JP2736066B2 - ３―アシロキシ―ビシクロ〔３．３．０〕オクタン―７―オン―２―カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割 - Google Patents

３―アシロキシ―ビシクロ〔３．３．０〕オクタン―７―オン―２―カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割

Info

Publication number
JP2736066B2
JP2736066B2 JP62506737A JP50673787A JP2736066B2 JP 2736066 B2 JP2736066 B2 JP 2736066B2 JP 62506737 A JP62506737 A JP 62506737A JP 50673787 A JP50673787 A JP 50673787A JP 2736066 B2 JP2736066 B2 JP 2736066B2
Authority
JP
Japan
Prior art keywords
bicyclo
atoms
cis
straight
lipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62506737A
Other languages
English (en)
Japanese (ja)
Other versions
JPH01501202A (ja
Inventor
ペツツオルト，カール
ダール，ヘルムート
スクバラ，ヴエルナー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHEERINGU AG
Original Assignee
SHEERINGU AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHEERINGU AG filed Critical SHEERINGU AG
Publication of JPH01501202A publication Critical patent/JPH01501202A/ja
Application granted granted Critical
Publication of JP2736066B2 publication Critical patent/JP2736066B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP62506737A 1986-11-13 1987-11-12 ３―アシロキシ―ビシクロ〔３．３．０〕オクタン―７―オン―２―カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割 Expired - Lifetime JP2736066B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3638758.4 1986-11-13
DE19863638758 DE3638758A1 (de) 1986-11-13 1986-11-13 Racematspaltung von 3-acyloxy-bicyclo(3.3.0)octan-7-on-2- carbonsaeureestern durch stereospezifische enzymatische oder mikrobiologische acylat-hydrolyse

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP9187953A Division JP2786437B2 (ja) 1986-11-13 1997-07-14 ３−アシロキシ−ビシクロ［３，３，０］オクタン−７−オン−２−カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割

Publications (2)

Publication Number Publication Date
JPH01501202A JPH01501202A (ja) 1989-04-27
JP2736066B2 true JP2736066B2 (ja) 1998-04-02

Family

ID=6313858

Family Applications (2)

Application Number Title Priority Date Filing Date
JP62506737A Expired - Lifetime JP2736066B2 (ja) 1986-11-13 1987-11-12 ３―アシロキシ―ビシクロ〔３．３．０〕オクタン―７―オン―２―カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割
JP9187953A Expired - Lifetime JP2786437B2 (ja) 1986-11-13 1997-07-14 ３−アシロキシ−ビシクロ［３，３，０］オクタン−７−オン−２−カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP9187953A Expired - Lifetime JP2786437B2 (ja) 1986-11-13 1997-07-14 ３−アシロキシ−ビシクロ［３，３，０］オクタン−７−オン−２−カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割

Country Status (20)

Country Link
US (1) US4894336A (https=)
EP (1) EP0271432B1 (https=)
JP (2) JP2736066B2 (https=)
AT (1) ATE80664T1 (https=)
AU (1) AU613328B2 (https=)
BG (1) BG48099A3 (https=)
CA (1) CA1301100C (https=)
CS (1) CS268542B2 (https=)
DD (1) DD264233A5 (https=)
DE (2) DE3638758A1 (https=)
DK (1) DK174394B1 (https=)
ES (1) ES2044969T3 (https=)
FI (1) FI92499C (https=)
GR (1) GR3006013T3 (https=)
HU (1) HU202596B (https=)
IE (1) IE61662B1 (https=)
NO (1) NO172903C (https=)
RU (1) RU1788968C (https=)
WO (1) WO1988003567A1 (https=)
ZA (1) ZA878542B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
DE3638760A1 (de) * 1986-11-13 1988-05-26 Schering Ag Verfahren zur herstellung von optisch aktiven bicyclo(3.3.0)octandioncarbonsaeureestern
JPH01257484A (ja) * 1987-12-14 1989-10-13 Idemitsu Kosan Co Ltd 光学活性な二級アルコールの製造方法
EP0604525A1 (en) * 1991-09-20 1994-07-06 Zeneca Limited Enzymatic production of optical isomers of tetrahydropyran-2-ones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644068A (en) * 1983-08-19 1987-02-17 Sagami Chemical Research Center Bicyclo[3.3.0]octenylaldehyde derivatives
US4681951A (en) * 1983-12-27 1987-07-21 Sagami Chemical Research Center Bicyclo(3.3.0)octene derivatives
JPS61280294A (ja) * 1985-06-04 1986-12-10 Nisshin Flour Milling Co Ltd 光学活性カルバサイクリン中間体の製造方法

Also Published As

Publication number Publication date
ES2044969T3 (es) 1994-01-16
BG48099A3 (bg) 1990-11-15
EP0271432B1 (de) 1992-09-16
EP0271432A3 (en) 1988-06-22
NO172903B (no) 1993-06-14
NO883109L (no) 1988-07-12
AU613328B2 (en) 1991-08-01
WO1988003567A1 (en) 1988-05-19
JPH1057095A (ja) 1998-03-03
US4894336A (en) 1990-01-16
JP2786437B2 (ja) 1998-08-13
ZA878542B (en) 1988-10-26
FI92499C (fi) 1994-11-25
JPH01501202A (ja) 1989-04-27
DK389188A (da) 1988-07-12
FI92499B (fi) 1994-08-15
CS815187A2 (en) 1989-06-13
GR3006013T3 (https=) 1993-06-21
NO883109D0 (no) 1988-07-12
IE61662B1 (en) 1994-11-16
NO172903C (no) 1993-09-22
CS268542B2 (en) 1990-03-14
DE3781775D1 (de) 1992-10-22
FI883316A7 (fi) 1988-07-12
IE873046L (en) 1988-05-13
HU202596B (en) 1991-03-28
ATE80664T1 (de) 1992-10-15
RU1788968C (ru) 1993-01-15
DE3638758A1 (de) 1988-05-26
DD264233A5 (de) 1989-01-25
AU8236487A (en) 1988-06-01
FI883316A0 (fi) 1988-07-12
EP0271432A2 (de) 1988-06-15
CA1301100C (en) 1992-05-19
DK389188D0 (da) 1988-07-12
DK174394B1 (da) 2003-01-27
HUT47157A (en) 1989-01-30

Similar Documents

Publication Publication Date Title
Drueckhammer et al. Chemoenzymic synthesis of chiral furan derivatives: useful building blocks for optically active structures
US4882451A (en) Optically active compounds and process for producing thereof
JP2736066B2 (ja) ３―アシロキシ―ビシクロ〔３．３．０〕オクタン―７―オン―２―カルボン酸エステルの立体特異性の酵素または微生物的アシレート加水分解によるラセミ分割
US5773240A (en) Optically active α-substituted carboxylic acid derivatives and method for producing the same
AU670088B2 (en) Enzymatic process to separate racemic mixtures of delta valerolactones
US5102793A (en) Stereospecific keto reduction of bicyclooctandione-carboxylic acid esters by microorganisms
JP3129775B2 (ja) 光学活性な２級アルコール化合物の製造方法
US5248609A (en) Racemic separation of 7α-acyloxy-6β-hydroxymethyl-2-oxabicyclo[3.]-octan-3-ones by stereospecific enzymatic acylate hydrolysis
HU202289B (en) Process for racemate-splitting 7-alpha-acyloxy-6-beta-(hydroxy-methyl)-2-oxabicyclo(3.3.0)octan-3-one derivatives with stereospecific enzymatic acylate-hydrolysis
JP2838527B2 (ja) 光学活性化合物の製造法
JP3217301B2 (ja) 光学活性グリシド酸エステル及び光学活性グリセリン酸エステルの製造方法
JP3007461B2 (ja) 光学活性２−シクロヘキセニル酢酸及びそのエステルの製造方法
KR840001055B1 (ko) Ml-236b 유도체의 제조방법
HU202290B (en) Process for producing optically active bicyclo(3.3.0)oktanedion-carboxylic acid esters
PT99836A (pt) Processo para a preparacao de novos compostos intermedios monoacilados utilizados na preparacao de antagonistas dos receptores do tromboxano
JPH1087613A (ja) 光学活性アジリン類およびその製造法
WO1990012798A2 (en) Cyclohexadienediols and their use
JPH08336396A (ja) 光学活性エンド−３−ヒドロキシジシクロペンタジエンの製造法

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term