461B2 (ja) 1992-07-16 1993-07-15 新規医薬組成物

Country Status (12)

Country Link
US (3) US5767092A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0650732B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3088461B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100277621B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1084623C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE200224T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU684466B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2140013C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69330096T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI950166A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW261533B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1994002168A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
ATE191916T1 (de) * 1992-10-22 2000-05-15 Kirin Brewery Neues sphingolglycolipid und verwendung davon
CA2160566C (en) * 1993-04-15 2004-07-13 Tatsuo Higa Novel sphingoglycolipids and uses thereof
US6026815A (en) * 1996-10-10 2000-02-22 Gholam A. Peyman Radiopaque liquid as radiation blocking agent
JP2002226377A (ja) * 1996-10-14 2002-08-14 Kirin Brewery Co Ltd 配糖体含有末梢血幹細胞増加剤
TW555562B (en) * 1996-12-27 2003-10-01 Kirin Brewery Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof
JP3382957B2 (ja) * 1997-02-05 2003-03-04 麒麟麦酒株式会社 スフィンゴ糖脂質含有凍結乾燥組成物およびその製造法
US6417167B1 (en) 1997-02-05 2002-07-09 Kirin Beer Kabushiki Kaisha Lyophilized compositions containing shingoglycolipid and process for preparing them
CN1222293C (zh) 1997-04-10 2005-10-12 麒麟麦酒株式会社 含有α－糖基神经酰胺的NKT细胞活化剂
TW575420B (en) * 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
AU2001268564A1 (en) * 2000-06-22 2002-01-02 The Brigham And Women's Hospital, Inc. Alpha-glycosylceramides for treating bacterial and fungal infections
CA2453880A1 (en) * 2001-07-25 2003-02-06 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
JP4064346B2 (ja) * 2001-08-16 2008-03-19 アスビオファーマ株式会社 新規な糖脂質及びこれを有効成分とする自己免疫疾患治療薬
US8443383B2 (en) * 2002-05-03 2013-05-14 Time Warner Cable Enterprises Llc Use of messages in program signal streams by set-top terminals
WO2004026318A1 (ja) * 2002-09-20 2004-04-01 Kirin Beer Kabushiki Kaisha α-グリコシルセラミドを有効成分とするＣ型肝炎ウイルス抑制剤
US7645873B2 (en) * 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
EP1611147A4 (en) * 2003-03-20 2007-10-17 Univ Brigham Young 6 "amino-6" -DEOXYGALACTOSYLCERAMIDE
US7309015B2 (en) * 2004-07-14 2007-12-18 Scanbuy, Inc. Mobile device gateway providing access to instant information
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
CN101080487B (zh) 2004-10-07 2012-11-14 阿戈斯治疗公司 成熟树突细胞组合物及其培养方法
US7923013B2 (en) * 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
US7534434B2 (en) * 2004-12-28 2009-05-19 The Rockefeller University Glycolipids and analogues thereof as antigens for NK T cells
BRPI0607299A2 (pt) 2005-01-28 2009-08-25 Univ Brigham Young ativação de glicolipìdio bacteriano de células nkt restritas a cd1d
US20090036658A1 (en) * 2005-03-04 2009-02-05 The Regents Of The University Of California Highly efficient synthesis of alpha-O-galactosyl ceramides
EP1905766A1 (en) * 2005-07-01 2008-04-02 Japan as represented by President of National Center of Neurology and Psychiatry Glycolipid derivative and therapeutic agent comprising the same as active ingredient
EP1776963A1 (en) 2005-10-19 2007-04-25 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
US20070231344A1 (en) * 2005-10-28 2007-10-04 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
AU2007234753B2 (en) 2006-04-07 2013-02-21 Brigham Young University Modified -galactosyl ceramides for staining and stimulating Natural Killer T cells
BRPI0713330A2 (pt) * 2006-06-30 2012-04-17 The Scripps Research Institute adjuvantes e métodos de uso
US8263576B2 (en) * 2006-08-15 2012-09-11 Mayo Foundation For Medical Education And Research Non-natural sphingolipid analogs and uses thereof
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
EP2483287B1 (en) * 2007-10-12 2016-03-16 Luigi Panza Analogues of glycolipids useful as immunoadjuvants
EP2058011A1 (en) * 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
WO2009101475A2 (en) * 2007-12-05 2009-08-20 Wittycell S.A.S. Compositions for and methods of enhancing the immune response to antigens
JP5809560B2 (ja) * 2008-10-08 2015-11-11 アビヴァックス インフルエンザに対して使用するためのワクチン組成物
KR101688547B1 (ko) 2009-02-16 2016-12-21 세레니스 쎄라퓨틱스 홀딩 에스에이 아포리포단백질 ａ-ｉ 모방체
NZ621551A (en) 2010-10-18 2015-09-25 Cerenis Therapeutics Holding Sa Compounds, compositions and methods useful for cholesterol mobilisation
ES2675582T3 (es) 2010-12-02 2018-07-11 Riken Inmunoterapia utilizando células alo-NKT, células para inmunoterapia en las que la cadena alfa del gen del receptor de las células T (TCR) ha sido redistribuida a V alfa-J alfa uniforme, y banco de células NKT derivadas de dichas células
WO2013119857A1 (en) 2012-02-07 2013-08-15 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
CA2882553A1 (en) 2012-08-22 2013-08-22 Regimmune Corporation Preparation for preventing or treating type i diabetes
WO2014059220A1 (en) 2012-10-12 2014-04-17 The Brigham And Women's Hospital, Inc. Glycosphingolipids and methods of use thereof
AU2013339046A1 (en) 2012-11-05 2015-05-21 Regimmune Corporation Immune-tolerance inducer
JP6599233B2 (ja) 2012-11-21 2019-10-30 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） 急性移植片対宿主病のリスクを決定する方法
JP2015205835A (ja) * 2014-04-21 2015-11-19 国立大学法人福井大学 中性子線障害防護剤
AU2021392472A1 (en) 2020-12-04 2023-07-06 Osaka University Cd1d-ligand-compound-containing liposome preparation having improved pharmacokinetics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2774194B2 (ja) 1991-08-29 1998-07-09 麒麟麦酒株式会社 新規スフィンゴ糖脂質およびその使用
JP3068910B2 (ja) 1990-11-08 2000-07-24 麒麟麦酒株式会社 新規スフィンゴ糖脂質、その製造法および使用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622666A (en) * 1968-03-04 1971-11-23 Stanley Drug Products Inc Methods for treating bacterial infections with phrenosin
US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4806466A (en) * 1981-10-29 1989-02-21 The Regents Of The University Of California Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes
IT1168205B (it) * 1983-07-21 1987-05-20 Wellcome Italia Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
JPS6157594A (ja) * 1984-08-30 1986-03-24 Suntory Ltd ガラクトスフインゴ脂質及びその製造法
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
ZA866023B (en) * 1985-08-13 1987-03-25 Solco Basel Ag New process for the preparation of sphingosine derivatives
JPH07116209B2 (ja) * 1986-04-11 1995-12-13 メクト株式会社 シアロシルセラミド類及びその製造方法
US4990603A (en) * 1986-07-04 1991-02-05 Mect Corporation Sialic acid derivatives and process therefor
US4937232A (en) * 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
JPS6495A (en) * 1986-12-19 1989-01-05 Tosoh Corp Alpha-glycosyl ceramide derivative
US5026557A (en) * 1987-09-09 1991-06-25 The Liposome Company, Inc. Adjuvant composition
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
US5041441A (en) * 1988-04-04 1991-08-20 The Regents Of The University Of Michigan Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
JP2631532B2 (ja) * 1988-10-14 1997-07-16 富士写真フイルム株式会社 熱転写受像材料
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
IT1235162B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisosfingolipidi
US5028715A (en) * 1989-02-06 1991-07-02 Southwest Research Institute Radioprotective agents and their method of manufacture
US5210073A (en) * 1989-09-29 1993-05-11 Ajinomoto Co., Inc. Method for treating cancer therapy radiation damage or arteriosclerosis using human adf
JPH06145189A (ja) * 1991-01-23 1994-05-24 Kitasato Inst:The スフィンゴ糖脂質
JP3034650B2 (ja) * 1991-06-19 2000-04-17 株式会社ジーシー 歯質用接着剤
CA2160566C (en) * 1993-04-15 2004-07-13 Tatsuo Higa Novel sphingoglycolipids and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3068910B2 (ja) 1990-11-08 2000-07-24 麒麟麦酒株式会社 新規スフィンゴ糖脂質、その製造法および使用
JP2774194B2 (ja) 1991-08-29 1998-07-09 麒麟麦酒株式会社 新規スフィンゴ糖脂質およびその使用

Also Published As

Publication number Publication date
EP0650732A1 (en) 1995-05-03
US6017892A (en) 2000-01-25
DE69330096D1 (de) 2001-05-10
US5767092A (en) 1998-06-16
FI950166A0 (fi) 1995-01-13
CN1088093A (zh) 1994-06-22
US6071884A (en) 2000-06-06
TW261533B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1995-11-01
KR950702431A (ko) 1995-07-29
KR100277621B1 (ko) 2001-02-01
AU684466B2 (en) 1997-12-18
AU4583593A (en) 1994-02-14
CA2140013C (en) 2002-08-27
HK1009937A1 (en) 1999-09-17
EP0650732A4 (en) 1998-04-01
CA2140013A1 (en) 1994-02-03
CN1084623C (zh) 2002-05-15
FI950166A7 (fi) 1995-01-31
ATE200224T1 (de) 2001-04-15
DE69330096T2 (de) 2001-10-18
EP0650732B1 (en) 2001-04-04
WO1994002168A1 (fr) 1994-02-03

Similar Documents

Publication Publication Date Title
JP3088461B2 (ja) 新規医薬組成物
JP2774194B2 (ja) 新規スフィンゴ糖脂質およびその使用
US5936076A (en) αgalactosylceramide derivatives
EP0666268B1 (en) Novel sphingoglycolipid and use thereof
EP0694558B1 (en) Novel sphingoglycolipid and use thereof
AU707779B2 (en) Substituted liposaccharides useful in the treatment and prevention of endotoxemia
EP1437358B1 (en) Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
EP1172107B1 (en) Drugs containing sulfopyranosylacylglycerol derivatives
JP3771446B2 (ja) 新規な免疫抑制剤
CA1329591C (en) Pharmaceutical products and new lactosyl compounds and the preparation thereof
CN110857285B (zh) 取代吡唑类化合物、其制备方法、药物组合物及用途
JPH03173896A (ja) 新規オキセタノシン誘導体、その塩およびその用途
HK1009937B (en) Novel medicinal composition
HUT74449A (en) Medicinal compositions contg. alpha-galactosyl-ceramides
HK40023498B (en) A substituted pyrazoles compound, its method of preparation, pharmaceutical composition and the usage
JP4841560B2 (ja) 乾癬の処置のためのアミグダリン類似体の使用
HK40023498A (en) A substituted pyrazoles compound, its method of preparation, pharmaceutical composition and the usage
EP1405640B1 (en) Novel immunosuppressants
CN114805454A (zh) α-半乳糖神经酰胺类化合物及其制备方法和用途
HK1009967B (en) Novel sphingoglycolipid and use thereof
JPH07258283A (ja) リボフラノース誘導体およびそれを含む放射線障害防護剤

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20070714

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080714

Year of fee payment: 8

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080714

Year of fee payment: 8

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313111

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080714

Year of fee payment: 8

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090714

Year of fee payment: 9

LAPS Cancellation because of no payment of annual fees