JP3063943B2 - 血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法 - Google Patents

血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法

Info

Publication number
JP3063943B2
JP3063943B2 JP5004389A JP438993A JP3063943B2 JP 3063943 B2 JP3063943 B2 JP 3063943B2 JP 5004389 A JP5004389 A JP 5004389A JP 438993 A JP438993 A JP 438993A JP 3063943 B2 JP3063943 B2 JP 3063943B2
Authority
JP
Japan
Prior art keywords
group
compound
represented
formula
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP5004389A
Other languages
English (en)
Japanese (ja)
Other versions
JPH069679A (ja
Inventor
慶一 味戸
健一 栗原
恒雄 石塚
哲郎 原
孝之 臼井
聖至 柴原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP5004389A priority Critical patent/JP3063943B2/ja
Priority to US08/022,165 priority patent/US5444174A/en
Priority to EP98105234A priority patent/EP0852231A3/de
Priority to DE69321632T priority patent/DE69321632T2/de
Priority to EP93103095A priority patent/EP0560147B1/de
Priority to ES93103095T priority patent/ES2124267T3/es
Publication of JPH069679A publication Critical patent/JPH069679A/ja
Application granted granted Critical
Publication of JP3063943B2 publication Critical patent/JP3063943B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP5004389A 1992-02-26 1993-01-13 血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法 Expired - Fee Related JP3063943B2 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP5004389A JP3063943B2 (ja) 1992-02-26 1993-01-13 血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法
US08/022,165 US5444174A (en) 1992-02-26 1993-02-25 16-membered macrolide derivative having sustained antibacterial activity in plasma, synthesis intermediate thereof and process for producing the same
EP98105234A EP0852231A3 (de) 1992-02-26 1993-02-26 16-gliedrige Makrolidderivate mit in Plasma verzögerter antibakterieller Wirkung, Zwischenprodukt dafür und Verfahren zur Herstellung
DE69321632T DE69321632T2 (de) 1992-02-26 1993-02-26 16-Gliedrige Makrolidderivate mit in Plasma verzögerter anti-bakterieller Wirkung, Zwischenprodukt dafür und Verfahren zur Herstellung
EP93103095A EP0560147B1 (de) 1992-02-26 1993-02-26 16-Gliedrige Makrolidderivate mit in Plasma verzögerter anti-bakterieller Wirkung, Zwischenprodukt dafür und Verfahren zur Herstellung
ES93103095T ES2124267T3 (es) 1992-02-26 1993-02-26 Derivados macrolidas de 16 eslabones con una actividad antibacteriana prolongada en el plasma, intermediarios de sintesis y procedimiento de preparacion.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3901392 1992-02-26
JP4-39013 1992-02-26
JP5004389A JP3063943B2 (ja) 1992-02-26 1993-01-13 血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法

Publications (2)

Publication Number Publication Date
JPH069679A JPH069679A (ja) 1994-01-18
JP3063943B2 true JP3063943B2 (ja) 2000-07-12

Family

ID=26338141

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5004389A Expired - Fee Related JP3063943B2 (ja) 1992-02-26 1993-01-13 血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法

Country Status (5)

Country Link
US (1) US5444174A (de)
EP (2) EP0560147B1 (de)
JP (1) JP3063943B2 (de)
DE (1) DE69321632T2 (de)
ES (1) ES2124267T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0595303B1 (de) * 1992-10-29 1999-04-14 Meiji Seika Kaisha Ltd. 16-Gliederige Makrolid-Derivate und Verfahren zu deren Herstellung
CA2127578A1 (en) * 1993-07-08 1995-01-09 Keiichi Ajito 16-membered macrolide derivatives and process for producing the same
AU2066799A (en) * 1998-01-14 1999-08-02 Glaxo Group Limited Polyketides and their synthesis
HRP980496B1 (en) * 1998-09-10 2007-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. New thilozine hydroxy derivatives and a process for the preparation thereof
US6680299B2 (en) * 2001-07-27 2004-01-20 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
US6576615B2 (en) * 2001-11-08 2003-06-10 Enanta Pharmaceuticals, Inc. 4′-O-substituted tylosin analogs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255564A (en) * 1977-03-09 1981-03-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Novel macrolactone derivatives and process of producing them
JPS6058998A (ja) * 1983-09-09 1985-04-05 Kyowa Hakko Kogyo Co Ltd ４″−ｏ−置換スピラマイシン１
IL75908A0 (en) * 1984-08-31 1985-12-31 Abbott Lab Macrolide alkylation process
JPS62234093A (ja) * 1986-04-02 1987-10-14 Sanraku Inc 含錫１６員環マクロライド系化合物
WO1988008426A1 (en) * 1987-04-29 1988-11-03 Schering Corporation 3-o-glycosyl 16-membered macrolide antibacterials and related derivatives

Also Published As

Publication number Publication date
EP0852231A3 (de) 1998-07-29
US5444174A (en) 1995-08-22
DE69321632T2 (de) 1999-07-08
JPH069679A (ja) 1994-01-18
EP0852231A2 (de) 1998-07-08
EP0560147B1 (de) 1998-10-21
DE69321632D1 (de) 1998-11-26
ES2124267T3 (es) 1999-02-01
EP0560147A1 (de) 1993-09-15

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