ZA878542B - Resolution of racemates of 3-acyloxy-bicyclo-(3.3.0)-octane-7-one-2-carboxylic acid esters by stereo specific enzymatic or microbiological acylate hydrolysis - Google Patents

Resolution of racemates of 3-acyloxy-bicyclo-(3.3.0)-octane-7-one-2-carboxylic acid esters by stereo specific enzymatic or microbiological acylate hydrolysis

Info

Publication number
ZA878542B
ZA878542B ZA878542A ZA878542A ZA878542B ZA 878542 B ZA878542 B ZA 878542B ZA 878542 A ZA878542 A ZA 878542A ZA 878542 A ZA878542 A ZA 878542A ZA 878542 B ZA878542 B ZA 878542B
Authority
ZA
South Africa
Prior art keywords
atoms
bicyclo
straight
acylate
pct
Prior art date
Application number
ZA878542A
Other languages
English (en)
Inventor
Karl Petzoldt
Petzoldt Karl
Helmut Dahl
Dahl Helmut
Werner Skuballa
Skuballa Werner
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA878542B publication Critical patent/ZA878542B/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/081,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/24Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26Ketones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA878542A 1986-11-13 1987-11-13 Resolution of racemates of 3-acyloxy-bicyclo-(3.3.0)-octane-7-one-2-carboxylic acid esters by stereo specific enzymatic or microbiological acylate hydrolysis ZA878542B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863638758 DE3638758A1 (de) 1986-11-13 1986-11-13 Racematspaltung von 3-acyloxy-bicyclo(3.3.0)octan-7-on-2- carbonsaeureestern durch stereospezifische enzymatische oder mikrobiologische acylat-hydrolyse

Publications (1)

Publication Number Publication Date
ZA878542B true ZA878542B (en) 1988-10-26

Family

ID=6313858

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA878542A ZA878542B (en) 1986-11-13 1987-11-13 Resolution of racemates of 3-acyloxy-bicyclo-(3.3.0)-octane-7-one-2-carboxylic acid esters by stereo specific enzymatic or microbiological acylate hydrolysis

Country Status (20)

Country Link
US (1) US4894336A (xx)
EP (1) EP0271432B1 (xx)
JP (2) JP2736066B2 (xx)
AT (1) ATE80664T1 (xx)
AU (1) AU613328B2 (xx)
BG (1) BG48099A3 (xx)
CA (1) CA1301100C (xx)
CS (1) CS268542B2 (xx)
DD (1) DD264233A5 (xx)
DE (2) DE3638758A1 (xx)
DK (1) DK174394B1 (xx)
ES (1) ES2044969T3 (xx)
FI (1) FI92499C (xx)
GR (1) GR3006013T3 (xx)
HU (1) HU202596B (xx)
IE (1) IE61662B1 (xx)
NO (1) NO172903C (xx)
RU (1) RU1788968C (xx)
WO (1) WO1988003567A1 (xx)
ZA (1) ZA878542B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
DE3638760A1 (de) * 1986-11-13 1988-05-26 Schering Ag Verfahren zur herstellung von optisch aktiven bicyclo(3.3.0)octandioncarbonsaeureestern
JPH01257484A (ja) * 1987-12-14 1989-10-13 Idemitsu Kosan Co Ltd 光学活性な二級アルコールの製造方法
CA2118795A1 (en) * 1991-09-20 1993-04-01 John Crosby Pyranones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644068A (en) * 1983-08-19 1987-02-17 Sagami Chemical Research Center Bicyclo[3.3.0]octenylaldehyde derivatives
US4681951A (en) * 1983-12-27 1987-07-21 Sagami Chemical Research Center Bicyclo(3.3.0)octene derivatives
JPS61280294A (ja) * 1985-06-04 1986-12-10 Nisshin Flour Milling Co Ltd 光学活性カルバサイクリン中間体の製造方法

Also Published As

Publication number Publication date
ES2044969T3 (es) 1994-01-16
FI92499B (fi) 1994-08-15
EP0271432B1 (de) 1992-09-16
CS815187A2 (en) 1989-06-13
AU8236487A (en) 1988-06-01
IE873046L (en) 1988-05-13
FI92499C (fi) 1994-11-25
NO172903C (no) 1993-09-22
IE61662B1 (en) 1994-11-16
FI883316A (fi) 1988-07-12
WO1988003567A1 (fr) 1988-05-19
NO883109D0 (no) 1988-07-12
JP2786437B2 (ja) 1998-08-13
CA1301100C (en) 1992-05-19
GR3006013T3 (xx) 1993-06-21
FI883316A0 (fi) 1988-07-12
HU202596B (en) 1991-03-28
CS268542B2 (en) 1990-03-14
ATE80664T1 (de) 1992-10-15
DK389188A (da) 1988-07-12
EP0271432A2 (de) 1988-06-15
DK389188D0 (da) 1988-07-12
JP2736066B2 (ja) 1998-04-02
US4894336A (en) 1990-01-16
NO883109L (no) 1988-07-12
DD264233A5 (de) 1989-01-25
AU613328B2 (en) 1991-08-01
DK174394B1 (da) 2003-01-27
JPH1057095A (ja) 1998-03-03
NO172903B (no) 1993-06-14
HUT47157A (en) 1989-01-30
BG48099A3 (en) 1990-11-15
RU1788968C (ru) 1993-01-15
DE3638758A1 (de) 1988-05-26
EP0271432A3 (en) 1988-06-22
DE3781775D1 (de) 1992-10-22
JPH01501202A (ja) 1989-04-27

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